Morphogenetic control of zebrafish cardiac looping by Bmp signaling

Autores
Lombardo, Veronica Andrea; Heise, Melina; Moghtadaei, Motahareh; Bornhorst, Dorothee; Männer, Jörg; Abdelilah Seyfried, Salim
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cardiac looping is an essential and highly conserved morphogenetic process that places the different regions of the developing vertebrate heart tube into proximity of their final topographical positions. Highresolution 4D live imaging of mosaically labelled cardiomyocytes reveals distinct cardiomyocyte behaviors that contribute to the deformation of the entire heart tube. Cardiomyocytes acquire a conical cell shape, which is most pronounced at the superior wall of the atrioventricular canal and contributes to S-shaped bending. Torsional deformation close to the outflow tract contributes to a torque-like winding of the entire heart tube between its two poles. Anisotropic growth of cardiomyocytes based on their positions reinforces Sshaping of the heart. During cardiac looping, bone morphogenetic protein pathway signaling is strongest at the future superior wall of the atrioventricular canal. Upon pharmacological or genetic inhibition of bone morphogenetic protein signaling, myocardial cells at the superior wall of the atrioventricular canal maintain cuboidal cell shapes and S-shaped bending is impaired. This description of cellular rearrangements and cardiac looping regulation may also be relevant for understanding the etiology of human congenital heart defects.
Fil: Lombardo, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario. Centro de Estudios Interdisciplinarios; Argentina
Fil: Heise, Melina. Institute of Molecular Biology; Alemania
Fil: Moghtadaei, Motahareh. Institute of Molecular Biology; Alemania. Universitat Potsdam; Alemania
Fil: Bornhorst, Dorothee. Institute of Molecular Biology; Alemania. Universitat Potsdam; Alemania
Fil: Männer, Jörg. Göttingen University; Alemania
Fil: Abdelilah Seyfried, Salim. Institute of Molecular Biology; Alemania. Universitat Potsdam; Alemania
Materia
BMP
CARDIAC LOOPING
HEMODYNAMICS
WNT
ZEBRAFISH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/151835
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Morphogenetic control of zebrafish cardiac looping by Bmp signalingLombardo, Veronica AndreaHeise, MelinaMoghtadaei, MotaharehBornhorst, DorotheeMänner, JörgAbdelilah Seyfried, SalimBMPCARDIAC LOOPINGHEMODYNAMICSWNTZEBRAFISHhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cardiac looping is an essential and highly conserved morphogenetic process that places the different regions of the developing vertebrate heart tube into proximity of their final topographical positions. Highresolution 4D live imaging of mosaically labelled cardiomyocytes reveals distinct cardiomyocyte behaviors that contribute to the deformation of the entire heart tube. Cardiomyocytes acquire a conical cell shape, which is most pronounced at the superior wall of the atrioventricular canal and contributes to S-shaped bending. Torsional deformation close to the outflow tract contributes to a torque-like winding of the entire heart tube between its two poles. Anisotropic growth of cardiomyocytes based on their positions reinforces Sshaping of the heart. During cardiac looping, bone morphogenetic protein pathway signaling is strongest at the future superior wall of the atrioventricular canal. Upon pharmacological or genetic inhibition of bone morphogenetic protein signaling, myocardial cells at the superior wall of the atrioventricular canal maintain cuboidal cell shapes and S-shaped bending is impaired. This description of cellular rearrangements and cardiac looping regulation may also be relevant for understanding the etiology of human congenital heart defects.Fil: Lombardo, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario. Centro de Estudios Interdisciplinarios; ArgentinaFil: Heise, Melina. Institute of Molecular Biology; AlemaniaFil: Moghtadaei, Motahareh. Institute of Molecular Biology; Alemania. Universitat Potsdam; AlemaniaFil: Bornhorst, Dorothee. Institute of Molecular Biology; Alemania. Universitat Potsdam; AlemaniaFil: Männer, Jörg. Göttingen University; AlemaniaFil: Abdelilah Seyfried, Salim. Institute of Molecular Biology; Alemania. Universitat Potsdam; AlemaniaCompany of Biologists2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/151835Lombardo, Veronica Andrea; Heise, Melina; Moghtadaei, Motahareh; Bornhorst, Dorothee; Männer, Jörg; et al.; Morphogenetic control of zebrafish cardiac looping by Bmp signaling; Company of Biologists; Development; 146; 22; 11-2019; 1-130950-1991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/lookup/doi/10.1242/dev.180091info:eu-repo/semantics/altIdentifier/doi/10.1242/dev.180091info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:21Zoai:ri.conicet.gov.ar:11336/151835instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:21.972CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Morphogenetic control of zebrafish cardiac looping by Bmp signaling
title Morphogenetic control of zebrafish cardiac looping by Bmp signaling
spellingShingle Morphogenetic control of zebrafish cardiac looping by Bmp signaling
Lombardo, Veronica Andrea
BMP
CARDIAC LOOPING
HEMODYNAMICS
WNT
ZEBRAFISH
title_short Morphogenetic control of zebrafish cardiac looping by Bmp signaling
title_full Morphogenetic control of zebrafish cardiac looping by Bmp signaling
title_fullStr Morphogenetic control of zebrafish cardiac looping by Bmp signaling
title_full_unstemmed Morphogenetic control of zebrafish cardiac looping by Bmp signaling
title_sort Morphogenetic control of zebrafish cardiac looping by Bmp signaling
dc.creator.none.fl_str_mv Lombardo, Veronica Andrea
Heise, Melina
Moghtadaei, Motahareh
Bornhorst, Dorothee
Männer, Jörg
Abdelilah Seyfried, Salim
author Lombardo, Veronica Andrea
author_facet Lombardo, Veronica Andrea
Heise, Melina
Moghtadaei, Motahareh
Bornhorst, Dorothee
Männer, Jörg
Abdelilah Seyfried, Salim
author_role author
author2 Heise, Melina
Moghtadaei, Motahareh
Bornhorst, Dorothee
Männer, Jörg
Abdelilah Seyfried, Salim
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BMP
CARDIAC LOOPING
HEMODYNAMICS
WNT
ZEBRAFISH
topic BMP
CARDIAC LOOPING
HEMODYNAMICS
WNT
ZEBRAFISH
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cardiac looping is an essential and highly conserved morphogenetic process that places the different regions of the developing vertebrate heart tube into proximity of their final topographical positions. Highresolution 4D live imaging of mosaically labelled cardiomyocytes reveals distinct cardiomyocyte behaviors that contribute to the deformation of the entire heart tube. Cardiomyocytes acquire a conical cell shape, which is most pronounced at the superior wall of the atrioventricular canal and contributes to S-shaped bending. Torsional deformation close to the outflow tract contributes to a torque-like winding of the entire heart tube between its two poles. Anisotropic growth of cardiomyocytes based on their positions reinforces Sshaping of the heart. During cardiac looping, bone morphogenetic protein pathway signaling is strongest at the future superior wall of the atrioventricular canal. Upon pharmacological or genetic inhibition of bone morphogenetic protein signaling, myocardial cells at the superior wall of the atrioventricular canal maintain cuboidal cell shapes and S-shaped bending is impaired. This description of cellular rearrangements and cardiac looping regulation may also be relevant for understanding the etiology of human congenital heart defects.
Fil: Lombardo, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina. Universidad Nacional de Rosario. Centro de Estudios Interdisciplinarios; Argentina
Fil: Heise, Melina. Institute of Molecular Biology; Alemania
Fil: Moghtadaei, Motahareh. Institute of Molecular Biology; Alemania. Universitat Potsdam; Alemania
Fil: Bornhorst, Dorothee. Institute of Molecular Biology; Alemania. Universitat Potsdam; Alemania
Fil: Männer, Jörg. Göttingen University; Alemania
Fil: Abdelilah Seyfried, Salim. Institute of Molecular Biology; Alemania. Universitat Potsdam; Alemania
description Cardiac looping is an essential and highly conserved morphogenetic process that places the different regions of the developing vertebrate heart tube into proximity of their final topographical positions. Highresolution 4D live imaging of mosaically labelled cardiomyocytes reveals distinct cardiomyocyte behaviors that contribute to the deformation of the entire heart tube. Cardiomyocytes acquire a conical cell shape, which is most pronounced at the superior wall of the atrioventricular canal and contributes to S-shaped bending. Torsional deformation close to the outflow tract contributes to a torque-like winding of the entire heart tube between its two poles. Anisotropic growth of cardiomyocytes based on their positions reinforces Sshaping of the heart. During cardiac looping, bone morphogenetic protein pathway signaling is strongest at the future superior wall of the atrioventricular canal. Upon pharmacological or genetic inhibition of bone morphogenetic protein signaling, myocardial cells at the superior wall of the atrioventricular canal maintain cuboidal cell shapes and S-shaped bending is impaired. This description of cellular rearrangements and cardiac looping regulation may also be relevant for understanding the etiology of human congenital heart defects.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/151835
Lombardo, Veronica Andrea; Heise, Melina; Moghtadaei, Motahareh; Bornhorst, Dorothee; Männer, Jörg; et al.; Morphogenetic control of zebrafish cardiac looping by Bmp signaling; Company of Biologists; Development; 146; 22; 11-2019; 1-13
0950-1991
CONICET Digital
CONICET
url http://hdl.handle.net/11336/151835
identifier_str_mv Lombardo, Veronica Andrea; Heise, Melina; Moghtadaei, Motahareh; Bornhorst, Dorothee; Männer, Jörg; et al.; Morphogenetic control of zebrafish cardiac looping by Bmp signaling; Company of Biologists; Development; 146; 22; 11-2019; 1-13
0950-1991
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/lookup/doi/10.1242/dev.180091
info:eu-repo/semantics/altIdentifier/doi/10.1242/dev.180091
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269219067002880
score 13.13397

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