Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina
- Autores
- Chahla, Rossana; Medina Ruiz, Luis Antonio; Ferre Contreras, Miguel Enrique; Raya, Mario; Herrera, Natalia; Ortega, Eugenia Silvana; Goroso, Daniel Gustavo; Peral, Maria de Los Angeles
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Purpose: The objective of this work is to make an observational study of the usage in moderate or severe state COVID-19 patients of a new therapeutic commercial product obtained after immunization of horses: CoviFab® ELEA F(ab´)2 fragmented equine immunoglobulins anti SARS-CoV2. Methods: Participant centers depend on the Public Health System of Tucumán, Argentina were recruitment. Subjects were assigned to the Moderate Patient Group (MPG) and the Severe Patient Group (SPG), classified according to WHO criteria. In total, n=84 were enrolled for this study. The subjects were divided into MPG and SPG. All participants were evaluated by physical examination and COVID-19 infection was diagnosed with positive RT-PCR. Each subject received two doses of 0.16 ml/kg, according to the subject´s body weight. A generalized linear model with binomial distribution was adjusted for the number of symptoms. Data was analysed using proportion, bivariate and logistic regression. P-value was consideredsignificant at the p<0.05 threshold. Results: Both groups were similar in age, sex, and comorbidities. A higher proportion of patient with medical discharge was observed in MPG (91.4%) vs. SPG (55.3%) (p=0.004). MPG showed 9 times more chance of receiving medical discharge than SPG (9.33 CI=[1.65, 52.81]; p=0.012). Then, the chance to get medical discharge was independent of variables sex,age, and comorbidities. Conclusion: Treatment with Equine Serum in patients with moderate and severe disease of COVID-19 managed to slightly reduce hospitalization time. This treatment improved the clinical state to obtain medical discharge. The bivariate analysis showed 8 times more chance in MGP versus SGP to receive of medical discharge and this chance was independentof the pre-existent comorbidities.
Fil: Chahla, Rossana. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
Fil: Medina Ruiz, Luis Antonio. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
Fil: Ferre Contreras, Miguel Enrique. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
Fil: Raya, Mario. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
Fil: Herrera, Natalia. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
Fil: Ortega, Eugenia Silvana. Provincia de Tucumán. Sistema Provincial de Salud; Argentina
Fil: Goroso, Daniel Gustavo. Mogi das Cruzes University; Brasil
Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Provincia de Tucumán. Sistema Provincial de Salud; Argentina - Materia
-
EQUINE SERUM
COVID-19
MODERATE
SEVERE PATIENT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/217647
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
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Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, ArgentinaChahla, RossanaMedina Ruiz, Luis AntonioFerre Contreras, Miguel EnriqueRaya, MarioHerrera, NataliaOrtega, Eugenia SilvanaGoroso, Daniel GustavoPeral, Maria de Los AngelesEQUINE SERUMCOVID-19MODERATESEVERE PATIENThttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: The objective of this work is to make an observational study of the usage in moderate or severe state COVID-19 patients of a new therapeutic commercial product obtained after immunization of horses: CoviFab® ELEA F(ab´)2 fragmented equine immunoglobulins anti SARS-CoV2. Methods: Participant centers depend on the Public Health System of Tucumán, Argentina were recruitment. Subjects were assigned to the Moderate Patient Group (MPG) and the Severe Patient Group (SPG), classified according to WHO criteria. In total, n=84 were enrolled for this study. The subjects were divided into MPG and SPG. All participants were evaluated by physical examination and COVID-19 infection was diagnosed with positive RT-PCR. Each subject received two doses of 0.16 ml/kg, according to the subject´s body weight. A generalized linear model with binomial distribution was adjusted for the number of symptoms. Data was analysed using proportion, bivariate and logistic regression. P-value was consideredsignificant at the p<0.05 threshold. Results: Both groups were similar in age, sex, and comorbidities. A higher proportion of patient with medical discharge was observed in MPG (91.4%) vs. SPG (55.3%) (p=0.004). MPG showed 9 times more chance of receiving medical discharge than SPG (9.33 CI=[1.65, 52.81]; p=0.012). Then, the chance to get medical discharge was independent of variables sex,age, and comorbidities. Conclusion: Treatment with Equine Serum in patients with moderate and severe disease of COVID-19 managed to slightly reduce hospitalization time. This treatment improved the clinical state to obtain medical discharge. The bivariate analysis showed 8 times more chance in MGP versus SGP to receive of medical discharge and this chance was independentof the pre-existent comorbidities.Fil: Chahla, Rossana. Provincia de Tucumán. Sistema Provincial de Salud; ArgentinaFil: Medina Ruiz, Luis Antonio. Provincia de Tucumán. Sistema Provincial de Salud; ArgentinaFil: Ferre Contreras, Miguel Enrique. Provincia de Tucumán. Sistema Provincial de Salud; ArgentinaFil: Raya, Mario. Provincia de Tucumán. Sistema Provincial de Salud; ArgentinaFil: Herrera, Natalia. Provincia de Tucumán. Sistema Provincial de Salud; ArgentinaFil: Ortega, Eugenia Silvana. Provincia de Tucumán. Sistema Provincial de Salud; ArgentinaFil: Goroso, Daniel Gustavo. Mogi das Cruzes University; BrasilFil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Provincia de Tucumán. Sistema Provincial de Salud; ArgentinaOMICS International2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217647Chahla, Rossana; Medina Ruiz, Luis Antonio; Ferre Contreras, Miguel Enrique; Raya, Mario; Herrera, Natalia; et al.; Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina; OMICS International; Journal of Infectious Diseases & Therapy; 10; S3; 6-2022; 1-52332-0877CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/observational-study-application-of-therapy-with-equine-serum-for-patients-diagnosed-with-covid19-in-tucumaacuten-argentina-119547.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:55Zoai:ri.conicet.gov.ar:11336/217647instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:55.568CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina |
title |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina |
spellingShingle |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina Chahla, Rossana EQUINE SERUM COVID-19 MODERATE SEVERE PATIENT |
title_short |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina |
title_full |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina |
title_fullStr |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina |
title_full_unstemmed |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina |
title_sort |
Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina |
dc.creator.none.fl_str_mv |
Chahla, Rossana Medina Ruiz, Luis Antonio Ferre Contreras, Miguel Enrique Raya, Mario Herrera, Natalia Ortega, Eugenia Silvana Goroso, Daniel Gustavo Peral, Maria de Los Angeles |
author |
Chahla, Rossana |
author_facet |
Chahla, Rossana Medina Ruiz, Luis Antonio Ferre Contreras, Miguel Enrique Raya, Mario Herrera, Natalia Ortega, Eugenia Silvana Goroso, Daniel Gustavo Peral, Maria de Los Angeles |
author_role |
author |
author2 |
Medina Ruiz, Luis Antonio Ferre Contreras, Miguel Enrique Raya, Mario Herrera, Natalia Ortega, Eugenia Silvana Goroso, Daniel Gustavo Peral, Maria de Los Angeles |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
EQUINE SERUM COVID-19 MODERATE SEVERE PATIENT |
topic |
EQUINE SERUM COVID-19 MODERATE SEVERE PATIENT |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Purpose: The objective of this work is to make an observational study of the usage in moderate or severe state COVID-19 patients of a new therapeutic commercial product obtained after immunization of horses: CoviFab® ELEA F(ab´)2 fragmented equine immunoglobulins anti SARS-CoV2. Methods: Participant centers depend on the Public Health System of Tucumán, Argentina were recruitment. Subjects were assigned to the Moderate Patient Group (MPG) and the Severe Patient Group (SPG), classified according to WHO criteria. In total, n=84 were enrolled for this study. The subjects were divided into MPG and SPG. All participants were evaluated by physical examination and COVID-19 infection was diagnosed with positive RT-PCR. Each subject received two doses of 0.16 ml/kg, according to the subject´s body weight. A generalized linear model with binomial distribution was adjusted for the number of symptoms. Data was analysed using proportion, bivariate and logistic regression. P-value was consideredsignificant at the p<0.05 threshold. Results: Both groups were similar in age, sex, and comorbidities. A higher proportion of patient with medical discharge was observed in MPG (91.4%) vs. SPG (55.3%) (p=0.004). MPG showed 9 times more chance of receiving medical discharge than SPG (9.33 CI=[1.65, 52.81]; p=0.012). Then, the chance to get medical discharge was independent of variables sex,age, and comorbidities. Conclusion: Treatment with Equine Serum in patients with moderate and severe disease of COVID-19 managed to slightly reduce hospitalization time. This treatment improved the clinical state to obtain medical discharge. The bivariate analysis showed 8 times more chance in MGP versus SGP to receive of medical discharge and this chance was independentof the pre-existent comorbidities. Fil: Chahla, Rossana. Provincia de Tucumán. Sistema Provincial de Salud; Argentina Fil: Medina Ruiz, Luis Antonio. Provincia de Tucumán. Sistema Provincial de Salud; Argentina Fil: Ferre Contreras, Miguel Enrique. Provincia de Tucumán. Sistema Provincial de Salud; Argentina Fil: Raya, Mario. Provincia de Tucumán. Sistema Provincial de Salud; Argentina Fil: Herrera, Natalia. Provincia de Tucumán. Sistema Provincial de Salud; Argentina Fil: Ortega, Eugenia Silvana. Provincia de Tucumán. Sistema Provincial de Salud; Argentina Fil: Goroso, Daniel Gustavo. Mogi das Cruzes University; Brasil Fil: Peral, Maria de Los Angeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Provincia de Tucumán. Sistema Provincial de Salud; Argentina |
description |
Purpose: The objective of this work is to make an observational study of the usage in moderate or severe state COVID-19 patients of a new therapeutic commercial product obtained after immunization of horses: CoviFab® ELEA F(ab´)2 fragmented equine immunoglobulins anti SARS-CoV2. Methods: Participant centers depend on the Public Health System of Tucumán, Argentina were recruitment. Subjects were assigned to the Moderate Patient Group (MPG) and the Severe Patient Group (SPG), classified according to WHO criteria. In total, n=84 were enrolled for this study. The subjects were divided into MPG and SPG. All participants were evaluated by physical examination and COVID-19 infection was diagnosed with positive RT-PCR. Each subject received two doses of 0.16 ml/kg, according to the subject´s body weight. A generalized linear model with binomial distribution was adjusted for the number of symptoms. Data was analysed using proportion, bivariate and logistic regression. P-value was consideredsignificant at the p<0.05 threshold. Results: Both groups were similar in age, sex, and comorbidities. A higher proportion of patient with medical discharge was observed in MPG (91.4%) vs. SPG (55.3%) (p=0.004). MPG showed 9 times more chance of receiving medical discharge than SPG (9.33 CI=[1.65, 52.81]; p=0.012). Then, the chance to get medical discharge was independent of variables sex,age, and comorbidities. Conclusion: Treatment with Equine Serum in patients with moderate and severe disease of COVID-19 managed to slightly reduce hospitalization time. This treatment improved the clinical state to obtain medical discharge. The bivariate analysis showed 8 times more chance in MGP versus SGP to receive of medical discharge and this chance was independentof the pre-existent comorbidities. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/217647 Chahla, Rossana; Medina Ruiz, Luis Antonio; Ferre Contreras, Miguel Enrique; Raya, Mario; Herrera, Natalia; et al.; Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina; OMICS International; Journal of Infectious Diseases & Therapy; 10; S3; 6-2022; 1-5 2332-0877 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/217647 |
identifier_str_mv |
Chahla, Rossana; Medina Ruiz, Luis Antonio; Ferre Contreras, Miguel Enrique; Raya, Mario; Herrera, Natalia; et al.; Observational Study: Application of Therapy with Equine Serum for Patients Diagnosed with COVID-19 in Tucumán, Argentina; OMICS International; Journal of Infectious Diseases & Therapy; 10; S3; 6-2022; 1-5 2332-0877 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/observational-study-application-of-therapy-with-equine-serum-for-patients-diagnosed-with-covid19-in-tucumaacuten-argentina-119547.html |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
OMICS International |
publisher.none.fl_str_mv |
OMICS International |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613729610629120 |
score |
13.070432 |