Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients

Autores
Farias, Eduardo Francisco; Ranuncolo, Stella Maris; Cresta Morgado, Carlos; Specterman, Sergio; Armanasco, Eduardo; Varela, Mirta; Lastiri, José; Pallotta, María Guadalupe; Bal, Elisa Dora; Puricelli, Lydia Ines
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Matrix metalloproteinases (MMP) have been implicated in tumor invasion and metastasis. We verified, by gelatin zymography, MMP activity in the euglobulin plasma fraction of 82 healthy controls, 66 patients with benign diseases and 149 patients with breast, lung, colon or brain cancer. The euglobulin fractions assayed showed 4 gelatinolytic bands of 62, 92, 120 and 200 kDa. The median (Md) value for 92 kDa-MMP activity was significantly increased in breast (Md 1.34 arbitrary units [AU]/ml plasma, range 0.0–7.2) and lung cancer patients (Md 1.43 AU/ml, range 0.0–3.6) compared with the controls (Md 0.48 AU/ml, range 0.0–1.8). Patients with colon cancer or gliomas presented values of MMP-9 similar to those of the healthy population. Multivariate analysis indicated that plasma MMP-9 activity was not predicted by the known clinicopathological parameters such as age, stage, tumor size, number of positive lymph nodes, histologic grade, histologic type, nuclear grade or mitotic index. Lung cancer patients also presented high values of MMP-9 (Md 1.43, range 0.0–3.6 [n = 26]), without association with tumor stage or histologic type. The levels of 92 kDa-MMP activity in the plasma euglobulin fraction could be a potentially useful tumor marker in breast and lung cancer.
Fil: Farias, Eduardo Francisco. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ranuncolo, Stella Maris. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cresta Morgado, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
Fil: Specterman, Sergio. Hospital Italiano; Argentina
Fil: Armanasco, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
Fil: Varela, Mirta. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lastiri, José. Hospital Italiano; Argentina
Fil: Pallotta, María Guadalupe. Hospital Italiano; Argentina
Fil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Materia
Mmp-9 Plasma Activity
Breast Cancer
Lung Cancer
Euglobulin Plasma Fraction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39139
Acceder
id CONICETDig_5cecf501d284a0a686e725ba431724f3
oai_identifier_str oai:ri.conicet.gov.ar:11336/39139
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patientsFarias, Eduardo FranciscoRanuncolo, Stella MarisCresta Morgado, CarlosSpecterman, SergioArmanasco, EduardoVarela, MirtaLastiri, JoséPallotta, María GuadalupeBal, Elisa DoraPuricelli, Lydia InesMmp-9 Plasma ActivityBreast CancerLung CancerEuglobulin Plasma Fractionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Matrix metalloproteinases (MMP) have been implicated in tumor invasion and metastasis. We verified, by gelatin zymography, MMP activity in the euglobulin plasma fraction of 82 healthy controls, 66 patients with benign diseases and 149 patients with breast, lung, colon or brain cancer. The euglobulin fractions assayed showed 4 gelatinolytic bands of 62, 92, 120 and 200 kDa. The median (Md) value for 92 kDa-MMP activity was significantly increased in breast (Md 1.34 arbitrary units [AU]/ml plasma, range 0.0–7.2) and lung cancer patients (Md 1.43 AU/ml, range 0.0–3.6) compared with the controls (Md 0.48 AU/ml, range 0.0–1.8). Patients with colon cancer or gliomas presented values of MMP-9 similar to those of the healthy population. Multivariate analysis indicated that plasma MMP-9 activity was not predicted by the known clinicopathological parameters such as age, stage, tumor size, number of positive lymph nodes, histologic grade, histologic type, nuclear grade or mitotic index. Lung cancer patients also presented high values of MMP-9 (Md 1.43, range 0.0–3.6 [n = 26]), without association with tumor stage or histologic type. The levels of 92 kDa-MMP activity in the plasma euglobulin fraction could be a potentially useful tumor marker in breast and lung cancer.Fil: Farias, Eduardo Francisco. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ranuncolo, Stella Maris. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cresta Morgado, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; ArgentinaFil: Specterman, Sergio. Hospital Italiano; ArgentinaFil: Armanasco, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; ArgentinaFil: Varela, Mirta. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lastiri, José. Hospital Italiano; ArgentinaFil: Pallotta, María Guadalupe. Hospital Italiano; ArgentinaFil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; ArgentinaJohn Wiley & Sons Inc2000-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39139Farias, Eduardo Francisco; Ranuncolo, Stella Maris; Cresta Morgado, Carlos; Specterman, Sergio; Armanasco, Eduardo; et al.; Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients; John Wiley & Sons Inc; International Journal of Cancer. Journal International du Cancer; 89; 4; 7-2000; 389-3940020-7136CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/1097-0215(20000720)89:4<389::AID-IJC12>3.0.CO;2-Jinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/1097-0215(20000720)89:4<389::AID-IJC12>3.0.CO;2-J/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:54Zoai:ri.conicet.gov.ar:11336/39139instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:54.645CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
title Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
spellingShingle Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
Farias, Eduardo Francisco
Mmp-9 Plasma Activity
Breast Cancer
Lung Cancer
Euglobulin Plasma Fraction
title_short Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
title_full Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
title_fullStr Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
title_full_unstemmed Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
title_sort Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients
dc.creator.none.fl_str_mv Farias, Eduardo Francisco
Ranuncolo, Stella Maris
Cresta Morgado, Carlos
Specterman, Sergio
Armanasco, Eduardo
Varela, Mirta
Lastiri, José
Pallotta, María Guadalupe
Bal, Elisa Dora
Puricelli, Lydia Ines
author Farias, Eduardo Francisco
author_facet Farias, Eduardo Francisco
Ranuncolo, Stella Maris
Cresta Morgado, Carlos
Specterman, Sergio
Armanasco, Eduardo
Varela, Mirta
Lastiri, José
Pallotta, María Guadalupe
Bal, Elisa Dora
Puricelli, Lydia Ines
author_role author
author2 Ranuncolo, Stella Maris
Cresta Morgado, Carlos
Specterman, Sergio
Armanasco, Eduardo
Varela, Mirta
Lastiri, José
Pallotta, María Guadalupe
Bal, Elisa Dora
Puricelli, Lydia Ines
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mmp-9 Plasma Activity
Breast Cancer
Lung Cancer
Euglobulin Plasma Fraction
topic Mmp-9 Plasma Activity
Breast Cancer
Lung Cancer
Euglobulin Plasma Fraction
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Matrix metalloproteinases (MMP) have been implicated in tumor invasion and metastasis. We verified, by gelatin zymography, MMP activity in the euglobulin plasma fraction of 82 healthy controls, 66 patients with benign diseases and 149 patients with breast, lung, colon or brain cancer. The euglobulin fractions assayed showed 4 gelatinolytic bands of 62, 92, 120 and 200 kDa. The median (Md) value for 92 kDa-MMP activity was significantly increased in breast (Md 1.34 arbitrary units [AU]/ml plasma, range 0.0–7.2) and lung cancer patients (Md 1.43 AU/ml, range 0.0–3.6) compared with the controls (Md 0.48 AU/ml, range 0.0–1.8). Patients with colon cancer or gliomas presented values of MMP-9 similar to those of the healthy population. Multivariate analysis indicated that plasma MMP-9 activity was not predicted by the known clinicopathological parameters such as age, stage, tumor size, number of positive lymph nodes, histologic grade, histologic type, nuclear grade or mitotic index. Lung cancer patients also presented high values of MMP-9 (Md 1.43, range 0.0–3.6 [n = 26]), without association with tumor stage or histologic type. The levels of 92 kDa-MMP activity in the plasma euglobulin fraction could be a potentially useful tumor marker in breast and lung cancer.
Fil: Farias, Eduardo Francisco. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ranuncolo, Stella Maris. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cresta Morgado, Carlos. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
Fil: Specterman, Sergio. Hospital Italiano; Argentina
Fil: Armanasco, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología ; Argentina
Fil: Varela, Mirta. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lastiri, José. Hospital Italiano; Argentina
Fil: Pallotta, María Guadalupe. Hospital Italiano; Argentina
Fil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Puricelli, Lydia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
description Matrix metalloproteinases (MMP) have been implicated in tumor invasion and metastasis. We verified, by gelatin zymography, MMP activity in the euglobulin plasma fraction of 82 healthy controls, 66 patients with benign diseases and 149 patients with breast, lung, colon or brain cancer. The euglobulin fractions assayed showed 4 gelatinolytic bands of 62, 92, 120 and 200 kDa. The median (Md) value for 92 kDa-MMP activity was significantly increased in breast (Md 1.34 arbitrary units [AU]/ml plasma, range 0.0–7.2) and lung cancer patients (Md 1.43 AU/ml, range 0.0–3.6) compared with the controls (Md 0.48 AU/ml, range 0.0–1.8). Patients with colon cancer or gliomas presented values of MMP-9 similar to those of the healthy population. Multivariate analysis indicated that plasma MMP-9 activity was not predicted by the known clinicopathological parameters such as age, stage, tumor size, number of positive lymph nodes, histologic grade, histologic type, nuclear grade or mitotic index. Lung cancer patients also presented high values of MMP-9 (Md 1.43, range 0.0–3.6 [n = 26]), without association with tumor stage or histologic type. The levels of 92 kDa-MMP activity in the plasma euglobulin fraction could be a potentially useful tumor marker in breast and lung cancer.
publishDate 2000
dc.date.none.fl_str_mv 2000-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39139
Farias, Eduardo Francisco; Ranuncolo, Stella Maris; Cresta Morgado, Carlos; Specterman, Sergio; Armanasco, Eduardo; et al.; Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients; John Wiley & Sons Inc; International Journal of Cancer. Journal International du Cancer; 89; 4; 7-2000; 389-394
0020-7136
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39139
identifier_str_mv Farias, Eduardo Francisco; Ranuncolo, Stella Maris; Cresta Morgado, Carlos; Specterman, Sergio; Armanasco, Eduardo; et al.; Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients; John Wiley & Sons Inc; International Journal of Cancer. Journal International du Cancer; 89; 4; 7-2000; 389-394
0020-7136
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/1097-0215(20000720)89:4<389::AID-IJC12>3.0.CO;2-J
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/1097-0215(20000720)89:4<389::AID-IJC12>3.0.CO;2-J/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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