The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
- Autores
- Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection.
Fil: Roberts, Mark L.. Imperial College London; Reino Unido
Fil: Buchanan, Katherine L.. Deakin University; Australia
Fil: Evans, Matthew R.. University of Exeter; Reino Unido
Fil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Satterlee,Daniel G.. State University of Louisiana; Estados Unidos - Materia
-
CORTICOSTERONE
IMMUNITY
JAPANESE QUAIL
PHA
SRBC
STRESS
TESTOSTERONE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/53232
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spelling |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone responseRoberts, Mark L.Buchanan, Katherine L.Evans, Matthew R.Marin, Raul HectorSatterlee,Daniel G.CORTICOSTERONEIMMUNITYJAPANESE QUAILPHASRBCSTRESSTESTOSTERONEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection.Fil: Roberts, Mark L.. Imperial College London; Reino UnidoFil: Buchanan, Katherine L.. Deakin University; AustraliaFil: Evans, Matthew R.. University of Exeter; Reino UnidoFil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Satterlee,Daniel G.. State University of Louisiana; Estados UnidosCompany of Biologists2009-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53232Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.; The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response; Company of Biologists; Journal of Experimental Biology; 212; 19; 10-2009; 3125-31310022-09491477-9145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/content/212/19/3125info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.030726info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:29Zoai:ri.conicet.gov.ar:11336/53232instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:30.076CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response |
title |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response |
spellingShingle |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response Roberts, Mark L. CORTICOSTERONE IMMUNITY JAPANESE QUAIL PHA SRBC STRESS TESTOSTERONE |
title_short |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response |
title_full |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response |
title_fullStr |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response |
title_full_unstemmed |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response |
title_sort |
The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response |
dc.creator.none.fl_str_mv |
Roberts, Mark L. Buchanan, Katherine L. Evans, Matthew R. Marin, Raul Hector Satterlee,Daniel G. |
author |
Roberts, Mark L. |
author_facet |
Roberts, Mark L. Buchanan, Katherine L. Evans, Matthew R. Marin, Raul Hector Satterlee,Daniel G. |
author_role |
author |
author2 |
Buchanan, Katherine L. Evans, Matthew R. Marin, Raul Hector Satterlee,Daniel G. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
CORTICOSTERONE IMMUNITY JAPANESE QUAIL PHA SRBC STRESS TESTOSTERONE |
topic |
CORTICOSTERONE IMMUNITY JAPANESE QUAIL PHA SRBC STRESS TESTOSTERONE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection. Fil: Roberts, Mark L.. Imperial College London; Reino Unido Fil: Buchanan, Katherine L.. Deakin University; Australia Fil: Evans, Matthew R.. University of Exeter; Reino Unido Fil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina Fil: Satterlee,Daniel G.. State University of Louisiana; Estados Unidos |
description |
The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/53232 Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.; The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response; Company of Biologists; Journal of Experimental Biology; 212; 19; 10-2009; 3125-3131 0022-0949 1477-9145 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/53232 |
identifier_str_mv |
Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.; The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response; Company of Biologists; Journal of Experimental Biology; 212; 19; 10-2009; 3125-3131 0022-0949 1477-9145 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/content/212/19/3125 info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.030726 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Company of Biologists |
publisher.none.fl_str_mv |
Company of Biologists |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613029493211136 |
score |
13.070432 |