The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response

Autores
Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection.
Fil: Roberts, Mark L.. Imperial College London; Reino Unido
Fil: Buchanan, Katherine L.. Deakin University; Australia
Fil: Evans, Matthew R.. University of Exeter; Reino Unido
Fil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Satterlee,Daniel G.. State University of Louisiana; Estados Unidos
Materia
CORTICOSTERONE
IMMUNITY
JAPANESE QUAIL
PHA
SRBC
STRESS
TESTOSTERONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53232

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network_name_str CONICET Digital (CONICET)
spelling The effects of testosterone on immune function in quail selected for divergent plasma corticosterone responseRoberts, Mark L.Buchanan, Katherine L.Evans, Matthew R.Marin, Raul HectorSatterlee,Daniel G.CORTICOSTERONEIMMUNITYJAPANESE QUAILPHASRBCSTRESSTESTOSTERONEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection.Fil: Roberts, Mark L.. Imperial College London; Reino UnidoFil: Buchanan, Katherine L.. Deakin University; AustraliaFil: Evans, Matthew R.. University of Exeter; Reino UnidoFil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Satterlee,Daniel G.. State University of Louisiana; Estados UnidosCompany of Biologists2009-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53232Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.; The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response; Company of Biologists; Journal of Experimental Biology; 212; 19; 10-2009; 3125-31310022-09491477-9145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/content/212/19/3125info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.030726info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:29Zoai:ri.conicet.gov.ar:11336/53232instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:30.076CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
title The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
spellingShingle The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
Roberts, Mark L.
CORTICOSTERONE
IMMUNITY
JAPANESE QUAIL
PHA
SRBC
STRESS
TESTOSTERONE
title_short The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
title_full The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
title_fullStr The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
title_full_unstemmed The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
title_sort The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response
dc.creator.none.fl_str_mv Roberts, Mark L.
Buchanan, Katherine L.
Evans, Matthew R.
Marin, Raul Hector
Satterlee,Daniel G.
author Roberts, Mark L.
author_facet Roberts, Mark L.
Buchanan, Katherine L.
Evans, Matthew R.
Marin, Raul Hector
Satterlee,Daniel G.
author_role author
author2 Buchanan, Katherine L.
Evans, Matthew R.
Marin, Raul Hector
Satterlee,Daniel G.
author2_role author
author
author
author
dc.subject.none.fl_str_mv CORTICOSTERONE
IMMUNITY
JAPANESE QUAIL
PHA
SRBC
STRESS
TESTOSTERONE
topic CORTICOSTERONE
IMMUNITY
JAPANESE QUAIL
PHA
SRBC
STRESS
TESTOSTERONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection.
Fil: Roberts, Mark L.. Imperial College London; Reino Unido
Fil: Buchanan, Katherine L.. Deakin University; Australia
Fil: Evans, Matthew R.. University of Exeter; Reino Unido
Fil: Marin, Raul Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Satterlee,Daniel G.. State University of Louisiana; Estados Unidos
description The immunocompetence handicap hypothesis (ICHH) suggests that the male sex hormone testosterone has a dual effect; it controls the development and expression of male sexually selected signals, and it suppresses the immune system. Therefore only high quality males are able to fully express secondary sexual traits because only they can tolerate the immunosuppressive qualities of testosterone. A modified version of the ICHH suggests that testosterone causes immunosuppression indirectly by increasing the stress hormone corticosterone (CORT). Lines of Japanese quail (Coturnix japónica) selected for divergent responses in levels of plasma CORT were used to test these hypotheses. Within each CORT response line (as well as in a control stock) we manipulated levels of testosterone in castrated quail by treatment with zero (sham), low or high testosterone implants, before testing the birds' humoral immunity and phytohaemagglutinin (PHA)-induced immune response, as well as body condition. The PHA-induced response was not significantly affected by CORT selected line, testosterone treatment or their interaction. There was, however, a significant effect of CORT line on humoral immunity in that the control birds exhibited the greatest antibody production, but there was no significant effect of testosterone manipulation on humoral immunity. The males in the sham implant treatment group had significantly greater mass than the males in the high testosterone group, suggesting a negative effect of high testosterone on general body condition. We discuss these results in the context of current hypotheses in the field of sexual selection.
publishDate 2009
dc.date.none.fl_str_mv 2009-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53232
Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.; The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response; Company of Biologists; Journal of Experimental Biology; 212; 19; 10-2009; 3125-3131
0022-0949
1477-9145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53232
identifier_str_mv Roberts, Mark L.; Buchanan, Katherine L.; Evans, Matthew R.; Marin, Raul Hector; Satterlee,Daniel G.; The effects of testosterone on immune function in quail selected for divergent plasma corticosterone response; Company of Biologists; Journal of Experimental Biology; 212; 19; 10-2009; 3125-3131
0022-0949
1477-9145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/content/212/19/3125
info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.030726
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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