Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties

Autores
Kloster, Gianina Andrea; Rivero, Guadalupe; Ballarre, Josefina; Herrera Seitz, Karina; Ceré, Silvia; Abraham, Gustavo Abel
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Metallic stainless steel bone implants are widely used due to their excellentmechanical properties, low cost, and ease of fabrication. Nanofibrous compositepolymers have been proposed as coatings to promote biocompatibility andosseointegration, thanks to their biomimetic morphology that resembles theextracellular matrix. However, critical practical issues are often overlookedin the literature. For instance, applying coatings to implants with differentshapes presents a significant technological challenge, as does evaluating viablesterilization procedures for hybrid devices containing electrospun polymers. Inaddition, infections pose a risk in any surgical procedure and can lead to implantfailure, there is a need for antimicrobial prevention during surgery as well as inthe short term afterward. In this work, we propose a new and straightforwardmethod for manufacturing nanofibrous composite coatings directly on thincylindrical-shaped metallic implants. Poly(ε-caprolactone) (PCL) nanofiberscontaining bioactive glass microparticles were electrospun onto stainless steelwires and then post-treated using two different strategies to achieve bothhydrophilicity and surface disinfection. To address antimicrobial properties,amoxicillin-loaded Eudragit®E nanofibers were co-electrospun to impart pHselective release behavior in event of a potential infection. The resultingcomposite hybrid coatings were characterized morphologically, physically,chemically, and electrochemically. The antibacterial behavior was evaluated atdifferent media, confirming the release of the antibiotic in the pH range whereinfection is likely to occur. The impact of this study lies in its potential tosignificantly enhance the safety and efficacy of orthopedic implants by offeringa novel, adaptable solution to combat infection. By integrating a pH-responsivedrug delivery system with antimicrobial coatings, this approach not only providesa preventive measure during and after surgery but also addresses the growingissue of antibiotic resistance by targeting specific infection conditions.
Fil: Kloster, Gianina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Rivero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Herrera Seitz, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
ELECTROSPINNING
ORTHOPEDIC IMPLANTS
ANTIBACTERIAL BEHAVIOR
BIOGLASS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/263364
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant propertiesKloster, Gianina AndreaRivero, GuadalupeBallarre, JosefinaHerrera Seitz, KarinaCeré, SilviaAbraham, Gustavo AbelELECTROSPINNINGORTHOPEDIC IMPLANTSANTIBACTERIAL BEHAVIORBIOGLASShttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Metallic stainless steel bone implants are widely used due to their excellentmechanical properties, low cost, and ease of fabrication. Nanofibrous compositepolymers have been proposed as coatings to promote biocompatibility andosseointegration, thanks to their biomimetic morphology that resembles theextracellular matrix. However, critical practical issues are often overlookedin the literature. For instance, applying coatings to implants with differentshapes presents a significant technological challenge, as does evaluating viablesterilization procedures for hybrid devices containing electrospun polymers. Inaddition, infections pose a risk in any surgical procedure and can lead to implantfailure, there is a need for antimicrobial prevention during surgery as well as inthe short term afterward. In this work, we propose a new and straightforwardmethod for manufacturing nanofibrous composite coatings directly on thincylindrical-shaped metallic implants. Poly(ε-caprolactone) (PCL) nanofiberscontaining bioactive glass microparticles were electrospun onto stainless steelwires and then post-treated using two different strategies to achieve bothhydrophilicity and surface disinfection. To address antimicrobial properties,amoxicillin-loaded Eudragit®E nanofibers were co-electrospun to impart pHselective release behavior in event of a potential infection. The resultingcomposite hybrid coatings were characterized morphologically, physically,chemically, and electrochemically. The antibacterial behavior was evaluated atdifferent media, confirming the release of the antibiotic in the pH range whereinfection is likely to occur. The impact of this study lies in its potential tosignificantly enhance the safety and efficacy of orthopedic implants by offeringa novel, adaptable solution to combat infection. By integrating a pH-responsivedrug delivery system with antimicrobial coatings, this approach not only providesa preventive measure during and after surgery but also addresses the growingissue of antibiotic resistance by targeting specific infection conditions.Fil: Kloster, Gianina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Rivero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Herrera Seitz, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFrontiers Media2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/263364Kloster, Gianina Andrea; Rivero, Guadalupe; Ballarre, Josefina; Herrera Seitz, Karina; Ceré, Silvia; et al.; Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties; Frontiers Media; Frontiers in Materials; 11; 9-2024; 1-142296-8016CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmats.2024.1484465/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmats.2024.1484465info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:06Zoai:ri.conicet.gov.ar:11336/263364instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:07.028CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
title Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
spellingShingle Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
Kloster, Gianina Andrea
ELECTROSPINNING
ORTHOPEDIC IMPLANTS
ANTIBACTERIAL BEHAVIOR
BIOGLASS
title_short Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
title_full Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
title_fullStr Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
title_full_unstemmed Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
title_sort Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties
dc.creator.none.fl_str_mv Kloster, Gianina Andrea
Rivero, Guadalupe
Ballarre, Josefina
Herrera Seitz, Karina
Ceré, Silvia
Abraham, Gustavo Abel
author Kloster, Gianina Andrea
author_facet Kloster, Gianina Andrea
Rivero, Guadalupe
Ballarre, Josefina
Herrera Seitz, Karina
Ceré, Silvia
Abraham, Gustavo Abel
author_role author
author2 Rivero, Guadalupe
Ballarre, Josefina
Herrera Seitz, Karina
Ceré, Silvia
Abraham, Gustavo Abel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ELECTROSPINNING
ORTHOPEDIC IMPLANTS
ANTIBACTERIAL BEHAVIOR
BIOGLASS
topic ELECTROSPINNING
ORTHOPEDIC IMPLANTS
ANTIBACTERIAL BEHAVIOR
BIOGLASS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Metallic stainless steel bone implants are widely used due to their excellentmechanical properties, low cost, and ease of fabrication. Nanofibrous compositepolymers have been proposed as coatings to promote biocompatibility andosseointegration, thanks to their biomimetic morphology that resembles theextracellular matrix. However, critical practical issues are often overlookedin the literature. For instance, applying coatings to implants with differentshapes presents a significant technological challenge, as does evaluating viablesterilization procedures for hybrid devices containing electrospun polymers. Inaddition, infections pose a risk in any surgical procedure and can lead to implantfailure, there is a need for antimicrobial prevention during surgery as well as inthe short term afterward. In this work, we propose a new and straightforwardmethod for manufacturing nanofibrous composite coatings directly on thincylindrical-shaped metallic implants. Poly(ε-caprolactone) (PCL) nanofiberscontaining bioactive glass microparticles were electrospun onto stainless steelwires and then post-treated using two different strategies to achieve bothhydrophilicity and surface disinfection. To address antimicrobial properties,amoxicillin-loaded Eudragit®E nanofibers were co-electrospun to impart pHselective release behavior in event of a potential infection. The resultingcomposite hybrid coatings were characterized morphologically, physically,chemically, and electrochemically. The antibacterial behavior was evaluated atdifferent media, confirming the release of the antibiotic in the pH range whereinfection is likely to occur. The impact of this study lies in its potential tosignificantly enhance the safety and efficacy of orthopedic implants by offeringa novel, adaptable solution to combat infection. By integrating a pH-responsivedrug delivery system with antimicrobial coatings, this approach not only providesa preventive measure during and after surgery but also addresses the growingissue of antibiotic resistance by targeting specific infection conditions.
Fil: Kloster, Gianina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Rivero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Herrera Seitz, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description Metallic stainless steel bone implants are widely used due to their excellentmechanical properties, low cost, and ease of fabrication. Nanofibrous compositepolymers have been proposed as coatings to promote biocompatibility andosseointegration, thanks to their biomimetic morphology that resembles theextracellular matrix. However, critical practical issues are often overlookedin the literature. For instance, applying coatings to implants with differentshapes presents a significant technological challenge, as does evaluating viablesterilization procedures for hybrid devices containing electrospun polymers. Inaddition, infections pose a risk in any surgical procedure and can lead to implantfailure, there is a need for antimicrobial prevention during surgery as well as inthe short term afterward. In this work, we propose a new and straightforwardmethod for manufacturing nanofibrous composite coatings directly on thincylindrical-shaped metallic implants. Poly(ε-caprolactone) (PCL) nanofiberscontaining bioactive glass microparticles were electrospun onto stainless steelwires and then post-treated using two different strategies to achieve bothhydrophilicity and surface disinfection. To address antimicrobial properties,amoxicillin-loaded Eudragit®E nanofibers were co-electrospun to impart pHselective release behavior in event of a potential infection. The resultingcomposite hybrid coatings were characterized morphologically, physically,chemically, and electrochemically. The antibacterial behavior was evaluated atdifferent media, confirming the release of the antibiotic in the pH range whereinfection is likely to occur. The impact of this study lies in its potential tosignificantly enhance the safety and efficacy of orthopedic implants by offeringa novel, adaptable solution to combat infection. By integrating a pH-responsivedrug delivery system with antimicrobial coatings, this approach not only providesa preventive measure during and after surgery but also addresses the growingissue of antibiotic resistance by targeting specific infection conditions.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/263364
Kloster, Gianina Andrea; Rivero, Guadalupe; Ballarre, Josefina; Herrera Seitz, Karina; Ceré, Silvia; et al.; Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties; Frontiers Media; Frontiers in Materials; 11; 9-2024; 1-14
2296-8016
CONICET Digital
CONICET
url http://hdl.handle.net/11336/263364
identifier_str_mv Kloster, Gianina Andrea; Rivero, Guadalupe; Ballarre, Josefina; Herrera Seitz, Karina; Ceré, Silvia; et al.; Innovative pH-triggered antibacterial nanofibrous coatings for enhanced metallic implant properties; Frontiers Media; Frontiers in Materials; 11; 9-2024; 1-14
2296-8016
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmats.2024.1484465/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmats.2024.1484465
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
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dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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