Methylation deficiency disrupts biological rhythms from bacteria to humans

Autores
Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; Yamano, Mayu; Versteven, Marijke; Grünewald, Ellen; Cargill, Samantha J.; Tamai, T. Katherine; Xu, Yao; Jabbur, Maria Luísa; Kojima, Rika; Lamberti, Melisa Luciana; Yoshioka Kobayashi, Kumiko; Whitmore, David; Tammam, Stephanie; Howell, P. Lynne; Kageyama, Ryoichiro; Matsuo, Takuya; Stanewsky, Ralf; Golombek, Diego Andrés; Johnson, Carl Hirschie; Kakeya, Hideaki; Van Ooijen, Gerben; Okamura, Hitoshi
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.
Fil: Fustin, Jean Michel. Kyoto University; Japón. University of Manchester; Reino Unido
Fil: Ye, Shiqi. Kyoto University; Japón
Fil: Rakers, Christin. Kyoto University; Japón
Fil: Kaneko, Kensuke. Kyoto University; Japón
Fil: Fukumoto, Kazuki. Kyoto University; Japón
Fil: Yamano, Mayu. Kyoto University; Japón
Fil: Versteven, Marijke. University of Münster; Alemania
Fil: Grünewald, Ellen. University of Edinburgh; Reino Unido
Fil: Cargill, Samantha J.. University of Edinburgh; Reino Unido
Fil: Tamai, T. Katherine. University of California at Los Angeles; Estados Unidos
Fil: Xu, Yao. Vanderbilt University; Estados Unidos
Fil: Jabbur, Maria Luísa. Vanderbilt University; Estados Unidos
Fil: Kojima, Rika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Lamberti, Melisa Luciana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Yoshioka Kobayashi, Kumiko. Kyoto University; Japón
Fil: Whitmore, David. University College London; Estados Unidos
Fil: Tammam, Stephanie. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Howell, P. Lynne. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Kageyama, Ryoichiro. Kyoto University; Japón
Fil: Matsuo, Takuya. Nagoya University; Japón
Fil: Stanewsky, Ralf. University of Münster; Alemania
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Johnson, Carl Hirschie. Vanderbilt University; Estados Unidos
Fil: Kakeya, Hideaki. Kyoto University; Japón
Fil: Van Ooijen, Gerben. University of Edinburgh; Reino Unido
Fil: Okamura, Hitoshi. Kyoto University; Japón
Materia
Circadian rhythms
Evolution
Metabolism
Methylation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/169425

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Methylation deficiency disrupts biological rhythms from bacteria to humansFustin, Jean MichelYe, ShiqiRakers, ChristinKaneko, KensukeFukumoto, KazukiYamano, MayuVersteven, MarijkeGrünewald, EllenCargill, Samantha J.Tamai, T. KatherineXu, YaoJabbur, Maria LuísaKojima, RikaLamberti, Melisa LucianaYoshioka Kobayashi, KumikoWhitmore, DavidTammam, StephanieHowell, P. LynneKageyama, RyoichiroMatsuo, TakuyaStanewsky, RalfGolombek, Diego AndrésJohnson, Carl HirschieKakeya, HideakiVan Ooijen, GerbenOkamura, HitoshiCircadian rhythmsEvolutionMetabolismMethylationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.Fil: Fustin, Jean Michel. Kyoto University; Japón. University of Manchester; Reino UnidoFil: Ye, Shiqi. Kyoto University; JapónFil: Rakers, Christin. Kyoto University; JapónFil: Kaneko, Kensuke. Kyoto University; JapónFil: Fukumoto, Kazuki. Kyoto University; JapónFil: Yamano, Mayu. Kyoto University; JapónFil: Versteven, Marijke. University of Münster; AlemaniaFil: Grünewald, Ellen. University of Edinburgh; Reino UnidoFil: Cargill, Samantha J.. University of Edinburgh; Reino UnidoFil: Tamai, T. Katherine. University of California at Los Angeles; Estados UnidosFil: Xu, Yao. Vanderbilt University; Estados UnidosFil: Jabbur, Maria Luísa. Vanderbilt University; Estados UnidosFil: Kojima, Rika. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Lamberti, Melisa Luciana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Yoshioka Kobayashi, Kumiko. Kyoto University; JapónFil: Whitmore, David. University College London; Estados UnidosFil: Tammam, Stephanie. University Of Toronto. Hospital For Sick Children; CanadáFil: Howell, P. Lynne. University Of Toronto. Hospital For Sick Children; CanadáFil: Kageyama, Ryoichiro. Kyoto University; JapónFil: Matsuo, Takuya. Nagoya University; JapónFil: Stanewsky, Ralf. University of Münster; AlemaniaFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Johnson, Carl Hirschie. Vanderbilt University; Estados UnidosFil: Kakeya, Hideaki. Kyoto University; JapónFil: Van Ooijen, Gerben. University of Edinburgh; Reino UnidoFil: Okamura, Hitoshi. Kyoto University; JapónSpringer2020-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169425Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; et al.; Methylation deficiency disrupts biological rhythms from bacteria to humans; Springer; Communications biology; 3; 1; 6-2020; 1-142399-3642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-020-0942-0info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-020-0942-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:34Zoai:ri.conicet.gov.ar:11336/169425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:35.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Methylation deficiency disrupts biological rhythms from bacteria to humans
title Methylation deficiency disrupts biological rhythms from bacteria to humans
spellingShingle Methylation deficiency disrupts biological rhythms from bacteria to humans
Fustin, Jean Michel
Circadian rhythms
Evolution
Metabolism
Methylation
title_short Methylation deficiency disrupts biological rhythms from bacteria to humans
title_full Methylation deficiency disrupts biological rhythms from bacteria to humans
title_fullStr Methylation deficiency disrupts biological rhythms from bacteria to humans
title_full_unstemmed Methylation deficiency disrupts biological rhythms from bacteria to humans
title_sort Methylation deficiency disrupts biological rhythms from bacteria to humans
dc.creator.none.fl_str_mv Fustin, Jean Michel
Ye, Shiqi
Rakers, Christin
Kaneko, Kensuke
Fukumoto, Kazuki
Yamano, Mayu
Versteven, Marijke
Grünewald, Ellen
Cargill, Samantha J.
Tamai, T. Katherine
Xu, Yao
Jabbur, Maria Luísa
Kojima, Rika
Lamberti, Melisa Luciana
Yoshioka Kobayashi, Kumiko
Whitmore, David
Tammam, Stephanie
Howell, P. Lynne
Kageyama, Ryoichiro
Matsuo, Takuya
Stanewsky, Ralf
Golombek, Diego Andrés
Johnson, Carl Hirschie
Kakeya, Hideaki
Van Ooijen, Gerben
Okamura, Hitoshi
author Fustin, Jean Michel
author_facet Fustin, Jean Michel
Ye, Shiqi
Rakers, Christin
Kaneko, Kensuke
Fukumoto, Kazuki
Yamano, Mayu
Versteven, Marijke
Grünewald, Ellen
Cargill, Samantha J.
Tamai, T. Katherine
Xu, Yao
Jabbur, Maria Luísa
Kojima, Rika
Lamberti, Melisa Luciana
Yoshioka Kobayashi, Kumiko
Whitmore, David
Tammam, Stephanie
Howell, P. Lynne
Kageyama, Ryoichiro
Matsuo, Takuya
Stanewsky, Ralf
Golombek, Diego Andrés
Johnson, Carl Hirschie
Kakeya, Hideaki
Van Ooijen, Gerben
Okamura, Hitoshi
author_role author
author2 Ye, Shiqi
Rakers, Christin
Kaneko, Kensuke
Fukumoto, Kazuki
Yamano, Mayu
Versteven, Marijke
Grünewald, Ellen
Cargill, Samantha J.
Tamai, T. Katherine
Xu, Yao
Jabbur, Maria Luísa
Kojima, Rika
Lamberti, Melisa Luciana
Yoshioka Kobayashi, Kumiko
Whitmore, David
Tammam, Stephanie
Howell, P. Lynne
Kageyama, Ryoichiro
Matsuo, Takuya
Stanewsky, Ralf
Golombek, Diego Andrés
Johnson, Carl Hirschie
Kakeya, Hideaki
Van Ooijen, Gerben
Okamura, Hitoshi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Circadian rhythms
Evolution
Metabolism
Methylation
topic Circadian rhythms
Evolution
Metabolism
Methylation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.
Fil: Fustin, Jean Michel. Kyoto University; Japón. University of Manchester; Reino Unido
Fil: Ye, Shiqi. Kyoto University; Japón
Fil: Rakers, Christin. Kyoto University; Japón
Fil: Kaneko, Kensuke. Kyoto University; Japón
Fil: Fukumoto, Kazuki. Kyoto University; Japón
Fil: Yamano, Mayu. Kyoto University; Japón
Fil: Versteven, Marijke. University of Münster; Alemania
Fil: Grünewald, Ellen. University of Edinburgh; Reino Unido
Fil: Cargill, Samantha J.. University of Edinburgh; Reino Unido
Fil: Tamai, T. Katherine. University of California at Los Angeles; Estados Unidos
Fil: Xu, Yao. Vanderbilt University; Estados Unidos
Fil: Jabbur, Maria Luísa. Vanderbilt University; Estados Unidos
Fil: Kojima, Rika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Lamberti, Melisa Luciana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Yoshioka Kobayashi, Kumiko. Kyoto University; Japón
Fil: Whitmore, David. University College London; Estados Unidos
Fil: Tammam, Stephanie. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Howell, P. Lynne. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Kageyama, Ryoichiro. Kyoto University; Japón
Fil: Matsuo, Takuya. Nagoya University; Japón
Fil: Stanewsky, Ralf. University of Münster; Alemania
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Johnson, Carl Hirschie. Vanderbilt University; Estados Unidos
Fil: Kakeya, Hideaki. Kyoto University; Japón
Fil: Van Ooijen, Gerben. University of Edinburgh; Reino Unido
Fil: Okamura, Hitoshi. Kyoto University; Japón
description The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.
publishDate 2020
dc.date.none.fl_str_mv 2020-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/169425
Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; et al.; Methylation deficiency disrupts biological rhythms from bacteria to humans; Springer; Communications biology; 3; 1; 6-2020; 1-14
2399-3642
CONICET Digital
CONICET
url http://hdl.handle.net/11336/169425
identifier_str_mv Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; et al.; Methylation deficiency disrupts biological rhythms from bacteria to humans; Springer; Communications biology; 3; 1; 6-2020; 1-14
2399-3642
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-020-0942-0
info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-020-0942-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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