Methylation deficiency disrupts biological rhythms from bacteria to humans
- Autores
- Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; Yamano, Mayu; Versteven, Marijke; Grünewald, Ellen; Cargill, Samantha J.; Tamai, T. Katherine; Xu, Yao; Jabbur, Maria Luísa; Kojima, Rika; Lamberti, Melisa Luciana; Yoshioka Kobayashi, Kumiko; Whitmore, David; Tammam, Stephanie; Howell, P. Lynne; Kageyama, Ryoichiro; Matsuo, Takuya; Stanewsky, Ralf; Golombek, Diego Andrés; Johnson, Carl Hirschie; Kakeya, Hideaki; Van Ooijen, Gerben; Okamura, Hitoshi
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.
Fil: Fustin, Jean Michel. Kyoto University; Japón. University of Manchester; Reino Unido
Fil: Ye, Shiqi. Kyoto University; Japón
Fil: Rakers, Christin. Kyoto University; Japón
Fil: Kaneko, Kensuke. Kyoto University; Japón
Fil: Fukumoto, Kazuki. Kyoto University; Japón
Fil: Yamano, Mayu. Kyoto University; Japón
Fil: Versteven, Marijke. University of Münster; Alemania
Fil: Grünewald, Ellen. University of Edinburgh; Reino Unido
Fil: Cargill, Samantha J.. University of Edinburgh; Reino Unido
Fil: Tamai, T. Katherine. University of California at Los Angeles; Estados Unidos
Fil: Xu, Yao. Vanderbilt University; Estados Unidos
Fil: Jabbur, Maria Luísa. Vanderbilt University; Estados Unidos
Fil: Kojima, Rika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Lamberti, Melisa Luciana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Yoshioka Kobayashi, Kumiko. Kyoto University; Japón
Fil: Whitmore, David. University College London; Estados Unidos
Fil: Tammam, Stephanie. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Howell, P. Lynne. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Kageyama, Ryoichiro. Kyoto University; Japón
Fil: Matsuo, Takuya. Nagoya University; Japón
Fil: Stanewsky, Ralf. University of Münster; Alemania
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Johnson, Carl Hirschie. Vanderbilt University; Estados Unidos
Fil: Kakeya, Hideaki. Kyoto University; Japón
Fil: Van Ooijen, Gerben. University of Edinburgh; Reino Unido
Fil: Okamura, Hitoshi. Kyoto University; Japón - Materia
-
Circadian rhythms
Evolution
Metabolism
Methylation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/169425
Ver los metadatos del registro completo
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Methylation deficiency disrupts biological rhythms from bacteria to humansFustin, Jean MichelYe, ShiqiRakers, ChristinKaneko, KensukeFukumoto, KazukiYamano, MayuVersteven, MarijkeGrünewald, EllenCargill, Samantha J.Tamai, T. KatherineXu, YaoJabbur, Maria LuísaKojima, RikaLamberti, Melisa LucianaYoshioka Kobayashi, KumikoWhitmore, DavidTammam, StephanieHowell, P. LynneKageyama, RyoichiroMatsuo, TakuyaStanewsky, RalfGolombek, Diego AndrésJohnson, Carl HirschieKakeya, HideakiVan Ooijen, GerbenOkamura, HitoshiCircadian rhythmsEvolutionMetabolismMethylationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies.Fil: Fustin, Jean Michel. Kyoto University; Japón. University of Manchester; Reino UnidoFil: Ye, Shiqi. Kyoto University; JapónFil: Rakers, Christin. Kyoto University; JapónFil: Kaneko, Kensuke. Kyoto University; JapónFil: Fukumoto, Kazuki. Kyoto University; JapónFil: Yamano, Mayu. Kyoto University; JapónFil: Versteven, Marijke. University of Münster; AlemaniaFil: Grünewald, Ellen. University of Edinburgh; Reino UnidoFil: Cargill, Samantha J.. University of Edinburgh; Reino UnidoFil: Tamai, T. Katherine. University of California at Los Angeles; Estados UnidosFil: Xu, Yao. Vanderbilt University; Estados UnidosFil: Jabbur, Maria Luísa. Vanderbilt University; Estados UnidosFil: Kojima, Rika. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Lamberti, Melisa Luciana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Yoshioka Kobayashi, Kumiko. Kyoto University; JapónFil: Whitmore, David. University College London; Estados UnidosFil: Tammam, Stephanie. University Of Toronto. Hospital For Sick Children; CanadáFil: Howell, P. Lynne. University Of Toronto. Hospital For Sick Children; CanadáFil: Kageyama, Ryoichiro. Kyoto University; JapónFil: Matsuo, Takuya. Nagoya University; JapónFil: Stanewsky, Ralf. University of Münster; AlemaniaFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Johnson, Carl Hirschie. Vanderbilt University; Estados UnidosFil: Kakeya, Hideaki. Kyoto University; JapónFil: Van Ooijen, Gerben. University of Edinburgh; Reino UnidoFil: Okamura, Hitoshi. Kyoto University; JapónSpringer2020-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169425Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; et al.; Methylation deficiency disrupts biological rhythms from bacteria to humans; Springer; Communications biology; 3; 1; 6-2020; 1-142399-3642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s42003-020-0942-0info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-020-0942-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:03Zoai:ri.conicet.gov.ar:11336/169425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:03.487CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Methylation deficiency disrupts biological rhythms from bacteria to humans |
| title |
Methylation deficiency disrupts biological rhythms from bacteria to humans |
| spellingShingle |
Methylation deficiency disrupts biological rhythms from bacteria to humans Fustin, Jean Michel Circadian rhythms Evolution Metabolism Methylation |
| title_short |
Methylation deficiency disrupts biological rhythms from bacteria to humans |
| title_full |
Methylation deficiency disrupts biological rhythms from bacteria to humans |
| title_fullStr |
Methylation deficiency disrupts biological rhythms from bacteria to humans |
| title_full_unstemmed |
Methylation deficiency disrupts biological rhythms from bacteria to humans |
| title_sort |
Methylation deficiency disrupts biological rhythms from bacteria to humans |
| dc.creator.none.fl_str_mv |
Fustin, Jean Michel Ye, Shiqi Rakers, Christin Kaneko, Kensuke Fukumoto, Kazuki Yamano, Mayu Versteven, Marijke Grünewald, Ellen Cargill, Samantha J. Tamai, T. Katherine Xu, Yao Jabbur, Maria Luísa Kojima, Rika Lamberti, Melisa Luciana Yoshioka Kobayashi, Kumiko Whitmore, David Tammam, Stephanie Howell, P. Lynne Kageyama, Ryoichiro Matsuo, Takuya Stanewsky, Ralf Golombek, Diego Andrés Johnson, Carl Hirschie Kakeya, Hideaki Van Ooijen, Gerben Okamura, Hitoshi |
| author |
Fustin, Jean Michel |
| author_facet |
Fustin, Jean Michel Ye, Shiqi Rakers, Christin Kaneko, Kensuke Fukumoto, Kazuki Yamano, Mayu Versteven, Marijke Grünewald, Ellen Cargill, Samantha J. Tamai, T. Katherine Xu, Yao Jabbur, Maria Luísa Kojima, Rika Lamberti, Melisa Luciana Yoshioka Kobayashi, Kumiko Whitmore, David Tammam, Stephanie Howell, P. Lynne Kageyama, Ryoichiro Matsuo, Takuya Stanewsky, Ralf Golombek, Diego Andrés Johnson, Carl Hirschie Kakeya, Hideaki Van Ooijen, Gerben Okamura, Hitoshi |
| author_role |
author |
| author2 |
Ye, Shiqi Rakers, Christin Kaneko, Kensuke Fukumoto, Kazuki Yamano, Mayu Versteven, Marijke Grünewald, Ellen Cargill, Samantha J. Tamai, T. Katherine Xu, Yao Jabbur, Maria Luísa Kojima, Rika Lamberti, Melisa Luciana Yoshioka Kobayashi, Kumiko Whitmore, David Tammam, Stephanie Howell, P. Lynne Kageyama, Ryoichiro Matsuo, Takuya Stanewsky, Ralf Golombek, Diego Andrés Johnson, Carl Hirschie Kakeya, Hideaki Van Ooijen, Gerben Okamura, Hitoshi |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Circadian rhythms Evolution Metabolism Methylation |
| topic |
Circadian rhythms Evolution Metabolism Methylation |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies. Fil: Fustin, Jean Michel. Kyoto University; Japón. University of Manchester; Reino Unido Fil: Ye, Shiqi. Kyoto University; Japón Fil: Rakers, Christin. Kyoto University; Japón Fil: Kaneko, Kensuke. Kyoto University; Japón Fil: Fukumoto, Kazuki. Kyoto University; Japón Fil: Yamano, Mayu. Kyoto University; Japón Fil: Versteven, Marijke. University of Münster; Alemania Fil: Grünewald, Ellen. University of Edinburgh; Reino Unido Fil: Cargill, Samantha J.. University of Edinburgh; Reino Unido Fil: Tamai, T. Katherine. University of California at Los Angeles; Estados Unidos Fil: Xu, Yao. Vanderbilt University; Estados Unidos Fil: Jabbur, Maria Luísa. Vanderbilt University; Estados Unidos Fil: Kojima, Rika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Lamberti, Melisa Luciana. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Yoshioka Kobayashi, Kumiko. Kyoto University; Japón Fil: Whitmore, David. University College London; Estados Unidos Fil: Tammam, Stephanie. University Of Toronto. Hospital For Sick Children; Canadá Fil: Howell, P. Lynne. University Of Toronto. Hospital For Sick Children; Canadá Fil: Kageyama, Ryoichiro. Kyoto University; Japón Fil: Matsuo, Takuya. Nagoya University; Japón Fil: Stanewsky, Ralf. University of Münster; Alemania Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Johnson, Carl Hirschie. Vanderbilt University; Estados Unidos Fil: Kakeya, Hideaki. Kyoto University; Japón Fil: Van Ooijen, Gerben. University of Edinburgh; Reino Unido Fil: Okamura, Hitoshi. Kyoto University; Japón |
| description |
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. Here, we show that methyl cycle inhibition affects biological rhythms in species ranging from unicellular algae to humans, separated by more than 1 billion years of evolution. In contrast, the cyanobacterial clock is resistant to methyl cycle inhibition, although we demonstrate that methylations themselves regulate circadian rhythms in this organism. Mammalian cells with a rewired bacteria-like methyl cycle are protected, like cyanobacteria, from methyl cycle inhibition, providing interesting new possibilities for the treatment of methylation deficiencies. |
| publishDate |
2020 |
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2020-06 |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/169425 Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; et al.; Methylation deficiency disrupts biological rhythms from bacteria to humans; Springer; Communications biology; 3; 1; 6-2020; 1-14 2399-3642 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/169425 |
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Fustin, Jean Michel; Ye, Shiqi; Rakers, Christin; Kaneko, Kensuke; Fukumoto, Kazuki; et al.; Methylation deficiency disrupts biological rhythms from bacteria to humans; Springer; Communications biology; 3; 1; 6-2020; 1-14 2399-3642 CONICET Digital CONICET |
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eng |
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