One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina
- Autores
- Vicario, Jose; Campo, Cesar; Piva, Julio; Faccio, Fernando; Gerardo, Luis; Becker, Carlos; Ortega, Hugo Hector; Pierini, Angel; Lofeudo, Carlos; Novero, Rafael; Baliño, Nestor Perez; Monti, Adrian; Benech, Rodolfo; Dallo, Matias; Pfeiffer, Hernan
- Año de publicación
- 2005
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Purpose: Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe. Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe.
Fil: Vicario, Jose. Hospital Iturraspe; Argentina
Fil: Campo, Cesar. Hospital Iturraspe; Argentina
Fil: Piva, Julio. Hospital Iturraspe; Argentina
Fil: Faccio, Fernando. Hospital San Gerónimo; Argentina
Fil: Gerardo, Luis. Hospital Garay; Argentina
Fil: Becker, Carlos. Hospital San Gerónimo; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Pierini, Angel. Hospital Iturraspe; Argentina
Fil: Lofeudo, Carlos. Hospital Garay; Argentina
Fil: Novero, Rafael. Hospital Garay; Argentina
Fil: Baliño, Nestor Perez. Hospital Santa Fe; Argentina
Fil: Monti, Adrian. Hospital Garay; Argentina
Fil: Benech, Rodolfo. Hospital Iturraspe; Argentina
Fil: Dallo, Matias. Hospital Garay; Argentina
Fil: Pfeiffer, Hernan. Hospital Iturraspe; Argentina - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/102845
Ver los metadatos del registro completo
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One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory anginaVicario, JoseCampo, CesarPiva, JulioFaccio, FernandoGerardo, LuisBecker, CarlosOrtega, Hugo HectorPierini, AngelLofeudo, CarlosNovero, RafaelBaliño, Nestor PerezMonti, AdrianBenech, RodolfoDallo, MatiasPfeiffer, Hernanhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Purpose: Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe. Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe.Fil: Vicario, Jose. Hospital Iturraspe; ArgentinaFil: Campo, Cesar. Hospital Iturraspe; ArgentinaFil: Piva, Julio. Hospital Iturraspe; ArgentinaFil: Faccio, Fernando. Hospital San Gerónimo; ArgentinaFil: Gerardo, Luis. Hospital Garay; ArgentinaFil: Becker, Carlos. Hospital San Gerónimo; ArgentinaFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Pierini, Angel. Hospital Iturraspe; ArgentinaFil: Lofeudo, Carlos. Hospital Garay; ArgentinaFil: Novero, Rafael. Hospital Garay; ArgentinaFil: Baliño, Nestor Perez. Hospital Santa Fe; ArgentinaFil: Monti, Adrian. Hospital Garay; ArgentinaFil: Benech, Rodolfo. Hospital Iturraspe; ArgentinaFil: Dallo, Matias. Hospital Garay; ArgentinaFil: Pfeiffer, Hernan. Hospital Iturraspe; ArgentinaElsevier2005-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102845Vicario, Jose; Campo, Cesar; Piva, Julio; Faccio, Fernando; Gerardo, Luis; et al.; One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina; Elsevier; Cardiovascular Revascularization Medicine; 6; 3; 7-2005; 99-1071553-8389CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.carrev.2005.08.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:46:48Zoai:ri.conicet.gov.ar:11336/102845instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:46:48.865CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
| title |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
| spellingShingle |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina Vicario, Jose |
| title_short |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
| title_full |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
| title_fullStr |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
| title_full_unstemmed |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
| title_sort |
One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
| dc.creator.none.fl_str_mv |
Vicario, Jose Campo, Cesar Piva, Julio Faccio, Fernando Gerardo, Luis Becker, Carlos Ortega, Hugo Hector Pierini, Angel Lofeudo, Carlos Novero, Rafael Baliño, Nestor Perez Monti, Adrian Benech, Rodolfo Dallo, Matias Pfeiffer, Hernan |
| author |
Vicario, Jose |
| author_facet |
Vicario, Jose Campo, Cesar Piva, Julio Faccio, Fernando Gerardo, Luis Becker, Carlos Ortega, Hugo Hector Pierini, Angel Lofeudo, Carlos Novero, Rafael Baliño, Nestor Perez Monti, Adrian Benech, Rodolfo Dallo, Matias Pfeiffer, Hernan |
| author_role |
author |
| author2 |
Campo, Cesar Piva, Julio Faccio, Fernando Gerardo, Luis Becker, Carlos Ortega, Hugo Hector Pierini, Angel Lofeudo, Carlos Novero, Rafael Baliño, Nestor Perez Monti, Adrian Benech, Rodolfo Dallo, Matias Pfeiffer, Hernan |
| author2_role |
author author author author author author author author author author author author author author |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
| dc.description.none.fl_txt_mv |
Purpose: Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe. Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe. Fil: Vicario, Jose. Hospital Iturraspe; Argentina Fil: Campo, Cesar. Hospital Iturraspe; Argentina Fil: Piva, Julio. Hospital Iturraspe; Argentina Fil: Faccio, Fernando. Hospital San Gerónimo; Argentina Fil: Gerardo, Luis. Hospital Garay; Argentina Fil: Becker, Carlos. Hospital San Gerónimo; Argentina Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Pierini, Angel. Hospital Iturraspe; Argentina Fil: Lofeudo, Carlos. Hospital Garay; Argentina Fil: Novero, Rafael. Hospital Garay; Argentina Fil: Baliño, Nestor Perez. Hospital Santa Fe; Argentina Fil: Monti, Adrian. Hospital Garay; Argentina Fil: Benech, Rodolfo. Hospital Iturraspe; Argentina Fil: Dallo, Matias. Hospital Garay; Argentina Fil: Pfeiffer, Hernan. Hospital Iturraspe; Argentina |
| description |
Purpose: Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe. Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up. Methods and materials: Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography. Results: There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0F0.53 at baseline, which improved to 1.6F0.63 at 1 year ( Pb.001). Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) ( Pb.01) and 45.3% at stress (26.5 vs. 14.5) ( Pb.05). Coronary angiography showed more collateral vessels in 10 of 15 patients. Conclusions: We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe. |
| publishDate |
2005 |
| dc.date.none.fl_str_mv |
2005-07 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/102845 Vicario, Jose; Campo, Cesar; Piva, Julio; Faccio, Fernando; Gerardo, Luis; et al.; One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina; Elsevier; Cardiovascular Revascularization Medicine; 6; 3; 7-2005; 99-107 1553-8389 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/102845 |
| identifier_str_mv |
Vicario, Jose; Campo, Cesar; Piva, Julio; Faccio, Fernando; Gerardo, Luis; et al.; One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina; Elsevier; Cardiovascular Revascularization Medicine; 6; 3; 7-2005; 99-107 1553-8389 CONICET Digital CONICET |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carrev.2005.08.002 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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Elsevier |
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Elsevier |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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