Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging

Autores
Koehler, Niklas K. U.; Stransky, Elle; Meyer, Mirjam; Gaertner, Susanne; Shing, Mona; Schnaidt, Martina; Celej, Maria Soledad; Jovin, Thomas M.; Leyhe, Thomas; Laske, Christoph; Batra, Anil; Buchkremer, Gerhard; Fallgatter, Andreas J.; Wernet, Dorothee; Richartz Salzburger, Elke
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.
Fil: Koehler, Niklas K. U.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
Fil: Stransky, Elle. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Meyer, Mirjam. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Gaertner, Susanne. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Shing, Mona. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Schnaidt, Martina. Zentrum für Klinische Transfusionsmedizin; Alemania
Fil: Celej, Maria Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina
Fil: Jovin, Thomas M.. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania
Fil: Leyhe, Thomas. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. Psychiatric University Hospital. Center of Old Age Psychiatry; Alemania
Fil: Laske, Christoph . Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
Fil: Batra, Anil. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Buchkremer, Gerhard. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Fallgatter, Andreas J.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Wernet, Dorothee. Zentrum für Klinische Transfusionsmedizin; Alemania
Fil: Richartz Salzburger, Elke. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Materia
ALPHA-SYNUCLEIN
PARKINSON
BLOOD PLASMA
BIOMARKER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10653
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/10653
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Alpha-Synuclein Levels in Blood Plasma Decline with Healthy AgingKoehler, Niklas K. U.Stransky, ElleMeyer, MirjamGaertner, SusanneShing, MonaSchnaidt, MartinaCelej, Maria SoledadJovin, Thomas M.Leyhe, ThomasLaske, Christoph Batra, AnilBuchkremer, GerhardFallgatter, Andreas J.Wernet, DorotheeRichartz Salzburger, ElkeALPHA-SYNUCLEINPARKINSONBLOOD PLASMABIOMARKERhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.Fil: Koehler, Niklas K. U.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; AlemaniaFil: Stransky, Elle. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaFil: Meyer, Mirjam. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaFil: Gaertner, Susanne. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaFil: Shing, Mona. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaFil: Schnaidt, Martina. Zentrum für Klinische Transfusionsmedizin; AlemaniaFil: Celej, Maria Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); ArgentinaFil: Jovin, Thomas M.. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; AlemaniaFil: Leyhe, Thomas. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. Psychiatric University Hospital. Center of Old Age Psychiatry; AlemaniaFil: Laske, Christoph . Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; AlemaniaFil: Batra, Anil. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaFil: Buchkremer, Gerhard. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaFil: Fallgatter, Andreas J.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaFil: Wernet, Dorothee. Zentrum für Klinische Transfusionsmedizin; AlemaniaFil: Richartz Salzburger, Elke. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; AlemaniaPublic Library of Science2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10653Koehler, Niklas K. U.; Stransky, Elle; Meyer, Mirjam; Gaertner, Susanne; Shing, Mona; et al.; Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging; Public Library of Science; Plos One; 10; 4; 4-2015; 1-161932-6203enginfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123444info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0123444info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:22Zoai:ri.conicet.gov.ar:11336/10653instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:22.665CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
title Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
spellingShingle Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
Koehler, Niklas K. U.
ALPHA-SYNUCLEIN
PARKINSON
BLOOD PLASMA
BIOMARKER
title_short Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
title_full Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
title_fullStr Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
title_full_unstemmed Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
title_sort Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
dc.creator.none.fl_str_mv Koehler, Niklas K. U.
Stransky, Elle
Meyer, Mirjam
Gaertner, Susanne
Shing, Mona
Schnaidt, Martina
Celej, Maria Soledad
Jovin, Thomas M.
Leyhe, Thomas
Laske, Christoph
Batra, Anil
Buchkremer, Gerhard
Fallgatter, Andreas J.
Wernet, Dorothee
Richartz Salzburger, Elke
author Koehler, Niklas K. U.
author_facet Koehler, Niklas K. U.
Stransky, Elle
Meyer, Mirjam
Gaertner, Susanne
Shing, Mona
Schnaidt, Martina
Celej, Maria Soledad
Jovin, Thomas M.
Leyhe, Thomas
Laske, Christoph
Batra, Anil
Buchkremer, Gerhard
Fallgatter, Andreas J.
Wernet, Dorothee
Richartz Salzburger, Elke
author_role author
author2 Stransky, Elle
Meyer, Mirjam
Gaertner, Susanne
Shing, Mona
Schnaidt, Martina
Celej, Maria Soledad
Jovin, Thomas M.
Leyhe, Thomas
Laske, Christoph
Batra, Anil
Buchkremer, Gerhard
Fallgatter, Andreas J.
Wernet, Dorothee
Richartz Salzburger, Elke
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALPHA-SYNUCLEIN
PARKINSON
BLOOD PLASMA
BIOMARKER
topic ALPHA-SYNUCLEIN
PARKINSON
BLOOD PLASMA
BIOMARKER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.
Fil: Koehler, Niklas K. U.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
Fil: Stransky, Elle. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Meyer, Mirjam. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Gaertner, Susanne. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Shing, Mona. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Schnaidt, Martina. Zentrum für Klinische Transfusionsmedizin; Alemania
Fil: Celej, Maria Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina
Fil: Jovin, Thomas M.. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania
Fil: Leyhe, Thomas. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. Psychiatric University Hospital. Center of Old Age Psychiatry; Alemania
Fil: Laske, Christoph . Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
Fil: Batra, Anil. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Buchkremer, Gerhard. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Fallgatter, Andreas J.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
Fil: Wernet, Dorothee. Zentrum für Klinische Transfusionsmedizin; Alemania
Fil: Richartz Salzburger, Elke. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
description There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10653
Koehler, Niklas K. U.; Stransky, Elle; Meyer, Mirjam; Gaertner, Susanne; Shing, Mona; et al.; Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging; Public Library of Science; Plos One; 10; 4; 4-2015; 1-16
1932-6203
url http://hdl.handle.net/11336/10653
identifier_str_mv Koehler, Niklas K. U.; Stransky, Elle; Meyer, Mirjam; Gaertner, Susanne; Shing, Mona; et al.; Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging; Public Library of Science; Plos One; 10; 4; 4-2015; 1-16
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123444
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0123444
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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