Psychopharmacological effects of Artemisia copa aqueous extract in mice

Autores
Miño, Jorge Horacio; Moscatelli, Valeria Andrea; Acevedo, Cristina; Ferraro, Graciela Ester
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To evaluate the aqueous extract from aerial parts of Artemisia copa Phil. (Asteraceae) administered orallyfor its psychopharmacological activities in several experimental models Methods: The extract was administered p.o. in Swiss albino mice and tested on pentobarbital-induced hypnosis, locomotor activity, exploration in the hole-board, anxiolytic like profile evaluated in the marble-burying test and anticonvulsant activity on convulsions induced by pentylenetetrazol. Results: Artemisia copa at doses up to 1.5g/kg produced a dose-dependent sleep induction and potentiation of sub-hypnotic and hypnotic doses of pentobarbital. The extract also produced a dose-dependent increase and decrease in the spontaneous motor activity (0.51.5g/kg, respectively), no disruption or a decrease on exploratory (hole-board) behavioral profiles (0.51.5g/kg respectively) and a dose-related anxiolytic-like activity as indicated by increases in the percentage of marbles they left uncovered in the marble-burying test at doses (0.5g/kg) that do not disrupt the motor activity. In addition, the extract (1.5g/kg) produced a significant increase in the latency time and a decrease in the duration of seizures and mortality induced by PTZ 75mg/kg in mice. Conclusion: These results suggest that the aqueous extract of Artemisia copa may contain sedative principles with potential anxiolytic and anticonvulsant activities.
Fil: Miño, Jorge Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Moscatelli, Valeria Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Acevedo, Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Ferraro, Graciela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
Anticonvulsant Activity
Anxiolytic Activity
Aqueous Extract
Artemisia Copa
Sedative Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67586
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67586
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Psychopharmacological effects of Artemisia copa aqueous extract in miceMiño, Jorge HoracioMoscatelli, Valeria AndreaAcevedo, CristinaFerraro, Graciela EsterAnticonvulsant ActivityAnxiolytic ActivityAqueous ExtractArtemisia CopaSedative Activityhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To evaluate the aqueous extract from aerial parts of Artemisia copa Phil. (Asteraceae) administered orallyfor its psychopharmacological activities in several experimental models Methods: The extract was administered p.o. in Swiss albino mice and tested on pentobarbital-induced hypnosis, locomotor activity, exploration in the hole-board, anxiolytic like profile evaluated in the marble-burying test and anticonvulsant activity on convulsions induced by pentylenetetrazol. Results: Artemisia copa at doses up to 1.5g/kg produced a dose-dependent sleep induction and potentiation of sub-hypnotic and hypnotic doses of pentobarbital. The extract also produced a dose-dependent increase and decrease in the spontaneous motor activity (0.51.5g/kg, respectively), no disruption or a decrease on exploratory (hole-board) behavioral profiles (0.51.5g/kg respectively) and a dose-related anxiolytic-like activity as indicated by increases in the percentage of marbles they left uncovered in the marble-burying test at doses (0.5g/kg) that do not disrupt the motor activity. In addition, the extract (1.5g/kg) produced a significant increase in the latency time and a decrease in the duration of seizures and mortality induced by PTZ 75mg/kg in mice. Conclusion: These results suggest that the aqueous extract of Artemisia copa may contain sedative principles with potential anxiolytic and anticonvulsant activities.Fil: Miño, Jorge Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Moscatelli, Valeria Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Acevedo, Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Ferraro, Graciela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaTaylor & Francis2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67586Miño, Jorge Horacio; Moscatelli, Valeria Andrea; Acevedo, Cristina; Ferraro, Graciela Ester; Psychopharmacological effects of Artemisia copa aqueous extract in mice; Taylor & Francis; Pharmaceutical Biology; 48; 12; 12-2010; 1392-13961388-0209CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/13880209.2010.486407info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/13880209.2010.486407info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:01:40Zoai:ri.conicet.gov.ar:11336/67586instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:01:40.608CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Psychopharmacological effects of Artemisia copa aqueous extract in mice
title Psychopharmacological effects of Artemisia copa aqueous extract in mice
spellingShingle Psychopharmacological effects of Artemisia copa aqueous extract in mice
Miño, Jorge Horacio
Anticonvulsant Activity
Anxiolytic Activity
Aqueous Extract
Artemisia Copa
Sedative Activity
title_short Psychopharmacological effects of Artemisia copa aqueous extract in mice
title_full Psychopharmacological effects of Artemisia copa aqueous extract in mice
title_fullStr Psychopharmacological effects of Artemisia copa aqueous extract in mice
title_full_unstemmed Psychopharmacological effects of Artemisia copa aqueous extract in mice
title_sort Psychopharmacological effects of Artemisia copa aqueous extract in mice
dc.creator.none.fl_str_mv Miño, Jorge Horacio
Moscatelli, Valeria Andrea
Acevedo, Cristina
Ferraro, Graciela Ester
author Miño, Jorge Horacio
author_facet Miño, Jorge Horacio
Moscatelli, Valeria Andrea
Acevedo, Cristina
Ferraro, Graciela Ester
author_role author
author2 Moscatelli, Valeria Andrea
Acevedo, Cristina
Ferraro, Graciela Ester
author2_role author
author
author
dc.subject.none.fl_str_mv Anticonvulsant Activity
Anxiolytic Activity
Aqueous Extract
Artemisia Copa
Sedative Activity
topic Anticonvulsant Activity
Anxiolytic Activity
Aqueous Extract
Artemisia Copa
Sedative Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To evaluate the aqueous extract from aerial parts of Artemisia copa Phil. (Asteraceae) administered orallyfor its psychopharmacological activities in several experimental models Methods: The extract was administered p.o. in Swiss albino mice and tested on pentobarbital-induced hypnosis, locomotor activity, exploration in the hole-board, anxiolytic like profile evaluated in the marble-burying test and anticonvulsant activity on convulsions induced by pentylenetetrazol. Results: Artemisia copa at doses up to 1.5g/kg produced a dose-dependent sleep induction and potentiation of sub-hypnotic and hypnotic doses of pentobarbital. The extract also produced a dose-dependent increase and decrease in the spontaneous motor activity (0.51.5g/kg, respectively), no disruption or a decrease on exploratory (hole-board) behavioral profiles (0.51.5g/kg respectively) and a dose-related anxiolytic-like activity as indicated by increases in the percentage of marbles they left uncovered in the marble-burying test at doses (0.5g/kg) that do not disrupt the motor activity. In addition, the extract (1.5g/kg) produced a significant increase in the latency time and a decrease in the duration of seizures and mortality induced by PTZ 75mg/kg in mice. Conclusion: These results suggest that the aqueous extract of Artemisia copa may contain sedative principles with potential anxiolytic and anticonvulsant activities.
Fil: Miño, Jorge Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Moscatelli, Valeria Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Acevedo, Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Ferraro, Graciela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description Objective: To evaluate the aqueous extract from aerial parts of Artemisia copa Phil. (Asteraceae) administered orallyfor its psychopharmacological activities in several experimental models Methods: The extract was administered p.o. in Swiss albino mice and tested on pentobarbital-induced hypnosis, locomotor activity, exploration in the hole-board, anxiolytic like profile evaluated in the marble-burying test and anticonvulsant activity on convulsions induced by pentylenetetrazol. Results: Artemisia copa at doses up to 1.5g/kg produced a dose-dependent sleep induction and potentiation of sub-hypnotic and hypnotic doses of pentobarbital. The extract also produced a dose-dependent increase and decrease in the spontaneous motor activity (0.51.5g/kg, respectively), no disruption or a decrease on exploratory (hole-board) behavioral profiles (0.51.5g/kg respectively) and a dose-related anxiolytic-like activity as indicated by increases in the percentage of marbles they left uncovered in the marble-burying test at doses (0.5g/kg) that do not disrupt the motor activity. In addition, the extract (1.5g/kg) produced a significant increase in the latency time and a decrease in the duration of seizures and mortality induced by PTZ 75mg/kg in mice. Conclusion: These results suggest that the aqueous extract of Artemisia copa may contain sedative principles with potential anxiolytic and anticonvulsant activities.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67586
Miño, Jorge Horacio; Moscatelli, Valeria Andrea; Acevedo, Cristina; Ferraro, Graciela Ester; Psychopharmacological effects of Artemisia copa aqueous extract in mice; Taylor & Francis; Pharmaceutical Biology; 48; 12; 12-2010; 1392-1396
1388-0209
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67586
identifier_str_mv Miño, Jorge Horacio; Moscatelli, Valeria Andrea; Acevedo, Cristina; Ferraro, Graciela Ester; Psychopharmacological effects of Artemisia copa aqueous extract in mice; Taylor & Francis; Pharmaceutical Biology; 48; 12; 12-2010; 1392-1396
1388-0209
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/13880209.2010.486407
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/13880209.2010.486407
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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