PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI
- Autores
- Srinivas, Mangala; Tel, Jurjen; Schreibelt, Gerty; Bonetto, Fernando Jose; Cruz, Luis Javier; Amiri, Houshang; Heerschap, Arend; Figdor, Carl G.; de Vries, I. Jolanda M.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Aim: In vivo imaging using 19F MRI is advantageous, due to its ability to quantify cell numbers, but is limited for a lack of suitable labels. Here, we formulate two stable and clinically applicable labels for tracking two populations of primary human dendritic cells (DCs) simultaneously. Materials & methods: Plasmacytoid and myeloid DCs are able to take up sufficient nanoparticles (200 nm) for imaging (1012 19F's per cell), despite being relatively nonphagocytic. Results: Clinically relevant numbers of labeled DCs could be imaged in about 10 min, even on a clinical scanner. Conclusion: We demonstrate the use of perfluorocarbon nanoparticles for simultaneous 19F MRI of distinct cell populations in a clinical setting, without spectroscopic imaging.
Fil: Srinivas, Mangala. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
Fil: Tel, Jurjen. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
Fil: Schreibelt, Gerty. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
Fil: Cruz, Luis Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina
Fil: Amiri, Houshang. Radboud University Medical Center. Department of Radiology; Países Bajos. Kerman University of Medical Sciences. Institute of Neuropharmacology. Neuroscience Research Center; Irán
Fil: Heerschap, Arend. Radboud University Medical Center. Department of Radiology; Países Bajos
Fil: Figdor, Carl G.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos
Fil: de Vries, I. Jolanda M.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos - Materia
-
Perfluorocarbons
19f Mri
Fluorescence
Cell Therapy
In-Vivo Imaging. - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/4426
Ver los metadatos del registro completo
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PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRISrinivas, MangalaTel, JurjenSchreibelt, GertyBonetto, Fernando JoseCruz, Luis JavierAmiri, HoushangHeerschap, ArendFigdor, Carl G.de Vries, I. Jolanda M.Perfluorocarbons19f MriFluorescenceCell TherapyIn-Vivo Imaging.https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Aim: In vivo imaging using 19F MRI is advantageous, due to its ability to quantify cell numbers, but is limited for a lack of suitable labels. Here, we formulate two stable and clinically applicable labels for tracking two populations of primary human dendritic cells (DCs) simultaneously. Materials & methods: Plasmacytoid and myeloid DCs are able to take up sufficient nanoparticles (200 nm) for imaging (1012 19F's per cell), despite being relatively nonphagocytic. Results: Clinically relevant numbers of labeled DCs could be imaged in about 10 min, even on a clinical scanner. Conclusion: We demonstrate the use of perfluorocarbon nanoparticles for simultaneous 19F MRI of distinct cell populations in a clinical setting, without spectroscopic imaging.Fil: Srinivas, Mangala. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países BajosFil: Tel, Jurjen. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países BajosFil: Schreibelt, Gerty. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países BajosFil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; ArgentinaFil: Cruz, Luis Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; ArgentinaFil: Amiri, Houshang. Radboud University Medical Center. Department of Radiology; Países Bajos. Kerman University of Medical Sciences. Institute of Neuropharmacology. Neuroscience Research Center; IránFil: Heerschap, Arend. Radboud University Medical Center. Department of Radiology; Países BajosFil: Figdor, Carl G.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países BajosFil: de Vries, I. Jolanda M.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países BajosFuture Medicine2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4426Srinivas, Mangala; Tel, Jurjen; Schreibelt, Gerty; Bonetto, Fernando Jose; Cruz, Luis Javier; et al.; PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI; Future Medicine; Nanomedicine; 10; 15; 9-2015; 2339-23481743-5889enginfo:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/abs/10.2217/NNM.15.76info:eu-repo/semantics/altIdentifier/doi/doi:10.2217/nnm.15.76info:eu-repo/semantics/altIdentifier/issn/1743-5889info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:22Zoai:ri.conicet.gov.ar:11336/4426instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:23.04CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI |
title |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI |
spellingShingle |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI Srinivas, Mangala Perfluorocarbons 19f Mri Fluorescence Cell Therapy In-Vivo Imaging. |
title_short |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI |
title_full |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI |
title_fullStr |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI |
title_full_unstemmed |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI |
title_sort |
PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI |
dc.creator.none.fl_str_mv |
Srinivas, Mangala Tel, Jurjen Schreibelt, Gerty Bonetto, Fernando Jose Cruz, Luis Javier Amiri, Houshang Heerschap, Arend Figdor, Carl G. de Vries, I. Jolanda M. |
author |
Srinivas, Mangala |
author_facet |
Srinivas, Mangala Tel, Jurjen Schreibelt, Gerty Bonetto, Fernando Jose Cruz, Luis Javier Amiri, Houshang Heerschap, Arend Figdor, Carl G. de Vries, I. Jolanda M. |
author_role |
author |
author2 |
Tel, Jurjen Schreibelt, Gerty Bonetto, Fernando Jose Cruz, Luis Javier Amiri, Houshang Heerschap, Arend Figdor, Carl G. de Vries, I. Jolanda M. |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Perfluorocarbons 19f Mri Fluorescence Cell Therapy In-Vivo Imaging. |
topic |
Perfluorocarbons 19f Mri Fluorescence Cell Therapy In-Vivo Imaging. |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Aim: In vivo imaging using 19F MRI is advantageous, due to its ability to quantify cell numbers, but is limited for a lack of suitable labels. Here, we formulate two stable and clinically applicable labels for tracking two populations of primary human dendritic cells (DCs) simultaneously. Materials & methods: Plasmacytoid and myeloid DCs are able to take up sufficient nanoparticles (200 nm) for imaging (1012 19F's per cell), despite being relatively nonphagocytic. Results: Clinically relevant numbers of labeled DCs could be imaged in about 10 min, even on a clinical scanner. Conclusion: We demonstrate the use of perfluorocarbon nanoparticles for simultaneous 19F MRI of distinct cell populations in a clinical setting, without spectroscopic imaging. Fil: Srinivas, Mangala. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos Fil: Tel, Jurjen. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos Fil: Schreibelt, Gerty. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina Fil: Cruz, Luis Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Física del Litoral; Argentina Fil: Amiri, Houshang. Radboud University Medical Center. Department of Radiology; Países Bajos. Kerman University of Medical Sciences. Institute of Neuropharmacology. Neuroscience Research Center; Irán Fil: Heerschap, Arend. Radboud University Medical Center. Department of Radiology; Países Bajos Fil: Figdor, Carl G.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos Fil: de Vries, I. Jolanda M.. Radboud University Medical Center. Radboud Institute for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos |
description |
Aim: In vivo imaging using 19F MRI is advantageous, due to its ability to quantify cell numbers, but is limited for a lack of suitable labels. Here, we formulate two stable and clinically applicable labels for tracking two populations of primary human dendritic cells (DCs) simultaneously. Materials & methods: Plasmacytoid and myeloid DCs are able to take up sufficient nanoparticles (200 nm) for imaging (1012 19F's per cell), despite being relatively nonphagocytic. Results: Clinically relevant numbers of labeled DCs could be imaged in about 10 min, even on a clinical scanner. Conclusion: We demonstrate the use of perfluorocarbon nanoparticles for simultaneous 19F MRI of distinct cell populations in a clinical setting, without spectroscopic imaging. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/4426 Srinivas, Mangala; Tel, Jurjen; Schreibelt, Gerty; Bonetto, Fernando Jose; Cruz, Luis Javier; et al.; PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI; Future Medicine; Nanomedicine; 10; 15; 9-2015; 2339-2348 1743-5889 |
url |
http://hdl.handle.net/11336/4426 |
identifier_str_mv |
Srinivas, Mangala; Tel, Jurjen; Schreibelt, Gerty; Bonetto, Fernando Jose; Cruz, Luis Javier; et al.; PLGA-encapsulated perfluorocarbon nanoparticles for simultaneous visualization of distinct cell populations by F MRI; Future Medicine; Nanomedicine; 10; 15; 9-2015; 2339-2348 1743-5889 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/abs/10.2217/NNM.15.76 info:eu-repo/semantics/altIdentifier/doi/doi:10.2217/nnm.15.76 info:eu-repo/semantics/altIdentifier/issn/1743-5889 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Future Medicine |
publisher.none.fl_str_mv |
Future Medicine |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613848813797376 |
score |
13.070432 |