Neurocristopathies: How new discnveries in neural crest research changed our understanding

Autores
Vega López, Guillermo Alfredo; Aybar, Manuel Javier
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neural Crest Cells (NCC) have long been recognized as the fourth layer of developing vertebrate embryos. Нe neural crest is a transient cell population that is probably heterogeneous but multipotent, giving rise to melanocytes, Schwann cells, sympathetic, parasympathetic and enteric neurons, enteric glia, endocrine cells, fibroblasts, muscle, bone, cartilage and meninges, among others cell types [1]. Нe disorders that stem from neural crest dysfunction, called Neurocristopathies (NCP), are still only partially understood. Despite the great advances in our understanding of NCC formation and development, the causal link leading to NCP has remained elusive. In a recent review dealing with NCP we provided a thorough analysis of 66 NCP associated with a dozen Cell Signaling Pathways, 4 different families of transcription factors and a wide diversity of cellular processes?. In over 5 model organisms (mouse, chicken, frog, fish and others, it has been demonstrated that NCP are linked to NCC faults during essential developmental processes. We also discussed the incorporation of new diseases or syndromes based on the defects of neural crest-derived tissues and organs that have also been unveiled very recently. In the light of recent discoveries, we also included RASopathies, Ciliopathies, Ribosomopathies, and defective epigenetic mechanisms as responsible for four newly established NCP categories.
Fil: Vega López, Guillermo Alfredo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Aybar, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
NEUROCRISTOPATIES
CONGENITAL DISEASES
CONGENITAL SYNDROMES
NEURAL CREST DEFECTS
CELL SIGNALING
EMBRYO
FETUS
DEVELOPMENTAL BIOLOGY
CILIOPATHIES
CLASSIFICATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/101458
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/101458
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neurocristopathies: How new discnveries in neural crest research changed our understandingVega López, Guillermo AlfredoAybar, Manuel JavierNEUROCRISTOPATIESCONGENITAL DISEASESCONGENITAL SYNDROMESNEURAL CREST DEFECTSCELL SIGNALINGEMBRYOFETUSDEVELOPMENTAL BIOLOGYCILIOPATHIESCLASSIFICATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Neural Crest Cells (NCC) have long been recognized as the fourth layer of developing vertebrate embryos. Нe neural crest is a transient cell population that is probably heterogeneous but multipotent, giving rise to melanocytes, Schwann cells, sympathetic, parasympathetic and enteric neurons, enteric glia, endocrine cells, fibroblasts, muscle, bone, cartilage and meninges, among others cell types [1]. Нe disorders that stem from neural crest dysfunction, called Neurocristopathies (NCP), are still only partially understood. Despite the great advances in our understanding of NCC formation and development, the causal link leading to NCP has remained elusive. In a recent review dealing with NCP we provided a thorough analysis of 66 NCP associated with a dozen Cell Signaling Pathways, 4 different families of transcription factors and a wide diversity of cellular processes?. In over 5 model organisms (mouse, chicken, frog, fish and others, it has been demonstrated that NCP are linked to NCC faults during essential developmental processes. We also discussed the incorporation of new diseases or syndromes based on the defects of neural crest-derived tissues and organs that have also been unveiled very recently. In the light of recent discoveries, we also included RASopathies, Ciliopathies, Ribosomopathies, and defective epigenetic mechanisms as responsible for four newly established NCP categories.Fil: Vega López, Guillermo Alfredo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Aybar, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaOmics International2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/101458Vega López, Guillermo Alfredo; Aybar, Manuel Javier; Neurocristopathies: How new discnveries in neural crest research changed our understanding; Omics International; Cell & Developmental Biology; 7; 2; 12-2018; 1-2;10001952168-9296CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/neurocristopathies-how-new-discoveries-in-neural-crest-research-changed-our-understanding-2168-9296-1000195-106441.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.4172/2168-9296.1000195info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:19Zoai:ri.conicet.gov.ar:11336/101458instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:20.266CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurocristopathies: How new discnveries in neural crest research changed our understanding
title Neurocristopathies: How new discnveries in neural crest research changed our understanding
spellingShingle Neurocristopathies: How new discnveries in neural crest research changed our understanding
Vega López, Guillermo Alfredo
NEUROCRISTOPATIES
CONGENITAL DISEASES
CONGENITAL SYNDROMES
NEURAL CREST DEFECTS
CELL SIGNALING
EMBRYO
FETUS
DEVELOPMENTAL BIOLOGY
CILIOPATHIES
CLASSIFICATION
title_short Neurocristopathies: How new discnveries in neural crest research changed our understanding
title_full Neurocristopathies: How new discnveries in neural crest research changed our understanding
title_fullStr Neurocristopathies: How new discnveries in neural crest research changed our understanding
title_full_unstemmed Neurocristopathies: How new discnveries in neural crest research changed our understanding
title_sort Neurocristopathies: How new discnveries in neural crest research changed our understanding
dc.creator.none.fl_str_mv Vega López, Guillermo Alfredo
Aybar, Manuel Javier
author Vega López, Guillermo Alfredo
author_facet Vega López, Guillermo Alfredo
Aybar, Manuel Javier
author_role author
author2 Aybar, Manuel Javier
author2_role author
dc.subject.none.fl_str_mv NEUROCRISTOPATIES
CONGENITAL DISEASES
CONGENITAL SYNDROMES
NEURAL CREST DEFECTS
CELL SIGNALING
EMBRYO
FETUS
DEVELOPMENTAL BIOLOGY
CILIOPATHIES
CLASSIFICATION
topic NEUROCRISTOPATIES
CONGENITAL DISEASES
CONGENITAL SYNDROMES
NEURAL CREST DEFECTS
CELL SIGNALING
EMBRYO
FETUS
DEVELOPMENTAL BIOLOGY
CILIOPATHIES
CLASSIFICATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Neural Crest Cells (NCC) have long been recognized as the fourth layer of developing vertebrate embryos. Нe neural crest is a transient cell population that is probably heterogeneous but multipotent, giving rise to melanocytes, Schwann cells, sympathetic, parasympathetic and enteric neurons, enteric glia, endocrine cells, fibroblasts, muscle, bone, cartilage and meninges, among others cell types [1]. Нe disorders that stem from neural crest dysfunction, called Neurocristopathies (NCP), are still only partially understood. Despite the great advances in our understanding of NCC formation and development, the causal link leading to NCP has remained elusive. In a recent review dealing with NCP we provided a thorough analysis of 66 NCP associated with a dozen Cell Signaling Pathways, 4 different families of transcription factors and a wide diversity of cellular processes?. In over 5 model organisms (mouse, chicken, frog, fish and others, it has been demonstrated that NCP are linked to NCC faults during essential developmental processes. We also discussed the incorporation of new diseases or syndromes based on the defects of neural crest-derived tissues and organs that have also been unveiled very recently. In the light of recent discoveries, we also included RASopathies, Ciliopathies, Ribosomopathies, and defective epigenetic mechanisms as responsible for four newly established NCP categories.
Fil: Vega López, Guillermo Alfredo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Aybar, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Neural Crest Cells (NCC) have long been recognized as the fourth layer of developing vertebrate embryos. Нe neural crest is a transient cell population that is probably heterogeneous but multipotent, giving rise to melanocytes, Schwann cells, sympathetic, parasympathetic and enteric neurons, enteric glia, endocrine cells, fibroblasts, muscle, bone, cartilage and meninges, among others cell types [1]. Нe disorders that stem from neural crest dysfunction, called Neurocristopathies (NCP), are still only partially understood. Despite the great advances in our understanding of NCC formation and development, the causal link leading to NCP has remained elusive. In a recent review dealing with NCP we provided a thorough analysis of 66 NCP associated with a dozen Cell Signaling Pathways, 4 different families of transcription factors and a wide diversity of cellular processes?. In over 5 model organisms (mouse, chicken, frog, fish and others, it has been demonstrated that NCP are linked to NCC faults during essential developmental processes. We also discussed the incorporation of new diseases or syndromes based on the defects of neural crest-derived tissues and organs that have also been unveiled very recently. In the light of recent discoveries, we also included RASopathies, Ciliopathies, Ribosomopathies, and defective epigenetic mechanisms as responsible for four newly established NCP categories.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/101458
Vega López, Guillermo Alfredo; Aybar, Manuel Javier; Neurocristopathies: How new discnveries in neural crest research changed our understanding; Omics International; Cell & Developmental Biology; 7; 2; 12-2018; 1-2;1000195
2168-9296
CONICET Digital
CONICET
url http://hdl.handle.net/11336/101458
identifier_str_mv Vega López, Guillermo Alfredo; Aybar, Manuel Javier; Neurocristopathies: How new discnveries in neural crest research changed our understanding; Omics International; Cell & Developmental Biology; 7; 2; 12-2018; 1-2;1000195
2168-9296
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/neurocristopathies-how-new-discoveries-in-neural-crest-research-changed-our-understanding-2168-9296-1000195-106441.html
info:eu-repo/semantics/altIdentifier/doi/10.4172/2168-9296.1000195
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Omics International
publisher.none.fl_str_mv Omics International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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