Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering

Autores
Galdopórpora, Juan Manuel; Pérez, Claudio Javier; Tuttolomondo, María Victoria; Desimone, Martín Federico
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The main objective of this study is to develop an economic, environmentally friendly and malleable biomaterial for tissue engineering applications. Water and glycerol have been used as solvents for the gelatin hydrogel synthesis. This solvent mixture led to a biomaterial with improved thermal properties. Indeed, a 16 °C increase in thermal transition temperature was achieved. Furthermore, to enhance mechanical properties, riboflavin was used as a crosslinking agent. Chemical crosslinking step was initiated with UV radiation to obtain riboflavin radical polymerization of gelatin chains, hence, rheological properties of gelatin hydrogel were improved. Thus, Gelatin-UV-Riboflavin hydrogel showed good swelling and increased mechanical properties, obtaining a novel material for drug delivery and medical purposes.
Fil: Galdopórpora, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Pérez, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Tuttolomondo, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
BIOPOLYMER
CROSSLINKING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/119180
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineeringGaldopórpora, Juan ManuelPérez, Claudio JavierTuttolomondo, María VictoriaDesimone, Martín FedericoBIOPOLYMERCROSSLINKINGhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The main objective of this study is to develop an economic, environmentally friendly and malleable biomaterial for tissue engineering applications. Water and glycerol have been used as solvents for the gelatin hydrogel synthesis. This solvent mixture led to a biomaterial with improved thermal properties. Indeed, a 16 °C increase in thermal transition temperature was achieved. Furthermore, to enhance mechanical properties, riboflavin was used as a crosslinking agent. Chemical crosslinking step was initiated with UV radiation to obtain riboflavin radical polymerization of gelatin chains, hence, rheological properties of gelatin hydrogel were improved. Thus, Gelatin-UV-Riboflavin hydrogel showed good swelling and increased mechanical properties, obtaining a novel material for drug delivery and medical purposes.Fil: Galdopórpora, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Pérez, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Tuttolomondo, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaVBRI Press2019-02-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/119180Galdopórpora, Juan Manuel; Pérez, Claudio Javier; Tuttolomondo, María Victoria; Desimone, Martín Federico; Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering; VBRI Press; Advanced Materials Letters; 10; 5; 14-2-2019; 324-3280976-397XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.vbripress.com/aml/articles/details/1353info:eu-repo/semantics/altIdentifier/doi/10.5185/amlett.2019.2210info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:21Zoai:ri.conicet.gov.ar:11336/119180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:21.456CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
title Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
spellingShingle Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
Galdopórpora, Juan Manuel
BIOPOLYMER
CROSSLINKING
title_short Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
title_full Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
title_fullStr Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
title_full_unstemmed Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
title_sort Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
dc.creator.none.fl_str_mv Galdopórpora, Juan Manuel
Pérez, Claudio Javier
Tuttolomondo, María Victoria
Desimone, Martín Federico
author Galdopórpora, Juan Manuel
author_facet Galdopórpora, Juan Manuel
Pérez, Claudio Javier
Tuttolomondo, María Victoria
Desimone, Martín Federico
author_role author
author2 Pérez, Claudio Javier
Tuttolomondo, María Victoria
Desimone, Martín Federico
author2_role author
author
author
dc.subject.none.fl_str_mv BIOPOLYMER
CROSSLINKING
topic BIOPOLYMER
CROSSLINKING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The main objective of this study is to develop an economic, environmentally friendly and malleable biomaterial for tissue engineering applications. Water and glycerol have been used as solvents for the gelatin hydrogel synthesis. This solvent mixture led to a biomaterial with improved thermal properties. Indeed, a 16 °C increase in thermal transition temperature was achieved. Furthermore, to enhance mechanical properties, riboflavin was used as a crosslinking agent. Chemical crosslinking step was initiated with UV radiation to obtain riboflavin radical polymerization of gelatin chains, hence, rheological properties of gelatin hydrogel were improved. Thus, Gelatin-UV-Riboflavin hydrogel showed good swelling and increased mechanical properties, obtaining a novel material for drug delivery and medical purposes.
Fil: Galdopórpora, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Pérez, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Tuttolomondo, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description The main objective of this study is to develop an economic, environmentally friendly and malleable biomaterial for tissue engineering applications. Water and glycerol have been used as solvents for the gelatin hydrogel synthesis. This solvent mixture led to a biomaterial with improved thermal properties. Indeed, a 16 °C increase in thermal transition temperature was achieved. Furthermore, to enhance mechanical properties, riboflavin was used as a crosslinking agent. Chemical crosslinking step was initiated with UV radiation to obtain riboflavin radical polymerization of gelatin chains, hence, rheological properties of gelatin hydrogel were improved. Thus, Gelatin-UV-Riboflavin hydrogel showed good swelling and increased mechanical properties, obtaining a novel material for drug delivery and medical purposes.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-14
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/119180
Galdopórpora, Juan Manuel; Pérez, Claudio Javier; Tuttolomondo, María Victoria; Desimone, Martín Federico; Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering; VBRI Press; Advanced Materials Letters; 10; 5; 14-2-2019; 324-328
0976-397X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/119180
identifier_str_mv Galdopórpora, Juan Manuel; Pérez, Claudio Javier; Tuttolomondo, María Victoria; Desimone, Martín Federico; Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering; VBRI Press; Advanced Materials Letters; 10; 5; 14-2-2019; 324-328
0976-397X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.vbripress.com/aml/articles/details/1353
info:eu-repo/semantics/altIdentifier/doi/10.5185/amlett.2019.2210
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv VBRI Press
publisher.none.fl_str_mv VBRI Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613888976355328
score 13.070432

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