Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice

Autores
Trouillet, Anne Charlotte; Keller, Matthieu; Weiss, Jan; Leinders Zufall, Trese; Birnbaumer, Lutz; Zufall, Frank; Chamero, Pablo
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infantdirected aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein a-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2 + VSNs and the brain circuits activated by these neurons play a central role in orchestrating and balancing territorial and infantdirected aggression of male mice through bidirectional activation and inhibition of different targets in the limbic system.
Fil: Trouillet, Anne Charlotte. Universite de Tours; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Keller, Matthieu. Universite de Tours; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Weiss, Jan. Universitat Saarland; Alemania
Fil: Leinders Zufall, Trese. Universitat Saarland; Alemania
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Zufall, Frank. Universitat Saarland; Alemania
Fil: Chamero, Pablo. Universite de Tours; Francia. Centre National de la Recherche Scientifique; Francia
Materia
GCAMP6F
INFANT-DIRECTED AGGRESSION
OLFACTORY
TERRITORIAL AGGRESSION
V1R RECEPTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120565
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/120565
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male miceTrouillet, Anne CharlotteKeller, MatthieuWeiss, JanLeinders Zufall, TreseBirnbaumer, LutzZufall, FrankChamero, PabloGCAMP6FINFANT-DIRECTED AGGRESSIONOLFACTORYTERRITORIAL AGGRESSIONV1R RECEPTORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infantdirected aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein a-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2 + VSNs and the brain circuits activated by these neurons play a central role in orchestrating and balancing territorial and infantdirected aggression of male mice through bidirectional activation and inhibition of different targets in the limbic system.Fil: Trouillet, Anne Charlotte. Universite de Tours; Francia. Centre National de la Recherche Scientifique; FranciaFil: Keller, Matthieu. Universite de Tours; Francia. Centre National de la Recherche Scientifique; FranciaFil: Weiss, Jan. Universitat Saarland; AlemaniaFil: Leinders Zufall, Trese. Universitat Saarland; AlemaniaFil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Zufall, Frank. Universitat Saarland; AlemaniaFil: Chamero, Pablo. Universite de Tours; Francia. Centre National de la Recherche Scientifique; FranciaNational Academy of Sciences2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120565Trouillet, Anne Charlotte; Keller, Matthieu; Weiss, Jan; Leinders Zufall, Trese; Birnbaumer, Lutz; et al.; Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 116; 11; 3-2019; 5135-51430027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1821492116info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/116/11/5135info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:58:07Zoai:ri.conicet.gov.ar:11336/120565instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:58:08.177CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
spellingShingle Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
Trouillet, Anne Charlotte
GCAMP6F
INFANT-DIRECTED AGGRESSION
OLFACTORY
TERRITORIAL AGGRESSION
V1R RECEPTOR
title_short Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_full Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_fullStr Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_full_unstemmed Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
title_sort Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice
dc.creator.none.fl_str_mv Trouillet, Anne Charlotte
Keller, Matthieu
Weiss, Jan
Leinders Zufall, Trese
Birnbaumer, Lutz
Zufall, Frank
Chamero, Pablo
author Trouillet, Anne Charlotte
author_facet Trouillet, Anne Charlotte
Keller, Matthieu
Weiss, Jan
Leinders Zufall, Trese
Birnbaumer, Lutz
Zufall, Frank
Chamero, Pablo
author_role author
author2 Keller, Matthieu
Weiss, Jan
Leinders Zufall, Trese
Birnbaumer, Lutz
Zufall, Frank
Chamero, Pablo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv GCAMP6F
INFANT-DIRECTED AGGRESSION
OLFACTORY
TERRITORIAL AGGRESSION
V1R RECEPTOR
topic GCAMP6F
INFANT-DIRECTED AGGRESSION
OLFACTORY
TERRITORIAL AGGRESSION
V1R RECEPTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infantdirected aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein a-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2 + VSNs and the brain circuits activated by these neurons play a central role in orchestrating and balancing territorial and infantdirected aggression of male mice through bidirectional activation and inhibition of different targets in the limbic system.
Fil: Trouillet, Anne Charlotte. Universite de Tours; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Keller, Matthieu. Universite de Tours; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Weiss, Jan. Universitat Saarland; Alemania
Fil: Leinders Zufall, Trese. Universitat Saarland; Alemania
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Zufall, Frank. Universitat Saarland; Alemania
Fil: Chamero, Pablo. Universite de Tours; Francia. Centre National de la Recherche Scientifique; Francia
description Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infantdirected aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein a-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2 + VSNs and the brain circuits activated by these neurons play a central role in orchestrating and balancing territorial and infantdirected aggression of male mice through bidirectional activation and inhibition of different targets in the limbic system.
publishDate 2019
dc.date.none.fl_str_mv 2019-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120565
Trouillet, Anne Charlotte; Keller, Matthieu; Weiss, Jan; Leinders Zufall, Trese; Birnbaumer, Lutz; et al.; Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 116; 11; 3-2019; 5135-5143
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120565
identifier_str_mv Trouillet, Anne Charlotte; Keller, Matthieu; Weiss, Jan; Leinders Zufall, Trese; Birnbaumer, Lutz; et al.; Central role of G protein Gαi2 and Gαi2 + vomeronasal neurons in balancing territorial and infant-directed aggression of male mice; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 116; 11; 3-2019; 5135-5143
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1821492116
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/116/11/5135
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1848598397248864256
score 13.223955

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