White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance

Autores
Ramirez, Maria Soledad; Traglia, German Matias; Pérez, Jorgelina Fernanda; Müller, Gabriela Leticia; Martínez, María Florencia; Golic, Adrián Ezequiel; Mussi, María Alejandra
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Minocycline (MIN) and tigecycline (TIG) are antibiotics currently used for treatment of multi-drug resistant nosocomial pathogens. In this work, we show that blue light, as well as white light, modulate susceptibility to these antibiotics in a temperature-dependent manner. The modulation of susceptibility by light depends on the content of iron, resulting an increase in iron in a reduction in antibiotic susceptibility both under light as well as in the dark, though the effect was more pronounced in the latter condition. We further provide insights into the mechanism by showing that reduction in susceptibility to MIN and TIG induced by light is likely triggered by the generation of 1O2, which, by an yet unknown mechanism, would ultimately lead to the activation of resistance genes such as those coding for the efflux pump AdeABC. The clinical relevance of these results may rely in surface-exposed wound infections, given the exposure to light in addition to the relatively lower temperatures recorded in these type or lesions. We further show that the modulation of antibiotic susceptibility not only occurs in A. baumannii but also in other microorganisms of clinical relevance such as Escherichia coli or Staphylococcus aureus. Overall, our findings allow us to suggest that MIN and TIG antibiotic treatments may be improved by the inclusion of an iron chelator, a condition that in addition to keeping the wounds in the dark would increase the effectiveness in the control of infections involving these microorganisms.
Fil: Ramirez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina. California State University; Estados Unidos
Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina
Fil: Pérez, Jorgelina Fernanda. Universidad Nacional de Rosario. Facultad de Cs.bioquimicas y Farmaceuticas. Departamento de Microbiologia; Argentina
Fil: Müller, Gabriela Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Martínez, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
Fil: Golic, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
Fil: Mussi, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Materia
Blue light
Acinetobacter baumannii
Tygecicline
Antimicrobial agents
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7853
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7853
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importanceRamirez, Maria SoledadTraglia, German MatiasPérez, Jorgelina FernandaMüller, Gabriela LeticiaMartínez, María FlorenciaGolic, Adrián EzequielMussi, María AlejandraBlue lightAcinetobacter baumanniiTygeciclineAntimicrobial agentshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Minocycline (MIN) and tigecycline (TIG) are antibiotics currently used for treatment of multi-drug resistant nosocomial pathogens. In this work, we show that blue light, as well as white light, modulate susceptibility to these antibiotics in a temperature-dependent manner. The modulation of susceptibility by light depends on the content of iron, resulting an increase in iron in a reduction in antibiotic susceptibility both under light as well as in the dark, though the effect was more pronounced in the latter condition. We further provide insights into the mechanism by showing that reduction in susceptibility to MIN and TIG induced by light is likely triggered by the generation of 1O2, which, by an yet unknown mechanism, would ultimately lead to the activation of resistance genes such as those coding for the efflux pump AdeABC. The clinical relevance of these results may rely in surface-exposed wound infections, given the exposure to light in addition to the relatively lower temperatures recorded in these type or lesions. We further show that the modulation of antibiotic susceptibility not only occurs in A. baumannii but also in other microorganisms of clinical relevance such as Escherichia coli or Staphylococcus aureus. Overall, our findings allow us to suggest that MIN and TIG antibiotic treatments may be improved by the inclusion of an iron chelator, a condition that in addition to keeping the wounds in the dark would increase the effectiveness in the control of infections involving these microorganisms.Fil: Ramirez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina. California State University; Estados UnidosFil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; ArgentinaFil: Pérez, Jorgelina Fernanda. Universidad Nacional de Rosario. Facultad de Cs.bioquimicas y Farmaceuticas. Departamento de Microbiologia; ArgentinaFil: Müller, Gabriela Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Martínez, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); ArgentinaFil: Golic, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); ArgentinaFil: Mussi, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaSociety For General Microbiology2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7853Ramirez, Maria Soledad; Traglia, German Matias; Pérez, Jorgelina Fernanda; Müller, Gabriela Leticia; Martínez, María Florencia; et al.; White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance; Society For General Microbiology; Journal Of Medical Microbiology; 64; 3-2015; 525-5370022-2615enginfo:eu-repo/semantics/altIdentifier/url/http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000048#tab2info:eu-repo/semantics/altIdentifier/doi/10.1099/jmm.0.000048info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:35Zoai:ri.conicet.gov.ar:11336/7853instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:36.184CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
title White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
spellingShingle White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
Ramirez, Maria Soledad
Blue light
Acinetobacter baumannii
Tygecicline
Antimicrobial agents
title_short White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
title_full White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
title_fullStr White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
title_full_unstemmed White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
title_sort White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance
dc.creator.none.fl_str_mv Ramirez, Maria Soledad
Traglia, German Matias
Pérez, Jorgelina Fernanda
Müller, Gabriela Leticia
Martínez, María Florencia
Golic, Adrián Ezequiel
Mussi, María Alejandra
author Ramirez, Maria Soledad
author_facet Ramirez, Maria Soledad
Traglia, German Matias
Pérez, Jorgelina Fernanda
Müller, Gabriela Leticia
Martínez, María Florencia
Golic, Adrián Ezequiel
Mussi, María Alejandra
author_role author
author2 Traglia, German Matias
Pérez, Jorgelina Fernanda
Müller, Gabriela Leticia
Martínez, María Florencia
Golic, Adrián Ezequiel
Mussi, María Alejandra
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Blue light
Acinetobacter baumannii
Tygecicline
Antimicrobial agents
topic Blue light
Acinetobacter baumannii
Tygecicline
Antimicrobial agents
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Minocycline (MIN) and tigecycline (TIG) are antibiotics currently used for treatment of multi-drug resistant nosocomial pathogens. In this work, we show that blue light, as well as white light, modulate susceptibility to these antibiotics in a temperature-dependent manner. The modulation of susceptibility by light depends on the content of iron, resulting an increase in iron in a reduction in antibiotic susceptibility both under light as well as in the dark, though the effect was more pronounced in the latter condition. We further provide insights into the mechanism by showing that reduction in susceptibility to MIN and TIG induced by light is likely triggered by the generation of 1O2, which, by an yet unknown mechanism, would ultimately lead to the activation of resistance genes such as those coding for the efflux pump AdeABC. The clinical relevance of these results may rely in surface-exposed wound infections, given the exposure to light in addition to the relatively lower temperatures recorded in these type or lesions. We further show that the modulation of antibiotic susceptibility not only occurs in A. baumannii but also in other microorganisms of clinical relevance such as Escherichia coli or Staphylococcus aureus. Overall, our findings allow us to suggest that MIN and TIG antibiotic treatments may be improved by the inclusion of an iron chelator, a condition that in addition to keeping the wounds in the dark would increase the effectiveness in the control of infections involving these microorganisms.
Fil: Ramirez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina. California State University; Estados Unidos
Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Médica; Argentina
Fil: Pérez, Jorgelina Fernanda. Universidad Nacional de Rosario. Facultad de Cs.bioquimicas y Farmaceuticas. Departamento de Microbiologia; Argentina
Fil: Müller, Gabriela Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Martínez, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
Fil: Golic, Adrián Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina
Fil: Mussi, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
description Minocycline (MIN) and tigecycline (TIG) are antibiotics currently used for treatment of multi-drug resistant nosocomial pathogens. In this work, we show that blue light, as well as white light, modulate susceptibility to these antibiotics in a temperature-dependent manner. The modulation of susceptibility by light depends on the content of iron, resulting an increase in iron in a reduction in antibiotic susceptibility both under light as well as in the dark, though the effect was more pronounced in the latter condition. We further provide insights into the mechanism by showing that reduction in susceptibility to MIN and TIG induced by light is likely triggered by the generation of 1O2, which, by an yet unknown mechanism, would ultimately lead to the activation of resistance genes such as those coding for the efflux pump AdeABC. The clinical relevance of these results may rely in surface-exposed wound infections, given the exposure to light in addition to the relatively lower temperatures recorded in these type or lesions. We further show that the modulation of antibiotic susceptibility not only occurs in A. baumannii but also in other microorganisms of clinical relevance such as Escherichia coli or Staphylococcus aureus. Overall, our findings allow us to suggest that MIN and TIG antibiotic treatments may be improved by the inclusion of an iron chelator, a condition that in addition to keeping the wounds in the dark would increase the effectiveness in the control of infections involving these microorganisms.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7853
Ramirez, Maria Soledad; Traglia, German Matias; Pérez, Jorgelina Fernanda; Müller, Gabriela Leticia; Martínez, María Florencia; et al.; White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance; Society For General Microbiology; Journal Of Medical Microbiology; 64; 3-2015; 525-537
0022-2615
url http://hdl.handle.net/11336/7853
identifier_str_mv Ramirez, Maria Soledad; Traglia, German Matias; Pérez, Jorgelina Fernanda; Müller, Gabriela Leticia; Martínez, María Florencia; et al.; White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter sp. and other bacteria of clinical importance; Society For General Microbiology; Journal Of Medical Microbiology; 64; 3-2015; 525-537
0022-2615
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000048#tab2
info:eu-repo/semantics/altIdentifier/doi/10.1099/jmm.0.000048
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society For General Microbiology
publisher.none.fl_str_mv Society For General Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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