Mechanisms of copper homeostasis in bacteria

Autores
Argüello, José M.; Raimunda, Daniel Cesar; Padilla Benavidez, Teresita
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu+ transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures.
Fil: Argüello, José M.. Worcester Polytechnic Institute; Estados Unidos
Fil: Raimunda, Daniel Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Padilla Benavidez, Teresita. Worcester Polytechnic Institute; Estados Unidos
Materia
Copper
Copper homeostasis
Transmembrane transport
Metalloenzymes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25848
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Mechanisms of copper homeostasis in bacteriaArgüello, José M.Raimunda, Daniel CesarPadilla Benavidez, TeresitaCopperCopper homeostasisTransmembrane transportMetalloenzymeshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu+ transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures.Fil: Argüello, José M.. Worcester Polytechnic Institute; Estados UnidosFil: Raimunda, Daniel Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Padilla Benavidez, Teresita. Worcester Polytechnic Institute; Estados UnidosFrontiers2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25848Argüello, José M.; Raimunda, Daniel Cesar; Padilla Benavidez, Teresita; Mechanisms of copper homeostasis in bacteria; Frontiers; Frontiers in Cellular and Infection Microbiology; 3; 11-2013; 1-14; 732235-2988CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2013.00073info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2013.00073/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:48:54Zoai:ri.conicet.gov.ar:11336/25848instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:48:54.486CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanisms of copper homeostasis in bacteria
title Mechanisms of copper homeostasis in bacteria
spellingShingle Mechanisms of copper homeostasis in bacteria
Argüello, José M.
Copper
Copper homeostasis
Transmembrane transport
Metalloenzymes
title_short Mechanisms of copper homeostasis in bacteria
title_full Mechanisms of copper homeostasis in bacteria
title_fullStr Mechanisms of copper homeostasis in bacteria
title_full_unstemmed Mechanisms of copper homeostasis in bacteria
title_sort Mechanisms of copper homeostasis in bacteria
dc.creator.none.fl_str_mv Argüello, José M.
Raimunda, Daniel Cesar
Padilla Benavidez, Teresita
author Argüello, José M.
author_facet Argüello, José M.
Raimunda, Daniel Cesar
Padilla Benavidez, Teresita
author_role author
author2 Raimunda, Daniel Cesar
Padilla Benavidez, Teresita
author2_role author
author
dc.subject.none.fl_str_mv Copper
Copper homeostasis
Transmembrane transport
Metalloenzymes
topic Copper
Copper homeostasis
Transmembrane transport
Metalloenzymes
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu+ transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures.
Fil: Argüello, José M.. Worcester Polytechnic Institute; Estados Unidos
Fil: Raimunda, Daniel Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Padilla Benavidez, Teresita. Worcester Polytechnic Institute; Estados Unidos
description Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu+ transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25848
Argüello, José M.; Raimunda, Daniel Cesar; Padilla Benavidez, Teresita; Mechanisms of copper homeostasis in bacteria; Frontiers; Frontiers in Cellular and Infection Microbiology; 3; 11-2013; 1-14; 73
2235-2988
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25848
identifier_str_mv Argüello, José M.; Raimunda, Daniel Cesar; Padilla Benavidez, Teresita; Mechanisms of copper homeostasis in bacteria; Frontiers; Frontiers in Cellular and Infection Microbiology; 3; 11-2013; 1-14; 73
2235-2988
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2013.00073
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2013.00073/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847978203643117568
score 13.121305

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