Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models

Autores
de Moreno, Maria Alejandra; del Carmen, Silvina Andrea; Chatel, Jean Marc; Miyoshi, Anderson; Azevedo, Vasco; Langella, Philippe; Bermudez Humaran, Luis G.; Leblanc, Jean Guy Joseph
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments. Probiotic microorganisms appear as an alternative for these patients; however, probiotic characteristics are strain dependent and each probiotic needs to be tested to understand the underlining mechanisms involved in their beneficial properties. Genetic modification of lactic acid bacteria (LAB) was also described as a tool for new IBD treatments.The first part of this review shows different genetically modified LAB (GM-LAB) described for IBD treatment since 2000.Then, the two principally studied strategies are discussed (i) GM-LAB producing antioxidant enzymes and (ii) GM-LAB producing the anti-inflammatory cytokine IL-10. Different delivery systems, including protein delivery and DNA delivery, will also be discussed. Studies show the efficacy of GM-LAB (using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative. These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Chatel, Jean Marc. Institut National de la Recherche Agronomique; Francia
Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil
Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
Fil: Bermudez Humaran, Luis G.. Institut National de la Recherche Agronomique; Francia
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Materia
LACTIC ACID BACTERIA
GENETICALLY MODIFIED
INFLAMMATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28726
Acceder
id CONICETDig_5453235f3cefe7be32a049f394a2b9ac
oai_identifier_str oai:ri.conicet.gov.ar:11336/28726
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine modelsde Moreno, Maria Alejandradel Carmen, Silvina AndreaChatel, Jean MarcMiyoshi, AndersonAzevedo, VascoLangella, PhilippeBermudez Humaran, Luis G.Leblanc, Jean Guy JosephLACTIC ACID BACTERIAGENETICALLY MODIFIEDINFLAMMATIONhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments. Probiotic microorganisms appear as an alternative for these patients; however, probiotic characteristics are strain dependent and each probiotic needs to be tested to understand the underlining mechanisms involved in their beneficial properties. Genetic modification of lactic acid bacteria (LAB) was also described as a tool for new IBD treatments.The first part of this review shows different genetically modified LAB (GM-LAB) described for IBD treatment since 2000.Then, the two principally studied strategies are discussed (i) GM-LAB producing antioxidant enzymes and (ii) GM-LAB producing the anti-inflammatory cytokine IL-10. Different delivery systems, including protein delivery and DNA delivery, will also be discussed. Studies show the efficacy of GM-LAB (using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative. These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Chatel, Jean Marc. Institut National de la Recherche Agronomique; FranciaFil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; BrasilFil: Azevedo, Vasco. Universidade Federal do Minas Gerais; BrasilFil: Langella, Philippe. Institut National de la Recherche Agronomique; FranciaFil: Bermudez Humaran, Luis G.. Institut National de la Recherche Agronomique; FranciaFil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaHindawi Publishing Corporation2015-05-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28726de Moreno, Maria Alejandra; del Carmen, Silvina Andrea; Chatel, Jean Marc; Miyoshi, Anderson; Azevedo, Vasco; et al.; Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models; Hindawi Publishing Corporation; Gastroenterology Research and Practice; 2015; 146972; 4-5-2015; 1-81687-61211687-630XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2015/146972info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/grp/2015/146972/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:01:12Zoai:ri.conicet.gov.ar:11336/28726instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:01:12.689CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
title Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
spellingShingle Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
de Moreno, Maria Alejandra
LACTIC ACID BACTERIA
GENETICALLY MODIFIED
INFLAMMATION
title_short Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
title_full Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
title_fullStr Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
title_full_unstemmed Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
title_sort Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models
dc.creator.none.fl_str_mv de Moreno, Maria Alejandra
del Carmen, Silvina Andrea
Chatel, Jean Marc
Miyoshi, Anderson
Azevedo, Vasco
Langella, Philippe
Bermudez Humaran, Luis G.
Leblanc, Jean Guy Joseph
author de Moreno, Maria Alejandra
author_facet de Moreno, Maria Alejandra
del Carmen, Silvina Andrea
Chatel, Jean Marc
Miyoshi, Anderson
Azevedo, Vasco
Langella, Philippe
Bermudez Humaran, Luis G.
Leblanc, Jean Guy Joseph
author_role author
author2 del Carmen, Silvina Andrea
Chatel, Jean Marc
Miyoshi, Anderson
Azevedo, Vasco
Langella, Philippe
Bermudez Humaran, Luis G.
Leblanc, Jean Guy Joseph
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv LACTIC ACID BACTERIA
GENETICALLY MODIFIED
INFLAMMATION
topic LACTIC ACID BACTERIA
GENETICALLY MODIFIED
INFLAMMATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments. Probiotic microorganisms appear as an alternative for these patients; however, probiotic characteristics are strain dependent and each probiotic needs to be tested to understand the underlining mechanisms involved in their beneficial properties. Genetic modification of lactic acid bacteria (LAB) was also described as a tool for new IBD treatments.The first part of this review shows different genetically modified LAB (GM-LAB) described for IBD treatment since 2000.Then, the two principally studied strategies are discussed (i) GM-LAB producing antioxidant enzymes and (ii) GM-LAB producing the anti-inflammatory cytokine IL-10. Different delivery systems, including protein delivery and DNA delivery, will also be discussed. Studies show the efficacy of GM-LAB (using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative. These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Chatel, Jean Marc. Institut National de la Recherche Agronomique; Francia
Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil
Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia
Fil: Bermudez Humaran, Luis G.. Institut National de la Recherche Agronomique; Francia
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
description Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments. Probiotic microorganisms appear as an alternative for these patients; however, probiotic characteristics are strain dependent and each probiotic needs to be tested to understand the underlining mechanisms involved in their beneficial properties. Genetic modification of lactic acid bacteria (LAB) was also described as a tool for new IBD treatments.The first part of this review shows different genetically modified LAB (GM-LAB) described for IBD treatment since 2000.Then, the two principally studied strategies are discussed (i) GM-LAB producing antioxidant enzymes and (ii) GM-LAB producing the anti-inflammatory cytokine IL-10. Different delivery systems, including protein delivery and DNA delivery, will also be discussed. Studies show the efficacy of GM-LAB (using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative. These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28726
de Moreno, Maria Alejandra; del Carmen, Silvina Andrea; Chatel, Jean Marc; Miyoshi, Anderson; Azevedo, Vasco; et al.; Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models; Hindawi Publishing Corporation; Gastroenterology Research and Practice; 2015; 146972; 4-5-2015; 1-8
1687-6121
1687-630X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28726
identifier_str_mv de Moreno, Maria Alejandra; del Carmen, Silvina Andrea; Chatel, Jean Marc; Miyoshi, Anderson; Azevedo, Vasco; et al.; Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models; Hindawi Publishing Corporation; Gastroenterology Research and Practice; 2015; 146972; 4-5-2015; 1-8
1687-6121
1687-630X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/146972
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/grp/2015/146972/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842979933277650944
score 12.48226

Publicaciones similares