Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats

Autores
Llopart, Emilce Elina; Cian, Raúl Esteban; López Oliva Muñoz, María Elvira; Zuleta, Angela; Weisstaub, Adriana Ruth; Drago, Silvina Rosa
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Colonic effects of extruded whole-grain sorghum diets were evaluated using a model of growing rats. In all, twenty-four male Wistar rats were fed control (C), extruded white sorghum (EWS) or red sorghum (ERS). Consumption of sorghum diets showed satiety properties, with reduction of caecal pH, and lower activity of β-glucosidase and β-glucuronidase enzymes. Decreased copper zinc superoxide dismutase and manganese superoxide dismutase and increased catalase and glutathione peroxidase levels were observed in colonic mucosa. The induction of antioxidant enzymes occurred through the activation of the nuclear factor erythroid 2-related factor 2 protein and its subsequent translocation into the nucleus. ERS was able to decrease the proliferation of proximal mucosa of colon, demonstrating a possible effect against colorectal tumourigenesis. EWS increased proliferation and also apoptosis, ensuring the re-establishment of homoeostasis of the colonic mucosa. No antioxidant systemic effect (serum or hepatic level) was observed. It is likely that despite the extrusion the low bioavailability of the phenolic compounds of sorghum diets caused them to exert mainly acute effects at the colon level. Extruded whole-grain sorghum is a good functional ingredient that might be promising in dietary prevention of intestinal diseases.
Fil: Llopart, Emilce Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina
Fil: Cian, Raúl Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina
Fil: López Oliva Muñoz, María Elvira. Universidad Complutense de Madrid; España
Fil: Zuleta, Angela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Weisstaub, Adriana Ruth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Materia
Whole Grain
Extruded Sorghum
Antioxidant Status
Lipid Profile
Colon Health
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44484
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/44484
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar ratsLlopart, Emilce ElinaCian, Raúl EstebanLópez Oliva Muñoz, María ElviraZuleta, AngelaWeisstaub, Adriana RuthDrago, Silvina RosaWhole GrainExtruded SorghumAntioxidant StatusLipid ProfileColon Healthhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Colonic effects of extruded whole-grain sorghum diets were evaluated using a model of growing rats. In all, twenty-four male Wistar rats were fed control (C), extruded white sorghum (EWS) or red sorghum (ERS). Consumption of sorghum diets showed satiety properties, with reduction of caecal pH, and lower activity of β-glucosidase and β-glucuronidase enzymes. Decreased copper zinc superoxide dismutase and manganese superoxide dismutase and increased catalase and glutathione peroxidase levels were observed in colonic mucosa. The induction of antioxidant enzymes occurred through the activation of the nuclear factor erythroid 2-related factor 2 protein and its subsequent translocation into the nucleus. ERS was able to decrease the proliferation of proximal mucosa of colon, demonstrating a possible effect against colorectal tumourigenesis. EWS increased proliferation and also apoptosis, ensuring the re-establishment of homoeostasis of the colonic mucosa. No antioxidant systemic effect (serum or hepatic level) was observed. It is likely that despite the extrusion the low bioavailability of the phenolic compounds of sorghum diets caused them to exert mainly acute effects at the colon level. Extruded whole-grain sorghum is a good functional ingredient that might be promising in dietary prevention of intestinal diseases.Fil: Llopart, Emilce Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; ArgentinaFil: Cian, Raúl Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; ArgentinaFil: López Oliva Muñoz, María Elvira. Universidad Complutense de Madrid; EspañaFil: Zuleta, Angela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Weisstaub, Adriana Ruth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaCambridge University Press2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44484Llopart, Emilce Elina; Cian, Raúl Esteban; López Oliva Muñoz, María Elvira; Zuleta, Angela; Weisstaub, Adriana Ruth; et al.; Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats; Cambridge University Press; British Journal of Nutrition; 118; 8; 10-2017; 589-5970007-1145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/colonic-and-systemic-effects-of-extruded-wholegrain-sorghum-consumption-in-growing-wistar-rats/E92A71DD14B7E7F2505310941D8F4A13info:eu-repo/semantics/altIdentifier/doi/10.1017/S0007114517002513info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:27Zoai:ri.conicet.gov.ar:11336/44484instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:27.98CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
title Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
spellingShingle Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
Llopart, Emilce Elina
Whole Grain
Extruded Sorghum
Antioxidant Status
Lipid Profile
Colon Health
title_short Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
title_full Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
title_fullStr Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
title_full_unstemmed Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
title_sort Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
dc.creator.none.fl_str_mv Llopart, Emilce Elina
Cian, Raúl Esteban
López Oliva Muñoz, María Elvira
Zuleta, Angela
Weisstaub, Adriana Ruth
Drago, Silvina Rosa
author Llopart, Emilce Elina
author_facet Llopart, Emilce Elina
Cian, Raúl Esteban
López Oliva Muñoz, María Elvira
Zuleta, Angela
Weisstaub, Adriana Ruth
Drago, Silvina Rosa
author_role author
author2 Cian, Raúl Esteban
López Oliva Muñoz, María Elvira
Zuleta, Angela
Weisstaub, Adriana Ruth
Drago, Silvina Rosa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Whole Grain
Extruded Sorghum
Antioxidant Status
Lipid Profile
Colon Health
topic Whole Grain
Extruded Sorghum
Antioxidant Status
Lipid Profile
Colon Health
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Colonic effects of extruded whole-grain sorghum diets were evaluated using a model of growing rats. In all, twenty-four male Wistar rats were fed control (C), extruded white sorghum (EWS) or red sorghum (ERS). Consumption of sorghum diets showed satiety properties, with reduction of caecal pH, and lower activity of β-glucosidase and β-glucuronidase enzymes. Decreased copper zinc superoxide dismutase and manganese superoxide dismutase and increased catalase and glutathione peroxidase levels were observed in colonic mucosa. The induction of antioxidant enzymes occurred through the activation of the nuclear factor erythroid 2-related factor 2 protein and its subsequent translocation into the nucleus. ERS was able to decrease the proliferation of proximal mucosa of colon, demonstrating a possible effect against colorectal tumourigenesis. EWS increased proliferation and also apoptosis, ensuring the re-establishment of homoeostasis of the colonic mucosa. No antioxidant systemic effect (serum or hepatic level) was observed. It is likely that despite the extrusion the low bioavailability of the phenolic compounds of sorghum diets caused them to exert mainly acute effects at the colon level. Extruded whole-grain sorghum is a good functional ingredient that might be promising in dietary prevention of intestinal diseases.
Fil: Llopart, Emilce Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina
Fil: Cian, Raúl Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina
Fil: López Oliva Muñoz, María Elvira. Universidad Complutense de Madrid; España
Fil: Zuleta, Angela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Weisstaub, Adriana Ruth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
description Colonic effects of extruded whole-grain sorghum diets were evaluated using a model of growing rats. In all, twenty-four male Wistar rats were fed control (C), extruded white sorghum (EWS) or red sorghum (ERS). Consumption of sorghum diets showed satiety properties, with reduction of caecal pH, and lower activity of β-glucosidase and β-glucuronidase enzymes. Decreased copper zinc superoxide dismutase and manganese superoxide dismutase and increased catalase and glutathione peroxidase levels were observed in colonic mucosa. The induction of antioxidant enzymes occurred through the activation of the nuclear factor erythroid 2-related factor 2 protein and its subsequent translocation into the nucleus. ERS was able to decrease the proliferation of proximal mucosa of colon, demonstrating a possible effect against colorectal tumourigenesis. EWS increased proliferation and also apoptosis, ensuring the re-establishment of homoeostasis of the colonic mucosa. No antioxidant systemic effect (serum or hepatic level) was observed. It is likely that despite the extrusion the low bioavailability of the phenolic compounds of sorghum diets caused them to exert mainly acute effects at the colon level. Extruded whole-grain sorghum is a good functional ingredient that might be promising in dietary prevention of intestinal diseases.
publishDate 2017
dc.date.none.fl_str_mv 2017-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44484
Llopart, Emilce Elina; Cian, Raúl Esteban; López Oliva Muñoz, María Elvira; Zuleta, Angela; Weisstaub, Adriana Ruth; et al.; Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats; Cambridge University Press; British Journal of Nutrition; 118; 8; 10-2017; 589-597
0007-1145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44484
identifier_str_mv Llopart, Emilce Elina; Cian, Raúl Esteban; López Oliva Muñoz, María Elvira; Zuleta, Angela; Weisstaub, Adriana Ruth; et al.; Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats; Cambridge University Press; British Journal of Nutrition; 118; 8; 10-2017; 589-597
0007-1145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/colonic-and-systemic-effects-of-extruded-wholegrain-sorghum-consumption-in-growing-wistar-rats/E92A71DD14B7E7F2505310941D8F4A13
info:eu-repo/semantics/altIdentifier/doi/10.1017/S0007114517002513
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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