Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases

Autores
Kim, Hyun Seok; Kim, Hyun Seok; Sookoian, Silvia Cristina; Sookoian, Silvia Cristina; Hernaez, Ruben; Hernaez, Ruben
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos
Materia
GWAS
GWAS
GENETICS
GENETICS
NASH
NASH
NAFLD
NAFLD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/167133

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spelling Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseasesGenome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseasesKim, Hyun SeokKim, Hyun SeokSookoian, Silvia CristinaSookoian, Silvia CristinaHernaez, RubenHernaez, RubenGWASGWASGENETICSGENETICSNASHNASHNAFLDNAFLDhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados UnidosFil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados UnidosFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados UnidosFil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados UnidosJohn Wiley & Sons Inc.John Wiley & Sons Inc.2021-122021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167133Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-35330270-91390270-9139CONICET DigitalCONICETengenginfo:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:41Zoai:ri.conicet.gov.ar:11336/167133instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:41.364CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
title Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
spellingShingle Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
Kim, Hyun Seok
GWAS
GWAS
GENETICS
GENETICS
NASH
NASH
NAFLD
NAFLD
title_short Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
title_full Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
title_fullStr Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
title_full_unstemmed Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
title_sort Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
dc.creator.none.fl_str_mv Kim, Hyun Seok
Kim, Hyun Seok
Sookoian, Silvia Cristina
Sookoian, Silvia Cristina
Hernaez, Ruben
Hernaez, Ruben
author Kim, Hyun Seok
author_facet Kim, Hyun Seok
Sookoian, Silvia Cristina
Hernaez, Ruben
author_role author
author2 Sookoian, Silvia Cristina
Hernaez, Ruben
author2_role author
author
dc.subject.none.fl_str_mv GWAS
GWAS
GENETICS
GENETICS
NASH
NASH
NAFLD
NAFLD
topic GWAS
GWAS
GENETICS
GENETICS
NASH
NASH
NAFLD
NAFLD
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos
description Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/167133
Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533
Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533
0270-9139
0270-9139
CONICET Digital
CONICET
url http://hdl.handle.net/11336/167133
identifier_str_mv Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533
0270-9139
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175
info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175
info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175
info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc.
John Wiley & Sons Inc.
publisher.none.fl_str_mv John Wiley & Sons Inc.
John Wiley & Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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