Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
- Autores
- Kim, Hyun Seok; Kim, Hyun Seok; Sookoian, Silvia Cristina; Sookoian, Silvia Cristina; Hernaez, Ruben; Hernaez, Ruben
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos
Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos - Materia
-
GWAS
GWAS
GENETICS
GENETICS
NASH
NASH
NAFLD
NAFLD - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/167133
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Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseasesGenome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseasesKim, Hyun SeokKim, Hyun SeokSookoian, Silvia CristinaSookoian, Silvia CristinaHernaez, RubenHernaez, RubenGWASGWASGENETICSGENETICSNASHNASHNAFLDNAFLDhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research.Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados UnidosFil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados UnidosFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados UnidosFil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados UnidosJohn Wiley & Sons Inc.John Wiley & Sons Inc.2021-122021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167133Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-35330270-91390270-9139CONICET DigitalCONICETengenginfo:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:41Zoai:ri.conicet.gov.ar:11336/167133instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:41.364CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases |
title |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases |
spellingShingle |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases Kim, Hyun Seok GWAS GWAS GENETICS GENETICS NASH NASH NAFLD NAFLD |
title_short |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases |
title_full |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases |
title_fullStr |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases |
title_full_unstemmed |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases |
title_sort |
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases |
dc.creator.none.fl_str_mv |
Kim, Hyun Seok Kim, Hyun Seok Sookoian, Silvia Cristina Sookoian, Silvia Cristina Hernaez, Ruben Hernaez, Ruben |
author |
Kim, Hyun Seok |
author_facet |
Kim, Hyun Seok Sookoian, Silvia Cristina Hernaez, Ruben |
author_role |
author |
author2 |
Sookoian, Silvia Cristina Hernaez, Ruben |
author2_role |
author author |
dc.subject.none.fl_str_mv |
GWAS GWAS GENETICS GENETICS NASH NASH NAFLD NAFLD |
topic |
GWAS GWAS GENETICS GENETICS NASH NASH NAFLD NAFLD |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research. Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research. Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos Fil: Kim, Hyun Seok. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos. University of Texas; Estados Unidos Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos Fil: Hernaez, Ruben. Baylor College of Medicine; Estados Unidos. Michael E. Debakey Va Medical Center; Estados Unidos |
description |
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a meta-analysis of GWAS collected in approximately 390,000 individuals of the UK BioBank and about 160,000 Japanese individuals from the BioBank Japan, to expand the understanding of the genetic determinants of serum levels of liver-related enzymes.(2) They identified 378 independent loci associated with serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). They found several associations of susceptibility loci potentially affecting the level of these enzymes with different traits (pleiotropism), including liver (e.g., steatosis) and non-liver (e.g., ulcerative colitis) diseases. They concluded that these associations were likely not causal, but they provided hypothesis-generating results that can open up avenues of new research. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12 2021-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/167133 Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533 Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533 0270-9139 0270-9139 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/167133 |
identifier_str_mv |
Kim, Hyun Seok; Sookoian, Silvia Cristina; Hernaez, Ruben; Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 74; 6; 12-2021; 3529-3533 0270-9139 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175 info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32175 info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175 info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.32175 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons Inc. John Wiley & Sons Inc. |
publisher.none.fl_str_mv |
John Wiley & Sons Inc. John Wiley & Sons Inc. |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |