Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence

Autores
Etcheverry, María Eugenia; Pasquale, Miguel Angel; Garavaglia, Mario Jose
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The main objective of the present study was to develop a violet LED light source suitable for medical application devoted to the diagnostic and treatment of non-melanoma skin cancers. For this propose, we constructed a 12 W violet LED lamp (with maximum emission peak at 405 nm) made up of four mobile 3 W LED. The LED lamp was characterized employing a spectrometer coupled to an optical fiber. The irradiance, the radiant power and the radiant intensity for different distances between the lamp and the detector was assessed. Data were compared with a simulated LED lamp by using the Zemax optic software for the realization of luminaries with the desired characteristics as required for medical applications.The developed lamp in combination with a portable spectrometer was employed under medical supervision to detect differences in the emission spectrum of skin suspicious regions and healthy ones of a patient with non-melanoma skin cancer. The light of the LED lamp was concentrated in the examined region by means of the proper focusing of the four individual LEDs, rendering a high intensity homogeneous spot. Thus, endogenous chromophores at the skin were excited, and the emission intensity appeared to be enough to detect an enhanced peaked structure around 600 nm for some suspicious regions before treatment, and that were absence in healthy regions. These differences can be related to the augmented protoporphyrin IX content in neoplastic regions. Results presented in this work indicates the usefulness of the developed LED lamp as an easy-to-use device for the non-invasive detection of skin neoplastic pathologies, before and after treatment, with the aim of better define the malignant regions as well as predict the outcome of a certain treatment.
Fil: Etcheverry, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Garavaglia, Mario Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Materia
NON-MELANOMA SKIN CANCER
ONE-POINT FLUORESCENCE DETECTION
VIOLET LED LAMP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227243
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/227243
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Applications in Light-induced Spectroscopy with violet LED lamp: AutofluorecenceEtcheverry, María EugeniaPasquale, Miguel AngelGaravaglia, Mario JoseNON-MELANOMA SKIN CANCERONE-POINT FLUORESCENCE DETECTIONVIOLET LED LAMPhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The main objective of the present study was to develop a violet LED light source suitable for medical application devoted to the diagnostic and treatment of non-melanoma skin cancers. For this propose, we constructed a 12 W violet LED lamp (with maximum emission peak at 405 nm) made up of four mobile 3 W LED. The LED lamp was characterized employing a spectrometer coupled to an optical fiber. The irradiance, the radiant power and the radiant intensity for different distances between the lamp and the detector was assessed. Data were compared with a simulated LED lamp by using the Zemax optic software for the realization of luminaries with the desired characteristics as required for medical applications.The developed lamp in combination with a portable spectrometer was employed under medical supervision to detect differences in the emission spectrum of skin suspicious regions and healthy ones of a patient with non-melanoma skin cancer. The light of the LED lamp was concentrated in the examined region by means of the proper focusing of the four individual LEDs, rendering a high intensity homogeneous spot. Thus, endogenous chromophores at the skin were excited, and the emission intensity appeared to be enough to detect an enhanced peaked structure around 600 nm for some suspicious regions before treatment, and that were absence in healthy regions. These differences can be related to the augmented protoporphyrin IX content in neoplastic regions. Results presented in this work indicates the usefulness of the developed LED lamp as an easy-to-use device for the non-invasive detection of skin neoplastic pathologies, before and after treatment, with the aim of better define the malignant regions as well as predict the outcome of a certain treatment.Fil: Etcheverry, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; ArgentinaFil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Garavaglia, Mario Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; ArgentinaJournal of Clinical Studies and Medical Images, Case Reports2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227243Etcheverry, María Eugenia; Pasquale, Miguel Angel; Garavaglia, Mario Jose; Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence; Journal of Clinical Studies and Medical Images, Case Reports; Journal of Clinical Studies and Medical Images, Case Reports; 1; 3; 1013; 6-2023; 1-52837-7567CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jcsmicasereports.org/articles/JCSMICR-1013.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:39:24Zoai:ri.conicet.gov.ar:11336/227243instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:39:25.033CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
title Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
spellingShingle Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
Etcheverry, María Eugenia
NON-MELANOMA SKIN CANCER
ONE-POINT FLUORESCENCE DETECTION
VIOLET LED LAMP
title_short Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
title_full Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
title_fullStr Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
title_full_unstemmed Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
title_sort Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence
dc.creator.none.fl_str_mv Etcheverry, María Eugenia
Pasquale, Miguel Angel
Garavaglia, Mario Jose
author Etcheverry, María Eugenia
author_facet Etcheverry, María Eugenia
Pasquale, Miguel Angel
Garavaglia, Mario Jose
author_role author
author2 Pasquale, Miguel Angel
Garavaglia, Mario Jose
author2_role author
author
dc.subject.none.fl_str_mv NON-MELANOMA SKIN CANCER
ONE-POINT FLUORESCENCE DETECTION
VIOLET LED LAMP
topic NON-MELANOMA SKIN CANCER
ONE-POINT FLUORESCENCE DETECTION
VIOLET LED LAMP
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The main objective of the present study was to develop a violet LED light source suitable for medical application devoted to the diagnostic and treatment of non-melanoma skin cancers. For this propose, we constructed a 12 W violet LED lamp (with maximum emission peak at 405 nm) made up of four mobile 3 W LED. The LED lamp was characterized employing a spectrometer coupled to an optical fiber. The irradiance, the radiant power and the radiant intensity for different distances between the lamp and the detector was assessed. Data were compared with a simulated LED lamp by using the Zemax optic software for the realization of luminaries with the desired characteristics as required for medical applications.The developed lamp in combination with a portable spectrometer was employed under medical supervision to detect differences in the emission spectrum of skin suspicious regions and healthy ones of a patient with non-melanoma skin cancer. The light of the LED lamp was concentrated in the examined region by means of the proper focusing of the four individual LEDs, rendering a high intensity homogeneous spot. Thus, endogenous chromophores at the skin were excited, and the emission intensity appeared to be enough to detect an enhanced peaked structure around 600 nm for some suspicious regions before treatment, and that were absence in healthy regions. These differences can be related to the augmented protoporphyrin IX content in neoplastic regions. Results presented in this work indicates the usefulness of the developed LED lamp as an easy-to-use device for the non-invasive detection of skin neoplastic pathologies, before and after treatment, with the aim of better define the malignant regions as well as predict the outcome of a certain treatment.
Fil: Etcheverry, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Pasquale, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Garavaglia, Mario Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
description The main objective of the present study was to develop a violet LED light source suitable for medical application devoted to the diagnostic and treatment of non-melanoma skin cancers. For this propose, we constructed a 12 W violet LED lamp (with maximum emission peak at 405 nm) made up of four mobile 3 W LED. The LED lamp was characterized employing a spectrometer coupled to an optical fiber. The irradiance, the radiant power and the radiant intensity for different distances between the lamp and the detector was assessed. Data were compared with a simulated LED lamp by using the Zemax optic software for the realization of luminaries with the desired characteristics as required for medical applications.The developed lamp in combination with a portable spectrometer was employed under medical supervision to detect differences in the emission spectrum of skin suspicious regions and healthy ones of a patient with non-melanoma skin cancer. The light of the LED lamp was concentrated in the examined region by means of the proper focusing of the four individual LEDs, rendering a high intensity homogeneous spot. Thus, endogenous chromophores at the skin were excited, and the emission intensity appeared to be enough to detect an enhanced peaked structure around 600 nm for some suspicious regions before treatment, and that were absence in healthy regions. These differences can be related to the augmented protoporphyrin IX content in neoplastic regions. Results presented in this work indicates the usefulness of the developed LED lamp as an easy-to-use device for the non-invasive detection of skin neoplastic pathologies, before and after treatment, with the aim of better define the malignant regions as well as predict the outcome of a certain treatment.
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227243
Etcheverry, María Eugenia; Pasquale, Miguel Angel; Garavaglia, Mario Jose; Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence; Journal of Clinical Studies and Medical Images, Case Reports; Journal of Clinical Studies and Medical Images, Case Reports; 1; 3; 1013; 6-2023; 1-5
2837-7567
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227243
identifier_str_mv Etcheverry, María Eugenia; Pasquale, Miguel Angel; Garavaglia, Mario Jose; Applications in Light-induced Spectroscopy with violet LED lamp: Autofluorecence; Journal of Clinical Studies and Medical Images, Case Reports; Journal of Clinical Studies and Medical Images, Case Reports; 1; 3; 1013; 6-2023; 1-5
2837-7567
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jcsmicasereports.org/articles/JCSMICR-1013.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Journal of Clinical Studies and Medical Images, Case Reports
publisher.none.fl_str_mv Journal of Clinical Studies and Medical Images, Case Reports
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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