Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors

Autores
Alarcon Segovia, Lilian Celeste; Bandodkar, Amay J.; Rogers, John A.; Rintoul, Ignacio
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Wearable skin sensors is a promising technology for real-time health care monitoring. They are of particular interest for monitoring glucose in diabetic patients. The concentration of glucose in sweat can be more than two orders of magnitude lower than in blood. In consequence, the scientific and technological efforts are focused in developing new concepts to enhance the sensitivity, decrease the limit of detection (LOD) and reduce the response time (RT) of glucose skin sensors. This work explores the effect of adsorbed superparamagnetic magnetite nanoparticles (MNPs) and conductive nanoparticles (CNPs) on carbon nanotube substrates (CNTs) used to immobilize glucose oxidase enzyme in the working electrode of skin sensors. MNPs and CNPs are made of magnetite and gold, respectively. The performance of the sensors was tested in standard buffer solution, artificial sweat, fresh sweat and on the skin of a healthy volunteer during an exercise session. In the case of artificial sweat, the presence of MNPs accelerated the RT from 7 to 5 s at the expense of increasing the LOD from 0.017 to 0.022 mM with slight increase of the sensitivity from 4.90 to 5.09 μAm M-1 cm-2. The presence of CNPs greatly accelerated the RT from 7 to 2 s and lowered the LOD from 0.017 to 0.014 mM at the expense of a great diminution of the sensitivity from 4.90 to 4.09 μAm M-1 cm-2. These effects were explained mechanistically by analyzing the changes in the concentration of free oxygen and electrons promoted by MNPs and CNPs in the CNTs and its consequences on the the glucose oxidation process.
Fil: Alarcon Segovia, Lilian Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
Fil: Bandodkar, Amay J.. Northwestern University; Estados Unidos
Fil: Rogers, John A.. Northwestern University; Estados Unidos
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
BIOMATERIALS
BIOSENSORS
DIABETICS
DIAGNOSTICS
INTEGRATED ELECTRONICS
NANOGOLD
NANOMAGNETITE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173680
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/173680
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensorsAlarcon Segovia, Lilian CelesteBandodkar, Amay J.Rogers, John A.Rintoul, IgnacioBIOMATERIALSBIOSENSORSDIABETICSDIAGNOSTICSINTEGRATED ELECTRONICSNANOGOLDNANOMAGNETITEhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Wearable skin sensors is a promising technology for real-time health care monitoring. They are of particular interest for monitoring glucose in diabetic patients. The concentration of glucose in sweat can be more than two orders of magnitude lower than in blood. In consequence, the scientific and technological efforts are focused in developing new concepts to enhance the sensitivity, decrease the limit of detection (LOD) and reduce the response time (RT) of glucose skin sensors. This work explores the effect of adsorbed superparamagnetic magnetite nanoparticles (MNPs) and conductive nanoparticles (CNPs) on carbon nanotube substrates (CNTs) used to immobilize glucose oxidase enzyme in the working electrode of skin sensors. MNPs and CNPs are made of magnetite and gold, respectively. The performance of the sensors was tested in standard buffer solution, artificial sweat, fresh sweat and on the skin of a healthy volunteer during an exercise session. In the case of artificial sweat, the presence of MNPs accelerated the RT from 7 to 5 s at the expense of increasing the LOD from 0.017 to 0.022 mM with slight increase of the sensitivity from 4.90 to 5.09 μAm M-1 cm-2. The presence of CNPs greatly accelerated the RT from 7 to 2 s and lowered the LOD from 0.017 to 0.014 mM at the expense of a great diminution of the sensitivity from 4.90 to 4.09 μAm M-1 cm-2. These effects were explained mechanistically by analyzing the changes in the concentration of free oxygen and electrons promoted by MNPs and CNPs in the CNTs and its consequences on the the glucose oxidation process.Fil: Alarcon Segovia, Lilian Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; ArgentinaFil: Bandodkar, Amay J.. Northwestern University; Estados UnidosFil: Rogers, John A.. Northwestern University; Estados UnidosFil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaIOP Publishing2021-06-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173680Alarcon Segovia, Lilian Celeste; Bandodkar, Amay J.; Rogers, John A.; Rintoul, Ignacio; Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors; IOP Publishing; Nanotechnology; 32; 37; 21-6-2021; 1-220957-4484CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://iopscience.iop.org/article/10.1088/1361-6528/ac0668info:eu-repo/semantics/altIdentifier/doi/10.1088/1361-6528/ac0668info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:12Zoai:ri.conicet.gov.ar:11336/173680instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:13.024CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
title Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
spellingShingle Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
Alarcon Segovia, Lilian Celeste
BIOMATERIALS
BIOSENSORS
DIABETICS
DIAGNOSTICS
INTEGRATED ELECTRONICS
NANOGOLD
NANOMAGNETITE
title_short Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
title_full Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
title_fullStr Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
title_full_unstemmed Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
title_sort Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors
dc.creator.none.fl_str_mv Alarcon Segovia, Lilian Celeste
Bandodkar, Amay J.
Rogers, John A.
Rintoul, Ignacio
author Alarcon Segovia, Lilian Celeste
author_facet Alarcon Segovia, Lilian Celeste
Bandodkar, Amay J.
Rogers, John A.
Rintoul, Ignacio
author_role author
author2 Bandodkar, Amay J.
Rogers, John A.
Rintoul, Ignacio
author2_role author
author
author
dc.subject.none.fl_str_mv BIOMATERIALS
BIOSENSORS
DIABETICS
DIAGNOSTICS
INTEGRATED ELECTRONICS
NANOGOLD
NANOMAGNETITE
topic BIOMATERIALS
BIOSENSORS
DIABETICS
DIAGNOSTICS
INTEGRATED ELECTRONICS
NANOGOLD
NANOMAGNETITE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Wearable skin sensors is a promising technology for real-time health care monitoring. They are of particular interest for monitoring glucose in diabetic patients. The concentration of glucose in sweat can be more than two orders of magnitude lower than in blood. In consequence, the scientific and technological efforts are focused in developing new concepts to enhance the sensitivity, decrease the limit of detection (LOD) and reduce the response time (RT) of glucose skin sensors. This work explores the effect of adsorbed superparamagnetic magnetite nanoparticles (MNPs) and conductive nanoparticles (CNPs) on carbon nanotube substrates (CNTs) used to immobilize glucose oxidase enzyme in the working electrode of skin sensors. MNPs and CNPs are made of magnetite and gold, respectively. The performance of the sensors was tested in standard buffer solution, artificial sweat, fresh sweat and on the skin of a healthy volunteer during an exercise session. In the case of artificial sweat, the presence of MNPs accelerated the RT from 7 to 5 s at the expense of increasing the LOD from 0.017 to 0.022 mM with slight increase of the sensitivity from 4.90 to 5.09 μAm M-1 cm-2. The presence of CNPs greatly accelerated the RT from 7 to 2 s and lowered the LOD from 0.017 to 0.014 mM at the expense of a great diminution of the sensitivity from 4.90 to 4.09 μAm M-1 cm-2. These effects were explained mechanistically by analyzing the changes in the concentration of free oxygen and electrons promoted by MNPs and CNPs in the CNTs and its consequences on the the glucose oxidation process.
Fil: Alarcon Segovia, Lilian Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina
Fil: Bandodkar, Amay J.. Northwestern University; Estados Unidos
Fil: Rogers, John A.. Northwestern University; Estados Unidos
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description Wearable skin sensors is a promising technology for real-time health care monitoring. They are of particular interest for monitoring glucose in diabetic patients. The concentration of glucose in sweat can be more than two orders of magnitude lower than in blood. In consequence, the scientific and technological efforts are focused in developing new concepts to enhance the sensitivity, decrease the limit of detection (LOD) and reduce the response time (RT) of glucose skin sensors. This work explores the effect of adsorbed superparamagnetic magnetite nanoparticles (MNPs) and conductive nanoparticles (CNPs) on carbon nanotube substrates (CNTs) used to immobilize glucose oxidase enzyme in the working electrode of skin sensors. MNPs and CNPs are made of magnetite and gold, respectively. The performance of the sensors was tested in standard buffer solution, artificial sweat, fresh sweat and on the skin of a healthy volunteer during an exercise session. In the case of artificial sweat, the presence of MNPs accelerated the RT from 7 to 5 s at the expense of increasing the LOD from 0.017 to 0.022 mM with slight increase of the sensitivity from 4.90 to 5.09 μAm M-1 cm-2. The presence of CNPs greatly accelerated the RT from 7 to 2 s and lowered the LOD from 0.017 to 0.014 mM at the expense of a great diminution of the sensitivity from 4.90 to 4.09 μAm M-1 cm-2. These effects were explained mechanistically by analyzing the changes in the concentration of free oxygen and electrons promoted by MNPs and CNPs in the CNTs and its consequences on the the glucose oxidation process.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173680
Alarcon Segovia, Lilian Celeste; Bandodkar, Amay J.; Rogers, John A.; Rintoul, Ignacio; Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors; IOP Publishing; Nanotechnology; 32; 37; 21-6-2021; 1-22
0957-4484
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173680
identifier_str_mv Alarcon Segovia, Lilian Celeste; Bandodkar, Amay J.; Rogers, John A.; Rintoul, Ignacio; Catalytic effects of magnetic and conductive nanoparticles on immobilized glucose oxidase in skin sensors; IOP Publishing; Nanotechnology; 32; 37; 21-6-2021; 1-22
0957-4484
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://iopscience.iop.org/article/10.1088/1361-6528/ac0668
info:eu-repo/semantics/altIdentifier/doi/10.1088/1361-6528/ac0668
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOP Publishing
publisher.none.fl_str_mv IOP Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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