Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis

Autores
Ramos Casals, Manuel; Retamozo, Maria Soledad; Siso Almirall, Antoni; Pérez Alvarez, Roberto; Pallarés, Lucio; Brito Zenón, Pilar
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Sarcoidosis is a complex systemic disease with a silent, long-term evolution, and a heterogeneous clinical presentation. The diagnostic approach is complex with no single diagnostic test that may confirm the disease. Areas covered: A large list of serum biomarkers has been tested during the last 40 years. In this review, we analyse the potential usefulness in the diagnosis and prognosis of sarcoidosis of serum biomarkers classified according to their corresponding cellular source. Expert commentary: Diagnosis of sarcoidosis must always be approached as a multistep process based on a case-by-case integration of clinical, radiological, histological and serological data, none of which being pathognomonic. We found sIL-2R, CRP, SAA and chitotriosidase to be the best markers to confirm sarcoidosis (highest sensitivity), while ACE, gammaglobulins and lysozyme may be more useful for discarding sarcoidosis (highest specificity), taking into account that with the use of a higher cut-off we can increase specificity and with a lower cut-off we can increase sensitivity. Other biomarkers (TNF-a and CCL18) could help to identify patients with an enhanced risk of developing pulmonary fibrosis or progressive disease. The future scenario of the serological diagnostic approach of sarcoidosis will be the use of multi-assays including biomarkers from different cellular sources.
Fil: Ramos Casals, Manuel. Sociedad Española de Medicina; España. Instituto Clínic de Medicina y Dermatología; España
Fil: Retamozo, Maria Soledad. Instituto Clínic de Medicina y Dermatología; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Instituto Modelo de Cardiología Privado; Argentina
Fil: Siso Almirall, Antoni. Instituto de Investigaciones Biomédicas August Pi i Sunyer; España
Fil: Pérez Alvarez, Roberto. Sociedad Española de Medicina; España
Fil: Pallarés, Lucio. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; España
Fil: Brito Zenón, Pilar. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; España
Materia
ANGIOTENSIN CONVERTASE ENZYME
B-CELLS
BIOMARKERS
CHITOTRIOSIDASE
CYTOKINES
MACROPHAGES
SARCOIDOSIS
T-CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125487
Acceder
id CONICETDig_5093f55ce414295ba7c4c0ac249c4422
oai_identifier_str oai:ri.conicet.gov.ar:11336/125487
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosisRamos Casals, ManuelRetamozo, Maria SoledadSiso Almirall, AntoniPérez Alvarez, RobertoPallarés, LucioBrito Zenón, PilarANGIOTENSIN CONVERTASE ENZYMEB-CELLSBIOMARKERSCHITOTRIOSIDASECYTOKINESMACROPHAGESSARCOIDOSIST-CELLShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Sarcoidosis is a complex systemic disease with a silent, long-term evolution, and a heterogeneous clinical presentation. The diagnostic approach is complex with no single diagnostic test that may confirm the disease. Areas covered: A large list of serum biomarkers has been tested during the last 40 years. In this review, we analyse the potential usefulness in the diagnosis and prognosis of sarcoidosis of serum biomarkers classified according to their corresponding cellular source. Expert commentary: Diagnosis of sarcoidosis must always be approached as a multistep process based on a case-by-case integration of clinical, radiological, histological and serological data, none of which being pathognomonic. We found sIL-2R, CRP, SAA and chitotriosidase to be the best markers to confirm sarcoidosis (highest sensitivity), while ACE, gammaglobulins and lysozyme may be more useful for discarding sarcoidosis (highest specificity), taking into account that with the use of a higher cut-off we can increase specificity and with a lower cut-off we can increase sensitivity. Other biomarkers (TNF-a and CCL18) could help to identify patients with an enhanced risk of developing pulmonary fibrosis or progressive disease. The future scenario of the serological diagnostic approach of sarcoidosis will be the use of multi-assays including biomarkers from different cellular sources.Fil: Ramos Casals, Manuel. Sociedad Española de Medicina; España. Instituto Clínic de Medicina y Dermatología; EspañaFil: Retamozo, Maria Soledad. Instituto Clínic de Medicina y Dermatología; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Instituto Modelo de Cardiología Privado; ArgentinaFil: Siso Almirall, Antoni. Instituto de Investigaciones Biomédicas August Pi i Sunyer; EspañaFil: Pérez Alvarez, Roberto. Sociedad Española de Medicina; EspañaFil: Pallarés, Lucio. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; EspañaFil: Brito Zenón, Pilar. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; EspañaTaylor & Francis2019-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125487Ramos Casals, Manuel; Retamozo, Maria Soledad; Siso Almirall, Antoni; Pérez Alvarez, Roberto; Pallarés, Lucio; et al.; Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis; Taylor & Francis; Expert Review Of Clinical Immunology; 15; 4; 4-2019; 391-4051744-666XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1568240info:eu-repo/semantics/altIdentifier/doi/10.1080/1744666X.2019.1568240info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:55:44Zoai:ri.conicet.gov.ar:11336/125487instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:55:44.816CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
title Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
spellingShingle Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
Ramos Casals, Manuel
ANGIOTENSIN CONVERTASE ENZYME
B-CELLS
BIOMARKERS
CHITOTRIOSIDASE
CYTOKINES
MACROPHAGES
SARCOIDOSIS
T-CELLS
title_short Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
title_full Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
title_fullStr Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
title_full_unstemmed Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
title_sort Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis
dc.creator.none.fl_str_mv Ramos Casals, Manuel
Retamozo, Maria Soledad
Siso Almirall, Antoni
Pérez Alvarez, Roberto
Pallarés, Lucio
Brito Zenón, Pilar
author Ramos Casals, Manuel
author_facet Ramos Casals, Manuel
Retamozo, Maria Soledad
Siso Almirall, Antoni
Pérez Alvarez, Roberto
Pallarés, Lucio
Brito Zenón, Pilar
author_role author
author2 Retamozo, Maria Soledad
Siso Almirall, Antoni
Pérez Alvarez, Roberto
Pallarés, Lucio
Brito Zenón, Pilar
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANGIOTENSIN CONVERTASE ENZYME
B-CELLS
BIOMARKERS
CHITOTRIOSIDASE
CYTOKINES
MACROPHAGES
SARCOIDOSIS
T-CELLS
topic ANGIOTENSIN CONVERTASE ENZYME
B-CELLS
BIOMARKERS
CHITOTRIOSIDASE
CYTOKINES
MACROPHAGES
SARCOIDOSIS
T-CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Sarcoidosis is a complex systemic disease with a silent, long-term evolution, and a heterogeneous clinical presentation. The diagnostic approach is complex with no single diagnostic test that may confirm the disease. Areas covered: A large list of serum biomarkers has been tested during the last 40 years. In this review, we analyse the potential usefulness in the diagnosis and prognosis of sarcoidosis of serum biomarkers classified according to their corresponding cellular source. Expert commentary: Diagnosis of sarcoidosis must always be approached as a multistep process based on a case-by-case integration of clinical, radiological, histological and serological data, none of which being pathognomonic. We found sIL-2R, CRP, SAA and chitotriosidase to be the best markers to confirm sarcoidosis (highest sensitivity), while ACE, gammaglobulins and lysozyme may be more useful for discarding sarcoidosis (highest specificity), taking into account that with the use of a higher cut-off we can increase specificity and with a lower cut-off we can increase sensitivity. Other biomarkers (TNF-a and CCL18) could help to identify patients with an enhanced risk of developing pulmonary fibrosis or progressive disease. The future scenario of the serological diagnostic approach of sarcoidosis will be the use of multi-assays including biomarkers from different cellular sources.
Fil: Ramos Casals, Manuel. Sociedad Española de Medicina; España. Instituto Clínic de Medicina y Dermatología; España
Fil: Retamozo, Maria Soledad. Instituto Clínic de Medicina y Dermatología; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Instituto Modelo de Cardiología Privado; Argentina
Fil: Siso Almirall, Antoni. Instituto de Investigaciones Biomédicas August Pi i Sunyer; España
Fil: Pérez Alvarez, Roberto. Sociedad Española de Medicina; España
Fil: Pallarés, Lucio. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; España
Fil: Brito Zenón, Pilar. Sociedad Española de Medicina; España. Sarco GEAS SEMI Study Group; España
description Introduction: Sarcoidosis is a complex systemic disease with a silent, long-term evolution, and a heterogeneous clinical presentation. The diagnostic approach is complex with no single diagnostic test that may confirm the disease. Areas covered: A large list of serum biomarkers has been tested during the last 40 years. In this review, we analyse the potential usefulness in the diagnosis and prognosis of sarcoidosis of serum biomarkers classified according to their corresponding cellular source. Expert commentary: Diagnosis of sarcoidosis must always be approached as a multistep process based on a case-by-case integration of clinical, radiological, histological and serological data, none of which being pathognomonic. We found sIL-2R, CRP, SAA and chitotriosidase to be the best markers to confirm sarcoidosis (highest sensitivity), while ACE, gammaglobulins and lysozyme may be more useful for discarding sarcoidosis (highest specificity), taking into account that with the use of a higher cut-off we can increase specificity and with a lower cut-off we can increase sensitivity. Other biomarkers (TNF-a and CCL18) could help to identify patients with an enhanced risk of developing pulmonary fibrosis or progressive disease. The future scenario of the serological diagnostic approach of sarcoidosis will be the use of multi-assays including biomarkers from different cellular sources.
publishDate 2019
dc.date.none.fl_str_mv 2019-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125487
Ramos Casals, Manuel; Retamozo, Maria Soledad; Siso Almirall, Antoni; Pérez Alvarez, Roberto; Pallarés, Lucio; et al.; Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis; Taylor & Francis; Expert Review Of Clinical Immunology; 15; 4; 4-2019; 391-405
1744-666X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125487
identifier_str_mv Ramos Casals, Manuel; Retamozo, Maria Soledad; Siso Almirall, Antoni; Pérez Alvarez, Roberto; Pallarés, Lucio; et al.; Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis; Taylor & Francis; Expert Review Of Clinical Immunology; 15; 4; 4-2019; 391-405
1744-666X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1568240
info:eu-repo/semantics/altIdentifier/doi/10.1080/1744666X.2019.1568240
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24909

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