Functional genomics and evolution of tick–Anaplasma interactions and vaccine development

Autores
de la Fuente, José; Kocan, Katherine M.; Blouin, Edmour F.; Zivkovic, Zorica; Naranjo, Victoria; Almazán, Consuelo; Esteves, Eliane; Jongejan, Frans; Daffre, Sirlei; Mangold, Atilio Jose
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick–pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick–Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick–pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick–Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.
Fil: de la Fuente, José. Oklahoma State University; Estados Unidos. Consejo Superior de Investigaciones Científicas; España
Fil: Kocan, Katherine M.. Oklahoma State University; Estados Unidos
Fil: Blouin, Edmour F.. Oklahoma State University; Estados Unidos
Fil: Zivkovic, Zorica. Utrecht University; Países Bajos
Fil: Naranjo, Victoria. Oklahoma State University; Estados Unidos. Oklahoma State University; Estados Unidos
Fil: Almazán, Consuelo. Universidad Autónoma de Tamaulipas; México
Fil: Esteves, Eliane. Universidade de Sao Paulo; Brasil
Fil: Jongejan, Frans. Utrecht University; Países Bajos. University of Pretoria; Sudáfrica
Fil: Daffre, Sirlei. Universidade de Sao Paulo; Brasil
Fil: Mangold, Atilio Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Tecnológica Nacional. Facultad Regional Rafaela; Argentina
Materia
Anaplasma
Major Surface Protein
Genomics
Rna Interference
Evolution
Vaccine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66282
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/66282
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Functional genomics and evolution of tick–Anaplasma interactions and vaccine developmentde la Fuente, JoséKocan, Katherine M.Blouin, Edmour F.Zivkovic, ZoricaNaranjo, VictoriaAlmazán, ConsueloEsteves, ElianeJongejan, FransDaffre, SirleiMangold, Atilio JoseAnaplasmaMajor Surface ProteinGenomicsRna InterferenceEvolutionVaccinehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick–pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick–Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick–pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick–Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.Fil: de la Fuente, José. Oklahoma State University; Estados Unidos. Consejo Superior de Investigaciones Científicas; EspañaFil: Kocan, Katherine M.. Oklahoma State University; Estados UnidosFil: Blouin, Edmour F.. Oklahoma State University; Estados UnidosFil: Zivkovic, Zorica. Utrecht University; Países BajosFil: Naranjo, Victoria. Oklahoma State University; Estados Unidos. Oklahoma State University; Estados UnidosFil: Almazán, Consuelo. Universidad Autónoma de Tamaulipas; MéxicoFil: Esteves, Eliane. Universidade de Sao Paulo; BrasilFil: Jongejan, Frans. Utrecht University; Países Bajos. University of Pretoria; SudáfricaFil: Daffre, Sirlei. Universidade de Sao Paulo; BrasilFil: Mangold, Atilio Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Tecnológica Nacional. Facultad Regional Rafaela; ArgentinaElsevier Science2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66282de la Fuente, José; Kocan, Katherine M.; Blouin, Edmour F.; Zivkovic, Zorica; Naranjo, Victoria; et al.; Functional genomics and evolution of tick–Anaplasma interactions and vaccine development; Elsevier Science; Veterinary Parasitology; 167; 2-4; 2-2010; 175-1860304-4017CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2009.09.019info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0304401709005524info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:28:52Zoai:ri.conicet.gov.ar:11336/66282instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:28:52.294CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
title Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
spellingShingle Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
de la Fuente, José
Anaplasma
Major Surface Protein
Genomics
Rna Interference
Evolution
Vaccine
title_short Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
title_full Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
title_fullStr Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
title_full_unstemmed Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
title_sort Functional genomics and evolution of tick–Anaplasma interactions and vaccine development
dc.creator.none.fl_str_mv de la Fuente, José
Kocan, Katherine M.
Blouin, Edmour F.
Zivkovic, Zorica
Naranjo, Victoria
Almazán, Consuelo
Esteves, Eliane
Jongejan, Frans
Daffre, Sirlei
Mangold, Atilio Jose
author de la Fuente, José
author_facet de la Fuente, José
Kocan, Katherine M.
Blouin, Edmour F.
Zivkovic, Zorica
Naranjo, Victoria
Almazán, Consuelo
Esteves, Eliane
Jongejan, Frans
Daffre, Sirlei
Mangold, Atilio Jose
author_role author
author2 Kocan, Katherine M.
Blouin, Edmour F.
Zivkovic, Zorica
Naranjo, Victoria
Almazán, Consuelo
Esteves, Eliane
Jongejan, Frans
Daffre, Sirlei
Mangold, Atilio Jose
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anaplasma
Major Surface Protein
Genomics
Rna Interference
Evolution
Vaccine
topic Anaplasma
Major Surface Protein
Genomics
Rna Interference
Evolution
Vaccine
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick–pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick–Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick–pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick–Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.
Fil: de la Fuente, José. Oklahoma State University; Estados Unidos. Consejo Superior de Investigaciones Científicas; España
Fil: Kocan, Katherine M.. Oklahoma State University; Estados Unidos
Fil: Blouin, Edmour F.. Oklahoma State University; Estados Unidos
Fil: Zivkovic, Zorica. Utrecht University; Países Bajos
Fil: Naranjo, Victoria. Oklahoma State University; Estados Unidos. Oklahoma State University; Estados Unidos
Fil: Almazán, Consuelo. Universidad Autónoma de Tamaulipas; México
Fil: Esteves, Eliane. Universidade de Sao Paulo; Brasil
Fil: Jongejan, Frans. Utrecht University; Países Bajos. University of Pretoria; Sudáfrica
Fil: Daffre, Sirlei. Universidade de Sao Paulo; Brasil
Fil: Mangold, Atilio Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Tecnológica Nacional. Facultad Regional Rafaela; Argentina
description The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick–pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick–Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick–pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick–Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66282
de la Fuente, José; Kocan, Katherine M.; Blouin, Edmour F.; Zivkovic, Zorica; Naranjo, Victoria; et al.; Functional genomics and evolution of tick–Anaplasma interactions and vaccine development; Elsevier Science; Veterinary Parasitology; 167; 2-4; 2-2010; 175-186
0304-4017
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66282
identifier_str_mv de la Fuente, José; Kocan, Katherine M.; Blouin, Edmour F.; Zivkovic, Zorica; Naranjo, Victoria; et al.; Functional genomics and evolution of tick–Anaplasma interactions and vaccine development; Elsevier Science; Veterinary Parasitology; 167; 2-4; 2-2010; 175-186
0304-4017
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2009.09.019
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0304401709005524
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781870012891136
score 12.982451

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