Under-replicated DNA: The byproduct of large genomes?

Autores
Bertolin, Agustina Paola; Hoffmann, Jean Sébastien; Gottifredi, Vanesa
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this review, we provide an overview of how proliferating eukaryotic cells overcome one of the main threats to genome stability: incomplete genomic DNA replication during S phase. We discuss why it is currently accepted that double fork stalling (DFS) events are unavoidable events in higher eukaryotes with large genomes and which responses have evolved to cope with its main consequence: the presence of under-replicated DNA (UR-DNA) outside S phase. Particular emphasis is placed on the processes that constrain the detrimental effects of UR-DNA. We discuss how mitotic DNA synthesis (MiDAS), mitotic end joining events and 53BP1 nuclear bodies (53BP1NBs) deal with such specific S phase DNA replication remnants during the subsequent phases of the cell cycle.
Fil: Bertolin, Agustina Paola. Francis Crick Institute; Reino Unido
Fil: Hoffmann, Jean Sébastien. Inserm; Francia
Fil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
53BP1
BREAK-INDUCED REPAIR (BIR)
COMMON FRAGILE SITES (CFS)
DNA REPLICATION STRESS
DOUBLE FORK STALLING (DFS)
GENOMIC INSTABILITY
MITOTIC DNA SYNTHESIS (MIDAS)
RAD52
UNDERREPLICATED DNA (UR-DNA)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/183028
Acceder
id CONICETDig_4e64fcc28ac6a2d562fbce730abbb717
oai_identifier_str oai:ri.conicet.gov.ar:11336/183028
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Under-replicated DNA: The byproduct of large genomes?Bertolin, Agustina PaolaHoffmann, Jean SébastienGottifredi, Vanesa53BP1BREAK-INDUCED REPAIR (BIR)COMMON FRAGILE SITES (CFS)DNA REPLICATION STRESSDOUBLE FORK STALLING (DFS)GENOMIC INSTABILITYMITOTIC DNA SYNTHESIS (MIDAS)RAD52UNDERREPLICATED DNA (UR-DNA)https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In this review, we provide an overview of how proliferating eukaryotic cells overcome one of the main threats to genome stability: incomplete genomic DNA replication during S phase. We discuss why it is currently accepted that double fork stalling (DFS) events are unavoidable events in higher eukaryotes with large genomes and which responses have evolved to cope with its main consequence: the presence of under-replicated DNA (UR-DNA) outside S phase. Particular emphasis is placed on the processes that constrain the detrimental effects of UR-DNA. We discuss how mitotic DNA synthesis (MiDAS), mitotic end joining events and 53BP1 nuclear bodies (53BP1NBs) deal with such specific S phase DNA replication remnants during the subsequent phases of the cell cycle.Fil: Bertolin, Agustina Paola. Francis Crick Institute; Reino UnidoFil: Hoffmann, Jean Sébastien. Inserm; FranciaFil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaMultidisciplinary Digital Publishing Institute2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/183028Bertolin, Agustina Paola; Hoffmann, Jean Sébastien; Gottifredi, Vanesa; Under-replicated DNA: The byproduct of large genomes?; Multidisciplinary Digital Publishing Institute; Cancers; 12; 10; 9-2020; 1-202072-6694CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/12/10/2764info:eu-repo/semantics/altIdentifier/doi/10.3390/cancers12102764info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:45Zoai:ri.conicet.gov.ar:11336/183028instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:45.604CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Under-replicated DNA: The byproduct of large genomes?
title Under-replicated DNA: The byproduct of large genomes?
spellingShingle Under-replicated DNA: The byproduct of large genomes?
Bertolin, Agustina Paola
53BP1
BREAK-INDUCED REPAIR (BIR)
COMMON FRAGILE SITES (CFS)
DNA REPLICATION STRESS
DOUBLE FORK STALLING (DFS)
GENOMIC INSTABILITY
MITOTIC DNA SYNTHESIS (MIDAS)
RAD52
UNDERREPLICATED DNA (UR-DNA)
title_short Under-replicated DNA: The byproduct of large genomes?
title_full Under-replicated DNA: The byproduct of large genomes?
title_fullStr Under-replicated DNA: The byproduct of large genomes?
title_full_unstemmed Under-replicated DNA: The byproduct of large genomes?
title_sort Under-replicated DNA: The byproduct of large genomes?
dc.creator.none.fl_str_mv Bertolin, Agustina Paola
Hoffmann, Jean Sébastien
Gottifredi, Vanesa
author Bertolin, Agustina Paola
author_facet Bertolin, Agustina Paola
Hoffmann, Jean Sébastien
Gottifredi, Vanesa
author_role author
author2 Hoffmann, Jean Sébastien
Gottifredi, Vanesa
author2_role author
author
dc.subject.none.fl_str_mv 53BP1
BREAK-INDUCED REPAIR (BIR)
COMMON FRAGILE SITES (CFS)
DNA REPLICATION STRESS
DOUBLE FORK STALLING (DFS)
GENOMIC INSTABILITY
MITOTIC DNA SYNTHESIS (MIDAS)
RAD52
UNDERREPLICATED DNA (UR-DNA)
topic 53BP1
BREAK-INDUCED REPAIR (BIR)
COMMON FRAGILE SITES (CFS)
DNA REPLICATION STRESS
DOUBLE FORK STALLING (DFS)
GENOMIC INSTABILITY
MITOTIC DNA SYNTHESIS (MIDAS)
RAD52
UNDERREPLICATED DNA (UR-DNA)
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this review, we provide an overview of how proliferating eukaryotic cells overcome one of the main threats to genome stability: incomplete genomic DNA replication during S phase. We discuss why it is currently accepted that double fork stalling (DFS) events are unavoidable events in higher eukaryotes with large genomes and which responses have evolved to cope with its main consequence: the presence of under-replicated DNA (UR-DNA) outside S phase. Particular emphasis is placed on the processes that constrain the detrimental effects of UR-DNA. We discuss how mitotic DNA synthesis (MiDAS), mitotic end joining events and 53BP1 nuclear bodies (53BP1NBs) deal with such specific S phase DNA replication remnants during the subsequent phases of the cell cycle.
Fil: Bertolin, Agustina Paola. Francis Crick Institute; Reino Unido
Fil: Hoffmann, Jean Sébastien. Inserm; Francia
Fil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description In this review, we provide an overview of how proliferating eukaryotic cells overcome one of the main threats to genome stability: incomplete genomic DNA replication during S phase. We discuss why it is currently accepted that double fork stalling (DFS) events are unavoidable events in higher eukaryotes with large genomes and which responses have evolved to cope with its main consequence: the presence of under-replicated DNA (UR-DNA) outside S phase. Particular emphasis is placed on the processes that constrain the detrimental effects of UR-DNA. We discuss how mitotic DNA synthesis (MiDAS), mitotic end joining events and 53BP1 nuclear bodies (53BP1NBs) deal with such specific S phase DNA replication remnants during the subsequent phases of the cell cycle.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/183028
Bertolin, Agustina Paola; Hoffmann, Jean Sébastien; Gottifredi, Vanesa; Under-replicated DNA: The byproduct of large genomes?; Multidisciplinary Digital Publishing Institute; Cancers; 12; 10; 9-2020; 1-20
2072-6694
CONICET Digital
CONICET
url http://hdl.handle.net/11336/183028
identifier_str_mv Bertolin, Agustina Paola; Hoffmann, Jean Sébastien; Gottifredi, Vanesa; Under-replicated DNA: The byproduct of large genomes?; Multidisciplinary Digital Publishing Institute; Cancers; 12; 10; 9-2020; 1-20
2072-6694
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/12/10/2764
info:eu-repo/semantics/altIdentifier/doi/10.3390/cancers12102764
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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