Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin

Autores
Bisagno, Veronica; Cadet, Jean Lud
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Stress sensitivity and sex are predictive factors for the development of neuropsychiatric disorders. Life stresses are not only risk factors for the development of addiction but also are triggers for relapse to drug use. Therefore, it is imperative to elucidate the molecular mechanisms underlying the interactions between stress and drug abuse, as an understanding of this may help in the development of novel and more effective therapeutic approaches to block the clinical manifestations of drug addiction. The development and clinical course of addiction-related disorders do appear to involve neuroadaptations within neurocircuitries that modulate stress responses and are influenced by several neuropeptides. These include corticotropin-releasing factor, the prototypic member of this class, as well as oxytocin and arginine-vasopressin that play important roles in affiliative behaviors. Interestingly, these peptides function to balance emotional behavior, with sexual dimorphism in the oxytocin/arginine-vasopressin systems, a fact that might play an important role in the differential responses of women and men to stressful stimuli and the specific sex-based prevalence of certain addictive disorders. Thus, this review aims to summarize (i) the contribution of sex differences to the function of dopamine systems, and (ii) the behavioral, neurochemical, and anatomical changes in brain stress systems.
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; Argentina
Fil: Cadet, Jean Lud. National Institute On Drug Abuse; Estados Unidos
Materia
addiction
arginine-vasopressin
corticotropin-releasing factor
oxytocin
sex
stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13800
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressinBisagno, VeronicaCadet, Jean Ludaddictionarginine-vasopressincorticotropin-releasing factoroxytocinsexstresshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Stress sensitivity and sex are predictive factors for the development of neuropsychiatric disorders. Life stresses are not only risk factors for the development of addiction but also are triggers for relapse to drug use. Therefore, it is imperative to elucidate the molecular mechanisms underlying the interactions between stress and drug abuse, as an understanding of this may help in the development of novel and more effective therapeutic approaches to block the clinical manifestations of drug addiction. The development and clinical course of addiction-related disorders do appear to involve neuroadaptations within neurocircuitries that modulate stress responses and are influenced by several neuropeptides. These include corticotropin-releasing factor, the prototypic member of this class, as well as oxytocin and arginine-vasopressin that play important roles in affiliative behaviors. Interestingly, these peptides function to balance emotional behavior, with sexual dimorphism in the oxytocin/arginine-vasopressin systems, a fact that might play an important role in the differential responses of women and men to stressful stimuli and the specific sex-based prevalence of certain addictive disorders. Thus, this review aims to summarize (i) the contribution of sex differences to the function of dopamine systems, and (ii) the behavioral, neurochemical, and anatomical changes in brain stress systems.Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; ArgentinaFil: Cadet, Jean Lud. National Institute On Drug Abuse; Estados UnidosLippincott Williams2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13800Bisagno, Veronica; Cadet, Jean Lud; Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin; Lippincott Williams; Behavioural Pharmacology; 25; 5-6; 9-2014; 445-4570955-88101473-5849enginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119500/info:eu-repo/semantics/altIdentifier/url/Stress,_sex,_and_addiction___potential_roles_of.11.aspxinfo:eu-repo/semantics/altIdentifier/url/http://ovidsp.tx.ovid.com/sp-3.24.1b/ovidweb.cgi?QS2=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:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:36Zoai:ri.conicet.gov.ar:11336/13800instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:37.029CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
title Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
spellingShingle Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
Bisagno, Veronica
addiction
arginine-vasopressin
corticotropin-releasing factor
oxytocin
sex
stress
title_short Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
title_full Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
title_fullStr Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
title_full_unstemmed Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
title_sort Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin
dc.creator.none.fl_str_mv Bisagno, Veronica
Cadet, Jean Lud
author Bisagno, Veronica
author_facet Bisagno, Veronica
Cadet, Jean Lud
author_role author
author2 Cadet, Jean Lud
author2_role author
dc.subject.none.fl_str_mv addiction
arginine-vasopressin
corticotropin-releasing factor
oxytocin
sex
stress
topic addiction
arginine-vasopressin
corticotropin-releasing factor
oxytocin
sex
stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Stress sensitivity and sex are predictive factors for the development of neuropsychiatric disorders. Life stresses are not only risk factors for the development of addiction but also are triggers for relapse to drug use. Therefore, it is imperative to elucidate the molecular mechanisms underlying the interactions between stress and drug abuse, as an understanding of this may help in the development of novel and more effective therapeutic approaches to block the clinical manifestations of drug addiction. The development and clinical course of addiction-related disorders do appear to involve neuroadaptations within neurocircuitries that modulate stress responses and are influenced by several neuropeptides. These include corticotropin-releasing factor, the prototypic member of this class, as well as oxytocin and arginine-vasopressin that play important roles in affiliative behaviors. Interestingly, these peptides function to balance emotional behavior, with sexual dimorphism in the oxytocin/arginine-vasopressin systems, a fact that might play an important role in the differential responses of women and men to stressful stimuli and the specific sex-based prevalence of certain addictive disorders. Thus, this review aims to summarize (i) the contribution of sex differences to the function of dopamine systems, and (ii) the behavioral, neurochemical, and anatomical changes in brain stress systems.
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; Argentina
Fil: Cadet, Jean Lud. National Institute On Drug Abuse; Estados Unidos
description Stress sensitivity and sex are predictive factors for the development of neuropsychiatric disorders. Life stresses are not only risk factors for the development of addiction but also are triggers for relapse to drug use. Therefore, it is imperative to elucidate the molecular mechanisms underlying the interactions between stress and drug abuse, as an understanding of this may help in the development of novel and more effective therapeutic approaches to block the clinical manifestations of drug addiction. The development and clinical course of addiction-related disorders do appear to involve neuroadaptations within neurocircuitries that modulate stress responses and are influenced by several neuropeptides. These include corticotropin-releasing factor, the prototypic member of this class, as well as oxytocin and arginine-vasopressin that play important roles in affiliative behaviors. Interestingly, these peptides function to balance emotional behavior, with sexual dimorphism in the oxytocin/arginine-vasopressin systems, a fact that might play an important role in the differential responses of women and men to stressful stimuli and the specific sex-based prevalence of certain addictive disorders. Thus, this review aims to summarize (i) the contribution of sex differences to the function of dopamine systems, and (ii) the behavioral, neurochemical, and anatomical changes in brain stress systems.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13800
Bisagno, Veronica; Cadet, Jean Lud; Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin; Lippincott Williams; Behavioural Pharmacology; 25; 5-6; 9-2014; 445-457
0955-8810
1473-5849
url http://hdl.handle.net/11336/13800
identifier_str_mv Bisagno, Veronica; Cadet, Jean Lud; Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin; Lippincott Williams; Behavioural Pharmacology; 25; 5-6; 9-2014; 445-457
0955-8810
1473-5849
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119500/
info:eu-repo/semantics/altIdentifier/url/Stress,_sex,_and_addiction___potential_roles_of.11.aspx
info:eu-repo/semantics/altIdentifier/url/http://ovidsp.tx.ovid.com/sp-3.24.1b/ovidweb.cgi?QS2=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
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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