Metritis in dairy cows: risk factors and reproductive performance

Autores
Giuliodori, M. J.; Magnasco, R. P.; Becu, Damasia; Lacau, Isabel Maria; Risco, C. A.; de la Sota, Rodolfo Luzbel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objectives of this study were to assess the risk factors for metritis, its effects on milk yield and on reproductive efficiency, and the efficacy of ceftiofur therapy in Holstein dairy cows. Cows (N = 303) from a commercial dairy herd in Argentina were studied. Cows were body condition scored and tail bled on days -14, 7, 21, 31, 41 and 50 relative to parturition. Cows having a watery, purulent or brown-colored, fetid vaginal discharge (VD) and rectal temperature <39.1ºC were diagnosed as having clinical metritis, and those having a similar VD and rectal temperature ≥ 39.1ºC were diagnosed as having puerperal metritis. Both, clinical and puerperal metritis cows were randomly assigned to control (no treatment) or ceftiofur group (2.2 mg/kg x 3 consecutive days). Cure was declared if clear VD was observed 21 days in milk (DIM). Blood samples were analyzed for non‐esterified fatty acids, -hydroxy butyric acid and blood urea nitrogen using commercial kits and insulin-like growth factor-1, insulin, and leptin by RIA. Data were analyzed with PROC MIXED, GENMOD, PHREG and LIFETEST from SAS. The risk for metritis increased with abnormal calving (AOR [adjusted odds ratio] = 2.58, 95% CI = 1.189 to 5.559, P = 0.008), and as prepartum NEFA levels increased (AOR = 1.001, 95% CI = 0.999 to 1.002, P = 0.177). Conversely, risk decreased as prepartum IGF-1 increased (AOR = 0.65, 95% CI = 0.349 to 1.219, P = 0.144). Cows having both, clinical and puerperal metritis produced less milk by 90 DIM than the normal cows (2,236  172 vs. 2,367  77 vs. 2,647  82 kg, respectively, P = 0.009). Cows with puerperal metritis had lower risk for pregnancy by 100 DIM (AOR = 0.189, 95% CI = 0.070 ? 0.479, P = 0.014), lower hazard rate for pregnancy by 150 DIM (0.753, 95% CI = 0.621 to 0.911, P = 0.014), and took longer to get pregnant (129 vs. 111 vs. 109 days, for puerperal metritis, clinical metritis and normal cows, respectively, P = 0.015). Ceftiofur had neither effect on cure rate nor on milk yield but increased the risk for TAI (AOR = 2.126, 95% CI = 0.983 to 4.597, P = 0.055) and for pregnancy at TAI (AOR = 2.688, 95% CI = 0.687 to 10.832, P = 0.142), and reduced the risk for reproductive cull (AOR = 0.121, 95% CI = 0.014 to 1.066, P = 0.057). In conclusion, abnormal calving and negative energy balance increase the risk for metritis. Metritis, especially the puerperal one, reduces both, milk production and reproductive efficiency. Finally, the likelihood for having a normal vaginal discharge (indicative of cure) increases 2.6 % for every day of increase in postpartum time and is 2 times higher for cows with clinical metritis than for those with puerperal metritis.
Fil: Giuliodori, M. J.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Magnasco, R. P.. Estudio Magnasco; Argentina
Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Lacau, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Risco, C. A.. University Of Florida; Estados Unidos
Fil: de la Sota, Rodolfo Luzbel. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Instituto de Teriogenologia. Catedra de Reproduccion Animal; Argentina
Materia
Dairy Cows
Metritis
Risk Factors
Reproductive Performances
Anti Bacterial Agents
Cattle
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7668

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network_name_str CONICET Digital (CONICET)
spelling Metritis in dairy cows: risk factors and reproductive performanceGiuliodori, M. J.Magnasco, R. P.Becu, DamasiaLacau, Isabel MariaRisco, C. A.de la Sota, Rodolfo LuzbelDairy CowsMetritisRisk FactorsReproductive PerformancesAnti Bacterial AgentsCattlehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/4.2https://purl.org/becyt/ford/4The objectives of this study were to assess the risk factors for metritis, its effects on milk yield and on reproductive efficiency, and the efficacy of ceftiofur therapy in Holstein dairy cows. Cows (N = 303) from a commercial dairy herd in Argentina were studied. Cows were body condition scored and tail bled on days -14, 7, 21, 31, 41 and 50 relative to parturition. Cows having a watery, purulent or brown-colored, fetid vaginal discharge (VD) and rectal temperature <39.1ºC were diagnosed as having clinical metritis, and those having a similar VD and rectal temperature ≥ 39.1ºC were diagnosed as having puerperal metritis. Both, clinical and puerperal metritis cows were randomly assigned to control (no treatment) or ceftiofur group (2.2 mg/kg x 3 consecutive days). Cure was declared if clear VD was observed 21 days in milk (DIM). Blood samples were analyzed for non‐esterified fatty acids, -hydroxy butyric acid and blood urea nitrogen using commercial kits and insulin-like growth factor-1, insulin, and leptin by RIA. Data were analyzed with PROC MIXED, GENMOD, PHREG and LIFETEST from SAS. The risk for metritis increased with abnormal calving (AOR [adjusted odds ratio] = 2.58, 95% CI = 1.189 to 5.559, P = 0.008), and as prepartum NEFA levels increased (AOR = 1.001, 95% CI = 0.999 to 1.002, P = 0.177). Conversely, risk decreased as prepartum IGF-1 increased (AOR = 0.65, 95% CI = 0.349 to 1.219, P = 0.144). Cows having both, clinical and puerperal metritis produced less milk by 90 DIM than the normal cows (2,236  172 vs. 2,367  77 vs. 2,647  82 kg, respectively, P = 0.009). Cows with puerperal metritis had lower risk for pregnancy by 100 DIM (AOR = 0.189, 95% CI = 0.070 ? 0.479, P = 0.014), lower hazard rate for pregnancy by 150 DIM (0.753, 95% CI = 0.621 to 0.911, P = 0.014), and took longer to get pregnant (129 vs. 111 vs. 109 days, for puerperal metritis, clinical metritis and normal cows, respectively, P = 0.015). Ceftiofur had neither effect on cure rate nor on milk yield but increased the risk for TAI (AOR = 2.126, 95% CI = 0.983 to 4.597, P = 0.055) and for pregnancy at TAI (AOR = 2.688, 95% CI = 0.687 to 10.832, P = 0.142), and reduced the risk for reproductive cull (AOR = 0.121, 95% CI = 0.014 to 1.066, P = 0.057). In conclusion, abnormal calving and negative energy balance increase the risk for metritis. Metritis, especially the puerperal one, reduces both, milk production and reproductive efficiency. Finally, the likelihood for having a normal vaginal discharge (indicative of cure) increases 2.6 % for every day of increase in postpartum time and is 2 times higher for cows with clinical metritis than for those with puerperal metritis.Fil: Giuliodori, M. J.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Magnasco, R. P.. Estudio Magnasco; ArgentinaFil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Lacau, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Risco, C. A.. University Of Florida; Estados UnidosFil: de la Sota, Rodolfo Luzbel. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Instituto de Teriogenologia. Catedra de Reproduccion Animal; ArgentinaAmer Dairy Science Assoc-adsa2013-03-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7668Giuliodori, M. J.; Magnasco, R. P.; Becu, Damasia; Lacau, Isabel Maria; Risco, C. A.; et al.; Metritis in dairy cows: risk factors and reproductive performance; Amer Dairy Science Assoc-adsa; Journal Of Dairy Science; 96; 30-3-2013; 3621-36310022-0302enginfo:eu-repo/semantics/altIdentifier/doi/10.3168/jds.2012-5922info:eu-repo/semantics/altIdentifier/pmid/23548288info:eu-repo/semantics/altIdentifier/url/http://www.journalofdairyscience.org/article/S0022-0302(13)00234-8/abstractinfo:eu-repo/semantics/altIdentifier/url/http://www.journalofdairyscience.org/article/S0022-0302(13)00234-8/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:22Zoai:ri.conicet.gov.ar:11336/7668instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:22.732CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metritis in dairy cows: risk factors and reproductive performance
title Metritis in dairy cows: risk factors and reproductive performance
spellingShingle Metritis in dairy cows: risk factors and reproductive performance
Giuliodori, M. J.
Dairy Cows
Metritis
Risk Factors
Reproductive Performances
Anti Bacterial Agents
Cattle
title_short Metritis in dairy cows: risk factors and reproductive performance
title_full Metritis in dairy cows: risk factors and reproductive performance
title_fullStr Metritis in dairy cows: risk factors and reproductive performance
title_full_unstemmed Metritis in dairy cows: risk factors and reproductive performance
title_sort Metritis in dairy cows: risk factors and reproductive performance
dc.creator.none.fl_str_mv Giuliodori, M. J.
Magnasco, R. P.
Becu, Damasia
Lacau, Isabel Maria
Risco, C. A.
de la Sota, Rodolfo Luzbel
author Giuliodori, M. J.
author_facet Giuliodori, M. J.
Magnasco, R. P.
Becu, Damasia
Lacau, Isabel Maria
Risco, C. A.
de la Sota, Rodolfo Luzbel
author_role author
author2 Magnasco, R. P.
Becu, Damasia
Lacau, Isabel Maria
Risco, C. A.
de la Sota, Rodolfo Luzbel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Dairy Cows
Metritis
Risk Factors
Reproductive Performances
Anti Bacterial Agents
Cattle
topic Dairy Cows
Metritis
Risk Factors
Reproductive Performances
Anti Bacterial Agents
Cattle
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/4.2
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The objectives of this study were to assess the risk factors for metritis, its effects on milk yield and on reproductive efficiency, and the efficacy of ceftiofur therapy in Holstein dairy cows. Cows (N = 303) from a commercial dairy herd in Argentina were studied. Cows were body condition scored and tail bled on days -14, 7, 21, 31, 41 and 50 relative to parturition. Cows having a watery, purulent or brown-colored, fetid vaginal discharge (VD) and rectal temperature <39.1ºC were diagnosed as having clinical metritis, and those having a similar VD and rectal temperature ≥ 39.1ºC were diagnosed as having puerperal metritis. Both, clinical and puerperal metritis cows were randomly assigned to control (no treatment) or ceftiofur group (2.2 mg/kg x 3 consecutive days). Cure was declared if clear VD was observed 21 days in milk (DIM). Blood samples were analyzed for non‐esterified fatty acids, -hydroxy butyric acid and blood urea nitrogen using commercial kits and insulin-like growth factor-1, insulin, and leptin by RIA. Data were analyzed with PROC MIXED, GENMOD, PHREG and LIFETEST from SAS. The risk for metritis increased with abnormal calving (AOR [adjusted odds ratio] = 2.58, 95% CI = 1.189 to 5.559, P = 0.008), and as prepartum NEFA levels increased (AOR = 1.001, 95% CI = 0.999 to 1.002, P = 0.177). Conversely, risk decreased as prepartum IGF-1 increased (AOR = 0.65, 95% CI = 0.349 to 1.219, P = 0.144). Cows having both, clinical and puerperal metritis produced less milk by 90 DIM than the normal cows (2,236  172 vs. 2,367  77 vs. 2,647  82 kg, respectively, P = 0.009). Cows with puerperal metritis had lower risk for pregnancy by 100 DIM (AOR = 0.189, 95% CI = 0.070 ? 0.479, P = 0.014), lower hazard rate for pregnancy by 150 DIM (0.753, 95% CI = 0.621 to 0.911, P = 0.014), and took longer to get pregnant (129 vs. 111 vs. 109 days, for puerperal metritis, clinical metritis and normal cows, respectively, P = 0.015). Ceftiofur had neither effect on cure rate nor on milk yield but increased the risk for TAI (AOR = 2.126, 95% CI = 0.983 to 4.597, P = 0.055) and for pregnancy at TAI (AOR = 2.688, 95% CI = 0.687 to 10.832, P = 0.142), and reduced the risk for reproductive cull (AOR = 0.121, 95% CI = 0.014 to 1.066, P = 0.057). In conclusion, abnormal calving and negative energy balance increase the risk for metritis. Metritis, especially the puerperal one, reduces both, milk production and reproductive efficiency. Finally, the likelihood for having a normal vaginal discharge (indicative of cure) increases 2.6 % for every day of increase in postpartum time and is 2 times higher for cows with clinical metritis than for those with puerperal metritis.
Fil: Giuliodori, M. J.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Magnasco, R. P.. Estudio Magnasco; Argentina
Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Lacau, Isabel Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Risco, C. A.. University Of Florida; Estados Unidos
Fil: de la Sota, Rodolfo Luzbel. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Instituto de Teriogenologia. Catedra de Reproduccion Animal; Argentina
description The objectives of this study were to assess the risk factors for metritis, its effects on milk yield and on reproductive efficiency, and the efficacy of ceftiofur therapy in Holstein dairy cows. Cows (N = 303) from a commercial dairy herd in Argentina were studied. Cows were body condition scored and tail bled on days -14, 7, 21, 31, 41 and 50 relative to parturition. Cows having a watery, purulent or brown-colored, fetid vaginal discharge (VD) and rectal temperature <39.1ºC were diagnosed as having clinical metritis, and those having a similar VD and rectal temperature ≥ 39.1ºC were diagnosed as having puerperal metritis. Both, clinical and puerperal metritis cows were randomly assigned to control (no treatment) or ceftiofur group (2.2 mg/kg x 3 consecutive days). Cure was declared if clear VD was observed 21 days in milk (DIM). Blood samples were analyzed for non‐esterified fatty acids, -hydroxy butyric acid and blood urea nitrogen using commercial kits and insulin-like growth factor-1, insulin, and leptin by RIA. Data were analyzed with PROC MIXED, GENMOD, PHREG and LIFETEST from SAS. The risk for metritis increased with abnormal calving (AOR [adjusted odds ratio] = 2.58, 95% CI = 1.189 to 5.559, P = 0.008), and as prepartum NEFA levels increased (AOR = 1.001, 95% CI = 0.999 to 1.002, P = 0.177). Conversely, risk decreased as prepartum IGF-1 increased (AOR = 0.65, 95% CI = 0.349 to 1.219, P = 0.144). Cows having both, clinical and puerperal metritis produced less milk by 90 DIM than the normal cows (2,236  172 vs. 2,367  77 vs. 2,647  82 kg, respectively, P = 0.009). Cows with puerperal metritis had lower risk for pregnancy by 100 DIM (AOR = 0.189, 95% CI = 0.070 ? 0.479, P = 0.014), lower hazard rate for pregnancy by 150 DIM (0.753, 95% CI = 0.621 to 0.911, P = 0.014), and took longer to get pregnant (129 vs. 111 vs. 109 days, for puerperal metritis, clinical metritis and normal cows, respectively, P = 0.015). Ceftiofur had neither effect on cure rate nor on milk yield but increased the risk for TAI (AOR = 2.126, 95% CI = 0.983 to 4.597, P = 0.055) and for pregnancy at TAI (AOR = 2.688, 95% CI = 0.687 to 10.832, P = 0.142), and reduced the risk for reproductive cull (AOR = 0.121, 95% CI = 0.014 to 1.066, P = 0.057). In conclusion, abnormal calving and negative energy balance increase the risk for metritis. Metritis, especially the puerperal one, reduces both, milk production and reproductive efficiency. Finally, the likelihood for having a normal vaginal discharge (indicative of cure) increases 2.6 % for every day of increase in postpartum time and is 2 times higher for cows with clinical metritis than for those with puerperal metritis.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7668
Giuliodori, M. J.; Magnasco, R. P.; Becu, Damasia; Lacau, Isabel Maria; Risco, C. A.; et al.; Metritis in dairy cows: risk factors and reproductive performance; Amer Dairy Science Assoc-adsa; Journal Of Dairy Science; 96; 30-3-2013; 3621-3631
0022-0302
url http://hdl.handle.net/11336/7668
identifier_str_mv Giuliodori, M. J.; Magnasco, R. P.; Becu, Damasia; Lacau, Isabel Maria; Risco, C. A.; et al.; Metritis in dairy cows: risk factors and reproductive performance; Amer Dairy Science Assoc-adsa; Journal Of Dairy Science; 96; 30-3-2013; 3621-3631
0022-0302
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3168/jds.2012-5922
info:eu-repo/semantics/altIdentifier/pmid/23548288
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info:eu-repo/semantics/altIdentifier/url/http://www.journalofdairyscience.org/article/S0022-0302(13)00234-8/abstract
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dc.publisher.none.fl_str_mv Amer Dairy Science Assoc-adsa
publisher.none.fl_str_mv Amer Dairy Science Assoc-adsa
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