Contribution of dysregulated DNA methylation to autoimmunity

Autores
Funes, Samanta Celeste; Fernández Fierro, Ayleen; Rebolledo Zelada, Diego; Mackern Oberti, Juan Pablo; Kalergis, Alexis M.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Fernández Fierro, Ayleen. Pontificia Universidad Católica de Chile; Chile
Fil: Rebolledo Zelada, Diego. Pontificia Universidad Católica de Chile; Chile
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
Materia
DNA METHYLATION
EPIGENETIC
RHEUMATOID ARTHRITIS
SYSTEMIC AUTOIMMUNITY
CPG
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/159471
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Contribution of dysregulated DNA methylation to autoimmunityFunes, Samanta CelesteFernández Fierro, AyleenRebolledo Zelada, DiegoMackern Oberti, Juan PabloKalergis, Alexis M.DNA METHYLATIONEPIGENETICRHEUMATOID ARTHRITISSYSTEMIC AUTOIMMUNITYCPGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Fernández Fierro, Ayleen. Pontificia Universidad Católica de Chile; ChileFil: Rebolledo Zelada, Diego. Pontificia Universidad Católica de Chile; ChileFil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; ChileMolecular Diversity Preservation International2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/159471Funes, Samanta Celeste; Fernández Fierro, Ayleen; Rebolledo Zelada, Diego; Mackern Oberti, Juan Pablo; Kalergis, Alexis M.; Contribution of dysregulated DNA methylation to autoimmunity; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 22; 21; 11-2021; 11892; 1-191422-00671422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/ijms222111892info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/21/11892info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:00Zoai:ri.conicet.gov.ar:11336/159471instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:01.224CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Contribution of dysregulated DNA methylation to autoimmunity
title Contribution of dysregulated DNA methylation to autoimmunity
spellingShingle Contribution of dysregulated DNA methylation to autoimmunity
Funes, Samanta Celeste
DNA METHYLATION
EPIGENETIC
RHEUMATOID ARTHRITIS
SYSTEMIC AUTOIMMUNITY
CPG
title_short Contribution of dysregulated DNA methylation to autoimmunity
title_full Contribution of dysregulated DNA methylation to autoimmunity
title_fullStr Contribution of dysregulated DNA methylation to autoimmunity
title_full_unstemmed Contribution of dysregulated DNA methylation to autoimmunity
title_sort Contribution of dysregulated DNA methylation to autoimmunity
dc.creator.none.fl_str_mv Funes, Samanta Celeste
Fernández Fierro, Ayleen
Rebolledo Zelada, Diego
Mackern Oberti, Juan Pablo
Kalergis, Alexis M.
author Funes, Samanta Celeste
author_facet Funes, Samanta Celeste
Fernández Fierro, Ayleen
Rebolledo Zelada, Diego
Mackern Oberti, Juan Pablo
Kalergis, Alexis M.
author_role author
author2 Fernández Fierro, Ayleen
Rebolledo Zelada, Diego
Mackern Oberti, Juan Pablo
Kalergis, Alexis M.
author2_role author
author
author
author
dc.subject.none.fl_str_mv DNA METHYLATION
EPIGENETIC
RHEUMATOID ARTHRITIS
SYSTEMIC AUTOIMMUNITY
CPG
topic DNA METHYLATION
EPIGENETIC
RHEUMATOID ARTHRITIS
SYSTEMIC AUTOIMMUNITY
CPG
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Fernández Fierro, Ayleen. Pontificia Universidad Católica de Chile; Chile
Fil: Rebolledo Zelada, Diego. Pontificia Universidad Católica de Chile; Chile
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
description Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs are known regulators of gene expression and genomic stability in cell growth, development, and differentiation. Because epigenetic mechanisms can regulate several immune system elements, epigenetic alterations have been found in several autoimmune diseases. The purpose of this review is to discuss the epigenetic modifications, mainly DNA methylation, involved in autoimmune diseases in which T cells play a significant role. For example, Rheumatoid Arthritis and Systemic Lupus Erythematosus display differential gene methylation, mostly hypomethylated 5′-C-phosphate-G-3′ (CpG) sites that may associate with disease activity. However, a clear association between DNA methylation, gene expression, and disease pathogenesis must be demonstrated. A better understanding of the impact of epigenetic modifications on the onset of autoimmunity will contribute to the design of novel therapeutic approaches for these diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/159471
Funes, Samanta Celeste; Fernández Fierro, Ayleen; Rebolledo Zelada, Diego; Mackern Oberti, Juan Pablo; Kalergis, Alexis M.; Contribution of dysregulated DNA methylation to autoimmunity; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 22; 21; 11-2021; 11892; 1-19
1422-0067
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/159471
identifier_str_mv Funes, Samanta Celeste; Fernández Fierro, Ayleen; Rebolledo Zelada, Diego; Mackern Oberti, Juan Pablo; Kalergis, Alexis M.; Contribution of dysregulated DNA methylation to autoimmunity; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 22; 21; 11-2021; 11892; 1-19
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms222111892
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/21/11892
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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