Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy

Autores
Klein, Stefanie; Sommer, Anja; Dell'Arciprete, Maria Laura; Wegmann, Marc; Ott, Susanne; Distel, Luitpold V. R.; Neuhuber, Winfried; Gonzalez, Monica Cristina; Kryschi, Carola
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of their direct interaction with the mitochondrial membrane. On the other hand, uncoated and citrate-coated superparamagnetic iron oxide nanoparticles were found to increase the reactive oxygen species formation in X-ray treated tumor cells via two particular surface features, being, first, the leakage of iron ions and second, the catalytic activity of nanoparticle surfaces. Both may initiate the Haber-Weiss and Fenton reaction.
Fil: Klein, Stefanie. Universitat Erlangen-Nuremberg; Alemania
Fil: Sommer, Anja. Universitat Erlangen-Nuremberg; Alemania
Fil: Dell'Arciprete, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Wegmann, Marc. Universitat Erlangen-Nuremberg; Alemania
Fil: Ott, Susanne. Universitat Erlangen-Nuremberg; Alemania
Fil: Distel, Luitpold V. R.. Universitat Erlangen-Nuremberg; Alemania
Fil: Neuhuber, Winfried . Universitat Erlangen-Nuremberg; Alemania
Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Kryschi, Carola. Universitat Erlangen-Nuremberg; Alemania
Materia
Silicon Nanoparticles
Superparamagnetic Iron Oxide Nanoparticles
Radiation Therapy
Reactive Oxygen Species Generation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5216
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/5216
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation TherapyKlein, StefanieSommer, AnjaDell'Arciprete, Maria LauraWegmann, MarcOtt, SusanneDistel, Luitpold V. R.Neuhuber, Winfried Gonzalez, Monica CristinaKryschi, CarolaSilicon NanoparticlesSuperparamagnetic Iron Oxide NanoparticlesRadiation TherapyReactive Oxygen Species Generationhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of their direct interaction with the mitochondrial membrane. On the other hand, uncoated and citrate-coated superparamagnetic iron oxide nanoparticles were found to increase the reactive oxygen species formation in X-ray treated tumor cells via two particular surface features, being, first, the leakage of iron ions and second, the catalytic activity of nanoparticle surfaces. Both may initiate the Haber-Weiss and Fenton reaction.Fil: Klein, Stefanie. Universitat Erlangen-Nuremberg; AlemaniaFil: Sommer, Anja. Universitat Erlangen-Nuremberg; AlemaniaFil: Dell'Arciprete, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Wegmann, Marc. Universitat Erlangen-Nuremberg; AlemaniaFil: Ott, Susanne. Universitat Erlangen-Nuremberg; AlemaniaFil: Distel, Luitpold V. R.. Universitat Erlangen-Nuremberg; AlemaniaFil: Neuhuber, Winfried . Universitat Erlangen-Nuremberg; AlemaniaFil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Kryschi, Carola. Universitat Erlangen-Nuremberg; AlemaniaSciTechnol2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5216Klein, Stefanie; Sommer, Anja; Dell'Arciprete, Maria Laura; Wegmann, Marc; Ott, Susanne; et al.; Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy; SciTechnol; Journal of Nanomaterials & Molecular Nanotechnology; S2; 6-2014; 1-72324-8777enginfo:eu-repo/semantics/altIdentifier/url/http://scitechnol.com/oxidized-silicon-nanoparticles-and-iron-oxide-nanoparticles-for-radiation-therapy-3DsQ.php?article_id=2169info:eu-repo/semantics/altIdentifier/doi/10.4172/2324-8777.S2-002info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:19:39Zoai:ri.conicet.gov.ar:11336/5216instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:19:40.012CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
title Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
spellingShingle Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
Klein, Stefanie
Silicon Nanoparticles
Superparamagnetic Iron Oxide Nanoparticles
Radiation Therapy
Reactive Oxygen Species Generation
title_short Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
title_full Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
title_fullStr Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
title_full_unstemmed Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
title_sort Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy
dc.creator.none.fl_str_mv Klein, Stefanie
Sommer, Anja
Dell'Arciprete, Maria Laura
Wegmann, Marc
Ott, Susanne
Distel, Luitpold V. R.
Neuhuber, Winfried
Gonzalez, Monica Cristina
Kryschi, Carola
author Klein, Stefanie
author_facet Klein, Stefanie
Sommer, Anja
Dell'Arciprete, Maria Laura
Wegmann, Marc
Ott, Susanne
Distel, Luitpold V. R.
Neuhuber, Winfried
Gonzalez, Monica Cristina
Kryschi, Carola
author_role author
author2 Sommer, Anja
Dell'Arciprete, Maria Laura
Wegmann, Marc
Ott, Susanne
Distel, Luitpold V. R.
Neuhuber, Winfried
Gonzalez, Monica Cristina
Kryschi, Carola
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Silicon Nanoparticles
Superparamagnetic Iron Oxide Nanoparticles
Radiation Therapy
Reactive Oxygen Species Generation
topic Silicon Nanoparticles
Superparamagnetic Iron Oxide Nanoparticles
Radiation Therapy
Reactive Oxygen Species Generation
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of their direct interaction with the mitochondrial membrane. On the other hand, uncoated and citrate-coated superparamagnetic iron oxide nanoparticles were found to increase the reactive oxygen species formation in X-ray treated tumor cells via two particular surface features, being, first, the leakage of iron ions and second, the catalytic activity of nanoparticle surfaces. Both may initiate the Haber-Weiss and Fenton reaction.
Fil: Klein, Stefanie. Universitat Erlangen-Nuremberg; Alemania
Fil: Sommer, Anja. Universitat Erlangen-Nuremberg; Alemania
Fil: Dell'Arciprete, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Wegmann, Marc. Universitat Erlangen-Nuremberg; Alemania
Fil: Ott, Susanne. Universitat Erlangen-Nuremberg; Alemania
Fil: Distel, Luitpold V. R.. Universitat Erlangen-Nuremberg; Alemania
Fil: Neuhuber, Winfried . Universitat Erlangen-Nuremberg; Alemania
Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Kryschi, Carola. Universitat Erlangen-Nuremberg; Alemania
description Our research objective is to develop superparamagnetic iron oxide nanoparticles and silicon nanoparticles as radiosensitizers for cancer therapy. After internalization by breast tumor cells and irradiation with X-rays, the nanoparticles were observed to enhance the oxidative stress in tumor cells. While silicon nanoparticles increase the reactive oxygen species production under X-ray treatment due to their incompletely oxidized surface, positively charged amino-functionalized silicon nanoparticles enhance the formation of mitochondrial reactive oxygen species formation because of their direct interaction with the mitochondrial membrane. On the other hand, uncoated and citrate-coated superparamagnetic iron oxide nanoparticles were found to increase the reactive oxygen species formation in X-ray treated tumor cells via two particular surface features, being, first, the leakage of iron ions and second, the catalytic activity of nanoparticle surfaces. Both may initiate the Haber-Weiss and Fenton reaction.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5216
Klein, Stefanie; Sommer, Anja; Dell'Arciprete, Maria Laura; Wegmann, Marc; Ott, Susanne; et al.; Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy; SciTechnol; Journal of Nanomaterials & Molecular Nanotechnology; S2; 6-2014; 1-7
2324-8777
url http://hdl.handle.net/11336/5216
identifier_str_mv Klein, Stefanie; Sommer, Anja; Dell'Arciprete, Maria Laura; Wegmann, Marc; Ott, Susanne; et al.; Oxidized Silicon Nanoparticles and Iron Oxide Nanoparticles for Radiation Therapy; SciTechnol; Journal of Nanomaterials & Molecular Nanotechnology; S2; 6-2014; 1-7
2324-8777
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://scitechnol.com/oxidized-silicon-nanoparticles-and-iron-oxide-nanoparticles-for-radiation-therapy-3DsQ.php?article_id=2169
info:eu-repo/semantics/altIdentifier/doi/10.4172/2324-8777.S2-002
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SciTechnol
publisher.none.fl_str_mv SciTechnol
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606540827754496
score 13.001348

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