Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters
- Autores
- De Bruijn, Henriëtte S.; Casas, Adriana Gabriela; Di Venosa, Gabriela Mariana; Gándara, Lautaro; Sterenborg, Henricus J. C. M.; Batlle, Alcira María del C.; Robinson, Dominic J.
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Light fractionation, with a long dark interval, significantly increases the response to ALA-PDT in pre-clinical models and in non-melanoma skin cancer. We investigated if this increase in efficacy can be replicated in PAM 212 cells in vitro. The results show a significant decrease in cell survival after light fractionation which is dependent on the PpIX concentration and light dose of the first light fraction. This study supports the hypothesis that an underlying cellular mechanism is involved in the response to light fractionation in which a first light fraction leads to sub-lethally damaged cells that are sensitised to a second light fraction 2 hours later. The current study reveals the in vitro circumstances under which we can investigate the cellular pathways involved.
Fil: De Bruijn, Henriëtte S.. Erasmus MC; Países Bajos
Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina
Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina
Fil: Gándara, Lautaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina
Fil: Sterenborg, Henricus J. C. M.. Erasmus MC; Países Bajos
Fil: Batlle, Alcira María del C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina
Fil: Robinson, Dominic J.. Erasmus MC; Países Bajos - Materia
-
ALA
PHOTODYNAMIC THERAPY
FRACTIONATION
LIGHT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/84738
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/84738 |
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repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parametersDe Bruijn, Henriëtte S.Casas, Adriana GabrielaDi Venosa, Gabriela MarianaGándara, LautaroSterenborg, Henricus J. C. M.Batlle, Alcira María del C.Robinson, Dominic J.ALAPHOTODYNAMIC THERAPYFRACTIONATIONLIGHThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Light fractionation, with a long dark interval, significantly increases the response to ALA-PDT in pre-clinical models and in non-melanoma skin cancer. We investigated if this increase in efficacy can be replicated in PAM 212 cells in vitro. The results show a significant decrease in cell survival after light fractionation which is dependent on the PpIX concentration and light dose of the first light fraction. This study supports the hypothesis that an underlying cellular mechanism is involved in the response to light fractionation in which a first light fraction leads to sub-lethally damaged cells that are sensitised to a second light fraction 2 hours later. The current study reveals the in vitro circumstances under which we can investigate the cellular pathways involved.Fil: De Bruijn, Henriëtte S.. Erasmus MC; Países BajosFil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Gándara, Lautaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Sterenborg, Henricus J. C. M.. Erasmus MC; Países BajosFil: Batlle, Alcira María del C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Robinson, Dominic J.. Erasmus MC; Países BajosRoyal Society of Chemistry2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84738De Bruijn, Henriëtte S.; Casas, Adriana Gabriela; Di Venosa, Gabriela Mariana; Gándara, Lautaro; Sterenborg, Henricus J. C. M.; et al.; Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 12; 2; 2-2013; 241-2451474-905XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c2pp25287binfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:19Zoai:ri.conicet.gov.ar:11336/84738instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:19.815CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters |
title |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters |
spellingShingle |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters De Bruijn, Henriëtte S. ALA PHOTODYNAMIC THERAPY FRACTIONATION LIGHT |
title_short |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters |
title_full |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters |
title_fullStr |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters |
title_full_unstemmed |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters |
title_sort |
Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters |
dc.creator.none.fl_str_mv |
De Bruijn, Henriëtte S. Casas, Adriana Gabriela Di Venosa, Gabriela Mariana Gándara, Lautaro Sterenborg, Henricus J. C. M. Batlle, Alcira María del C. Robinson, Dominic J. |
author |
De Bruijn, Henriëtte S. |
author_facet |
De Bruijn, Henriëtte S. Casas, Adriana Gabriela Di Venosa, Gabriela Mariana Gándara, Lautaro Sterenborg, Henricus J. C. M. Batlle, Alcira María del C. Robinson, Dominic J. |
author_role |
author |
author2 |
Casas, Adriana Gabriela Di Venosa, Gabriela Mariana Gándara, Lautaro Sterenborg, Henricus J. C. M. Batlle, Alcira María del C. Robinson, Dominic J. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
ALA PHOTODYNAMIC THERAPY FRACTIONATION LIGHT |
topic |
ALA PHOTODYNAMIC THERAPY FRACTIONATION LIGHT |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Light fractionation, with a long dark interval, significantly increases the response to ALA-PDT in pre-clinical models and in non-melanoma skin cancer. We investigated if this increase in efficacy can be replicated in PAM 212 cells in vitro. The results show a significant decrease in cell survival after light fractionation which is dependent on the PpIX concentration and light dose of the first light fraction. This study supports the hypothesis that an underlying cellular mechanism is involved in the response to light fractionation in which a first light fraction leads to sub-lethally damaged cells that are sensitised to a second light fraction 2 hours later. The current study reveals the in vitro circumstances under which we can investigate the cellular pathways involved. Fil: De Bruijn, Henriëtte S.. Erasmus MC; Países Bajos Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina Fil: Gándara, Lautaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina Fil: Sterenborg, Henricus J. C. M.. Erasmus MC; Países Bajos Fil: Batlle, Alcira María del C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina Fil: Robinson, Dominic J.. Erasmus MC; Países Bajos |
description |
Light fractionation, with a long dark interval, significantly increases the response to ALA-PDT in pre-clinical models and in non-melanoma skin cancer. We investigated if this increase in efficacy can be replicated in PAM 212 cells in vitro. The results show a significant decrease in cell survival after light fractionation which is dependent on the PpIX concentration and light dose of the first light fraction. This study supports the hypothesis that an underlying cellular mechanism is involved in the response to light fractionation in which a first light fraction leads to sub-lethally damaged cells that are sensitised to a second light fraction 2 hours later. The current study reveals the in vitro circumstances under which we can investigate the cellular pathways involved. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/84738 De Bruijn, Henriëtte S.; Casas, Adriana Gabriela; Di Venosa, Gabriela Mariana; Gándara, Lautaro; Sterenborg, Henricus J. C. M.; et al.; Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 12; 2; 2-2013; 241-245 1474-905X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/84738 |
identifier_str_mv |
De Bruijn, Henriëtte S.; Casas, Adriana Gabriela; Di Venosa, Gabriela Mariana; Gándara, Lautaro; Sterenborg, Henricus J. C. M.; et al.; Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; The influence of PpIX concentration and illumination parameters; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 12; 2; 2-2013; 241-245 1474-905X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1039/c2pp25287b |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269279382142976 |
score |
13.13397 |