Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation

Autores
Ameta, K. L.; Rathore, Nitu S.; Kumari, Maya; Khyaliya, Priyanka; Dangi R. R.; Parellada, Eduardo Alberto; Neske, Adriana
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An expeditious synthesis of some 4´-nitrochalcones (3a-n) and their subsequent facile one-pot transformation to 1, 3,
5-triaryl-2-pyrazolines (4a-n) has been carried out using montmorrilonite K10 via microwave mediated solvent free protocol.
An emphasis is given to highlighting the greenness of the processes, and a fair comparison is also provided between different
inorganic solid supports as catalysts. Both conventional as well as non-conventional approaches have been explored by
comparing the reaction conditions and yields. The newly synthesized pyrazolines were studied for their in vitro antimicrobial
evaluation against bacterial strains Bacillus pumilus and Escherichia coli and fungal strains Aspergillus niger and Penicillium
chrysogenum. Findings of biological evaluation highlighted 4b, 4e, 4j and 4m as potential new leads in the search of new
antimicrobial agents. The structures of newly synthesized compounds have been established on the basis of elemental analysis
and spectroscopic studies.
Fil: Ameta, K. L.. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Rathore, Nitu S.. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Kumari, Maya. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Khyaliya, Priyanka. University of Science and Technology; India
Fil: Dangi R. R.. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Parellada, Eduardo Alberto. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; Argentina
Fil: Neske, Adriana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina
Materia
Chalcones
Pyrazolines
Montmorrilonite K10
Microwave
Antibacterial activity
Antifungal activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120485
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluationAmeta, K. L.Rathore, Nitu S.Kumari, MayaKhyaliya, PriyankaDangi R. R.Parellada, Eduardo AlbertoNeske, AdrianaChalconesPyrazolinesMontmorrilonite K10MicrowaveAntibacterial activityAntifungal activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1An expeditious synthesis of some 4´-nitrochalcones (3a-n) and their subsequent facile one-pot transformation to 1, 3,<br />5-triaryl-2-pyrazolines (4a-n) has been carried out using montmorrilonite K10 via microwave mediated solvent free protocol.<br />An emphasis is given to highlighting the greenness of the processes, and a fair comparison is also provided between different<br />inorganic solid supports as catalysts. Both conventional as well as non-conventional approaches have been explored by<br />comparing the reaction conditions and yields. The newly synthesized pyrazolines were studied for their in vitro antimicrobial<br />evaluation against bacterial strains Bacillus pumilus and Escherichia coli and fungal strains Aspergillus niger and Penicillium<br />chrysogenum. Findings of biological evaluation highlighted 4b, 4e, 4j and 4m as potential new leads in the search of new<br />antimicrobial agents. The structures of newly synthesized compounds have been established on the basis of elemental analysis<br />and spectroscopic studies.Fil: Ameta, K. L.. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Rathore, Nitu S.. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Kumari, Maya. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Khyaliya, Priyanka. University of Science and Technology; IndiaFil: Dangi R. R.. Faculty Of Arts, Science & Commerce, Mody University Of; IndiaFil: Parellada, Eduardo Alberto. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; ArgentinaFil: Neske, Adriana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; ArgentinaIslamic Azad University Of Qaemshahr2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120485Ameta, K. L. ; Rathore, Nitu S. ; Kumari, Maya ; Khyaliya, Priyanka; Dangi R. R. ; et al.; Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation; Islamic Azad University Of Qaemshahr; IranJOC Iranian Journal of Organic Chemistry; 8; 3; 7-2016; 1833-18442008-3599CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://iranjoc.qaemiau.ac.ir/article_541742_e502217e9243c10ff679bb2b60d524fd.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:09:55Zoai:ri.conicet.gov.ar:11336/120485instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:09:55.88CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
title Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
spellingShingle Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
Ameta, K. L.
Chalcones
Pyrazolines
Montmorrilonite K10
Microwave
Antibacterial activity
Antifungal activity
title_short Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
title_full Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
title_fullStr Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
title_full_unstemmed Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
title_sort Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation
dc.creator.none.fl_str_mv Ameta, K. L.
Rathore, Nitu S.
Kumari, Maya
Khyaliya, Priyanka
Dangi R. R.
Parellada, Eduardo Alberto
Neske, Adriana
author Ameta, K. L.
author_facet Ameta, K. L.
Rathore, Nitu S.
Kumari, Maya
Khyaliya, Priyanka
Dangi R. R.
Parellada, Eduardo Alberto
Neske, Adriana
author_role author
author2 Rathore, Nitu S.
Kumari, Maya
Khyaliya, Priyanka
Dangi R. R.
Parellada, Eduardo Alberto
Neske, Adriana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Chalcones
Pyrazolines
Montmorrilonite K10
Microwave
Antibacterial activity
Antifungal activity
topic Chalcones
Pyrazolines
Montmorrilonite K10
Microwave
Antibacterial activity
Antifungal activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An expeditious synthesis of some 4´-nitrochalcones (3a-n) and their subsequent facile one-pot transformation to 1, 3,<br />5-triaryl-2-pyrazolines (4a-n) has been carried out using montmorrilonite K10 via microwave mediated solvent free protocol.<br />An emphasis is given to highlighting the greenness of the processes, and a fair comparison is also provided between different<br />inorganic solid supports as catalysts. Both conventional as well as non-conventional approaches have been explored by<br />comparing the reaction conditions and yields. The newly synthesized pyrazolines were studied for their in vitro antimicrobial<br />evaluation against bacterial strains Bacillus pumilus and Escherichia coli and fungal strains Aspergillus niger and Penicillium<br />chrysogenum. Findings of biological evaluation highlighted 4b, 4e, 4j and 4m as potential new leads in the search of new<br />antimicrobial agents. The structures of newly synthesized compounds have been established on the basis of elemental analysis<br />and spectroscopic studies.
Fil: Ameta, K. L.. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Rathore, Nitu S.. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Kumari, Maya. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Khyaliya, Priyanka. University of Science and Technology; India
Fil: Dangi R. R.. Faculty Of Arts, Science & Commerce, Mody University Of; India
Fil: Parellada, Eduardo Alberto. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina. Universidad Nacional de Santiago del Estero. Instituto de Bionanotecnología del Noa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Bionanotecnología del Noa; Argentina
Fil: Neske, Adriana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica. Cátedra de Química Orgánica III; Argentina
description An expeditious synthesis of some 4´-nitrochalcones (3a-n) and their subsequent facile one-pot transformation to 1, 3,<br />5-triaryl-2-pyrazolines (4a-n) has been carried out using montmorrilonite K10 via microwave mediated solvent free protocol.<br />An emphasis is given to highlighting the greenness of the processes, and a fair comparison is also provided between different<br />inorganic solid supports as catalysts. Both conventional as well as non-conventional approaches have been explored by<br />comparing the reaction conditions and yields. The newly synthesized pyrazolines were studied for their in vitro antimicrobial<br />evaluation against bacterial strains Bacillus pumilus and Escherichia coli and fungal strains Aspergillus niger and Penicillium<br />chrysogenum. Findings of biological evaluation highlighted 4b, 4e, 4j and 4m as potential new leads in the search of new<br />antimicrobial agents. The structures of newly synthesized compounds have been established on the basis of elemental analysis<br />and spectroscopic studies.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120485
Ameta, K. L. ; Rathore, Nitu S. ; Kumari, Maya ; Khyaliya, Priyanka; Dangi R. R. ; et al.; Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation; Islamic Azad University Of Qaemshahr; IranJOC Iranian Journal of Organic Chemistry; 8; 3; 7-2016; 1833-1844
2008-3599
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120485
identifier_str_mv Ameta, K. L. ; Rathore, Nitu S. ; Kumari, Maya ; Khyaliya, Priyanka; Dangi R. R. ; et al.; Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation; Islamic Azad University Of Qaemshahr; IranJOC Iranian Journal of Organic Chemistry; 8; 3; 7-2016; 1833-1844
2008-3599
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://iranjoc.qaemiau.ac.ir/article_541742_e502217e9243c10ff679bb2b60d524fd.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Islamic Azad University Of Qaemshahr
publisher.none.fl_str_mv Islamic Azad University Of Qaemshahr
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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