Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions

Autores
Martínez-Abadías, Neus; Esparza, Mireia; Sjøvold, Torstein; González José, Rolando; Santos, Mauro; Hernández, Miquel
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Quantitative craniometrical traits have been successfully incorporated into population genetic methods to provide insight into human population structure. However, little is known about the degree of genetic and non-genetic influences on the phenotypic expression of functionally based traits. Many studies have assessed the heritability of craniofacial traits, but complex patterns of correlation among traits have been disregarded. This is a pitfall as the human skull is strongly integrated. Here we reconsider the evolutionary potential of craniometric traits by assessing their heritability values as well as their patterns of genetic and phenotypic correlation using a large pedigree-structured skull series from Hallstatt (Austria). The sample includes 355 complete adult skulls that have been analysed using 3D geometric morphometric techniques. Heritability estimates for 58 cranial linear distances were computed using maximum likelihood methods. These distances were assigned to the main functional and developmental regions of the skull. Results showed that the human skull has substantial amounts of genetic variation, and a t-test showed that there are no statistically significant differences among the heritabilities of facial, neurocranial and basal dimensions. However, skull evolvability is limited by complex patterns of genetic correlation. Phenotypic and genetic patterns of correlation are consistent but do not support traditional hypotheses of integration of the human shape, showing that the classification between brachy- and dolicephalic skulls is not grounded on the genetic level. Here we support previous findings in the mouse cranium and provide empirical evidence that covariation between the maximum widths of the main developmental regions of the skull is the dominant factor of integration in the human skull.
Fil: Martínez-Abadías, Neus. Universidad de Barcelona; España
Fil: Esparza, Mireia. Universidad de Barcelona; España
Fil: Sjøvold, Torstein. Stockholms Universitet; Suecia
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Santos, Mauro. Universitat Autònoma de Barcelona; España
Fil: Hernández, Miquel. Universidad de Barcelona; España
Materia
EVOLVABILITY
HERITABILITY
HUMAN SKULL
QUANTITATIVE GENETICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94588
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Heritability of human cranial dimensions: Comparing the evolvability of different cranial regionsMartínez-Abadías, NeusEsparza, MireiaSjøvold, TorsteinGonzález José, RolandoSantos, MauroHernández, MiquelEVOLVABILITYHERITABILITYHUMAN SKULLQUANTITATIVE GENETICShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Quantitative craniometrical traits have been successfully incorporated into population genetic methods to provide insight into human population structure. However, little is known about the degree of genetic and non-genetic influences on the phenotypic expression of functionally based traits. Many studies have assessed the heritability of craniofacial traits, but complex patterns of correlation among traits have been disregarded. This is a pitfall as the human skull is strongly integrated. Here we reconsider the evolutionary potential of craniometric traits by assessing their heritability values as well as their patterns of genetic and phenotypic correlation using a large pedigree-structured skull series from Hallstatt (Austria). The sample includes 355 complete adult skulls that have been analysed using 3D geometric morphometric techniques. Heritability estimates for 58 cranial linear distances were computed using maximum likelihood methods. These distances were assigned to the main functional and developmental regions of the skull. Results showed that the human skull has substantial amounts of genetic variation, and a t-test showed that there are no statistically significant differences among the heritabilities of facial, neurocranial and basal dimensions. However, skull evolvability is limited by complex patterns of genetic correlation. Phenotypic and genetic patterns of correlation are consistent but do not support traditional hypotheses of integration of the human shape, showing that the classification between brachy- and dolicephalic skulls is not grounded on the genetic level. Here we support previous findings in the mouse cranium and provide empirical evidence that covariation between the maximum widths of the main developmental regions of the skull is the dominant factor of integration in the human skull.Fil: Martínez-Abadías, Neus. Universidad de Barcelona; EspañaFil: Esparza, Mireia. Universidad de Barcelona; EspañaFil: Sjøvold, Torstein. Stockholms Universitet; SueciaFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Santos, Mauro. Universitat Autònoma de Barcelona; EspañaFil: Hernández, Miquel. Universidad de Barcelona; EspañaWiley Blackwell Publishing, Inc2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94588Martínez-Abadías, Neus; Esparza, Mireia; Sjøvold, Torstein; González José, Rolando; Santos, Mauro; et al.; Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions; Wiley Blackwell Publishing, Inc; Journal of Anatomy; 214; 1; 12-2009; 19-350021-8782CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1469-7580.2008.01015.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-7580.2008.01015.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:30:10Zoai:ri.conicet.gov.ar:11336/94588instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:30:10.653CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
title Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
spellingShingle Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
Martínez-Abadías, Neus
EVOLVABILITY
HERITABILITY
HUMAN SKULL
QUANTITATIVE GENETICS
title_short Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
title_full Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
title_fullStr Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
title_full_unstemmed Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
title_sort Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions
dc.creator.none.fl_str_mv Martínez-Abadías, Neus
Esparza, Mireia
Sjøvold, Torstein
González José, Rolando
Santos, Mauro
Hernández, Miquel
author Martínez-Abadías, Neus
author_facet Martínez-Abadías, Neus
Esparza, Mireia
Sjøvold, Torstein
González José, Rolando
Santos, Mauro
Hernández, Miquel
author_role author
author2 Esparza, Mireia
Sjøvold, Torstein
González José, Rolando
Santos, Mauro
Hernández, Miquel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv EVOLVABILITY
HERITABILITY
HUMAN SKULL
QUANTITATIVE GENETICS
topic EVOLVABILITY
HERITABILITY
HUMAN SKULL
QUANTITATIVE GENETICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Quantitative craniometrical traits have been successfully incorporated into population genetic methods to provide insight into human population structure. However, little is known about the degree of genetic and non-genetic influences on the phenotypic expression of functionally based traits. Many studies have assessed the heritability of craniofacial traits, but complex patterns of correlation among traits have been disregarded. This is a pitfall as the human skull is strongly integrated. Here we reconsider the evolutionary potential of craniometric traits by assessing their heritability values as well as their patterns of genetic and phenotypic correlation using a large pedigree-structured skull series from Hallstatt (Austria). The sample includes 355 complete adult skulls that have been analysed using 3D geometric morphometric techniques. Heritability estimates for 58 cranial linear distances were computed using maximum likelihood methods. These distances were assigned to the main functional and developmental regions of the skull. Results showed that the human skull has substantial amounts of genetic variation, and a t-test showed that there are no statistically significant differences among the heritabilities of facial, neurocranial and basal dimensions. However, skull evolvability is limited by complex patterns of genetic correlation. Phenotypic and genetic patterns of correlation are consistent but do not support traditional hypotheses of integration of the human shape, showing that the classification between brachy- and dolicephalic skulls is not grounded on the genetic level. Here we support previous findings in the mouse cranium and provide empirical evidence that covariation between the maximum widths of the main developmental regions of the skull is the dominant factor of integration in the human skull.
Fil: Martínez-Abadías, Neus. Universidad de Barcelona; España
Fil: Esparza, Mireia. Universidad de Barcelona; España
Fil: Sjøvold, Torstein. Stockholms Universitet; Suecia
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Santos, Mauro. Universitat Autònoma de Barcelona; España
Fil: Hernández, Miquel. Universidad de Barcelona; España
description Quantitative craniometrical traits have been successfully incorporated into population genetic methods to provide insight into human population structure. However, little is known about the degree of genetic and non-genetic influences on the phenotypic expression of functionally based traits. Many studies have assessed the heritability of craniofacial traits, but complex patterns of correlation among traits have been disregarded. This is a pitfall as the human skull is strongly integrated. Here we reconsider the evolutionary potential of craniometric traits by assessing their heritability values as well as their patterns of genetic and phenotypic correlation using a large pedigree-structured skull series from Hallstatt (Austria). The sample includes 355 complete adult skulls that have been analysed using 3D geometric morphometric techniques. Heritability estimates for 58 cranial linear distances were computed using maximum likelihood methods. These distances were assigned to the main functional and developmental regions of the skull. Results showed that the human skull has substantial amounts of genetic variation, and a t-test showed that there are no statistically significant differences among the heritabilities of facial, neurocranial and basal dimensions. However, skull evolvability is limited by complex patterns of genetic correlation. Phenotypic and genetic patterns of correlation are consistent but do not support traditional hypotheses of integration of the human shape, showing that the classification between brachy- and dolicephalic skulls is not grounded on the genetic level. Here we support previous findings in the mouse cranium and provide empirical evidence that covariation between the maximum widths of the main developmental regions of the skull is the dominant factor of integration in the human skull.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94588
Martínez-Abadías, Neus; Esparza, Mireia; Sjøvold, Torstein; González José, Rolando; Santos, Mauro; et al.; Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions; Wiley Blackwell Publishing, Inc; Journal of Anatomy; 214; 1; 12-2009; 19-35
0021-8782
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94588
identifier_str_mv Martínez-Abadías, Neus; Esparza, Mireia; Sjøvold, Torstein; González José, Rolando; Santos, Mauro; et al.; Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions; Wiley Blackwell Publishing, Inc; Journal of Anatomy; 214; 1; 12-2009; 19-35
0021-8782
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1469-7580.2008.01015.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-7580.2008.01015.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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