The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha

Autores
Mecchia, Martin Alejandro; Garcia Hourquet, Mariano; Lozano Elena, Fidel; Planas Riverola, Ainoa; Blasco Escamez, David; Marquès Bueno, Mar; Mora Garcia, Santiago; Caño Delgado, Ana I.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Brassinosteroids (BRs) play essential roles in growth and development in seed plants;1 disturbances in BR homeostasis lead to altered mitotic activity in meristems2,3 and organ boundaries4,5 and to changes in meristem determinacy.6 An intricate signaling cascade linking the perception of BRs at the plasma membrane to the regulation of master transcriptional regulators belonging to the BEH, for BES1 homologues, family7 has been described in great detail in model angiosperms. Homologs of these transcription factors are present in streptophyte algae and in land plant lineages where BR signaling or function is absent or has not yet been characterized. The genome of the bryophyte Marchantia polymorpha does not encode for BR receptors but includes one close ortholog of Arabidopsis thaliana BRI1-EMS-SUPPRESSOR 1 (AtBES1)8 and Arabidopsis thaliana BRASSINAZOLE-RESISTANT 1 (AtBZR1),9 MpBES1. Altered levels of MpBES1 severely compromised cell division and differentiation, resulting in stunted thalli that failed to differentiate adult tissues and reproductive organs. The transcriptome of Mpbes1 knockout plants revealed a significant overlap with homologous functions controlled by AtBES1 and AtBZR1, suggesting that members of this gene family share a subset of common targets. Indeed, MpBES1 behaved as a gain-of-function substitute of AtBES1/AtBZR1 when expressed in Arabidopsis, probably because it mediates conserved functions but evades the regulatory mechanisms that native counterparts are subject to. Our results show that this family of transcription factors plays an ancestral role in the control of cell division and differentiation in plants and that BR signaling likely co-opted this function and imposed additional regulatory checkpoints upon it.
Fil: Mecchia, Martin Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España. Universitat Zurich; Suiza
Fil: Garcia Hourquet, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Lozano Elena, Fidel. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Planas Riverola, Ainoa. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Blasco Escamez, David. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Marquès Bueno, Mar. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Mora Garcia, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Caño Delgado, Ana I.. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Materia
ARABIDOPSIS THALIANA
BRASSINOSTEROIDS
MARCHANTIA POLYMORPHA
MPBES1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/212016
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorphaMecchia, Martin AlejandroGarcia Hourquet, MarianoLozano Elena, FidelPlanas Riverola, AinoaBlasco Escamez, DavidMarquès Bueno, MarMora Garcia, SantiagoCaño Delgado, Ana I.ARABIDOPSIS THALIANABRASSINOSTEROIDSMARCHANTIA POLYMORPHAMPBES1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Brassinosteroids (BRs) play essential roles in growth and development in seed plants;1 disturbances in BR homeostasis lead to altered mitotic activity in meristems2,3 and organ boundaries4,5 and to changes in meristem determinacy.6 An intricate signaling cascade linking the perception of BRs at the plasma membrane to the regulation of master transcriptional regulators belonging to the BEH, for BES1 homologues, family7 has been described in great detail in model angiosperms. Homologs of these transcription factors are present in streptophyte algae and in land plant lineages where BR signaling or function is absent or has not yet been characterized. The genome of the bryophyte Marchantia polymorpha does not encode for BR receptors but includes one close ortholog of Arabidopsis thaliana BRI1-EMS-SUPPRESSOR 1 (AtBES1)8 and Arabidopsis thaliana BRASSINAZOLE-RESISTANT 1 (AtBZR1),9 MpBES1. Altered levels of MpBES1 severely compromised cell division and differentiation, resulting in stunted thalli that failed to differentiate adult tissues and reproductive organs. The transcriptome of Mpbes1 knockout plants revealed a significant overlap with homologous functions controlled by AtBES1 and AtBZR1, suggesting that members of this gene family share a subset of common targets. Indeed, MpBES1 behaved as a gain-of-function substitute of AtBES1/AtBZR1 when expressed in Arabidopsis, probably because it mediates conserved functions but evades the regulatory mechanisms that native counterparts are subject to. Our results show that this family of transcription factors plays an ancestral role in the control of cell division and differentiation in plants and that BR signaling likely co-opted this function and imposed additional regulatory checkpoints upon it.Fil: Mecchia, Martin Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España. Universitat Zurich; SuizaFil: Garcia Hourquet, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Lozano Elena, Fidel. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; EspañaFil: Planas Riverola, Ainoa. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; EspañaFil: Blasco Escamez, David. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; EspañaFil: Marquès Bueno, Mar. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; EspañaFil: Mora Garcia, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Caño Delgado, Ana I.. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; EspañaCell Press2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/212016Mecchia, Martin Alejandro; Garcia Hourquet, Mariano; Lozano Elena, Fidel; Planas Riverola, Ainoa; Blasco Escamez, David; et al.; The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha; Cell Press; Current Biology; 31; 21; 11-2021; 4860-4869.e80960-9822CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982221011866info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2021.08.050info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:31Zoai:ri.conicet.gov.ar:11336/212016instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:32.242CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
title The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
spellingShingle The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
Mecchia, Martin Alejandro
ARABIDOPSIS THALIANA
BRASSINOSTEROIDS
MARCHANTIA POLYMORPHA
MPBES1
title_short The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
title_full The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
title_fullStr The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
title_full_unstemmed The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
title_sort The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha
dc.creator.none.fl_str_mv Mecchia, Martin Alejandro
Garcia Hourquet, Mariano
Lozano Elena, Fidel
Planas Riverola, Ainoa
Blasco Escamez, David
Marquès Bueno, Mar
Mora Garcia, Santiago
Caño Delgado, Ana I.
author Mecchia, Martin Alejandro
author_facet Mecchia, Martin Alejandro
Garcia Hourquet, Mariano
Lozano Elena, Fidel
Planas Riverola, Ainoa
Blasco Escamez, David
Marquès Bueno, Mar
Mora Garcia, Santiago
Caño Delgado, Ana I.
author_role author
author2 Garcia Hourquet, Mariano
Lozano Elena, Fidel
Planas Riverola, Ainoa
Blasco Escamez, David
Marquès Bueno, Mar
Mora Garcia, Santiago
Caño Delgado, Ana I.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARABIDOPSIS THALIANA
BRASSINOSTEROIDS
MARCHANTIA POLYMORPHA
MPBES1
topic ARABIDOPSIS THALIANA
BRASSINOSTEROIDS
MARCHANTIA POLYMORPHA
MPBES1
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Brassinosteroids (BRs) play essential roles in growth and development in seed plants;1 disturbances in BR homeostasis lead to altered mitotic activity in meristems2,3 and organ boundaries4,5 and to changes in meristem determinacy.6 An intricate signaling cascade linking the perception of BRs at the plasma membrane to the regulation of master transcriptional regulators belonging to the BEH, for BES1 homologues, family7 has been described in great detail in model angiosperms. Homologs of these transcription factors are present in streptophyte algae and in land plant lineages where BR signaling or function is absent or has not yet been characterized. The genome of the bryophyte Marchantia polymorpha does not encode for BR receptors but includes one close ortholog of Arabidopsis thaliana BRI1-EMS-SUPPRESSOR 1 (AtBES1)8 and Arabidopsis thaliana BRASSINAZOLE-RESISTANT 1 (AtBZR1),9 MpBES1. Altered levels of MpBES1 severely compromised cell division and differentiation, resulting in stunted thalli that failed to differentiate adult tissues and reproductive organs. The transcriptome of Mpbes1 knockout plants revealed a significant overlap with homologous functions controlled by AtBES1 and AtBZR1, suggesting that members of this gene family share a subset of common targets. Indeed, MpBES1 behaved as a gain-of-function substitute of AtBES1/AtBZR1 when expressed in Arabidopsis, probably because it mediates conserved functions but evades the regulatory mechanisms that native counterparts are subject to. Our results show that this family of transcription factors plays an ancestral role in the control of cell division and differentiation in plants and that BR signaling likely co-opted this function and imposed additional regulatory checkpoints upon it.
Fil: Mecchia, Martin Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España. Universitat Zurich; Suiza
Fil: Garcia Hourquet, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Lozano Elena, Fidel. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Planas Riverola, Ainoa. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Blasco Escamez, David. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Marquès Bueno, Mar. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
Fil: Mora Garcia, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Caño Delgado, Ana I.. Consejo Superior de Investigaciones Cientificas. Center For Research In Agricultural Genomics; España
description Brassinosteroids (BRs) play essential roles in growth and development in seed plants;1 disturbances in BR homeostasis lead to altered mitotic activity in meristems2,3 and organ boundaries4,5 and to changes in meristem determinacy.6 An intricate signaling cascade linking the perception of BRs at the plasma membrane to the regulation of master transcriptional regulators belonging to the BEH, for BES1 homologues, family7 has been described in great detail in model angiosperms. Homologs of these transcription factors are present in streptophyte algae and in land plant lineages where BR signaling or function is absent or has not yet been characterized. The genome of the bryophyte Marchantia polymorpha does not encode for BR receptors but includes one close ortholog of Arabidopsis thaliana BRI1-EMS-SUPPRESSOR 1 (AtBES1)8 and Arabidopsis thaliana BRASSINAZOLE-RESISTANT 1 (AtBZR1),9 MpBES1. Altered levels of MpBES1 severely compromised cell division and differentiation, resulting in stunted thalli that failed to differentiate adult tissues and reproductive organs. The transcriptome of Mpbes1 knockout plants revealed a significant overlap with homologous functions controlled by AtBES1 and AtBZR1, suggesting that members of this gene family share a subset of common targets. Indeed, MpBES1 behaved as a gain-of-function substitute of AtBES1/AtBZR1 when expressed in Arabidopsis, probably because it mediates conserved functions but evades the regulatory mechanisms that native counterparts are subject to. Our results show that this family of transcription factors plays an ancestral role in the control of cell division and differentiation in plants and that BR signaling likely co-opted this function and imposed additional regulatory checkpoints upon it.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/212016
Mecchia, Martin Alejandro; Garcia Hourquet, Mariano; Lozano Elena, Fidel; Planas Riverola, Ainoa; Blasco Escamez, David; et al.; The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha; Cell Press; Current Biology; 31; 21; 11-2021; 4860-4869.e8
0960-9822
CONICET Digital
CONICET
url http://hdl.handle.net/11336/212016
identifier_str_mv Mecchia, Martin Alejandro; Garcia Hourquet, Mariano; Lozano Elena, Fidel; Planas Riverola, Ainoa; Blasco Escamez, David; et al.; The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha; Cell Press; Current Biology; 31; 21; 11-2021; 4860-4869.e8
0960-9822
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982221011866
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2021.08.050
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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