Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies
- Autores
- Caviglia, Horacio Alberto; Landro, María Eulalia; Oneto, Paula; Cambiaggi, Guillermo; Galatro, Gustavo; Berni, Micaela; Caliogna, Laura; Carrera Silva, Eugenio Antonio; Pasta, Gianluigi
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Intra-articular blood, iron and hemosiderin, hydroxyl radical cytokines, and neo-angiogenesiscause synovial inflammation, which leads to cartilage and joint damage. Platelet-rich plasma (PRP)inhibits most of the mediators that produce and maintain synovitis. We compile here our workshowing the clinical effectiveness of intra-articular PRP injections and their potential role in stoppingarticular cartilage damage due to bleeding and its possible repair. A total of 116 joints, includingknees (63%), elbows (19.8%), and ankles (17.2%), were treated with intra-articular injections of PRP.Moreover, we also show here the number of extracellular DNA traps (ETs) and the PRP effect in thesynovial fluid of patients at the time of treatment and six months after. Clinically, it is demonstratedthat PRP is effective in reducing bleeding episodes (p < 0.001) and pain (p < 0.0001) and improvingthe hemophilia joint health score (HJHS) (p < 0.001) at one year of follow-up. Furthermore, our resultsdemonstrate that PRP inhibits ET formation in vitro and reconstitutes the immune system’s cellularcomponents in the synovial fluid of patients after treatment. We conclude that PRP can be consideredan effective, safe, and easy treatment for hemophilic synovitis.
Fil: Caviglia, Horacio Alberto. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Landro, María Eulalia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Oneto, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Cambiaggi, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Galatro, Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Berni, Micaela. Universita Degli Studi Di Pavia; Italia
Fil: Caliogna, Laura. Universita Degli Studi Di Pavia; Italia
Fil: Carrera Silva, Eugenio Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Pasta, Gianluigi. Universita Degli Studi Di Pavia; Italia - Materia
-
Hemophilia
Platelet
Joint
Synovitis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/266835
Ver los metadatos del registro completo
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Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro StudiesCaviglia, Horacio AlbertoLandro, María EulaliaOneto, PaulaCambiaggi, GuillermoGalatro, GustavoBerni, MicaelaCaliogna, LauraCarrera Silva, Eugenio AntonioPasta, GianluigiHemophiliaPlateletJointSynovitishttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Intra-articular blood, iron and hemosiderin, hydroxyl radical cytokines, and neo-angiogenesiscause synovial inflammation, which leads to cartilage and joint damage. Platelet-rich plasma (PRP)inhibits most of the mediators that produce and maintain synovitis. We compile here our workshowing the clinical effectiveness of intra-articular PRP injections and their potential role in stoppingarticular cartilage damage due to bleeding and its possible repair. A total of 116 joints, includingknees (63%), elbows (19.8%), and ankles (17.2%), were treated with intra-articular injections of PRP.Moreover, we also show here the number of extracellular DNA traps (ETs) and the PRP effect in thesynovial fluid of patients at the time of treatment and six months after. Clinically, it is demonstratedthat PRP is effective in reducing bleeding episodes (p < 0.001) and pain (p < 0.0001) and improvingthe hemophilia joint health score (HJHS) (p < 0.001) at one year of follow-up. Furthermore, our resultsdemonstrate that PRP inhibits ET formation in vitro and reconstitutes the immune system’s cellularcomponents in the synovial fluid of patients after treatment. We conclude that PRP can be consideredan effective, safe, and easy treatment for hemophilic synovitis.Fil: Caviglia, Horacio Alberto. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; ArgentinaFil: Landro, María Eulalia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Oneto, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Cambiaggi, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Galatro, Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Berni, Micaela. Universita Degli Studi Di Pavia; ItaliaFil: Caliogna, Laura. Universita Degli Studi Di Pavia; ItaliaFil: Carrera Silva, Eugenio Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Pasta, Gianluigi. Universita Degli Studi Di Pavia; ItaliaMolecular Diversity Preservation International2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266835Caviglia, Horacio Alberto; Landro, María Eulalia; Oneto, Paula; Cambiaggi, Guillermo; Galatro, Gustavo; et al.; Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 17; 8-2024; 1-121422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/25/17/9140info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms25179140info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:42Zoai:ri.conicet.gov.ar:11336/266835instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:42.581CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies |
title |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies |
spellingShingle |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies Caviglia, Horacio Alberto Hemophilia Platelet Joint Synovitis |
title_short |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies |
title_full |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies |
title_fullStr |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies |
title_full_unstemmed |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies |
title_sort |
Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies |
dc.creator.none.fl_str_mv |
Caviglia, Horacio Alberto Landro, María Eulalia Oneto, Paula Cambiaggi, Guillermo Galatro, Gustavo Berni, Micaela Caliogna, Laura Carrera Silva, Eugenio Antonio Pasta, Gianluigi |
author |
Caviglia, Horacio Alberto |
author_facet |
Caviglia, Horacio Alberto Landro, María Eulalia Oneto, Paula Cambiaggi, Guillermo Galatro, Gustavo Berni, Micaela Caliogna, Laura Carrera Silva, Eugenio Antonio Pasta, Gianluigi |
author_role |
author |
author2 |
Landro, María Eulalia Oneto, Paula Cambiaggi, Guillermo Galatro, Gustavo Berni, Micaela Caliogna, Laura Carrera Silva, Eugenio Antonio Pasta, Gianluigi |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Hemophilia Platelet Joint Synovitis |
topic |
Hemophilia Platelet Joint Synovitis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Intra-articular blood, iron and hemosiderin, hydroxyl radical cytokines, and neo-angiogenesiscause synovial inflammation, which leads to cartilage and joint damage. Platelet-rich plasma (PRP)inhibits most of the mediators that produce and maintain synovitis. We compile here our workshowing the clinical effectiveness of intra-articular PRP injections and their potential role in stoppingarticular cartilage damage due to bleeding and its possible repair. A total of 116 joints, includingknees (63%), elbows (19.8%), and ankles (17.2%), were treated with intra-articular injections of PRP.Moreover, we also show here the number of extracellular DNA traps (ETs) and the PRP effect in thesynovial fluid of patients at the time of treatment and six months after. Clinically, it is demonstratedthat PRP is effective in reducing bleeding episodes (p < 0.001) and pain (p < 0.0001) and improvingthe hemophilia joint health score (HJHS) (p < 0.001) at one year of follow-up. Furthermore, our resultsdemonstrate that PRP inhibits ET formation in vitro and reconstitutes the immune system’s cellularcomponents in the synovial fluid of patients after treatment. We conclude that PRP can be consideredan effective, safe, and easy treatment for hemophilic synovitis. Fil: Caviglia, Horacio Alberto. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina Fil: Landro, María Eulalia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina Fil: Oneto, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Cambiaggi, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina Fil: Galatro, Gustavo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina Fil: Berni, Micaela. Universita Degli Studi Di Pavia; Italia Fil: Caliogna, Laura. Universita Degli Studi Di Pavia; Italia Fil: Carrera Silva, Eugenio Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Pasta, Gianluigi. Universita Degli Studi Di Pavia; Italia |
description |
Intra-articular blood, iron and hemosiderin, hydroxyl radical cytokines, and neo-angiogenesiscause synovial inflammation, which leads to cartilage and joint damage. Platelet-rich plasma (PRP)inhibits most of the mediators that produce and maintain synovitis. We compile here our workshowing the clinical effectiveness of intra-articular PRP injections and their potential role in stoppingarticular cartilage damage due to bleeding and its possible repair. A total of 116 joints, includingknees (63%), elbows (19.8%), and ankles (17.2%), were treated with intra-articular injections of PRP.Moreover, we also show here the number of extracellular DNA traps (ETs) and the PRP effect in thesynovial fluid of patients at the time of treatment and six months after. Clinically, it is demonstratedthat PRP is effective in reducing bleeding episodes (p < 0.001) and pain (p < 0.0001) and improvingthe hemophilia joint health score (HJHS) (p < 0.001) at one year of follow-up. Furthermore, our resultsdemonstrate that PRP inhibits ET formation in vitro and reconstitutes the immune system’s cellularcomponents in the synovial fluid of patients after treatment. We conclude that PRP can be consideredan effective, safe, and easy treatment for hemophilic synovitis. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/266835 Caviglia, Horacio Alberto; Landro, María Eulalia; Oneto, Paula; Cambiaggi, Guillermo; Galatro, Gustavo; et al.; Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 17; 8-2024; 1-12 1422-0067 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/266835 |
identifier_str_mv |
Caviglia, Horacio Alberto; Landro, María Eulalia; Oneto, Paula; Cambiaggi, Guillermo; Galatro, Gustavo; et al.; Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 17; 8-2024; 1-12 1422-0067 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/25/17/9140 info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms25179140 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Molecular Diversity Preservation International |
publisher.none.fl_str_mv |
Molecular Diversity Preservation International |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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