Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology

Autores
Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Response surface methodology was successfully used to study effect of formulation parameters on progesterone release from rings made of ethylene-vinyl acetate copolymers. Significant effects were estimated by an analyses of variance (ANOVA) and statistical model was constructed. Model predictions showed good agreement with experimental data. Results showed that mass of progesterone released can be enhanced by several strategies. In addition, model behavior was compared with previously validated model reported in the literature obtaining satisfactory results. The statistical model was also employed to optimize formulation parameters with the aim to reach release rate of about 3.545 ± 0.020 mg cm-2 days-1/2. Optimized prototype was tested in vitro. Results showed that optimized IVR has similar profiles than the commercial silicone device used as reference. Optimized ring would have several advantages over commercial one like lower initial and residual content of progesterone and the possibility of recycling rings after their usage avoiding incineration of used device (as in the case of silicone commercial device). Pharmacokinetics studies must be done to corroborate in vivo performance of optimized IVRs made of EVA.
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Materia
Drug Delivery
Controlled Release
Intravaginal Ring
Response Surface Metodology
Progesterone
Ethylene Vinyl Acetate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10053
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/10053
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation and optimization of progesterone release from intravaginal rings using response surface methodologyHelbling, Ignacio MarceloIbarra, Juan Carlos DanielLuna, Julio AlbertoDrug DeliveryControlled ReleaseIntravaginal RingResponse Surface MetodologyProgesteroneEthylene Vinyl Acetatehttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1Response surface methodology was successfully used to study effect of formulation parameters on progesterone release from rings made of ethylene-vinyl acetate copolymers. Significant effects were estimated by an analyses of variance (ANOVA) and statistical model was constructed. Model predictions showed good agreement with experimental data. Results showed that mass of progesterone released can be enhanced by several strategies. In addition, model behavior was compared with previously validated model reported in the literature obtaining satisfactory results. The statistical model was also employed to optimize formulation parameters with the aim to reach release rate of about 3.545 ± 0.020 mg cm-2 days-1/2. Optimized prototype was tested in vitro. Results showed that optimized IVR has similar profiles than the commercial silicone device used as reference. Optimized ring would have several advantages over commercial one like lower initial and residual content of progesterone and the possibility of recycling rings after their usage avoiding incineration of used device (as in the case of silicone commercial device). Pharmacokinetics studies must be done to corroborate in vivo performance of optimized IVRs made of EVA.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaElsevier2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10053Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto; Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology; Elsevier; Journal Of Drug Delivery Science And Technology; 29; 8-2015; 218-2251773-2247enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2015.08.002info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1773224715300010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:21:13Zoai:ri.conicet.gov.ar:11336/10053instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:21:14.126CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
title Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
spellingShingle Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
Helbling, Ignacio Marcelo
Drug Delivery
Controlled Release
Intravaginal Ring
Response Surface Metodology
Progesterone
Ethylene Vinyl Acetate
title_short Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
title_full Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
title_fullStr Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
title_full_unstemmed Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
title_sort Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
dc.creator.none.fl_str_mv Helbling, Ignacio Marcelo
Ibarra, Juan Carlos Daniel
Luna, Julio Alberto
author Helbling, Ignacio Marcelo
author_facet Helbling, Ignacio Marcelo
Ibarra, Juan Carlos Daniel
Luna, Julio Alberto
author_role author
author2 Ibarra, Juan Carlos Daniel
Luna, Julio Alberto
author2_role author
author
dc.subject.none.fl_str_mv Drug Delivery
Controlled Release
Intravaginal Ring
Response Surface Metodology
Progesterone
Ethylene Vinyl Acetate
topic Drug Delivery
Controlled Release
Intravaginal Ring
Response Surface Metodology
Progesterone
Ethylene Vinyl Acetate
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Response surface methodology was successfully used to study effect of formulation parameters on progesterone release from rings made of ethylene-vinyl acetate copolymers. Significant effects were estimated by an analyses of variance (ANOVA) and statistical model was constructed. Model predictions showed good agreement with experimental data. Results showed that mass of progesterone released can be enhanced by several strategies. In addition, model behavior was compared with previously validated model reported in the literature obtaining satisfactory results. The statistical model was also employed to optimize formulation parameters with the aim to reach release rate of about 3.545 ± 0.020 mg cm-2 days-1/2. Optimized prototype was tested in vitro. Results showed that optimized IVR has similar profiles than the commercial silicone device used as reference. Optimized ring would have several advantages over commercial one like lower initial and residual content of progesterone and the possibility of recycling rings after their usage avoiding incineration of used device (as in the case of silicone commercial device). Pharmacokinetics studies must be done to corroborate in vivo performance of optimized IVRs made of EVA.
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
description Response surface methodology was successfully used to study effect of formulation parameters on progesterone release from rings made of ethylene-vinyl acetate copolymers. Significant effects were estimated by an analyses of variance (ANOVA) and statistical model was constructed. Model predictions showed good agreement with experimental data. Results showed that mass of progesterone released can be enhanced by several strategies. In addition, model behavior was compared with previously validated model reported in the literature obtaining satisfactory results. The statistical model was also employed to optimize formulation parameters with the aim to reach release rate of about 3.545 ± 0.020 mg cm-2 days-1/2. Optimized prototype was tested in vitro. Results showed that optimized IVR has similar profiles than the commercial silicone device used as reference. Optimized ring would have several advantages over commercial one like lower initial and residual content of progesterone and the possibility of recycling rings after their usage avoiding incineration of used device (as in the case of silicone commercial device). Pharmacokinetics studies must be done to corroborate in vivo performance of optimized IVRs made of EVA.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10053
Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto; Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology; Elsevier; Journal Of Drug Delivery Science And Technology; 29; 8-2015; 218-225
1773-2247
url http://hdl.handle.net/11336/10053
identifier_str_mv Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto; Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology; Elsevier; Journal Of Drug Delivery Science And Technology; 29; 8-2015; 218-225
1773-2247
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2015.08.002
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1773224715300010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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