Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves

Autores
Bermeo Varón, Leonardo Antonio; Barreto Orlande, Helcio Rangel; Elicabe, Guillermo Enrique
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
One of the major difficulties in any cancer treatment is to kill the cells of the tumor without affecting healthy cells. Recently, with the advancement of nanotechnology, the localized hyperthermia treatment of cancer has again gained interest from the scientific community. In this technique, the application of electromagnetic waves, possibly even over the surface of the patient's body, causes temperature increases in the tissues. By concentrating nanoparticles in the tumorous tissues, cell damages can be inflicted mostly to the region of interest. This paper deals with numerical simulations under uncertainties of the treatment of cancer based on hyperthermia induced by radiofrequency electromagnetic waves, where the tumor is supposed to be loaded with nanoparticles. The focus of the paper is on the solution of the inverse problem dealing with the estimation of state variables, like the temperature distribution in the tissues. The state estimation problem is solved with the Particle Filter, by utilizing the Sampling Importance Resampling (SIR) algorithm. An excellent agreement between estimated and exact temperatures is obtained, which may help medical doctors in the future to prescribe treatment protocols and also opens the possibility of devising control strategies for the hyperthermia treatment of cancer.
Fil: Bermeo Varón, Leonardo Antonio. Universidade Federal do Rio de Janeiro; Brasil
Fil: Barreto Orlande, Helcio Rangel. Universidade Federal do Rio de Janeiro; Brasil
Fil: Elicabe, Guillermo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
HYPERTHERMIA
INVERSE PROBLEM
NANOPARTICLES
PARTICLE FILTER
RADIOFREQUENCY
SIR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2895
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic wavesBermeo Varón, Leonardo AntonioBarreto Orlande, Helcio RangelElicabe, Guillermo EnriqueHYPERTHERMIAINVERSE PROBLEMNANOPARTICLESPARTICLE FILTERRADIOFREQUENCYSIRhttps://purl.org/becyt/ford/2.3https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2One of the major difficulties in any cancer treatment is to kill the cells of the tumor without affecting healthy cells. Recently, with the advancement of nanotechnology, the localized hyperthermia treatment of cancer has again gained interest from the scientific community. In this technique, the application of electromagnetic waves, possibly even over the surface of the patient's body, causes temperature increases in the tissues. By concentrating nanoparticles in the tumorous tissues, cell damages can be inflicted mostly to the region of interest. This paper deals with numerical simulations under uncertainties of the treatment of cancer based on hyperthermia induced by radiofrequency electromagnetic waves, where the tumor is supposed to be loaded with nanoparticles. The focus of the paper is on the solution of the inverse problem dealing with the estimation of state variables, like the temperature distribution in the tissues. The state estimation problem is solved with the Particle Filter, by utilizing the Sampling Importance Resampling (SIR) algorithm. An excellent agreement between estimated and exact temperatures is obtained, which may help medical doctors in the future to prescribe treatment protocols and also opens the possibility of devising control strategies for the hyperthermia treatment of cancer.Fil: Bermeo Varón, Leonardo Antonio. Universidade Federal do Rio de Janeiro; BrasilFil: Barreto Orlande, Helcio Rangel. Universidade Federal do Rio de Janeiro; BrasilFil: Elicabe, Guillermo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaElsevier France-editions Scientifiques Medicales Elsevier2015-12-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2895Bermeo Varón, Leonardo Antonio; Barreto Orlande, Helcio Rangel; Elicabe, Guillermo Enrique; Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves; Elsevier France-editions Scientifiques Medicales Elsevier; International Journal Of Thermal Sciences; 98; 10-12-2015; 228-2361290-0729enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijthermalsci.2015.06.022info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1290072915002094info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:46Zoai:ri.conicet.gov.ar:11336/2895instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:46.473CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
title Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
spellingShingle Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
Bermeo Varón, Leonardo Antonio
HYPERTHERMIA
INVERSE PROBLEM
NANOPARTICLES
PARTICLE FILTER
RADIOFREQUENCY
SIR
title_short Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
title_full Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
title_fullStr Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
title_full_unstemmed Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
title_sort Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves
dc.creator.none.fl_str_mv Bermeo Varón, Leonardo Antonio
Barreto Orlande, Helcio Rangel
Elicabe, Guillermo Enrique
author Bermeo Varón, Leonardo Antonio
author_facet Bermeo Varón, Leonardo Antonio
Barreto Orlande, Helcio Rangel
Elicabe, Guillermo Enrique
author_role author
author2 Barreto Orlande, Helcio Rangel
Elicabe, Guillermo Enrique
author2_role author
author
dc.subject.none.fl_str_mv HYPERTHERMIA
INVERSE PROBLEM
NANOPARTICLES
PARTICLE FILTER
RADIOFREQUENCY
SIR
topic HYPERTHERMIA
INVERSE PROBLEM
NANOPARTICLES
PARTICLE FILTER
RADIOFREQUENCY
SIR
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.3
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv One of the major difficulties in any cancer treatment is to kill the cells of the tumor without affecting healthy cells. Recently, with the advancement of nanotechnology, the localized hyperthermia treatment of cancer has again gained interest from the scientific community. In this technique, the application of electromagnetic waves, possibly even over the surface of the patient's body, causes temperature increases in the tissues. By concentrating nanoparticles in the tumorous tissues, cell damages can be inflicted mostly to the region of interest. This paper deals with numerical simulations under uncertainties of the treatment of cancer based on hyperthermia induced by radiofrequency electromagnetic waves, where the tumor is supposed to be loaded with nanoparticles. The focus of the paper is on the solution of the inverse problem dealing with the estimation of state variables, like the temperature distribution in the tissues. The state estimation problem is solved with the Particle Filter, by utilizing the Sampling Importance Resampling (SIR) algorithm. An excellent agreement between estimated and exact temperatures is obtained, which may help medical doctors in the future to prescribe treatment protocols and also opens the possibility of devising control strategies for the hyperthermia treatment of cancer.
Fil: Bermeo Varón, Leonardo Antonio. Universidade Federal do Rio de Janeiro; Brasil
Fil: Barreto Orlande, Helcio Rangel. Universidade Federal do Rio de Janeiro; Brasil
Fil: Elicabe, Guillermo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description One of the major difficulties in any cancer treatment is to kill the cells of the tumor without affecting healthy cells. Recently, with the advancement of nanotechnology, the localized hyperthermia treatment of cancer has again gained interest from the scientific community. In this technique, the application of electromagnetic waves, possibly even over the surface of the patient's body, causes temperature increases in the tissues. By concentrating nanoparticles in the tumorous tissues, cell damages can be inflicted mostly to the region of interest. This paper deals with numerical simulations under uncertainties of the treatment of cancer based on hyperthermia induced by radiofrequency electromagnetic waves, where the tumor is supposed to be loaded with nanoparticles. The focus of the paper is on the solution of the inverse problem dealing with the estimation of state variables, like the temperature distribution in the tissues. The state estimation problem is solved with the Particle Filter, by utilizing the Sampling Importance Resampling (SIR) algorithm. An excellent agreement between estimated and exact temperatures is obtained, which may help medical doctors in the future to prescribe treatment protocols and also opens the possibility of devising control strategies for the hyperthermia treatment of cancer.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2895
Bermeo Varón, Leonardo Antonio; Barreto Orlande, Helcio Rangel; Elicabe, Guillermo Enrique; Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves; Elsevier France-editions Scientifiques Medicales Elsevier; International Journal Of Thermal Sciences; 98; 10-12-2015; 228-236
1290-0729
url http://hdl.handle.net/11336/2895
identifier_str_mv Bermeo Varón, Leonardo Antonio; Barreto Orlande, Helcio Rangel; Elicabe, Guillermo Enrique; Estimation of state variables in the hyperthermia therapy of cancer with heating imposed by radiofrequency electromagnetic waves; Elsevier France-editions Scientifiques Medicales Elsevier; International Journal Of Thermal Sciences; 98; 10-12-2015; 228-236
1290-0729
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijthermalsci.2015.06.022
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1290072915002094
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
publisher.none.fl_str_mv Elsevier France-editions Scientifiques Medicales Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614257132437504
score 13.070432

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