Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression
- Autores
- Moreno Adaro, Oscar Fernando; Berríos Bravo, Claudio; Guevara, Manuel Alejandro; Mesones, Gonzalo; Sabina, Leticia; Mulet, Daniela; Okasova, Ainura; Andrada, Ricardo; Gargiulo, Ángel José Martín; Gargiulo, Mercedes María Lucrecia; Ítalo Gargiulo, Augusto Pascual; Gargiulo, Marcos Constantino Josué; Velásquez, Norman López; Vicente Lafuente, José; Landa De Gargiulo, Adriana Inés; Mesones Arroyo, Humberto Luis; Gargiulo, Pascual Angel
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A relevant role has been attributed to phenethylamine in depressive disorders. It has been measured in human urine and rat brain in pathological conditions and after drug administration. Furthermore, a clinical correlation has been proposed between urinary elimination and depressive symptoms. Furthermore, its metabolic predecessor, D-phenylalanine, has been used as an antidepressant drug in the treatment of depressive disorders. The use of this amino acid hasbeen realized alone, or in combination with classical antidepressants. In the present study, we tried to characterize its behavioural profile comparing it with imipramine and fluoxetine. Antidepressant drugs have been studied using diverse animal models. We used here the Porsolt test, or Forced Swimming Test (FST), measuring times of climbing, swimming and resting. When a comparison was performed between groups in climbing behaviour, significant differences were observed between imipramine treated group and saline controls (p < 0.05), and imipramine versus fluoxetine and D-phenylalanine (p<0.01). When swimming was evaluated, clear differences between D-phenylalanine and the other groups were observed (p<0.001). Additionally, a significant difference was also observed between imipramine and fluoxetine (p<0.01). When resting was evaluated, high differences between D-phenylalanine versus all other groups were shown (p<0.001). Observed behavioural profile was according to serotonergic antidepressant drugs effects. It is supported by the fact that swimming behaviours were increased, and a correlative decrease in resting was also present. We conclude that D-phenylalanine showed higher antidepressant potency than other classical antidepressants, at least at the doses used.
Fil: Moreno Adaro, Oscar Fernando. Universidad Nacional de Cuyo; Argentina
Fil: Berríos Bravo, Claudio. Universidad Nacional de Cuyo; Argentina
Fil: Guevara, Manuel Alejandro. Universidad Nacional de Cuyo; Argentina
Fil: Mesones, Gonzalo. Universidad Nacional de Cuyo; Argentina
Fil: Sabina, Leticia. Universidad Nacional de Cuyo; Argentina
Fil: Mulet, Daniela. Universidad Nacional de Cuyo; Argentina
Fil: Okasova, Ainura. Universidad Nacional de Cuyo; Argentina
Fil: Andrada, Ricardo. Universidad Nacional de Cuyo; Argentina
Fil: Gargiulo, Ángel José Martín. Universidad Nacional de Cuyo; Argentina
Fil: Gargiulo, Mercedes María Lucrecia. Universidad Nacional de Cuyo; Argentina
Fil: Ítalo Gargiulo, Augusto Pascual. Universidad Nacional de Cuyo; Argentina
Fil: Gargiulo, Marcos Constantino Josué. Universidad Nacional de Cuyo; Argentina
Fil: Velásquez, Norman López. Universidad de la Costa.; Colombia
Fil: Vicente Lafuente, José. Universidad del País Vasco; España
Fil: Landa De Gargiulo, Adriana Inés. Universidad Nacional de Cuyo; Argentina
Fil: Mesones Arroyo, Humberto Luis. Universidad Nacional de Cuyo; Argentina
Fil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina - Materia
-
Phenylalanine
Imipramine
Fluoxetine
Antidepressive agents
Behaviour - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/239991
Ver los metadatos del registro completo
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Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of DepressionMoreno Adaro, Oscar FernandoBerríos Bravo, ClaudioGuevara, Manuel AlejandroMesones, GonzaloSabina, LeticiaMulet, DanielaOkasova, AinuraAndrada, RicardoGargiulo, Ángel José MartínGargiulo, Mercedes María LucreciaÍtalo Gargiulo, Augusto PascualGargiulo, Marcos Constantino JosuéVelásquez, Norman LópezVicente Lafuente, JoséLanda De Gargiulo, Adriana InésMesones Arroyo, Humberto LuisGargiulo, Pascual AngelPhenylalanineImipramineFluoxetineAntidepressive agentsBehaviourhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A relevant role has been attributed to phenethylamine in depressive disorders. It has been measured in human urine and rat brain in pathological conditions and after drug administration. Furthermore, a clinical correlation has been proposed between urinary elimination and depressive symptoms. Furthermore, its metabolic predecessor, D-phenylalanine, has been used as an antidepressant drug in the treatment of depressive disorders. The use of this amino acid hasbeen realized alone, or in combination with classical antidepressants. In the present study, we tried to characterize its behavioural profile comparing it with imipramine and fluoxetine. Antidepressant drugs have been studied using diverse animal models. We used here the Porsolt test, or Forced Swimming Test (FST), measuring times of climbing, swimming and resting. When a comparison was performed between groups in climbing behaviour, significant differences were observed between imipramine treated group and saline controls (p < 0.05), and imipramine versus fluoxetine and D-phenylalanine (p<0.01). When swimming was evaluated, clear differences between D-phenylalanine and the other groups were observed (p<0.001). Additionally, a significant difference was also observed between imipramine and fluoxetine (p<0.01). When resting was evaluated, high differences between D-phenylalanine versus all other groups were shown (p<0.001). Observed behavioural profile was according to serotonergic antidepressant drugs effects. It is supported by the fact that swimming behaviours were increased, and a correlative decrease in resting was also present. We conclude that D-phenylalanine showed higher antidepressant potency than other classical antidepressants, at least at the doses used.Fil: Moreno Adaro, Oscar Fernando. Universidad Nacional de Cuyo; ArgentinaFil: Berríos Bravo, Claudio. Universidad Nacional de Cuyo; ArgentinaFil: Guevara, Manuel Alejandro. Universidad Nacional de Cuyo; ArgentinaFil: Mesones, Gonzalo. Universidad Nacional de Cuyo; ArgentinaFil: Sabina, Leticia. Universidad Nacional de Cuyo; ArgentinaFil: Mulet, Daniela. Universidad Nacional de Cuyo; ArgentinaFil: Okasova, Ainura. Universidad Nacional de Cuyo; ArgentinaFil: Andrada, Ricardo. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Ángel José Martín. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Mercedes María Lucrecia. Universidad Nacional de Cuyo; ArgentinaFil: Ítalo Gargiulo, Augusto Pascual. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Marcos Constantino Josué. Universidad Nacional de Cuyo; ArgentinaFil: Velásquez, Norman López. Universidad de la Costa.; ColombiaFil: Vicente Lafuente, José. Universidad del País Vasco; EspañaFil: Landa De Gargiulo, Adriana Inés. Universidad Nacional de Cuyo; ArgentinaFil: Mesones Arroyo, Humberto Luis. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaUniversity Hospital Center Sestre Milosrdnice2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239991Moreno Adaro, Oscar Fernando; Berríos Bravo, Claudio; Guevara, Manuel Alejandro; Mesones, Gonzalo; Sabina, Leticia; et al.; Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression; University Hospital Center Sestre Milosrdnice; Archives of Psychiatry Research; 59; 2; 7-2023; 219-2242671-10792671-2008CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://hrcak.srce.hr/clanak/438522info:eu-repo/semantics/altIdentifier/doi/10.20471/dec.2023.59.02.05info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:39:34Zoai:ri.conicet.gov.ar:11336/239991instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:39:34.998CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression |
| title |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression |
| spellingShingle |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression Moreno Adaro, Oscar Fernando Phenylalanine Imipramine Fluoxetine Antidepressive agents Behaviour |
| title_short |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression |
| title_full |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression |
| title_fullStr |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression |
| title_full_unstemmed |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression |
| title_sort |
Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression |
| dc.creator.none.fl_str_mv |
Moreno Adaro, Oscar Fernando Berríos Bravo, Claudio Guevara, Manuel Alejandro Mesones, Gonzalo Sabina, Leticia Mulet, Daniela Okasova, Ainura Andrada, Ricardo Gargiulo, Ángel José Martín Gargiulo, Mercedes María Lucrecia Ítalo Gargiulo, Augusto Pascual Gargiulo, Marcos Constantino Josué Velásquez, Norman López Vicente Lafuente, José Landa De Gargiulo, Adriana Inés Mesones Arroyo, Humberto Luis Gargiulo, Pascual Angel |
| author |
Moreno Adaro, Oscar Fernando |
| author_facet |
Moreno Adaro, Oscar Fernando Berríos Bravo, Claudio Guevara, Manuel Alejandro Mesones, Gonzalo Sabina, Leticia Mulet, Daniela Okasova, Ainura Andrada, Ricardo Gargiulo, Ángel José Martín Gargiulo, Mercedes María Lucrecia Ítalo Gargiulo, Augusto Pascual Gargiulo, Marcos Constantino Josué Velásquez, Norman López Vicente Lafuente, José Landa De Gargiulo, Adriana Inés Mesones Arroyo, Humberto Luis Gargiulo, Pascual Angel |
| author_role |
author |
| author2 |
Berríos Bravo, Claudio Guevara, Manuel Alejandro Mesones, Gonzalo Sabina, Leticia Mulet, Daniela Okasova, Ainura Andrada, Ricardo Gargiulo, Ángel José Martín Gargiulo, Mercedes María Lucrecia Ítalo Gargiulo, Augusto Pascual Gargiulo, Marcos Constantino Josué Velásquez, Norman López Vicente Lafuente, José Landa De Gargiulo, Adriana Inés Mesones Arroyo, Humberto Luis Gargiulo, Pascual Angel |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Phenylalanine Imipramine Fluoxetine Antidepressive agents Behaviour |
| topic |
Phenylalanine Imipramine Fluoxetine Antidepressive agents Behaviour |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
A relevant role has been attributed to phenethylamine in depressive disorders. It has been measured in human urine and rat brain in pathological conditions and after drug administration. Furthermore, a clinical correlation has been proposed between urinary elimination and depressive symptoms. Furthermore, its metabolic predecessor, D-phenylalanine, has been used as an antidepressant drug in the treatment of depressive disorders. The use of this amino acid hasbeen realized alone, or in combination with classical antidepressants. In the present study, we tried to characterize its behavioural profile comparing it with imipramine and fluoxetine. Antidepressant drugs have been studied using diverse animal models. We used here the Porsolt test, or Forced Swimming Test (FST), measuring times of climbing, swimming and resting. When a comparison was performed between groups in climbing behaviour, significant differences were observed between imipramine treated group and saline controls (p < 0.05), and imipramine versus fluoxetine and D-phenylalanine (p<0.01). When swimming was evaluated, clear differences between D-phenylalanine and the other groups were observed (p<0.001). Additionally, a significant difference was also observed between imipramine and fluoxetine (p<0.01). When resting was evaluated, high differences between D-phenylalanine versus all other groups were shown (p<0.001). Observed behavioural profile was according to serotonergic antidepressant drugs effects. It is supported by the fact that swimming behaviours were increased, and a correlative decrease in resting was also present. We conclude that D-phenylalanine showed higher antidepressant potency than other classical antidepressants, at least at the doses used. Fil: Moreno Adaro, Oscar Fernando. Universidad Nacional de Cuyo; Argentina Fil: Berríos Bravo, Claudio. Universidad Nacional de Cuyo; Argentina Fil: Guevara, Manuel Alejandro. Universidad Nacional de Cuyo; Argentina Fil: Mesones, Gonzalo. Universidad Nacional de Cuyo; Argentina Fil: Sabina, Leticia. Universidad Nacional de Cuyo; Argentina Fil: Mulet, Daniela. Universidad Nacional de Cuyo; Argentina Fil: Okasova, Ainura. Universidad Nacional de Cuyo; Argentina Fil: Andrada, Ricardo. Universidad Nacional de Cuyo; Argentina Fil: Gargiulo, Ángel José Martín. Universidad Nacional de Cuyo; Argentina Fil: Gargiulo, Mercedes María Lucrecia. Universidad Nacional de Cuyo; Argentina Fil: Ítalo Gargiulo, Augusto Pascual. Universidad Nacional de Cuyo; Argentina Fil: Gargiulo, Marcos Constantino Josué. Universidad Nacional de Cuyo; Argentina Fil: Velásquez, Norman López. Universidad de la Costa.; Colombia Fil: Vicente Lafuente, José. Universidad del País Vasco; España Fil: Landa De Gargiulo, Adriana Inés. Universidad Nacional de Cuyo; Argentina Fil: Mesones Arroyo, Humberto Luis. Universidad Nacional de Cuyo; Argentina Fil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina |
| description |
A relevant role has been attributed to phenethylamine in depressive disorders. It has been measured in human urine and rat brain in pathological conditions and after drug administration. Furthermore, a clinical correlation has been proposed between urinary elimination and depressive symptoms. Furthermore, its metabolic predecessor, D-phenylalanine, has been used as an antidepressant drug in the treatment of depressive disorders. The use of this amino acid hasbeen realized alone, or in combination with classical antidepressants. In the present study, we tried to characterize its behavioural profile comparing it with imipramine and fluoxetine. Antidepressant drugs have been studied using diverse animal models. We used here the Porsolt test, or Forced Swimming Test (FST), measuring times of climbing, swimming and resting. When a comparison was performed between groups in climbing behaviour, significant differences were observed between imipramine treated group and saline controls (p < 0.05), and imipramine versus fluoxetine and D-phenylalanine (p<0.01). When swimming was evaluated, clear differences between D-phenylalanine and the other groups were observed (p<0.001). Additionally, a significant difference was also observed between imipramine and fluoxetine (p<0.01). When resting was evaluated, high differences between D-phenylalanine versus all other groups were shown (p<0.001). Observed behavioural profile was according to serotonergic antidepressant drugs effects. It is supported by the fact that swimming behaviours were increased, and a correlative decrease in resting was also present. We conclude that D-phenylalanine showed higher antidepressant potency than other classical antidepressants, at least at the doses used. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/239991 Moreno Adaro, Oscar Fernando; Berríos Bravo, Claudio; Guevara, Manuel Alejandro; Mesones, Gonzalo; Sabina, Leticia; et al.; Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression; University Hospital Center Sestre Milosrdnice; Archives of Psychiatry Research; 59; 2; 7-2023; 219-224 2671-1079 2671-2008 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/239991 |
| identifier_str_mv |
Moreno Adaro, Oscar Fernando; Berríos Bravo, Claudio; Guevara, Manuel Alejandro; Mesones, Gonzalo; Sabina, Leticia; et al.; Comparative Effect between Antidepressants and D-phenylalanine, a Phenethylamine Precursor, in an Animal Model of Depression; University Hospital Center Sestre Milosrdnice; Archives of Psychiatry Research; 59; 2; 7-2023; 219-224 2671-1079 2671-2008 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/altIdentifier/url/https://hrcak.srce.hr/clanak/438522 info:eu-repo/semantics/altIdentifier/doi/10.20471/dec.2023.59.02.05 |
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openAccess |
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application/pdf application/pdf |
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University Hospital Center Sestre Milosrdnice |
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University Hospital Center Sestre Milosrdnice |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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