Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences

Autores
Bocanegra, Yamile; García, Adolfo Martín; Pineda, David; Buriticá, Omar; Villegas, Andrés; Lopera, Francisco; Gómez, Diana; Gómez Arias, Catalina; Cardona Londoño, Juan Felipe; Trujillo, Natalia; Ibañez, Agustin Mariano
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances -viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics.
Fil: Bocanegra, Yamile. Universidad de San Buenaventura; Colombia. Universidad de Antioquia; Colombia
Fil: García, Adolfo Martín. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pineda, David. Universidad de Antioquia; Colombia
Fil: Buriticá, Omar. Universidad de Antioquia; Colombia. Hospital Pablo Tobón Uribe; Colombia
Fil: Villegas, Andrés. Universidad de Antioquia; Colombia
Fil: Lopera, Francisco. Universidad de Antioquia; Colombia
Fil: Gómez, Diana. Universidad de Antioquia; Colombia
Fil: Gómez Arias, Catalina. Universidad de San Buenaventura; Colombia
Fil: Cardona Londoño, Juan Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Valle; Colombia
Fil: Trujillo, Natalia. Universidad de Antioquia; Colombia
Fil: Ibáñez Barassi, Agustín Mariano. Universidad Autónoma Del Caribe; Colombia. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Antioquia; Colombia
Materia
ACTION SEMANTICS
ACTION VERBS
EXECUTIVE FUNCTIONS
MILD COGNITIVE IMPAIRMENT
OBJECT SEMANTICS
PARKINSON'S DISEASE
SYNTAX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98520
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98520
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influencesBocanegra, YamileGarcía, Adolfo MartínPineda, DavidBuriticá, OmarVillegas, AndrésLopera, FranciscoGómez, DianaGómez Arias, CatalinaCardona Londoño, Juan FelipeTrujillo, NataliaIbañez, Agustin MarianoACTION SEMANTICSACTION VERBSEXECUTIVE FUNCTIONSMILD COGNITIVE IMPAIRMENTOBJECT SEMANTICSPARKINSON'S DISEASESYNTAXhttps://purl.org/becyt/ford/6.2https://purl.org/becyt/ford/6https://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances -viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics.Fil: Bocanegra, Yamile. Universidad de San Buenaventura; Colombia. Universidad de Antioquia; ColombiaFil: García, Adolfo Martín. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pineda, David. Universidad de Antioquia; ColombiaFil: Buriticá, Omar. Universidad de Antioquia; Colombia. Hospital Pablo Tobón Uribe; ColombiaFil: Villegas, Andrés. Universidad de Antioquia; ColombiaFil: Lopera, Francisco. Universidad de Antioquia; ColombiaFil: Gómez, Diana. Universidad de Antioquia; ColombiaFil: Gómez Arias, Catalina. Universidad de San Buenaventura; ColombiaFil: Cardona Londoño, Juan Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Valle; ColombiaFil: Trujillo, Natalia. Universidad de Antioquia; ColombiaFil: Ibáñez Barassi, Agustín Mariano. Universidad Autónoma Del Caribe; Colombia. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Antioquia; ColombiaElsevier Masson2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98520Bocanegra, Yamile; García, Adolfo Martín; Pineda, David; Buriticá, Omar; Villegas, Andrés; et al.; Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences; Elsevier Masson; Cortex; 69; 8-2015; 237-2540010-9452CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0010945215001811info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2015.05.022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:18Zoai:ri.conicet.gov.ar:11336/98520instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:18.528CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
title Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
spellingShingle Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
Bocanegra, Yamile
ACTION SEMANTICS
ACTION VERBS
EXECUTIVE FUNCTIONS
MILD COGNITIVE IMPAIRMENT
OBJECT SEMANTICS
PARKINSON'S DISEASE
SYNTAX
title_short Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
title_full Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
title_fullStr Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
title_full_unstemmed Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
title_sort Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences
dc.creator.none.fl_str_mv Bocanegra, Yamile
García, Adolfo Martín
Pineda, David
Buriticá, Omar
Villegas, Andrés
Lopera, Francisco
Gómez, Diana
Gómez Arias, Catalina
Cardona Londoño, Juan Felipe
Trujillo, Natalia
Ibañez, Agustin Mariano
author Bocanegra, Yamile
author_facet Bocanegra, Yamile
García, Adolfo Martín
Pineda, David
Buriticá, Omar
Villegas, Andrés
Lopera, Francisco
Gómez, Diana
Gómez Arias, Catalina
Cardona Londoño, Juan Felipe
Trujillo, Natalia
Ibañez, Agustin Mariano
author_role author
author2 García, Adolfo Martín
Pineda, David
Buriticá, Omar
Villegas, Andrés
Lopera, Francisco
Gómez, Diana
Gómez Arias, Catalina
Cardona Londoño, Juan Felipe
Trujillo, Natalia
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACTION SEMANTICS
ACTION VERBS
EXECUTIVE FUNCTIONS
MILD COGNITIVE IMPAIRMENT
OBJECT SEMANTICS
PARKINSON'S DISEASE
SYNTAX
topic ACTION SEMANTICS
ACTION VERBS
EXECUTIVE FUNCTIONS
MILD COGNITIVE IMPAIRMENT
OBJECT SEMANTICS
PARKINSON'S DISEASE
SYNTAX
purl_subject.fl_str_mv https://purl.org/becyt/ford/6.2
https://purl.org/becyt/ford/6
https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances -viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics.
Fil: Bocanegra, Yamile. Universidad de San Buenaventura; Colombia. Universidad de Antioquia; Colombia
Fil: García, Adolfo Martín. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pineda, David. Universidad de Antioquia; Colombia
Fil: Buriticá, Omar. Universidad de Antioquia; Colombia. Hospital Pablo Tobón Uribe; Colombia
Fil: Villegas, Andrés. Universidad de Antioquia; Colombia
Fil: Lopera, Francisco. Universidad de Antioquia; Colombia
Fil: Gómez, Diana. Universidad de Antioquia; Colombia
Fil: Gómez Arias, Catalina. Universidad de San Buenaventura; Colombia
Fil: Cardona Londoño, Juan Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Valle; Colombia
Fil: Trujillo, Natalia. Universidad de Antioquia; Colombia
Fil: Ibáñez Barassi, Agustín Mariano. Universidad Autónoma Del Caribe; Colombia. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Antioquia; Colombia
description Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances -viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98520
Bocanegra, Yamile; García, Adolfo Martín; Pineda, David; Buriticá, Omar; Villegas, Andrés; et al.; Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences; Elsevier Masson; Cortex; 69; 8-2015; 237-254
0010-9452
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98520
identifier_str_mv Bocanegra, Yamile; García, Adolfo Martín; Pineda, David; Buriticá, Omar; Villegas, Andrés; et al.; Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences; Elsevier Masson; Cortex; 69; 8-2015; 237-254
0010-9452
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0010945215001811
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2015.05.022
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Masson
publisher.none.fl_str_mv Elsevier Masson
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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