A review of recent patents on the protozoan parasite HSP90 as a drug target

Autores
Angel, Sergio Oscar; Matrajt, Mariana; Echeverria, Pablo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diseases caused by protozoan parasites are still an important health problem. These parasites can cause a wide spectrum of diseases, some of which are severe and have high morbidity or mortality if untreated. Since they are still uncontrolled, it is important to find novel drug targets and develop new therapies to decrease their remarkable social and economic impact on human societies. In the past years, human HSP90 has become an interesting drug target that has led to a large number of investigations both at state organizations and pharmaceutical companies, followed by clinical trials. The finding that HSP90 has important biological roles in some protozoan parasites like Plasmodium spp, Toxoplasma gondii and trypanosomatids has allowed the expansion of the results obtained in human cancer to these infections. This review summarizes the latest important findings showing protozoan HSP90 as a drug target and presents three patents targeting T. gondii, P. falciparum and trypanosomatids HSP90.
Fil: Angel, Sergio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
Fil: Matrajt, Mariana. University of Vermont; Estados Unidos
Fil: Echeverria, Pablo. Université de Genève Sciences III; Suiza
Materia
Toxoplasma Gondii
Choque Termico
Hsp90
Terapia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11111
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A review of recent patents on the protozoan parasite HSP90 as a drug targetAngel, Sergio OscarMatrajt, MarianaEcheverria, PabloToxoplasma GondiiChoque TermicoHsp90Terapiahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Diseases caused by protozoan parasites are still an important health problem. These parasites can cause a wide spectrum of diseases, some of which are severe and have high morbidity or mortality if untreated. Since they are still uncontrolled, it is important to find novel drug targets and develop new therapies to decrease their remarkable social and economic impact on human societies. In the past years, human HSP90 has become an interesting drug target that has led to a large number of investigations both at state organizations and pharmaceutical companies, followed by clinical trials. The finding that HSP90 has important biological roles in some protozoan parasites like Plasmodium spp, Toxoplasma gondii and trypanosomatids has allowed the expansion of the results obtained in human cancer to these infections. This review summarizes the latest important findings showing protozoan HSP90 as a drug target and presents three patents targeting T. gondii, P. falciparum and trypanosomatids HSP90.Fil: Angel, Sergio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); ArgentinaFil: Matrajt, Mariana. University of Vermont; Estados UnidosFil: Echeverria, Pablo. Université de Genève Sciences III; SuizaBentham Science2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11111Angel, Sergio Oscar; Matrajt, Mariana; Echeverria, Pablo; A review of recent patents on the protozoan parasite HSP90 as a drug target; Bentham Science; Recent Patent on Biotechnology; 7; 3-2013; 2-81872-2083enginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706948/info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/108369/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/1872208311307010002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:13Zoai:ri.conicet.gov.ar:11336/11111instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:13.679CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A review of recent patents on the protozoan parasite HSP90 as a drug target
title A review of recent patents on the protozoan parasite HSP90 as a drug target
spellingShingle A review of recent patents on the protozoan parasite HSP90 as a drug target
Angel, Sergio Oscar
Toxoplasma Gondii
Choque Termico
Hsp90
Terapia
title_short A review of recent patents on the protozoan parasite HSP90 as a drug target
title_full A review of recent patents on the protozoan parasite HSP90 as a drug target
title_fullStr A review of recent patents on the protozoan parasite HSP90 as a drug target
title_full_unstemmed A review of recent patents on the protozoan parasite HSP90 as a drug target
title_sort A review of recent patents on the protozoan parasite HSP90 as a drug target
dc.creator.none.fl_str_mv Angel, Sergio Oscar
Matrajt, Mariana
Echeverria, Pablo
author Angel, Sergio Oscar
author_facet Angel, Sergio Oscar
Matrajt, Mariana
Echeverria, Pablo
author_role author
author2 Matrajt, Mariana
Echeverria, Pablo
author2_role author
author
dc.subject.none.fl_str_mv Toxoplasma Gondii
Choque Termico
Hsp90
Terapia
topic Toxoplasma Gondii
Choque Termico
Hsp90
Terapia
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Diseases caused by protozoan parasites are still an important health problem. These parasites can cause a wide spectrum of diseases, some of which are severe and have high morbidity or mortality if untreated. Since they are still uncontrolled, it is important to find novel drug targets and develop new therapies to decrease their remarkable social and economic impact on human societies. In the past years, human HSP90 has become an interesting drug target that has led to a large number of investigations both at state organizations and pharmaceutical companies, followed by clinical trials. The finding that HSP90 has important biological roles in some protozoan parasites like Plasmodium spp, Toxoplasma gondii and trypanosomatids has allowed the expansion of the results obtained in human cancer to these infections. This review summarizes the latest important findings showing protozoan HSP90 as a drug target and presents three patents targeting T. gondii, P. falciparum and trypanosomatids HSP90.
Fil: Angel, Sergio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Investigaciones Biotecnológicas - Instituto Tecnológico Chascomús. Instituto de Investigaciones Biotecnológicas (sede Chascomús); Argentina
Fil: Matrajt, Mariana. University of Vermont; Estados Unidos
Fil: Echeverria, Pablo. Université de Genève Sciences III; Suiza
description Diseases caused by protozoan parasites are still an important health problem. These parasites can cause a wide spectrum of diseases, some of which are severe and have high morbidity or mortality if untreated. Since they are still uncontrolled, it is important to find novel drug targets and develop new therapies to decrease their remarkable social and economic impact on human societies. In the past years, human HSP90 has become an interesting drug target that has led to a large number of investigations both at state organizations and pharmaceutical companies, followed by clinical trials. The finding that HSP90 has important biological roles in some protozoan parasites like Plasmodium spp, Toxoplasma gondii and trypanosomatids has allowed the expansion of the results obtained in human cancer to these infections. This review summarizes the latest important findings showing protozoan HSP90 as a drug target and presents three patents targeting T. gondii, P. falciparum and trypanosomatids HSP90.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11111
Angel, Sergio Oscar; Matrajt, Mariana; Echeverria, Pablo; A review of recent patents on the protozoan parasite HSP90 as a drug target; Bentham Science; Recent Patent on Biotechnology; 7; 3-2013; 2-8
1872-2083
url http://hdl.handle.net/11336/11111
identifier_str_mv Angel, Sergio Oscar; Matrajt, Mariana; Echeverria, Pablo; A review of recent patents on the protozoan parasite HSP90 as a drug target; Bentham Science; Recent Patent on Biotechnology; 7; 3-2013; 2-8
1872-2083
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706948/
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/108369/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/1872208311307010002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science
publisher.none.fl_str_mv Bentham Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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