Burning fat: role of polyphenols in white adipose tissue browning

Autores
Perdicaro, Diahann Jeanette
Año de publicación
2020
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Obesity is one of the main public health concerns worldwide. White adipose tissue (WAT) is an endocrine organ that stores energy excess as triglycerides. Increased adiposity, mainly visceral WAT, is strongly associated with insulin resistance, type 2 diabetes and cardiovascular disease, among others. In contrast to WAT, brown adipose tissue (BAT) has the ability to dissipate energy in the form of heat due to the presence of the uncoupling protein 1 (UCP-1), a key determinant of mitochondrial thermogenesis. Interestingly, ?brown-like? adipocytes can be observed in WAT and are characterized by the presence of multilocular lipid droplets and high number of mitochondria which are associated with a reduction of total adiposity and improvement of metabolic alterations. WAT browning can be triggered by different stimuli such as cold, exercise or pharmacological treatment, such as β-adrenergic stimulation or peroxisome proliferator-activated receptor-γ (PPARγ) agonists. In addition, bioactive compounds such as polyphenols had been recently implicated in the emergence of brown-like cells in WAT. Polyphenols are bioactive compounds widely distributed in fruits and vegetables with an important role in preventing and managing increased adiposity and its comorbidities. We observed in rodent models of high fat-induced increased adiposity and metabolic alterations that supplementation with grape pomace extract (GPE), rich in polyphenols, stimulate the expression of the main transcriptional regulators of brown-like cell development, i.e., PPARγ-coactivator-1α (PGC-1α), PPARγ, PR domain containing 16 (PRDM16), and UCP-1 reducing adipose hypertrophy and inflammation in WAT and insulin resistance. GPE and two of the major GPE flavonoids, quercetin and (-)-epicatechin, enhanced the expression of transcriptional regulators of browning and UCP-1 through the up-regulation of the β-adrenergic receptor downstream cascade in 3T3-L1 adipocytes treated with palmitate. Overall, this finding highlights the potential utilization of bioactive grape-derived compounds to prevent/attenuate adiposity-associated pathologies.
Fil: Perdicaro, Diahann Jeanette. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Reunión Anual de Sociedades de Biociencias; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Ciudad Autónoma de Buenos Aires
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
Materia
POLYPHENOLS
WHITE ADIPOSE TISSUE
BROWNING
HIGH FAT DIET
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/209057
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Burning fat: role of polyphenols in white adipose tissue browningPerdicaro, Diahann JeanettePOLYPHENOLSWHITE ADIPOSE TISSUEBROWNINGHIGH FAT DIEThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Obesity is one of the main public health concerns worldwide. White adipose tissue (WAT) is an endocrine organ that stores energy excess as triglycerides. Increased adiposity, mainly visceral WAT, is strongly associated with insulin resistance, type 2 diabetes and cardiovascular disease, among others. In contrast to WAT, brown adipose tissue (BAT) has the ability to dissipate energy in the form of heat due to the presence of the uncoupling protein 1 (UCP-1), a key determinant of mitochondrial thermogenesis. Interestingly, ?brown-like? adipocytes can be observed in WAT and are characterized by the presence of multilocular lipid droplets and high number of mitochondria which are associated with a reduction of total adiposity and improvement of metabolic alterations. WAT browning can be triggered by different stimuli such as cold, exercise or pharmacological treatment, such as β-adrenergic stimulation or peroxisome proliferator-activated receptor-γ (PPARγ) agonists. In addition, bioactive compounds such as polyphenols had been recently implicated in the emergence of brown-like cells in WAT. Polyphenols are bioactive compounds widely distributed in fruits and vegetables with an important role in preventing and managing increased adiposity and its comorbidities. We observed in rodent models of high fat-induced increased adiposity and metabolic alterations that supplementation with grape pomace extract (GPE), rich in polyphenols, stimulate the expression of the main transcriptional regulators of brown-like cell development, i.e., PPARγ-coactivator-1α (PGC-1α), PPARγ, PR domain containing 16 (PRDM16), and UCP-1 reducing adipose hypertrophy and inflammation in WAT and insulin resistance. GPE and two of the major GPE flavonoids, quercetin and (-)-epicatechin, enhanced the expression of transcriptional regulators of browning and UCP-1 through the up-regulation of the β-adrenergic receptor downstream cascade in 3T3-L1 adipocytes treated with palmitate. Overall, this finding highlights the potential utilization of bioactive grape-derived compounds to prevent/attenuate adiposity-associated pathologies.Fil: Perdicaro, Diahann Jeanette. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaReunión Anual de Sociedades de Biociencias; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de FisiologíaCiudad Autónoma de Buenos AiresArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaSociedad Argentina de FisiologíaFundación Revista Medicina2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/209057Burning fat: role of polyphenols in white adipose tissue browning; Reunión Anual de Sociedades de Biociencias; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Ciudad Autónoma de Buenos Aires; Argentina; 2020; 35-350025-7680CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/indices-de-2020/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:02Zoai:ri.conicet.gov.ar:11336/209057instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:02.606CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Burning fat: role of polyphenols in white adipose tissue browning
title Burning fat: role of polyphenols in white adipose tissue browning
spellingShingle Burning fat: role of polyphenols in white adipose tissue browning
Perdicaro, Diahann Jeanette
POLYPHENOLS
WHITE ADIPOSE TISSUE
BROWNING
HIGH FAT DIET
title_short Burning fat: role of polyphenols in white adipose tissue browning
title_full Burning fat: role of polyphenols in white adipose tissue browning
title_fullStr Burning fat: role of polyphenols in white adipose tissue browning
title_full_unstemmed Burning fat: role of polyphenols in white adipose tissue browning
title_sort Burning fat: role of polyphenols in white adipose tissue browning
dc.creator.none.fl_str_mv Perdicaro, Diahann Jeanette
author Perdicaro, Diahann Jeanette
author_facet Perdicaro, Diahann Jeanette
author_role author
dc.subject.none.fl_str_mv POLYPHENOLS
WHITE ADIPOSE TISSUE
BROWNING
HIGH FAT DIET
topic POLYPHENOLS
WHITE ADIPOSE TISSUE
BROWNING
HIGH FAT DIET
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Obesity is one of the main public health concerns worldwide. White adipose tissue (WAT) is an endocrine organ that stores energy excess as triglycerides. Increased adiposity, mainly visceral WAT, is strongly associated with insulin resistance, type 2 diabetes and cardiovascular disease, among others. In contrast to WAT, brown adipose tissue (BAT) has the ability to dissipate energy in the form of heat due to the presence of the uncoupling protein 1 (UCP-1), a key determinant of mitochondrial thermogenesis. Interestingly, ?brown-like? adipocytes can be observed in WAT and are characterized by the presence of multilocular lipid droplets and high number of mitochondria which are associated with a reduction of total adiposity and improvement of metabolic alterations. WAT browning can be triggered by different stimuli such as cold, exercise or pharmacological treatment, such as β-adrenergic stimulation or peroxisome proliferator-activated receptor-γ (PPARγ) agonists. In addition, bioactive compounds such as polyphenols had been recently implicated in the emergence of brown-like cells in WAT. Polyphenols are bioactive compounds widely distributed in fruits and vegetables with an important role in preventing and managing increased adiposity and its comorbidities. We observed in rodent models of high fat-induced increased adiposity and metabolic alterations that supplementation with grape pomace extract (GPE), rich in polyphenols, stimulate the expression of the main transcriptional regulators of brown-like cell development, i.e., PPARγ-coactivator-1α (PGC-1α), PPARγ, PR domain containing 16 (PRDM16), and UCP-1 reducing adipose hypertrophy and inflammation in WAT and insulin resistance. GPE and two of the major GPE flavonoids, quercetin and (-)-epicatechin, enhanced the expression of transcriptional regulators of browning and UCP-1 through the up-regulation of the β-adrenergic receptor downstream cascade in 3T3-L1 adipocytes treated with palmitate. Overall, this finding highlights the potential utilization of bioactive grape-derived compounds to prevent/attenuate adiposity-associated pathologies.
Fil: Perdicaro, Diahann Jeanette. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Reunión Anual de Sociedades de Biociencias; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Ciudad Autónoma de Buenos Aires
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
description Obesity is one of the main public health concerns worldwide. White adipose tissue (WAT) is an endocrine organ that stores energy excess as triglycerides. Increased adiposity, mainly visceral WAT, is strongly associated with insulin resistance, type 2 diabetes and cardiovascular disease, among others. In contrast to WAT, brown adipose tissue (BAT) has the ability to dissipate energy in the form of heat due to the presence of the uncoupling protein 1 (UCP-1), a key determinant of mitochondrial thermogenesis. Interestingly, ?brown-like? adipocytes can be observed in WAT and are characterized by the presence of multilocular lipid droplets and high number of mitochondria which are associated with a reduction of total adiposity and improvement of metabolic alterations. WAT browning can be triggered by different stimuli such as cold, exercise or pharmacological treatment, such as β-adrenergic stimulation or peroxisome proliferator-activated receptor-γ (PPARγ) agonists. In addition, bioactive compounds such as polyphenols had been recently implicated in the emergence of brown-like cells in WAT. Polyphenols are bioactive compounds widely distributed in fruits and vegetables with an important role in preventing and managing increased adiposity and its comorbidities. We observed in rodent models of high fat-induced increased adiposity and metabolic alterations that supplementation with grape pomace extract (GPE), rich in polyphenols, stimulate the expression of the main transcriptional regulators of brown-like cell development, i.e., PPARγ-coactivator-1α (PGC-1α), PPARγ, PR domain containing 16 (PRDM16), and UCP-1 reducing adipose hypertrophy and inflammation in WAT and insulin resistance. GPE and two of the major GPE flavonoids, quercetin and (-)-epicatechin, enhanced the expression of transcriptional regulators of browning and UCP-1 through the up-regulation of the β-adrenergic receptor downstream cascade in 3T3-L1 adipocytes treated with palmitate. Overall, this finding highlights the potential utilization of bioactive grape-derived compounds to prevent/attenuate adiposity-associated pathologies.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/209057
Burning fat: role of polyphenols in white adipose tissue browning; Reunión Anual de Sociedades de Biociencias; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Ciudad Autónoma de Buenos Aires; Argentina; 2020; 35-35
0025-7680
CONICET Digital
CONICET
url http://hdl.handle.net/11336/209057
identifier_str_mv Burning fat: role of polyphenols in white adipose tissue browning; Reunión Anual de Sociedades de Biociencias; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Ciudad Autónoma de Buenos Aires; Argentina; 2020; 35-35
0025-7680
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.medicinabuenosaires.com/indices-de-2020/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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