Topical microbicides for the prevention of genital herpes infection

Autores
Keller, Marla J.; Tuyama, Ana; Carlucci, Maria Josefina; Herold, Betsy C.
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Genital herpes is one of the most prevalent sexually transmitted infections worldwide and is the most common cause of genital ulcers. Despite increased public awareness and the initiation of efforts to prevent transmission, the prevalence of herpes simplex virus (HSV) type 2 continues to increase. What makes HSV so difficult to control is that most sexual and perinatal transmission occurs during unrecognized or asymptomatic shedding. The impact of genital herpes as a public health threat is amplified because of its epidemiological synergy with HIV/AIDS. Thus, there is an urgent need for novel prophylactic methods, such as topical microbicides designed for genital application, to prevent both HSV and HIV transmission. Several candidate microbicides are being advanced to clinical trials based on in vitro activity and animal studies. These include compounds that inactivate virus directly, those that enhance innate immunity, and drugs that block viral binding and entry. A more vigorous evaluation of the safety of these and other candidate topical microbicides in development should include assessment of the impact of repeated application on innate host defences in the genital tract.
Fil: Keller, Marla J.. Mount Sinai School of Medicine; Estados Unidos
Fil: Tuyama, Ana. Mount Sinai School of Medicine; Estados Unidos
Fil: Carlucci, Maria Josefina. Mount Sinai School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herold, Betsy C.. Mount Sinai School of Medicine; Estados Unidos
Materia
HIV
HSV
INNATE IMMUNITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/97500
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Topical microbicides for the prevention of genital herpes infectionKeller, Marla J.Tuyama, AnaCarlucci, Maria JosefinaHerold, Betsy C.HIVHSVINNATE IMMUNITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Genital herpes is one of the most prevalent sexually transmitted infections worldwide and is the most common cause of genital ulcers. Despite increased public awareness and the initiation of efforts to prevent transmission, the prevalence of herpes simplex virus (HSV) type 2 continues to increase. What makes HSV so difficult to control is that most sexual and perinatal transmission occurs during unrecognized or asymptomatic shedding. The impact of genital herpes as a public health threat is amplified because of its epidemiological synergy with HIV/AIDS. Thus, there is an urgent need for novel prophylactic methods, such as topical microbicides designed for genital application, to prevent both HSV and HIV transmission. Several candidate microbicides are being advanced to clinical trials based on in vitro activity and animal studies. These include compounds that inactivate virus directly, those that enhance innate immunity, and drugs that block viral binding and entry. A more vigorous evaluation of the safety of these and other candidate topical microbicides in development should include assessment of the impact of repeated application on innate host defences in the genital tract.Fil: Keller, Marla J.. Mount Sinai School of Medicine; Estados UnidosFil: Tuyama, Ana. Mount Sinai School of Medicine; Estados UnidosFil: Carlucci, Maria Josefina. Mount Sinai School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herold, Betsy C.. Mount Sinai School of Medicine; Estados UnidosOxford University Press2005-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/97500Keller, Marla J.; Tuyama, Ana; Carlucci, Maria Josefina; Herold, Betsy C.; Topical microbicides for the prevention of genital herpes infection; Oxford University Press; Journal of Antimicrobial Chemotherapy; 55; 4; 4-2005; 420-4230305-7453CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dki056info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article/55/4/420/801226info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:12Zoai:ri.conicet.gov.ar:11336/97500instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:13.176CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Topical microbicides for the prevention of genital herpes infection
title Topical microbicides for the prevention of genital herpes infection
spellingShingle Topical microbicides for the prevention of genital herpes infection
Keller, Marla J.
HIV
HSV
INNATE IMMUNITY
title_short Topical microbicides for the prevention of genital herpes infection
title_full Topical microbicides for the prevention of genital herpes infection
title_fullStr Topical microbicides for the prevention of genital herpes infection
title_full_unstemmed Topical microbicides for the prevention of genital herpes infection
title_sort Topical microbicides for the prevention of genital herpes infection
dc.creator.none.fl_str_mv Keller, Marla J.
Tuyama, Ana
Carlucci, Maria Josefina
Herold, Betsy C.
author Keller, Marla J.
author_facet Keller, Marla J.
Tuyama, Ana
Carlucci, Maria Josefina
Herold, Betsy C.
author_role author
author2 Tuyama, Ana
Carlucci, Maria Josefina
Herold, Betsy C.
author2_role author
author
author
dc.subject.none.fl_str_mv HIV
HSV
INNATE IMMUNITY
topic HIV
HSV
INNATE IMMUNITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Genital herpes is one of the most prevalent sexually transmitted infections worldwide and is the most common cause of genital ulcers. Despite increased public awareness and the initiation of efforts to prevent transmission, the prevalence of herpes simplex virus (HSV) type 2 continues to increase. What makes HSV so difficult to control is that most sexual and perinatal transmission occurs during unrecognized or asymptomatic shedding. The impact of genital herpes as a public health threat is amplified because of its epidemiological synergy with HIV/AIDS. Thus, there is an urgent need for novel prophylactic methods, such as topical microbicides designed for genital application, to prevent both HSV and HIV transmission. Several candidate microbicides are being advanced to clinical trials based on in vitro activity and animal studies. These include compounds that inactivate virus directly, those that enhance innate immunity, and drugs that block viral binding and entry. A more vigorous evaluation of the safety of these and other candidate topical microbicides in development should include assessment of the impact of repeated application on innate host defences in the genital tract.
Fil: Keller, Marla J.. Mount Sinai School of Medicine; Estados Unidos
Fil: Tuyama, Ana. Mount Sinai School of Medicine; Estados Unidos
Fil: Carlucci, Maria Josefina. Mount Sinai School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herold, Betsy C.. Mount Sinai School of Medicine; Estados Unidos
description Genital herpes is one of the most prevalent sexually transmitted infections worldwide and is the most common cause of genital ulcers. Despite increased public awareness and the initiation of efforts to prevent transmission, the prevalence of herpes simplex virus (HSV) type 2 continues to increase. What makes HSV so difficult to control is that most sexual and perinatal transmission occurs during unrecognized or asymptomatic shedding. The impact of genital herpes as a public health threat is amplified because of its epidemiological synergy with HIV/AIDS. Thus, there is an urgent need for novel prophylactic methods, such as topical microbicides designed for genital application, to prevent both HSV and HIV transmission. Several candidate microbicides are being advanced to clinical trials based on in vitro activity and animal studies. These include compounds that inactivate virus directly, those that enhance innate immunity, and drugs that block viral binding and entry. A more vigorous evaluation of the safety of these and other candidate topical microbicides in development should include assessment of the impact of repeated application on innate host defences in the genital tract.
publishDate 2005
dc.date.none.fl_str_mv 2005-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97500
Keller, Marla J.; Tuyama, Ana; Carlucci, Maria Josefina; Herold, Betsy C.; Topical microbicides for the prevention of genital herpes infection; Oxford University Press; Journal of Antimicrobial Chemotherapy; 55; 4; 4-2005; 420-423
0305-7453
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97500
identifier_str_mv Keller, Marla J.; Tuyama, Ana; Carlucci, Maria Josefina; Herold, Betsy C.; Topical microbicides for the prevention of genital herpes infection; Oxford University Press; Journal of Antimicrobial Chemotherapy; 55; 4; 4-2005; 420-423
0305-7453
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/jac/dki056
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article/55/4/420/801226
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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