Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects

Autores
Montalto, Maria; Bartel, Laura Cecilia; Rodríguez de Castro, Carmen; Castro, Jose Alberto
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats after intragastric administration. No cytosolic Bz nitroreductases were detected, while a microsomal NADPH dependent Bz nitroreductase activity was found, which was mediated by P450 reductase. No ultrastructurally observable Bz deleterious effects were detected, in contrast to the cardiac effects previously reported for Nfx. As conclusion, if these drugs were used in chagasic patients, Bz would be less risky to heart function than Nfx, when any cardiopathy is present.
Fil: Montalto, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
Fil: Bartel, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
Fil: Rodríguez de Castro, Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
Materia
CHAGAS DISEASE
BENZNIDAZOLE
NIFURTIMOX
NITROREDUCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/82108
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effectsMontalto, MariaBartel, Laura CeciliaRodríguez de Castro, CarmenCastro, Jose AlbertoCHAGAS DISEASEBENZNIDAZOLENIFURTIMOXNITROREDUCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats after intragastric administration. No cytosolic Bz nitroreductases were detected, while a microsomal NADPH dependent Bz nitroreductase activity was found, which was mediated by P450 reductase. No ultrastructurally observable Bz deleterious effects were detected, in contrast to the cardiac effects previously reported for Nfx. As conclusion, if these drugs were used in chagasic patients, Bz would be less risky to heart function than Nfx, when any cardiopathy is present.Fil: Montalto, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); ArgentinaFil: Bartel, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); ArgentinaFil: Rodríguez de Castro, Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); ArgentinaFil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); ArgentinaFundação Oswaldo Cruz2008-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/82108Montalto, Maria; Bartel, Laura Cecilia; Rodríguez de Castro, Carmen; Castro, Jose Alberto; Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 103; 6; 9-2008; 549-5530074-02761678-8060CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/ffcbdminfo:eu-repo/semantics/altIdentifier/doi/10.1590/S0074-02762008000600007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:00Zoai:ri.conicet.gov.ar:11336/82108instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:00.5CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
title Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
spellingShingle Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
Montalto, Maria
CHAGAS DISEASE
BENZNIDAZOLE
NIFURTIMOX
NITROREDUCTION
title_short Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
title_full Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
title_fullStr Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
title_full_unstemmed Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
title_sort Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
dc.creator.none.fl_str_mv Montalto, Maria
Bartel, Laura Cecilia
Rodríguez de Castro, Carmen
Castro, Jose Alberto
author Montalto, Maria
author_facet Montalto, Maria
Bartel, Laura Cecilia
Rodríguez de Castro, Carmen
Castro, Jose Alberto
author_role author
author2 Bartel, Laura Cecilia
Rodríguez de Castro, Carmen
Castro, Jose Alberto
author2_role author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
BENZNIDAZOLE
NIFURTIMOX
NITROREDUCTION
topic CHAGAS DISEASE
BENZNIDAZOLE
NIFURTIMOX
NITROREDUCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats after intragastric administration. No cytosolic Bz nitroreductases were detected, while a microsomal NADPH dependent Bz nitroreductase activity was found, which was mediated by P450 reductase. No ultrastructurally observable Bz deleterious effects were detected, in contrast to the cardiac effects previously reported for Nfx. As conclusion, if these drugs were used in chagasic patients, Bz would be less risky to heart function than Nfx, when any cardiopathy is present.
Fil: Montalto, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
Fil: Bartel, Laura Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
Fil: Rodríguez de Castro, Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina
description Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats after intragastric administration. No cytosolic Bz nitroreductases were detected, while a microsomal NADPH dependent Bz nitroreductase activity was found, which was mediated by P450 reductase. No ultrastructurally observable Bz deleterious effects were detected, in contrast to the cardiac effects previously reported for Nfx. As conclusion, if these drugs were used in chagasic patients, Bz would be less risky to heart function than Nfx, when any cardiopathy is present.
publishDate 2008
dc.date.none.fl_str_mv 2008-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/82108
Montalto, Maria; Bartel, Laura Cecilia; Rodríguez de Castro, Carmen; Castro, Jose Alberto; Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 103; 6; 9-2008; 549-553
0074-0276
1678-8060
CONICET Digital
CONICET
url http://hdl.handle.net/11336/82108
identifier_str_mv Montalto, Maria; Bartel, Laura Cecilia; Rodríguez de Castro, Carmen; Castro, Jose Alberto; Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 103; 6; 9-2008; 549-553
0074-0276
1678-8060
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/ffcbdm
info:eu-repo/semantics/altIdentifier/doi/10.1590/S0074-02762008000600007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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