Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

Autores
Ríos, José Luis; Andújar, Isabel; Schinella, Guillermo Raúl; Francini, Flavio
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.
Fil: Ríos, José Luis. Universidad de Valencia; España
Fil: Andújar, Isabel. Universidad de Valencia; España. Universidad Europea de Valencia.; España
Fil: Schinella, Guillermo Raúl. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
Materia
DIPEPTIDYL PEPTIDASE-4
DPP-4
GIP
GLP-1
GLUCAGON-LIKE PEPTIDE-1
GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE
INCRETINS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/122447
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/122447
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of Diabetes by Natural Products and Medicinal Plants via IncretinsRíos, José LuisAndújar, IsabelSchinella, Guillermo RaúlFrancini, FlavioDIPEPTIDYL PEPTIDASE-4DPP-4GIPGLP-1GLUCAGON-LIKE PEPTIDE-1GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDEINCRETINShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.Fil: Ríos, José Luis. Universidad de Valencia; EspañaFil: Andújar, Isabel. Universidad de Valencia; España. Universidad Europea de Valencia.; EspañaFil: Schinella, Guillermo Raúl. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaGeorg Thieme Verlag Kg2019-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/122447Ríos, José Luis; Andújar, Isabel; Schinella, Guillermo Raúl; Francini, Flavio; Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins; Georg Thieme Verlag Kg; Planta Medica; 85; 11-12; 4-2019; 825-8390032-0943CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1055/a-0897-7492info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0897-7492info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:15Zoai:ri.conicet.gov.ar:11336/122447instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:15.924CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
title Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
spellingShingle Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
Ríos, José Luis
DIPEPTIDYL PEPTIDASE-4
DPP-4
GIP
GLP-1
GLUCAGON-LIKE PEPTIDE-1
GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE
INCRETINS
title_short Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
title_full Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
title_fullStr Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
title_full_unstemmed Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
title_sort Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
dc.creator.none.fl_str_mv Ríos, José Luis
Andújar, Isabel
Schinella, Guillermo Raúl
Francini, Flavio
author Ríos, José Luis
author_facet Ríos, José Luis
Andújar, Isabel
Schinella, Guillermo Raúl
Francini, Flavio
author_role author
author2 Andújar, Isabel
Schinella, Guillermo Raúl
Francini, Flavio
author2_role author
author
author
dc.subject.none.fl_str_mv DIPEPTIDYL PEPTIDASE-4
DPP-4
GIP
GLP-1
GLUCAGON-LIKE PEPTIDE-1
GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE
INCRETINS
topic DIPEPTIDYL PEPTIDASE-4
DPP-4
GIP
GLP-1
GLUCAGON-LIKE PEPTIDE-1
GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE
INCRETINS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.
Fil: Ríos, José Luis. Universidad de Valencia; España
Fil: Andújar, Isabel. Universidad de Valencia; España. Universidad Europea de Valencia.; España
Fil: Schinella, Guillermo Raúl. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
description Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.
publishDate 2019
dc.date.none.fl_str_mv 2019-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/122447
Ríos, José Luis; Andújar, Isabel; Schinella, Guillermo Raúl; Francini, Flavio; Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins; Georg Thieme Verlag Kg; Planta Medica; 85; 11-12; 4-2019; 825-839
0032-0943
CONICET Digital
CONICET
url http://hdl.handle.net/11336/122447
identifier_str_mv Ríos, José Luis; Andújar, Isabel; Schinella, Guillermo Raúl; Francini, Flavio; Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins; Georg Thieme Verlag Kg; Planta Medica; 85; 11-12; 4-2019; 825-839
0032-0943
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1055/a-0897-7492
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0897-7492
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614263631511552
score 13.070432

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