Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases

Autores
Cao, Gabriel Fernando; Mendez, Julián; Navacchia, Daniel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pancreatoblastoma is a rare paediatric malignant neoplasm. The treatment of choice is complete surgical resection. However, it is often unresectable due to its large size, local infiltration or distant metastasis. Since the condition is rare, there is currently no standard treatment regimen. We outline the case of a 4-year-old child who presented with abdominal pain and distention, together with an enlarged liver and elevated serum α-fetoprotein levels. Imaging studies showed the presence of an abnormal pancreatic tumour and multiple nodular lesions in the liver, the biopsies from which led to a diagnosis of pancreatoblastoma. In this case, the patient received cycles of neoadjuvant chemotherapy, combining cisplatin and doxorubicin. The patient subsequently underwent scheduled surgery in which the primary pancreatic lesion was resected, obtaining a circumscribed and nodular specimen measuring 7 × 6 cm and weighing 150 g. Given the extent of the metastasis, the child is currently awaiting a liver transplant.
Fil: Cao, Gabriel Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mendez, Julián. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Navacchia, Daniel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Materia
pediatric pancreatoblastoma
pathology
treatment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93987
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastasesCao, Gabriel FernandoMendez, JuliánNavacchia, Danielpediatric pancreatoblastomapathologytreatmenthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pancreatoblastoma is a rare paediatric malignant neoplasm. The treatment of choice is complete surgical resection. However, it is often unresectable due to its large size, local infiltration or distant metastasis. Since the condition is rare, there is currently no standard treatment regimen. We outline the case of a 4-year-old child who presented with abdominal pain and distention, together with an enlarged liver and elevated serum α-fetoprotein levels. Imaging studies showed the presence of an abnormal pancreatic tumour and multiple nodular lesions in the liver, the biopsies from which led to a diagnosis of pancreatoblastoma. In this case, the patient received cycles of neoadjuvant chemotherapy, combining cisplatin and doxorubicin. The patient subsequently underwent scheduled surgery in which the primary pancreatic lesion was resected, obtaining a circumscribed and nodular specimen measuring 7 × 6 cm and weighing 150 g. Given the extent of the metastasis, the child is currently awaiting a liver transplant.Fil: Cao, Gabriel Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mendez, Julián. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Navacchia, Daniel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentinaecancer Global Foundation2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93987Cao, Gabriel Fernando; Mendez, Julián; Navacchia, Daniel; Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases; ecancer Global Foundation; ecancermedicalscience; 12; 8-2018; 861-8661754-6605CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3332/ecancer.2018.861info:eu-repo/semantics/altIdentifier/url/https://ecancer.org/en/journal/article/861-pancreatoblastoma-in-a-paediatric-patient-anatomo-pathological-aspects-of-a-case-with-multiple-hepatic-metastasesinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:54Zoai:ri.conicet.gov.ar:11336/93987instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:55.03CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
title Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
spellingShingle Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
Cao, Gabriel Fernando
pediatric pancreatoblastoma
pathology
treatment
title_short Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
title_full Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
title_fullStr Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
title_full_unstemmed Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
title_sort Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases
dc.creator.none.fl_str_mv Cao, Gabriel Fernando
Mendez, Julián
Navacchia, Daniel
author Cao, Gabriel Fernando
author_facet Cao, Gabriel Fernando
Mendez, Julián
Navacchia, Daniel
author_role author
author2 Mendez, Julián
Navacchia, Daniel
author2_role author
author
dc.subject.none.fl_str_mv pediatric pancreatoblastoma
pathology
treatment
topic pediatric pancreatoblastoma
pathology
treatment
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pancreatoblastoma is a rare paediatric malignant neoplasm. The treatment of choice is complete surgical resection. However, it is often unresectable due to its large size, local infiltration or distant metastasis. Since the condition is rare, there is currently no standard treatment regimen. We outline the case of a 4-year-old child who presented with abdominal pain and distention, together with an enlarged liver and elevated serum α-fetoprotein levels. Imaging studies showed the presence of an abnormal pancreatic tumour and multiple nodular lesions in the liver, the biopsies from which led to a diagnosis of pancreatoblastoma. In this case, the patient received cycles of neoadjuvant chemotherapy, combining cisplatin and doxorubicin. The patient subsequently underwent scheduled surgery in which the primary pancreatic lesion was resected, obtaining a circumscribed and nodular specimen measuring 7 × 6 cm and weighing 150 g. Given the extent of the metastasis, the child is currently awaiting a liver transplant.
Fil: Cao, Gabriel Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mendez, Julián. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Navacchia, Daniel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
description Pancreatoblastoma is a rare paediatric malignant neoplasm. The treatment of choice is complete surgical resection. However, it is often unresectable due to its large size, local infiltration or distant metastasis. Since the condition is rare, there is currently no standard treatment regimen. We outline the case of a 4-year-old child who presented with abdominal pain and distention, together with an enlarged liver and elevated serum α-fetoprotein levels. Imaging studies showed the presence of an abnormal pancreatic tumour and multiple nodular lesions in the liver, the biopsies from which led to a diagnosis of pancreatoblastoma. In this case, the patient received cycles of neoadjuvant chemotherapy, combining cisplatin and doxorubicin. The patient subsequently underwent scheduled surgery in which the primary pancreatic lesion was resected, obtaining a circumscribed and nodular specimen measuring 7 × 6 cm and weighing 150 g. Given the extent of the metastasis, the child is currently awaiting a liver transplant.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93987
Cao, Gabriel Fernando; Mendez, Julián; Navacchia, Daniel; Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases; ecancer Global Foundation; ecancermedicalscience; 12; 8-2018; 861-866
1754-6605
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93987
identifier_str_mv Cao, Gabriel Fernando; Mendez, Julián; Navacchia, Daniel; Pancreatoblastoma in a paediatric patient: anatomo-pathological aspects of a case with multiple hepatic metastases; ecancer Global Foundation; ecancermedicalscience; 12; 8-2018; 861-866
1754-6605
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3332/ecancer.2018.861
info:eu-repo/semantics/altIdentifier/url/https://ecancer.org/en/journal/article/861-pancreatoblastoma-in-a-paediatric-patient-anatomo-pathological-aspects-of-a-case-with-multiple-hepatic-metastases
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ecancer Global Foundation
publisher.none.fl_str_mv ecancer Global Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269980043771904
score 13.13397

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