Endothelinergic cells in the subependymal region of mice

Autores
Castañeda, Mauricio Martin; Cubilla, Marisa Angélica; López Vicchi, Martín Miguel; Suburo, Angela Maria
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Endothelin (ET) is a small peptide that activates astrocyte proliferation, regulates proliferation and migration of embryonic neural precursor cells and stimulates glioblastoma growth. We found that in mouse brain, ET and its receptor B (ETRB) were highly expressed in the subependymal zone (SEZ), an adult neurogenic niche. Cells with ET immunoreactivity (ET+ cells) selectively appeared along the lateral and dorsal walls of the lateral ventricle. They also appeared in the cingular region of the corpus callosum. Subependymal ET+ cells also displayed prominin (PRO), glial fibrillary acidic protein (GFAP) and ETRB immunoreactivities. ET+ processes traversed the ependymal epithelium and approached the ventricular lumen. Ependymal cells only showed ETRB-ir. A small but consistent number of ET+ cells displayed proliferation markers: 5-bromo-2′-deoxyuridine (BrdU) incorporation, and minichromosome maintenance protein 2 (Mcm2). Cortical injury and G-CSF increased subependymal endothelinergic cells and their proliferation markers. Our findings suggest that ET and ETRB might be associated with regulation of adult neural stem cells and their migration through neurogenic and gliogenic pathways.
Fil: Castañeda, Mauricio Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Cubilla, Marisa Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: López Vicchi, Martín Miguel. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Suburo, Angela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Materia
ADULT NEUROGENESIS
ASTROCYTE
CINGULUM
ENDOTHELIN
GRANULOCYTE-COLONY STIMULATING FACTOR
NEURAL STEM CELL
STROKE
SUBEPENDYMAL ZONE
SUBVENTRICULAR ZONE
TRAUMATIC BRAIN INJURY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98834
Acceder
id CONICETDig_419e3c5ee8fe2fe6ebf117d12237b5cb
oai_identifier_str oai:ri.conicet.gov.ar:11336/98834
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endothelinergic cells in the subependymal region of miceCastañeda, Mauricio MartinCubilla, Marisa AngélicaLópez Vicchi, Martín MiguelSuburo, Angela MariaADULT NEUROGENESISASTROCYTECINGULUMENDOTHELINGRANULOCYTE-COLONY STIMULATING FACTORNEURAL STEM CELLSTROKESUBEPENDYMAL ZONESUBVENTRICULAR ZONETRAUMATIC BRAIN INJURYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Endothelin (ET) is a small peptide that activates astrocyte proliferation, regulates proliferation and migration of embryonic neural precursor cells and stimulates glioblastoma growth. We found that in mouse brain, ET and its receptor B (ETRB) were highly expressed in the subependymal zone (SEZ), an adult neurogenic niche. Cells with ET immunoreactivity (ET+ cells) selectively appeared along the lateral and dorsal walls of the lateral ventricle. They also appeared in the cingular region of the corpus callosum. Subependymal ET+ cells also displayed prominin (PRO), glial fibrillary acidic protein (GFAP) and ETRB immunoreactivities. ET+ processes traversed the ependymal epithelium and approached the ventricular lumen. Ependymal cells only showed ETRB-ir. A small but consistent number of ET+ cells displayed proliferation markers: 5-bromo-2′-deoxyuridine (BrdU) incorporation, and minichromosome maintenance protein 2 (Mcm2). Cortical injury and G-CSF increased subependymal endothelinergic cells and their proliferation markers. Our findings suggest that ET and ETRB might be associated with regulation of adult neural stem cells and their migration through neurogenic and gliogenic pathways.Fil: Castañeda, Mauricio Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Cubilla, Marisa Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: López Vicchi, Martín Miguel. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Suburo, Angela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaElsevier Science2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98834Castañeda, Mauricio Martin; Cubilla, Marisa Angélica; López Vicchi, Martín Miguel; Suburo, Angela Maria; Endothelinergic cells in the subependymal region of mice; Elsevier Science; Brain Research; 1321; 3-2010; 20-300006-8993CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/hhttps://www.sciencedirect.com/science/article/pii/S0006899310002106info:eu-repo/semantics/altIdentifier/doi/10.1016/j.brainres.2010.01.056info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:49Zoai:ri.conicet.gov.ar:11336/98834instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:50.109CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endothelinergic cells in the subependymal region of mice
title Endothelinergic cells in the subependymal region of mice
spellingShingle Endothelinergic cells in the subependymal region of mice
Castañeda, Mauricio Martin
ADULT NEUROGENESIS
ASTROCYTE
CINGULUM
ENDOTHELIN
GRANULOCYTE-COLONY STIMULATING FACTOR
NEURAL STEM CELL
STROKE
SUBEPENDYMAL ZONE
SUBVENTRICULAR ZONE
TRAUMATIC BRAIN INJURY
title_short Endothelinergic cells in the subependymal region of mice
title_full Endothelinergic cells in the subependymal region of mice
title_fullStr Endothelinergic cells in the subependymal region of mice
title_full_unstemmed Endothelinergic cells in the subependymal region of mice
title_sort Endothelinergic cells in the subependymal region of mice
dc.creator.none.fl_str_mv Castañeda, Mauricio Martin
Cubilla, Marisa Angélica
López Vicchi, Martín Miguel
Suburo, Angela Maria
author Castañeda, Mauricio Martin
author_facet Castañeda, Mauricio Martin
Cubilla, Marisa Angélica
López Vicchi, Martín Miguel
Suburo, Angela Maria
author_role author
author2 Cubilla, Marisa Angélica
López Vicchi, Martín Miguel
Suburo, Angela Maria
author2_role author
author
author
dc.subject.none.fl_str_mv ADULT NEUROGENESIS
ASTROCYTE
CINGULUM
ENDOTHELIN
GRANULOCYTE-COLONY STIMULATING FACTOR
NEURAL STEM CELL
STROKE
SUBEPENDYMAL ZONE
SUBVENTRICULAR ZONE
TRAUMATIC BRAIN INJURY
topic ADULT NEUROGENESIS
ASTROCYTE
CINGULUM
ENDOTHELIN
GRANULOCYTE-COLONY STIMULATING FACTOR
NEURAL STEM CELL
STROKE
SUBEPENDYMAL ZONE
SUBVENTRICULAR ZONE
TRAUMATIC BRAIN INJURY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Endothelin (ET) is a small peptide that activates astrocyte proliferation, regulates proliferation and migration of embryonic neural precursor cells and stimulates glioblastoma growth. We found that in mouse brain, ET and its receptor B (ETRB) were highly expressed in the subependymal zone (SEZ), an adult neurogenic niche. Cells with ET immunoreactivity (ET+ cells) selectively appeared along the lateral and dorsal walls of the lateral ventricle. They also appeared in the cingular region of the corpus callosum. Subependymal ET+ cells also displayed prominin (PRO), glial fibrillary acidic protein (GFAP) and ETRB immunoreactivities. ET+ processes traversed the ependymal epithelium and approached the ventricular lumen. Ependymal cells only showed ETRB-ir. A small but consistent number of ET+ cells displayed proliferation markers: 5-bromo-2′-deoxyuridine (BrdU) incorporation, and minichromosome maintenance protein 2 (Mcm2). Cortical injury and G-CSF increased subependymal endothelinergic cells and their proliferation markers. Our findings suggest that ET and ETRB might be associated with regulation of adult neural stem cells and their migration through neurogenic and gliogenic pathways.
Fil: Castañeda, Mauricio Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Cubilla, Marisa Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: López Vicchi, Martín Miguel. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Suburo, Angela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
description Endothelin (ET) is a small peptide that activates astrocyte proliferation, regulates proliferation and migration of embryonic neural precursor cells and stimulates glioblastoma growth. We found that in mouse brain, ET and its receptor B (ETRB) were highly expressed in the subependymal zone (SEZ), an adult neurogenic niche. Cells with ET immunoreactivity (ET+ cells) selectively appeared along the lateral and dorsal walls of the lateral ventricle. They also appeared in the cingular region of the corpus callosum. Subependymal ET+ cells also displayed prominin (PRO), glial fibrillary acidic protein (GFAP) and ETRB immunoreactivities. ET+ processes traversed the ependymal epithelium and approached the ventricular lumen. Ependymal cells only showed ETRB-ir. A small but consistent number of ET+ cells displayed proliferation markers: 5-bromo-2′-deoxyuridine (BrdU) incorporation, and minichromosome maintenance protein 2 (Mcm2). Cortical injury and G-CSF increased subependymal endothelinergic cells and their proliferation markers. Our findings suggest that ET and ETRB might be associated with regulation of adult neural stem cells and their migration through neurogenic and gliogenic pathways.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98834
Castañeda, Mauricio Martin; Cubilla, Marisa Angélica; López Vicchi, Martín Miguel; Suburo, Angela Maria; Endothelinergic cells in the subependymal region of mice; Elsevier Science; Brain Research; 1321; 3-2010; 20-30
0006-8993
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98834
identifier_str_mv Castañeda, Mauricio Martin; Cubilla, Marisa Angélica; López Vicchi, Martín Miguel; Suburo, Angela Maria; Endothelinergic cells in the subependymal region of mice; Elsevier Science; Brain Research; 1321; 3-2010; 20-30
0006-8993
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/hhttps://www.sciencedirect.com/science/article/pii/S0006899310002106
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.brainres.2010.01.056
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268997086609408
score 12.885934

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