Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins

Autores
Wang, HongBin; Gutierrez Uzquiza, Alvaro; Garg, Rachana; Barrio Real, Laura; Abera, Mahlet B; Lopez Haber, Cynthia; Rosemblit, Cinthia; Lu, Huaisheng; Abba, Martín Carlos; Kazanietz, Marcelo G.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.
Fil: Wang, HongBin. University of Pennsylvania; Estados Unidos
Fil: Gutierrez Uzquiza, Alvaro. University of Pennsylvania; Estados Unidos
Fil: Garg, Rachana. University of Pennsylvania; Estados Unidos
Fil: Barrio Real, Laura. University of Pennsylvania; Estados Unidos
Fil: Abera, Mahlet B. University of Pennsylvania; Estados Unidos
Fil: Lopez Haber, Cynthia. University of Pennsylvania; Estados Unidos
Fil: Rosemblit, Cinthia. University of Pennsylvania; Estados Unidos
Fil: Lu, Huaisheng. University of Pennsylvania; Estados Unidos
Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina
Fil: Kazanietz, Marcelo G.. University of Pennsylvania; Estados Unidos
Materia
BREAST CANCER
DIACYLGLYCEROL
GENE EXPRESSION
PROTEIN KINASE C EPSILON
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32973
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/32973
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 ProteinsWang, HongBinGutierrez Uzquiza, AlvaroGarg, RachanaBarrio Real, LauraAbera, Mahlet BLopez Haber, CynthiaRosemblit, CinthiaLu, HuaishengAbba, Martín CarlosKazanietz, Marcelo G.BREAST CANCERDIACYLGLYCEROLGENE EXPRESSIONPROTEIN KINASE C EPSILONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.Fil: Wang, HongBin. University of Pennsylvania; Estados UnidosFil: Gutierrez Uzquiza, Alvaro. University of Pennsylvania; Estados UnidosFil: Garg, Rachana. University of Pennsylvania; Estados UnidosFil: Barrio Real, Laura. University of Pennsylvania; Estados UnidosFil: Abera, Mahlet B. University of Pennsylvania; Estados UnidosFil: Lopez Haber, Cynthia. University of Pennsylvania; Estados UnidosFil: Rosemblit, Cinthia. University of Pennsylvania; Estados UnidosFil: Lu, Huaisheng. University of Pennsylvania; Estados UnidosFil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; ArgentinaFil: Kazanietz, Marcelo G.. University of Pennsylvania; Estados UnidosAmerican Society for Biochemistry and Molecular Biology2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32973Lopez Haber, Cynthia; Garg, Rachana; Rosemblit, Cinthia; Abera, Mahlet B; Gutierrez Uzquiza, Alvaro; Kazanietz, Marcelo G.; et al.; Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 289; 7-2014; 19823-198381083-351XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1074/jbc.M114.548446info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/289/28/19823info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:29Zoai:ri.conicet.gov.ar:11336/32973instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:29.251CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
title Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
spellingShingle Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
Wang, HongBin
BREAST CANCER
DIACYLGLYCEROL
GENE EXPRESSION
PROTEIN KINASE C EPSILON
title_short Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
title_full Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
title_fullStr Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
title_full_unstemmed Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
title_sort Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins
dc.creator.none.fl_str_mv Wang, HongBin
Gutierrez Uzquiza, Alvaro
Garg, Rachana
Barrio Real, Laura
Abera, Mahlet B
Lopez Haber, Cynthia
Rosemblit, Cinthia
Lu, Huaisheng
Abba, Martín Carlos
Kazanietz, Marcelo G.
author Wang, HongBin
author_facet Wang, HongBin
Gutierrez Uzquiza, Alvaro
Garg, Rachana
Barrio Real, Laura
Abera, Mahlet B
Lopez Haber, Cynthia
Rosemblit, Cinthia
Lu, Huaisheng
Abba, Martín Carlos
Kazanietz, Marcelo G.
author_role author
author2 Gutierrez Uzquiza, Alvaro
Garg, Rachana
Barrio Real, Laura
Abera, Mahlet B
Lopez Haber, Cynthia
Rosemblit, Cinthia
Lu, Huaisheng
Abba, Martín Carlos
Kazanietz, Marcelo G.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BREAST CANCER
DIACYLGLYCEROL
GENE EXPRESSION
PROTEIN KINASE C EPSILON
topic BREAST CANCER
DIACYLGLYCEROL
GENE EXPRESSION
PROTEIN KINASE C EPSILON
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.
Fil: Wang, HongBin. University of Pennsylvania; Estados Unidos
Fil: Gutierrez Uzquiza, Alvaro. University of Pennsylvania; Estados Unidos
Fil: Garg, Rachana. University of Pennsylvania; Estados Unidos
Fil: Barrio Real, Laura. University of Pennsylvania; Estados Unidos
Fil: Abera, Mahlet B. University of Pennsylvania; Estados Unidos
Fil: Lopez Haber, Cynthia. University of Pennsylvania; Estados Unidos
Fil: Rosemblit, Cinthia. University of Pennsylvania; Estados Unidos
Fil: Lu, Huaisheng. University of Pennsylvania; Estados Unidos
Fil: Abba, Martín Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina
Fil: Kazanietz, Marcelo G.. University of Pennsylvania; Estados Unidos
description Background: PKCϵ, a kinase widely implicated in tumorigenesis and metastasis, is overexpressed in many cancers. Results: Transcription factors Sp1 and STAT1 control the expression of PKCϵ in cancer cells. Conclusion: Up-regulation of PKCϵ is mediated by dysregulated transcriptional mechanisms. Significance: Our results may have significant implications for the development of approaches to target PKCϵ and its effectors in cancer therapeutics.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32973
Lopez Haber, Cynthia; Garg, Rachana; Rosemblit, Cinthia; Abera, Mahlet B; Gutierrez Uzquiza, Alvaro; Kazanietz, Marcelo G.; et al.; Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 289; 7-2014; 19823-19838
1083-351X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32973
identifier_str_mv Lopez Haber, Cynthia; Garg, Rachana; Rosemblit, Cinthia; Abera, Mahlet B; Gutierrez Uzquiza, Alvaro; Kazanietz, Marcelo G.; et al.; Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 289; 7-2014; 19823-19838
1083-351X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1074/jbc.M114.548446
info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/289/28/19823
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083053096534016
score 13.22299

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