Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field

Autores
Rico, Maria Jose; Perroud, Herman Andrés; Mainetti, Leandro Ernesto; Rozados, Viviana Rosa; Scharovsky, Olga Graciela
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic
Fil: Rico, Maria Jose. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perroud, Herman Andrés. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mainetti, Leandro Ernesto. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rozados, Viviana Rosa. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina
Fil: Scharovsky, Olga Graciela. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina
Materia
Metronomic Chemotherapy
Combined Treatment
Cyclophosphamide
Doxorubicin
Celecoxib
Mammary Adenocarcinoma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29853
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical FieldRico, Maria JosePerroud, Herman AndrésMainetti, Leandro ErnestoRozados, Viviana RosaScharovsky, Olga GracielaMetronomic ChemotherapyCombined TreatmentCyclophosphamideDoxorubicinCelecoxibMammary Adenocarcinomahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinicFil: Rico, Maria Jose. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perroud, Herman Andrés. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mainetti, Leandro Ernesto. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rozados, Viviana Rosa. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaFil: Scharovsky, Olga Graciela. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; ArgentinaTaylor2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29853Rico, Maria Jose; Perroud, Herman Andrés; Mainetti, Leandro Ernesto; Rozados, Viviana Rosa; Scharovsky, Olga Graciela; Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field; Taylor; Cancer Investigation; 32; 3; 2-2014; 92-980735-7907CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/07357907.2013.877480info:eu-repo/semantics/altIdentifier/doi/10.3109/07357907.2013.877480info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:45Zoai:ri.conicet.gov.ar:11336/29853instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:45.892CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
title Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
spellingShingle Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
Rico, Maria Jose
Metronomic Chemotherapy
Combined Treatment
Cyclophosphamide
Doxorubicin
Celecoxib
Mammary Adenocarcinoma
title_short Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
title_full Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
title_fullStr Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
title_full_unstemmed Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
title_sort Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field
dc.creator.none.fl_str_mv Rico, Maria Jose
Perroud, Herman Andrés
Mainetti, Leandro Ernesto
Rozados, Viviana Rosa
Scharovsky, Olga Graciela
author Rico, Maria Jose
author_facet Rico, Maria Jose
Perroud, Herman Andrés
Mainetti, Leandro Ernesto
Rozados, Viviana Rosa
Scharovsky, Olga Graciela
author_role author
author2 Perroud, Herman Andrés
Mainetti, Leandro Ernesto
Rozados, Viviana Rosa
Scharovsky, Olga Graciela
author2_role author
author
author
author
dc.subject.none.fl_str_mv Metronomic Chemotherapy
Combined Treatment
Cyclophosphamide
Doxorubicin
Celecoxib
Mammary Adenocarcinoma
topic Metronomic Chemotherapy
Combined Treatment
Cyclophosphamide
Doxorubicin
Celecoxib
Mammary Adenocarcinoma
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic
Fil: Rico, Maria Jose. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perroud, Herman Andrés. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mainetti, Leandro Ernesto. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rozados, Viviana Rosa. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina
Fil: Scharovsky, Olga Graciela. Universidad Nacional de Rosario. Facultad de Cs.médicas. Instituto de Genética Experimental. Sección de Oncología Experimental; Argentina
description Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29853
Rico, Maria Jose; Perroud, Herman Andrés; Mainetti, Leandro Ernesto; Rozados, Viviana Rosa; Scharovsky, Olga Graciela; Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field; Taylor; Cancer Investigation; 32; 3; 2-2014; 92-98
0735-7907
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29853
identifier_str_mv Rico, Maria Jose; Perroud, Herman Andrés; Mainetti, Leandro Ernesto; Rozados, Viviana Rosa; Scharovsky, Olga Graciela; Comparative Effectiveness of Two Metronomic Chemotherapy Schedules—Our Experience in the Preclinical Field; Taylor; Cancer Investigation; 32; 3; 2-2014; 92-98
0735-7907
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/07357907.2013.877480
info:eu-repo/semantics/altIdentifier/doi/10.3109/07357907.2013.877480
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor
publisher.none.fl_str_mv Taylor
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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