The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies

Autores
Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches.
Fil: Fagoonee, Sharmila. Institute of Biostructure and Bioimaging; Italia
Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Defilippi, Paola. Università di Torino; Italia
Fil: Weiskirchen, Ralf. University Hospital Aachen; Alemania
Materia
BILIARY TRACT DISEASES
SECRETOME
CHOLANGIOCYTE
EXTRACELLULAR VESICLES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271542
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and CholangiopathiesFagoonee, SharmilaBolontrade, Marcela FabianaDefilippi, PaolaWeiskirchen, RalfBILIARY TRACT DISEASESSECRETOMECHOLANGIOCYTEEXTRACELLULAR VESICLEShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches.Fil: Fagoonee, Sharmila. Institute of Biostructure and Bioimaging; ItaliaFil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Defilippi, Paola. Università di Torino; ItaliaFil: Weiskirchen, Ralf. University Hospital Aachen; AlemaniaMDPI2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271542Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf; The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies; MDPI; Cells; 14; 16; 8-2025; 1-192073-44092073-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/14/16/1274info:eu-repo/semantics/altIdentifier/doi/10.3390/cells14161274info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:58:19Zoai:ri.conicet.gov.ar:11336/271542instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:58:20.096CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
title The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
spellingShingle The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
Fagoonee, Sharmila
BILIARY TRACT DISEASES
SECRETOME
CHOLANGIOCYTE
EXTRACELLULAR VESICLES
title_short The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
title_full The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
title_fullStr The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
title_full_unstemmed The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
title_sort The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
dc.creator.none.fl_str_mv Fagoonee, Sharmila
Bolontrade, Marcela Fabiana
Defilippi, Paola
Weiskirchen, Ralf
author Fagoonee, Sharmila
author_facet Fagoonee, Sharmila
Bolontrade, Marcela Fabiana
Defilippi, Paola
Weiskirchen, Ralf
author_role author
author2 Bolontrade, Marcela Fabiana
Defilippi, Paola
Weiskirchen, Ralf
author2_role author
author
author
dc.subject.none.fl_str_mv BILIARY TRACT DISEASES
SECRETOME
CHOLANGIOCYTE
EXTRACELLULAR VESICLES
topic BILIARY TRACT DISEASES
SECRETOME
CHOLANGIOCYTE
EXTRACELLULAR VESICLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches.
Fil: Fagoonee, Sharmila. Institute of Biostructure and Bioimaging; Italia
Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Defilippi, Paola. Università di Torino; Italia
Fil: Weiskirchen, Ralf. University Hospital Aachen; Alemania
description Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches.
publishDate 2025
dc.date.none.fl_str_mv 2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271542
Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf; The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies; MDPI; Cells; 14; 16; 8-2025; 1-19
2073-4409
2073-4409
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271542
identifier_str_mv Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf; The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies; MDPI; Cells; 14; 16; 8-2025; 1-19
2073-4409
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/14/16/1274
info:eu-repo/semantics/altIdentifier/doi/10.3390/cells14161274
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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