The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies
- Autores
- Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches.
Fil: Fagoonee, Sharmila. Institute of Biostructure and Bioimaging; Italia
Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Defilippi, Paola. Università di Torino; Italia
Fil: Weiskirchen, Ralf. University Hospital Aachen; Alemania - Materia
-
BILIARY TRACT DISEASES
SECRETOME
CHOLANGIOCYTE
EXTRACELLULAR VESICLES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/271542
Ver los metadatos del registro completo
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The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and CholangiopathiesFagoonee, SharmilaBolontrade, Marcela FabianaDefilippi, PaolaWeiskirchen, RalfBILIARY TRACT DISEASESSECRETOMECHOLANGIOCYTEEXTRACELLULAR VESICLEShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches.Fil: Fagoonee, Sharmila. Institute of Biostructure and Bioimaging; ItaliaFil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Defilippi, Paola. Università di Torino; ItaliaFil: Weiskirchen, Ralf. University Hospital Aachen; AlemaniaMDPI2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271542Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf; The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies; MDPI; Cells; 14; 16; 8-2025; 1-192073-44092073-4409CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/14/16/1274info:eu-repo/semantics/altIdentifier/doi/10.3390/cells14161274info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:14Zoai:ri.conicet.gov.ar:11336/271542instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:15.228CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies |
title |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies |
spellingShingle |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies Fagoonee, Sharmila BILIARY TRACT DISEASES SECRETOME CHOLANGIOCYTE EXTRACELLULAR VESICLES |
title_short |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies |
title_full |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies |
title_fullStr |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies |
title_full_unstemmed |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies |
title_sort |
The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies |
dc.creator.none.fl_str_mv |
Fagoonee, Sharmila Bolontrade, Marcela Fabiana Defilippi, Paola Weiskirchen, Ralf |
author |
Fagoonee, Sharmila |
author_facet |
Fagoonee, Sharmila Bolontrade, Marcela Fabiana Defilippi, Paola Weiskirchen, Ralf |
author_role |
author |
author2 |
Bolontrade, Marcela Fabiana Defilippi, Paola Weiskirchen, Ralf |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
BILIARY TRACT DISEASES SECRETOME CHOLANGIOCYTE EXTRACELLULAR VESICLES |
topic |
BILIARY TRACT DISEASES SECRETOME CHOLANGIOCYTE EXTRACELLULAR VESICLES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches. Fil: Fagoonee, Sharmila. Institute of Biostructure and Bioimaging; Italia Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina Fil: Defilippi, Paola. Università di Torino; Italia Fil: Weiskirchen, Ralf. University Hospital Aachen; Alemania |
description |
Cholangiopathies, a diverse group of diseases affecting the biliary tract, are characterized by ac-tivation of cholangiocytes, fibrosis, and inflammation. Recent research hasidentified extracellular vesicles (EVs) as crucial mediators of communication within the hepatobiliary system. This review aims to explore the impact of EVs on cholangiocyte behavior and their role in disease develop-ment. EVs originating from cholangiocytes, hepatocytes, and immune cells carry a variety of mol-ecules, including non-coding RNAs, proteins, and lipids, which influence immune responses, fi-brosis, and epithelial repair. Specifically, EVs released by activated or senescent cholangiocytes can worsen inflammation and fibrosis by delivering molecules such as lncRNA H19, miR-21, and damage-associated molecular patterns(DAMPs) to hepatic stellate and immune cells. Additionally, the polarity and content of EVs are influenced by specific subcellular domains of cholangiocytes, indicating distinct signaling functions. In conditions such as primary sclerosing cholangitis (PSC), cholangiocarcinoma (CCA), and biliary atresia, EVs play a role in disease progression and offer potential as non-invasive biomarkers and therapeutic targets. This review underscores the im-portance of in-depth profiling and validation of EVs to fully utilize their diagnostic and therapeu-tic capabilities. Overall, EV-mediated signaling is a critical mechanism in cholangiopathies, providing a new avenue for understanding disease progression and developing precision medi-cine approaches. |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/271542 Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf; The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies; MDPI; Cells; 14; 16; 8-2025; 1-19 2073-4409 2073-4409 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/271542 |
identifier_str_mv |
Fagoonee, Sharmila; Bolontrade, Marcela Fabiana; Defilippi, Paola; Weiskirchen, Ralf; The Role of Extracellular Vesicles in Mediating Signaling in Biliary Epithelial Cell Activation and Cholangiopathies; MDPI; Cells; 14; 16; 8-2025; 1-19 2073-4409 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/14/16/1274 info:eu-repo/semantics/altIdentifier/doi/10.3390/cells14161274 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |