Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

Autores
Perello, Mario; Sakata, Ichiro; Birnbaum, Shari; Chuang, Jen-Chieh; Osborne Lawrence, Sherri; Rovinsky, Sherry A.; Woloszyn, Jakub; Yanagisawa, Masashi; Lutter, Michael; Zigman, Jeffrey M.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic, hedonic aspects of eating behavior. Methods: In the current study, we assessed the effects of different pharmacological, physiological, and genetic models of increased ghrelin and/or ghrelin-signaling blockade on two classic behavioral tests of reward behavior: conditioned place preference (CPP) and operant conditioning. Results: Using both CPP and operant conditioning, we found that ghrelin enhanced the rewarding value of high-fat diet (HFD) when administered to ad lib-fed mice. Conversely, wild-type mice treated with ghrelin receptor antagonist and ghrelin receptor-null mice both failed to show CPP to HFD normally observed under calorie restriction. Interestingly, neither pharmacologic nor genetic blockade of ghrelin signaling inhibited the body weight homeostasis-related, compensatory hyperphagia associated with chronic calorie restriction. Also, ghrelin’s effects on HFD reward were blocked in orexin-deficient mice and wild-type mice treated with an orexin 1 receptor antagonist. Conclusions: Our results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Sakata, Ichiro. Saitama University; Japón
Fil: Birnbaum, Shari. UT Southwestern Medical Center; Estados Unidos
Fil: Chuang, Jen-Chieh. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Osborne Lawrence, Sherri. UT Southwestern Medical Center; Estados Unidos
Fil: Rovinsky, Sherry A.. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Woloszyn, Jakub. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Yanagisawa, Masashi. University of Tsukuba; Japón
Fil: Lutter, Michael. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas Southwestern Medical Center; Estados Unidos
Materia
Ghrelin
Food intake
Orexin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280325
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/280325
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network_name_str CONICET Digital (CONICET)
spelling Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent MannerPerello, MarioSakata, IchiroBirnbaum, ShariChuang, Jen-ChiehOsborne Lawrence, SherriRovinsky, Sherry A.Woloszyn, JakubYanagisawa, MasashiLutter, MichaelZigman, Jeffrey M.GhrelinFood intakeOrexinhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic, hedonic aspects of eating behavior. Methods: In the current study, we assessed the effects of different pharmacological, physiological, and genetic models of increased ghrelin and/or ghrelin-signaling blockade on two classic behavioral tests of reward behavior: conditioned place preference (CPP) and operant conditioning. Results: Using both CPP and operant conditioning, we found that ghrelin enhanced the rewarding value of high-fat diet (HFD) when administered to ad lib-fed mice. Conversely, wild-type mice treated with ghrelin receptor antagonist and ghrelin receptor-null mice both failed to show CPP to HFD normally observed under calorie restriction. Interestingly, neither pharmacologic nor genetic blockade of ghrelin signaling inhibited the body weight homeostasis-related, compensatory hyperphagia associated with chronic calorie restriction. Also, ghrelin’s effects on HFD reward were blocked in orexin-deficient mice and wild-type mice treated with an orexin 1 receptor antagonist. Conclusions: Our results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Sakata, Ichiro. Saitama University; JapónFil: Birnbaum, Shari. UT Southwestern Medical Center; Estados UnidosFil: Chuang, Jen-Chieh. University of Texas Southwestern Medical Center; Estados UnidosFil: Osborne Lawrence, Sherri. UT Southwestern Medical Center; Estados UnidosFil: Rovinsky, Sherry A.. University of Texas Southwestern Medical Center; Estados UnidosFil: Woloszyn, Jakub. University of Texas Southwestern Medical Center; Estados UnidosFil: Yanagisawa, Masashi. University of Tsukuba; JapónFil: Lutter, Michael. University of Texas Southwestern Medical Center; Estados UnidosFil: Zigman, Jeffrey M.. University of Texas Southwestern Medical Center; Estados UnidosElsevier Science Inc.2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280325Perello, Mario; Sakata, Ichiro; Birnbaum, Shari; Chuang, Jen-Chieh; Osborne Lawrence, Sherri; et al.; Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner; Elsevier Science Inc.; Biological Psychiatry; 67; 9; 5-2010; 880-8860006-3223CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0006322309013183info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsych.2009.10.030info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:29:26Zoai:ri.conicet.gov.ar:11336/280325instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:29:26.463CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
title Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
spellingShingle Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
Perello, Mario
Ghrelin
Food intake
Orexin
title_short Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
title_full Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
title_fullStr Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
title_full_unstemmed Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
title_sort Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner
dc.creator.none.fl_str_mv Perello, Mario
Sakata, Ichiro
Birnbaum, Shari
Chuang, Jen-Chieh
Osborne Lawrence, Sherri
Rovinsky, Sherry A.
Woloszyn, Jakub
Yanagisawa, Masashi
Lutter, Michael
Zigman, Jeffrey M.
author Perello, Mario
author_facet Perello, Mario
Sakata, Ichiro
Birnbaum, Shari
Chuang, Jen-Chieh
Osborne Lawrence, Sherri
Rovinsky, Sherry A.
Woloszyn, Jakub
Yanagisawa, Masashi
Lutter, Michael
Zigman, Jeffrey M.
author_role author
author2 Sakata, Ichiro
Birnbaum, Shari
Chuang, Jen-Chieh
Osborne Lawrence, Sherri
Rovinsky, Sherry A.
Woloszyn, Jakub
Yanagisawa, Masashi
Lutter, Michael
Zigman, Jeffrey M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ghrelin
Food intake
Orexin
topic Ghrelin
Food intake
Orexin
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic, hedonic aspects of eating behavior. Methods: In the current study, we assessed the effects of different pharmacological, physiological, and genetic models of increased ghrelin and/or ghrelin-signaling blockade on two classic behavioral tests of reward behavior: conditioned place preference (CPP) and operant conditioning. Results: Using both CPP and operant conditioning, we found that ghrelin enhanced the rewarding value of high-fat diet (HFD) when administered to ad lib-fed mice. Conversely, wild-type mice treated with ghrelin receptor antagonist and ghrelin receptor-null mice both failed to show CPP to HFD normally observed under calorie restriction. Interestingly, neither pharmacologic nor genetic blockade of ghrelin signaling inhibited the body weight homeostasis-related, compensatory hyperphagia associated with chronic calorie restriction. Also, ghrelin’s effects on HFD reward were blocked in orexin-deficient mice and wild-type mice treated with an orexin 1 receptor antagonist. Conclusions: Our results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Sakata, Ichiro. Saitama University; Japón
Fil: Birnbaum, Shari. UT Southwestern Medical Center; Estados Unidos
Fil: Chuang, Jen-Chieh. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Osborne Lawrence, Sherri. UT Southwestern Medical Center; Estados Unidos
Fil: Rovinsky, Sherry A.. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Woloszyn, Jakub. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Yanagisawa, Masashi. University of Tsukuba; Japón
Fil: Lutter, Michael. University of Texas Southwestern Medical Center; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas Southwestern Medical Center; Estados Unidos
description Background: Ghrelin is a potent orexigenic hormone that likely impacts eating via several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic, hedonic aspects of eating behavior. Methods: In the current study, we assessed the effects of different pharmacological, physiological, and genetic models of increased ghrelin and/or ghrelin-signaling blockade on two classic behavioral tests of reward behavior: conditioned place preference (CPP) and operant conditioning. Results: Using both CPP and operant conditioning, we found that ghrelin enhanced the rewarding value of high-fat diet (HFD) when administered to ad lib-fed mice. Conversely, wild-type mice treated with ghrelin receptor antagonist and ghrelin receptor-null mice both failed to show CPP to HFD normally observed under calorie restriction. Interestingly, neither pharmacologic nor genetic blockade of ghrelin signaling inhibited the body weight homeostasis-related, compensatory hyperphagia associated with chronic calorie restriction. Also, ghrelin’s effects on HFD reward were blocked in orexin-deficient mice and wild-type mice treated with an orexin 1 receptor antagonist. Conclusions: Our results demonstrate an obligatory role for ghrelin in certain rewarding aspects of eating that is separate from eating associated with body weight homeostasis and that requires the presence of intact orexin signaling.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280325
Perello, Mario; Sakata, Ichiro; Birnbaum, Shari; Chuang, Jen-Chieh; Osborne Lawrence, Sherri; et al.; Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner; Elsevier Science Inc.; Biological Psychiatry; 67; 9; 5-2010; 880-886
0006-3223
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280325
identifier_str_mv Perello, Mario; Sakata, Ichiro; Birnbaum, Shari; Chuang, Jen-Chieh; Osborne Lawrence, Sherri; et al.; Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner; Elsevier Science Inc.; Biological Psychiatry; 67; 9; 5-2010; 880-886
0006-3223
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0006322309013183
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsych.2009.10.030
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.665996

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