4D Computed Tomography Analysis of the Bicuspid Aortic Valve

Autores
Fikani, Amine; Craiem, Damian; Cuenin, Cyrille; Soulat, Gilles; Mousseaux, Elie; Jouan, Jerome
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: To evaluate the role of 4D (3D+time) analysis using multiphase cardiac computed tomography (MCCT) in the description of the aortic annulus (AA) of bicuspid aortic valves (BAV) with regards to the latest expert consensus classification. Methods: ECG-gated MCCT of 15 patients with BAV were analyzed using an in-house software and compared to 15 patients with normal tricuspid aortic valve (TAV). The AA border was pinpointed on 9 reconstructed planes and the 3D coordinates of the 18 consecutive points were interpolated in 3D using a cubic spline to calculate 3D areas, perimeters, diameters, eccentricity indexes and global height. Measurements were repeated through the cardiac cycle (10 phases). Three additional planes were generated at the level of the left ventricular outflow tract (LVOT), the Valsalva sinuses and the sinotubular junction (STJ). Results: The annulus area was significantly larger in BAV than in TAV (Mean indexed 3D area 5.64±0.84 cm²/m2 vs 4.3±0.38 cm²/m² respectively, < 0.001). The AA was also larger in BAV than in TAV in terms of perimeter, diameters, and height (p<0.001). The Valsalva sinuses and the STJ were also significantly larger in BAV compared to TAV (mean area in end-diastole of 6.06±1.00 cm² vs 4.69±1.00 cm², p<0.001 and 5.13±1.62 cm² vs 3.62±0.99 cm², p<0.001 respectively). In BAV, 3D AA shape analysis helps to distinguish the 3 types of BAV: the 2-sinus type (symmetrical), the fused type, and the partial-fusion type or “form fruste” (both asymmetrical). It also allows to determine the position and the height of the nonfunctional commissure. In symmetrical BAV, the non-functional commissure was significantly lower than the other commissures (6.01±4.27mm vs 18.24±3.20mm vs 17.15±3.60mm, p <0.001) whereas in asymmetrical BAV, the 3 commissures had comparable heights (16.38±0.86mm vs 15.88±1.69mm vs 15.37±0.88mm, p=0.316). There was no difference in AA eccentricity indexes between TAV and BAV in all phases of the cardiac cycle.  However, there was a spectrum of ellipticity for the other components of the aortic root between the different types of valves: going from TAV to asymmetrical BAV to symmetrical BAV, at end-diastole, the LVOT became more circular, and the Valsalva sinuses became more elliptical. Conclusion: 3D morphometric analysis of the BAV using MCCT allows to identify the type of BAV, and to describe the position and height of the nonfunctional commissure. There are significant differences in the morphology of the aortic root between TAV and the different types of BAV. Further studies should be done to evaluate the impact of 3D analysis on the procedural planning of pathological BAV.
Fil: Fikani, Amine. Universite de Limoges; Francia
Fil: Craiem, Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
Fil: Cuenin, Cyrille. Universite de Limoges; Francia
Fil: Soulat, Gilles. Hopital Europeen Georges Pompidou; Francia
Fil: Mousseaux, Elie. Hopital Europeen Georges Pompidou; Francia
Fil: Jouan, Jerome. Universite de Limoges; Francia
Materia
BICUSPID AORTIC VALVE
AORTIC ROOT
AORTIC ANNULUS
COMPUTED TOMOGRAPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/261010

id CONICETDig_3bc39a0968f1d2e3e9edb4fbe4fee90f
oai_identifier_str oai:ri.conicet.gov.ar:11336/261010
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 4D Computed Tomography Analysis of the Bicuspid Aortic ValveFikani, AmineCraiem, DamianCuenin, CyrilleSoulat, GillesMousseaux, ElieJouan, JeromeBICUSPID AORTIC VALVEAORTIC ROOTAORTIC ANNULUSCOMPUTED TOMOGRAPHYhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Objectives: To evaluate the role of 4D (3D+time) analysis using multiphase cardiac computed tomography (MCCT) in the description of the aortic annulus (AA) of bicuspid aortic valves (BAV) with regards to the latest expert consensus classification. Methods: ECG-gated MCCT of 15 patients with BAV were analyzed using an in-house software and compared to 15 patients with normal tricuspid aortic valve (TAV). The AA border was pinpointed on 9 reconstructed planes and the 3D coordinates of the 18 consecutive points were interpolated in 3D using a cubic spline to calculate 3D areas, perimeters, diameters, eccentricity indexes and global height. Measurements were repeated through the cardiac cycle (10 phases). Three additional planes were generated at the level of the left ventricular outflow tract (LVOT), the Valsalva sinuses and the sinotubular junction (STJ). Results: The annulus area was significantly larger in BAV than in TAV (Mean indexed 3D area 5.64±0.84 cm²/m2 vs 4.3±0.38 cm²/m² respectively, < 0.001). The AA was also larger in BAV than in TAV in terms of perimeter, diameters, and height (p<0.001). The Valsalva sinuses and the STJ were also significantly larger in BAV compared to TAV (mean area in end-diastole of 6.06±1.00 cm² vs 4.69±1.00 cm², p<0.001 and 5.13±1.62 cm² vs 3.62±0.99 cm², p<0.001 respectively). In BAV, 3D AA shape analysis helps to distinguish the 3 types of BAV: the 2-sinus type (symmetrical), the fused type, and the partial-fusion type or “form fruste” (both asymmetrical). It also allows to determine the position and the height of the nonfunctional commissure. In symmetrical BAV, the non-functional commissure was significantly lower than the other commissures (6.01±4.27mm vs 18.24±3.20mm vs 17.15±3.60mm, p <0.001) whereas in asymmetrical BAV, the 3 commissures had comparable heights (16.38±0.86mm vs 15.88±1.69mm vs 15.37±0.88mm, p=0.316). There was no difference in AA eccentricity indexes between TAV and BAV in all phases of the cardiac cycle.  However, there was a spectrum of ellipticity for the other components of the aortic root between the different types of valves: going from TAV to asymmetrical BAV to symmetrical BAV, at end-diastole, the LVOT became more circular, and the Valsalva sinuses became more elliptical. Conclusion: 3D morphometric analysis of the BAV using MCCT allows to identify the type of BAV, and to describe the position and height of the nonfunctional commissure. There are significant differences in the morphology of the aortic root between TAV and the different types of BAV. Further studies should be done to evaluate the impact of 3D analysis on the procedural planning of pathological BAV.Fil: Fikani, Amine. Universite de Limoges; FranciaFil: Craiem, Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; ArgentinaFil: Cuenin, Cyrille. Universite de Limoges; FranciaFil: Soulat, Gilles. Hopital Europeen Georges Pompidou; FranciaFil: Mousseaux, Elie. Hopital Europeen Georges Pompidou; FranciaFil: Jouan, Jerome. Universite de Limoges; FranciaElsevier2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261010Fikani, Amine; Craiem, Damian; Cuenin, Cyrille; Soulat, Gilles; Mousseaux, Elie; et al.; 4D Computed Tomography Analysis of the Bicuspid Aortic Valve; Elsevier; JTCVS Techniques; 27; 7-2024; 60-672666-2507CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S266625072400261Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.xjtc.2024.06.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:14Zoai:ri.conicet.gov.ar:11336/261010instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:14.673CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
title 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
spellingShingle 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
Fikani, Amine
BICUSPID AORTIC VALVE
AORTIC ROOT
AORTIC ANNULUS
COMPUTED TOMOGRAPHY
title_short 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
title_full 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
title_fullStr 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
title_full_unstemmed 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
title_sort 4D Computed Tomography Analysis of the Bicuspid Aortic Valve
dc.creator.none.fl_str_mv Fikani, Amine
Craiem, Damian
Cuenin, Cyrille
Soulat, Gilles
Mousseaux, Elie
Jouan, Jerome
author Fikani, Amine
author_facet Fikani, Amine
Craiem, Damian
Cuenin, Cyrille
Soulat, Gilles
Mousseaux, Elie
Jouan, Jerome
author_role author
author2 Craiem, Damian
Cuenin, Cyrille
Soulat, Gilles
Mousseaux, Elie
Jouan, Jerome
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BICUSPID AORTIC VALVE
AORTIC ROOT
AORTIC ANNULUS
COMPUTED TOMOGRAPHY
topic BICUSPID AORTIC VALVE
AORTIC ROOT
AORTIC ANNULUS
COMPUTED TOMOGRAPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Objectives: To evaluate the role of 4D (3D+time) analysis using multiphase cardiac computed tomography (MCCT) in the description of the aortic annulus (AA) of bicuspid aortic valves (BAV) with regards to the latest expert consensus classification. Methods: ECG-gated MCCT of 15 patients with BAV were analyzed using an in-house software and compared to 15 patients with normal tricuspid aortic valve (TAV). The AA border was pinpointed on 9 reconstructed planes and the 3D coordinates of the 18 consecutive points were interpolated in 3D using a cubic spline to calculate 3D areas, perimeters, diameters, eccentricity indexes and global height. Measurements were repeated through the cardiac cycle (10 phases). Three additional planes were generated at the level of the left ventricular outflow tract (LVOT), the Valsalva sinuses and the sinotubular junction (STJ). Results: The annulus area was significantly larger in BAV than in TAV (Mean indexed 3D area 5.64±0.84 cm²/m2 vs 4.3±0.38 cm²/m² respectively, < 0.001). The AA was also larger in BAV than in TAV in terms of perimeter, diameters, and height (p<0.001). The Valsalva sinuses and the STJ were also significantly larger in BAV compared to TAV (mean area in end-diastole of 6.06±1.00 cm² vs 4.69±1.00 cm², p<0.001 and 5.13±1.62 cm² vs 3.62±0.99 cm², p<0.001 respectively). In BAV, 3D AA shape analysis helps to distinguish the 3 types of BAV: the 2-sinus type (symmetrical), the fused type, and the partial-fusion type or “form fruste” (both asymmetrical). It also allows to determine the position and the height of the nonfunctional commissure. In symmetrical BAV, the non-functional commissure was significantly lower than the other commissures (6.01±4.27mm vs 18.24±3.20mm vs 17.15±3.60mm, p <0.001) whereas in asymmetrical BAV, the 3 commissures had comparable heights (16.38±0.86mm vs 15.88±1.69mm vs 15.37±0.88mm, p=0.316). There was no difference in AA eccentricity indexes between TAV and BAV in all phases of the cardiac cycle.  However, there was a spectrum of ellipticity for the other components of the aortic root between the different types of valves: going from TAV to asymmetrical BAV to symmetrical BAV, at end-diastole, the LVOT became more circular, and the Valsalva sinuses became more elliptical. Conclusion: 3D morphometric analysis of the BAV using MCCT allows to identify the type of BAV, and to describe the position and height of the nonfunctional commissure. There are significant differences in the morphology of the aortic root between TAV and the different types of BAV. Further studies should be done to evaluate the impact of 3D analysis on the procedural planning of pathological BAV.
Fil: Fikani, Amine. Universite de Limoges; Francia
Fil: Craiem, Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
Fil: Cuenin, Cyrille. Universite de Limoges; Francia
Fil: Soulat, Gilles. Hopital Europeen Georges Pompidou; Francia
Fil: Mousseaux, Elie. Hopital Europeen Georges Pompidou; Francia
Fil: Jouan, Jerome. Universite de Limoges; Francia
description Objectives: To evaluate the role of 4D (3D+time) analysis using multiphase cardiac computed tomography (MCCT) in the description of the aortic annulus (AA) of bicuspid aortic valves (BAV) with regards to the latest expert consensus classification. Methods: ECG-gated MCCT of 15 patients with BAV were analyzed using an in-house software and compared to 15 patients with normal tricuspid aortic valve (TAV). The AA border was pinpointed on 9 reconstructed planes and the 3D coordinates of the 18 consecutive points were interpolated in 3D using a cubic spline to calculate 3D areas, perimeters, diameters, eccentricity indexes and global height. Measurements were repeated through the cardiac cycle (10 phases). Three additional planes were generated at the level of the left ventricular outflow tract (LVOT), the Valsalva sinuses and the sinotubular junction (STJ). Results: The annulus area was significantly larger in BAV than in TAV (Mean indexed 3D area 5.64±0.84 cm²/m2 vs 4.3±0.38 cm²/m² respectively, < 0.001). The AA was also larger in BAV than in TAV in terms of perimeter, diameters, and height (p<0.001). The Valsalva sinuses and the STJ were also significantly larger in BAV compared to TAV (mean area in end-diastole of 6.06±1.00 cm² vs 4.69±1.00 cm², p<0.001 and 5.13±1.62 cm² vs 3.62±0.99 cm², p<0.001 respectively). In BAV, 3D AA shape analysis helps to distinguish the 3 types of BAV: the 2-sinus type (symmetrical), the fused type, and the partial-fusion type or “form fruste” (both asymmetrical). It also allows to determine the position and the height of the nonfunctional commissure. In symmetrical BAV, the non-functional commissure was significantly lower than the other commissures (6.01±4.27mm vs 18.24±3.20mm vs 17.15±3.60mm, p <0.001) whereas in asymmetrical BAV, the 3 commissures had comparable heights (16.38±0.86mm vs 15.88±1.69mm vs 15.37±0.88mm, p=0.316). There was no difference in AA eccentricity indexes between TAV and BAV in all phases of the cardiac cycle.  However, there was a spectrum of ellipticity for the other components of the aortic root between the different types of valves: going from TAV to asymmetrical BAV to symmetrical BAV, at end-diastole, the LVOT became more circular, and the Valsalva sinuses became more elliptical. Conclusion: 3D morphometric analysis of the BAV using MCCT allows to identify the type of BAV, and to describe the position and height of the nonfunctional commissure. There are significant differences in the morphology of the aortic root between TAV and the different types of BAV. Further studies should be done to evaluate the impact of 3D analysis on the procedural planning of pathological BAV.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/261010
Fikani, Amine; Craiem, Damian; Cuenin, Cyrille; Soulat, Gilles; Mousseaux, Elie; et al.; 4D Computed Tomography Analysis of the Bicuspid Aortic Valve; Elsevier; JTCVS Techniques; 27; 7-2024; 60-67
2666-2507
CONICET Digital
CONICET
url http://hdl.handle.net/11336/261010
identifier_str_mv Fikani, Amine; Craiem, Damian; Cuenin, Cyrille; Soulat, Gilles; Mousseaux, Elie; et al.; 4D Computed Tomography Analysis of the Bicuspid Aortic Valve; Elsevier; JTCVS Techniques; 27; 7-2024; 60-67
2666-2507
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S266625072400261X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.xjtc.2024.06.012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269745756241920
score 13.13397