Statement of Argentine pediatric endocrinologists on growth hormone interchangeability
- Autores
- Alonso, Guillermo; Balbi, Viviana; Bazán de Casella, María Cristina del Valle; Belgorosky, Alicia; Bergadá, Ignacio; Brunetto, Oscar; Cassinelli, Hamilton Raul; Ciaccio, Marta Graciela Cristina; Keselman, Ana Claudia; Miras, Mirta Beatriz; Morín, Analía
- Año de publicación
- 2019
- Idioma
- español castellano
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Growth hormone (GH), just like vaccines, antibodies, and other hormones, is a biological medicinal product (BMP); therefore, it is produced by a complex mechanism that is specific to each (trademark) product. BMPs are subjected to prolonged, comprehensive assessment processes and must be approved prior to their use. The patents of early recombinant human GHs are starting to expire, and this has encouraged pharmaceutical companies to manufacture GH in accordance with the processes corresponding to the original products, thus resulting in biosimilar recombinant GH. In Argentina, there are seven different GH trademarks; only one is a biosimilar product: Omnitrope® (Sandoz) is biosimilar to Genotropin® (Pfizer). Other products available in the market include HHT® (Biosidus), Hutrope® (Elly Lilly), NorditropinFlexpro® (Novo Nordisk), Saizen® (Merck), and Zomacton® (Ferring). For an adequate understanding of this article, it is important to outline the characteristics of the different BMPs.1-5
Fil: Alonso, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Balbi, Viviana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bazán de Casella, María Cristina del Valle. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Belgorosky, Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Brunetto, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Cassinelli, Hamilton Raul. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ciaccio, Marta Graciela Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Keselman, Ana Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Miras, Mirta Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Morín, Analía. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina - Materia
-
GH
DNA
INTERCHANGEABILITY
BMP - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/175511
Ver los metadatos del registro completo
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Statement of Argentine pediatric endocrinologists on growth hormone interchangeabilityAlonso, GuillermoBalbi, VivianaBazán de Casella, María Cristina del ValleBelgorosky, AliciaBergadá, IgnacioBrunetto, OscarCassinelli, Hamilton RaulCiaccio, Marta Graciela CristinaKeselman, Ana ClaudiaMiras, Mirta BeatrizMorín, AnalíaGHDNAINTERCHANGEABILITYBMPhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Growth hormone (GH), just like vaccines, antibodies, and other hormones, is a biological medicinal product (BMP); therefore, it is produced by a complex mechanism that is specific to each (trademark) product. BMPs are subjected to prolonged, comprehensive assessment processes and must be approved prior to their use. The patents of early recombinant human GHs are starting to expire, and this has encouraged pharmaceutical companies to manufacture GH in accordance with the processes corresponding to the original products, thus resulting in biosimilar recombinant GH. In Argentina, there are seven different GH trademarks; only one is a biosimilar product: Omnitrope® (Sandoz) is biosimilar to Genotropin® (Pfizer). Other products available in the market include HHT® (Biosidus), Hutrope® (Elly Lilly), NorditropinFlexpro® (Novo Nordisk), Saizen® (Merck), and Zomacton® (Ferring). For an adequate understanding of this article, it is important to outline the characteristics of the different BMPs.1-5Fil: Alonso, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Balbi, Viviana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Bazán de Casella, María Cristina del Valle. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Belgorosky, Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Brunetto, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Cassinelli, Hamilton Raul. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Ciaccio, Marta Graciela Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Keselman, Ana Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Miras, Mirta Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Morín, Analía. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaSociedad Argentina de Pediatría2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175511Alonso, Guillermo; Balbi, Viviana; Bazán de Casella, María Cristina del Valle; Belgorosky, Alicia; Bergadá, Ignacio; et al.; Statement of Argentine pediatric endocrinologists on growth hormone interchangeability; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 117; 4; 11-2019; 212-2150325-00751668-3501CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2019.eng.213info:eu-repo/semantics/altIdentifier/url/https://www.sap.org.ar/docs/publicaciones/archivosarg/2019/v117n4a03e.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:36Zoai:ri.conicet.gov.ar:11336/175511instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:37.124CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability |
| title |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability |
| spellingShingle |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability Alonso, Guillermo GH DNA INTERCHANGEABILITY BMP |
| title_short |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability |
| title_full |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability |
| title_fullStr |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability |
| title_full_unstemmed |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability |
| title_sort |
Statement of Argentine pediatric endocrinologists on growth hormone interchangeability |
| dc.creator.none.fl_str_mv |
Alonso, Guillermo Balbi, Viviana Bazán de Casella, María Cristina del Valle Belgorosky, Alicia Bergadá, Ignacio Brunetto, Oscar Cassinelli, Hamilton Raul Ciaccio, Marta Graciela Cristina Keselman, Ana Claudia Miras, Mirta Beatriz Morín, Analía |
| author |
Alonso, Guillermo |
| author_facet |
Alonso, Guillermo Balbi, Viviana Bazán de Casella, María Cristina del Valle Belgorosky, Alicia Bergadá, Ignacio Brunetto, Oscar Cassinelli, Hamilton Raul Ciaccio, Marta Graciela Cristina Keselman, Ana Claudia Miras, Mirta Beatriz Morín, Analía |
| author_role |
author |
| author2 |
Balbi, Viviana Bazán de Casella, María Cristina del Valle Belgorosky, Alicia Bergadá, Ignacio Brunetto, Oscar Cassinelli, Hamilton Raul Ciaccio, Marta Graciela Cristina Keselman, Ana Claudia Miras, Mirta Beatriz Morín, Analía |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
GH DNA INTERCHANGEABILITY BMP |
| topic |
GH DNA INTERCHANGEABILITY BMP |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Growth hormone (GH), just like vaccines, antibodies, and other hormones, is a biological medicinal product (BMP); therefore, it is produced by a complex mechanism that is specific to each (trademark) product. BMPs are subjected to prolonged, comprehensive assessment processes and must be approved prior to their use. The patents of early recombinant human GHs are starting to expire, and this has encouraged pharmaceutical companies to manufacture GH in accordance with the processes corresponding to the original products, thus resulting in biosimilar recombinant GH. In Argentina, there are seven different GH trademarks; only one is a biosimilar product: Omnitrope® (Sandoz) is biosimilar to Genotropin® (Pfizer). Other products available in the market include HHT® (Biosidus), Hutrope® (Elly Lilly), NorditropinFlexpro® (Novo Nordisk), Saizen® (Merck), and Zomacton® (Ferring). For an adequate understanding of this article, it is important to outline the characteristics of the different BMPs.1-5 Fil: Alonso, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Balbi, Viviana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Bazán de Casella, María Cristina del Valle. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Belgorosky, Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Brunetto, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Cassinelli, Hamilton Raul. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Ciaccio, Marta Graciela Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Keselman, Ana Claudia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Miras, Mirta Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Morín, Analía. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina |
| description |
Growth hormone (GH), just like vaccines, antibodies, and other hormones, is a biological medicinal product (BMP); therefore, it is produced by a complex mechanism that is specific to each (trademark) product. BMPs are subjected to prolonged, comprehensive assessment processes and must be approved prior to their use. The patents of early recombinant human GHs are starting to expire, and this has encouraged pharmaceutical companies to manufacture GH in accordance with the processes corresponding to the original products, thus resulting in biosimilar recombinant GH. In Argentina, there are seven different GH trademarks; only one is a biosimilar product: Omnitrope® (Sandoz) is biosimilar to Genotropin® (Pfizer). Other products available in the market include HHT® (Biosidus), Hutrope® (Elly Lilly), NorditropinFlexpro® (Novo Nordisk), Saizen® (Merck), and Zomacton® (Ferring). For an adequate understanding of this article, it is important to outline the characteristics of the different BMPs.1-5 |
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2019 |
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2019-11 |
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http://hdl.handle.net/11336/175511 Alonso, Guillermo; Balbi, Viviana; Bazán de Casella, María Cristina del Valle; Belgorosky, Alicia; Bergadá, Ignacio; et al.; Statement of Argentine pediatric endocrinologists on growth hormone interchangeability; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 117; 4; 11-2019; 212-215 0325-0075 1668-3501 CONICET Digital CONICET |
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Alonso, Guillermo; Balbi, Viviana; Bazán de Casella, María Cristina del Valle; Belgorosky, Alicia; Bergadá, Ignacio; et al.; Statement of Argentine pediatric endocrinologists on growth hormone interchangeability; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 117; 4; 11-2019; 212-215 0325-0075 1668-3501 CONICET Digital CONICET |
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