Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers

Autores
Villanueva, Martín Eduardo; Lanterna, Anabel Estela; Vico, Raquel Viviana
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The interaction of hydrophobic silver nanoparticles with different phospholipids and stratum corneum mimic (SCM) membranes is studied in Langmuir monolayers. Thus, silver nanoparticles coated with oleic acid (AgNP-OA) were synthesized, characterized and incorporated in Langmuir monolayers of single phospholipids –having different chain length, saturation degree and phase state– or of a SCM mixture. The incorporation of AgNP-OA to the lipid monolayers generated an expansion of the monolayers and a decrease of the surface compressional modulus compared to the pure lipid. X-ray photoelectron spectroscopy (XPS) suggested that the zwitterionic choline-phospholipids can be adsorbed onto the nanoparticles’ surface, which is relevant considering that phospholipids are the major constituents of the cell membrane. We also studied the changes in the topography at the mesoscale level using Brewster angle microscopy. We found the most prominent changes in the lipids with liquid-condensed phase, such as SCM, showing segregation of their components. This could have major implications in the barrier function of the membrane, affecting for example the skin permeability towards hydrophobic nanoparticles. Finally, the capability of hydrophobic AgNP-OA for delivering Ag + ions was studied in aqueous media in the absence and presence of phospholipids. In both conditions, AgNP-OA released Ag + at reported-bactericidal concentrations, being double in the presence of phospholipids.
Fil: Villanueva, Martín Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Vico, Raquel Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
LANGMUIR MONOLAYERS
NANO-BIOINTERFACE
PHOSPHATIDYLCHOLINE ADSORPTION
PHOSPHOLIPIDS
SILVER ION DELIVERY
SILVER NANOPARTICLES
STRATUM CORNEUM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125446
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/125446
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayersVillanueva, Martín EduardoLanterna, Anabel EstelaVico, Raquel VivianaLANGMUIR MONOLAYERSNANO-BIOINTERFACEPHOSPHATIDYLCHOLINE ADSORPTIONPHOSPHOLIPIDSSILVER ION DELIVERYSILVER NANOPARTICLESSTRATUM CORNEUMhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The interaction of hydrophobic silver nanoparticles with different phospholipids and stratum corneum mimic (SCM) membranes is studied in Langmuir monolayers. Thus, silver nanoparticles coated with oleic acid (AgNP-OA) were synthesized, characterized and incorporated in Langmuir monolayers of single phospholipids –having different chain length, saturation degree and phase state– or of a SCM mixture. The incorporation of AgNP-OA to the lipid monolayers generated an expansion of the monolayers and a decrease of the surface compressional modulus compared to the pure lipid. X-ray photoelectron spectroscopy (XPS) suggested that the zwitterionic choline-phospholipids can be adsorbed onto the nanoparticles’ surface, which is relevant considering that phospholipids are the major constituents of the cell membrane. We also studied the changes in the topography at the mesoscale level using Brewster angle microscopy. We found the most prominent changes in the lipids with liquid-condensed phase, such as SCM, showing segregation of their components. This could have major implications in the barrier function of the membrane, affecting for example the skin permeability towards hydrophobic nanoparticles. Finally, the capability of hydrophobic AgNP-OA for delivering Ag + ions was studied in aqueous media in the absence and presence of phospholipids. In both conditions, AgNP-OA released Ag + at reported-bactericidal concentrations, being double in the presence of phospholipids.Fil: Villanueva, Martín Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Vico, Raquel Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaAcademic Press Inc Elsevier Science2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125446Villanueva, Martín Eduardo; Lanterna, Anabel Estela; Vico, Raquel Viviana; Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers; Academic Press Inc Elsevier Science; Journal of Colloid and Interface Science; 543; 5-2019; 247-2550021-9797CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021979719302437info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcis.2019.02.069info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:10:09Zoai:ri.conicet.gov.ar:11336/125446instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:10:09.911CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
title Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
spellingShingle Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
Villanueva, Martín Eduardo
LANGMUIR MONOLAYERS
NANO-BIOINTERFACE
PHOSPHATIDYLCHOLINE ADSORPTION
PHOSPHOLIPIDS
SILVER ION DELIVERY
SILVER NANOPARTICLES
STRATUM CORNEUM
title_short Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
title_full Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
title_fullStr Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
title_full_unstemmed Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
title_sort Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers
dc.creator.none.fl_str_mv Villanueva, Martín Eduardo
Lanterna, Anabel Estela
Vico, Raquel Viviana
author Villanueva, Martín Eduardo
author_facet Villanueva, Martín Eduardo
Lanterna, Anabel Estela
Vico, Raquel Viviana
author_role author
author2 Lanterna, Anabel Estela
Vico, Raquel Viviana
author2_role author
author
dc.subject.none.fl_str_mv LANGMUIR MONOLAYERS
NANO-BIOINTERFACE
PHOSPHATIDYLCHOLINE ADSORPTION
PHOSPHOLIPIDS
SILVER ION DELIVERY
SILVER NANOPARTICLES
STRATUM CORNEUM
topic LANGMUIR MONOLAYERS
NANO-BIOINTERFACE
PHOSPHATIDYLCHOLINE ADSORPTION
PHOSPHOLIPIDS
SILVER ION DELIVERY
SILVER NANOPARTICLES
STRATUM CORNEUM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The interaction of hydrophobic silver nanoparticles with different phospholipids and stratum corneum mimic (SCM) membranes is studied in Langmuir monolayers. Thus, silver nanoparticles coated with oleic acid (AgNP-OA) were synthesized, characterized and incorporated in Langmuir monolayers of single phospholipids –having different chain length, saturation degree and phase state– or of a SCM mixture. The incorporation of AgNP-OA to the lipid monolayers generated an expansion of the monolayers and a decrease of the surface compressional modulus compared to the pure lipid. X-ray photoelectron spectroscopy (XPS) suggested that the zwitterionic choline-phospholipids can be adsorbed onto the nanoparticles’ surface, which is relevant considering that phospholipids are the major constituents of the cell membrane. We also studied the changes in the topography at the mesoscale level using Brewster angle microscopy. We found the most prominent changes in the lipids with liquid-condensed phase, such as SCM, showing segregation of their components. This could have major implications in the barrier function of the membrane, affecting for example the skin permeability towards hydrophobic nanoparticles. Finally, the capability of hydrophobic AgNP-OA for delivering Ag + ions was studied in aqueous media in the absence and presence of phospholipids. In both conditions, AgNP-OA released Ag + at reported-bactericidal concentrations, being double in the presence of phospholipids.
Fil: Villanueva, Martín Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Lanterna, Anabel Estela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Vico, Raquel Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description The interaction of hydrophobic silver nanoparticles with different phospholipids and stratum corneum mimic (SCM) membranes is studied in Langmuir monolayers. Thus, silver nanoparticles coated with oleic acid (AgNP-OA) were synthesized, characterized and incorporated in Langmuir monolayers of single phospholipids –having different chain length, saturation degree and phase state– or of a SCM mixture. The incorporation of AgNP-OA to the lipid monolayers generated an expansion of the monolayers and a decrease of the surface compressional modulus compared to the pure lipid. X-ray photoelectron spectroscopy (XPS) suggested that the zwitterionic choline-phospholipids can be adsorbed onto the nanoparticles’ surface, which is relevant considering that phospholipids are the major constituents of the cell membrane. We also studied the changes in the topography at the mesoscale level using Brewster angle microscopy. We found the most prominent changes in the lipids with liquid-condensed phase, such as SCM, showing segregation of their components. This could have major implications in the barrier function of the membrane, affecting for example the skin permeability towards hydrophobic nanoparticles. Finally, the capability of hydrophobic AgNP-OA for delivering Ag + ions was studied in aqueous media in the absence and presence of phospholipids. In both conditions, AgNP-OA released Ag + at reported-bactericidal concentrations, being double in the presence of phospholipids.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125446
Villanueva, Martín Eduardo; Lanterna, Anabel Estela; Vico, Raquel Viviana; Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers; Academic Press Inc Elsevier Science; Journal of Colloid and Interface Science; 543; 5-2019; 247-255
0021-9797
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125446
identifier_str_mv Villanueva, Martín Eduardo; Lanterna, Anabel Estela; Vico, Raquel Viviana; Hydrophobic silver nanoparticles interacting with phospholipids and stratum corneum mimic membranes in Langmuir monolayers; Academic Press Inc Elsevier Science; Journal of Colloid and Interface Science; 543; 5-2019; 247-255
0021-9797
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021979719302437
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcis.2019.02.069
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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